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Sequential combinations of flavopiridol and docetaxel inhibit prostate tumors, induce apoptosis, and decrease angiogenesis in the Ggamma/T-15 transgenic mouse model of prostate cancer.
Reiner T, de las Pozas A, Perez-Stable C. Reiner T, et al. Prostate. 2006 Oct 1;66(14):1487-97. doi: 10.1002/pros.20478. Prostate. 2006. PMID: 16921509
An increase in apoptosis and a decrease in angiogenesis resulted in the greatest inhibition of prostate cancers....
An increase in apoptosis and a decrease in angiogenesis resulted in the greatest inhibition of prostate cancers....
Mcl-1 protects prostate cancer cells from cell death mediated by chemotherapy-induced DNA damage.
Reiner T, de Las Pozas A, Parrondo R, Palenzuela D, Cayuso W, Rai P, Perez-Stable C. Reiner T, et al. Among authors: de las pozas a. Oncoscience. 2015 Sep 1;2(8):703-15. doi: 10.18632/oncoscience.231. eCollection 2015. Oncoscience. 2015. PMID: 26425662 Free PMC article.
Betulinic acid selectively increases protein degradation and enhances prostate cancer-specific apoptosis: possible role for inhibition of deubiquitinase activity.
Reiner T, Parrondo R, de Las Pozas A, Palenzuela D, Perez-Stable C. Reiner T, et al. Among authors: de las pozas a. PLoS One. 2013;8(2):e56234. doi: 10.1371/journal.pone.0056234. Epub 2013 Feb 12. PLoS One. 2013. PMID: 23424652 Free PMC article.
NF-kappaB activation enhances cell death by antimitotic drugs in human prostate cancer cells.
Parrondo R, de las Pozas A, Reiner T, Rai P, Perez-Stable C. Parrondo R, et al. Among authors: de las pozas a. Mol Cancer. 2010 Jul 9;9:182. doi: 10.1186/1476-4598-9-182. Mol Cancer. 2010. PMID: 20618955 Free PMC article.
Low dose combinations of 2-methoxyestradiol and docetaxel block prostate cancer cells in mitosis and increase apoptosis.
Reiner T, de las Pozas A, Gomez LA, Perez-Stable C. Reiner T, et al. Among authors: de las pozas a. Cancer Lett. 2009 Apr 8;276(1):21-31. doi: 10.1016/j.canlet.2008.10.026. Epub 2008 Nov 28. Cancer Lett. 2009. PMID: 19046802
Progression of prostate cancer from a subset of p63-positive basal epithelial cells in FG/Tag transgenic mice.
Reiner T, de Las Pozas A, Parrondo R, Perez-Stable C. Reiner T, et al. Mol Cancer Res. 2007 Nov;5(11):1171-9. doi: 10.1158/1541-7786.MCR-07-0024. Epub 2007 Nov 2. Mol Cancer Res. 2007. PMID: 17982114
Transgenic mice that allow targeting of SV40 T antigen (Tag) to the prostate provide a unique model to identify cancer-initiating cells and follow their progression from a normal cell phenotype into prostate cancer cells. ...As in the case of human prostate cancer, …
Transgenic mice that allow targeting of SV40 T antigen (Tag) to the prostate provide a unique model to identify cancer-initiating cel …
Increased expression of cyclin B1 sensitizes prostate cancer cells to apoptosis induced by chemotherapy.
Gomez LA, de Las Pozas A, Reiner T, Burnstein K, Perez-Stable C. Gomez LA, et al. Mol Cancer Ther. 2007 May;6(5):1534-43. doi: 10.1158/1535-7163.MCT-06-0727. Mol Cancer Ther. 2007. PMID: 17513602
In this study, we established a positive correlation between cyclin B1 protein and apoptosis induced by chemotherapy in prostate cancer cells. ...Our results also suggest that higher levels of cyclin B1 in prostate cancer cells may be a good prognostic marker for ch …
In this study, we established a positive correlation between cyclin B1 protein and apoptosis induced by chemotherapy in prostate canc …
Sequential combination of flavopiridol and docetaxel reduces the levels of X-linked inhibitor of apoptosis and AKT proteins and stimulates apoptosis in human LNCaP prostate cancer cells.
Gomez LA, de Las Pozas A, Perez-Stable C. Gomez LA, et al. Mol Cancer Ther. 2006 May;5(5):1216-26. doi: 10.1158/1535-7163.MCT-05-0467. Mol Cancer Ther. 2006. PMID: 16731754
We investigated whether the combination of docetaxel and flavopiridol, a broad cyclin-dependent kinase inhibitor, can increase apoptotic cell death in prostate cancer cells. ...Overall, our data suggest that the docetaxel and flavopiridol combination requires a maxi …
We investigated whether the combination of docetaxel and flavopiridol, a broad cyclin-dependent kinase inhibitor, can increase apopto …
Low Oxygen Modulates Multiple Signaling Pathways, Increasing Self-Renewal, While Decreasing Differentiation, Senescence, and Apoptosis in Stromal MIAMI Cells.
Rios C, D'Ippolito G, Curtis KM, Delcroix GJ, Gomez LA, El Hokayem J, Rieger M, Parrondo R, de Las Pozas A, Perez-Stable C, Howard GA, Schiller PC. Rios C, et al. Among authors: de las pozas a. Stem Cells Dev. 2016 Jun 1;25(11):848-60. doi: 10.1089/scd.2015.0362. Epub 2016 May 9. Stem Cells Dev. 2016. PMID: 27059084 Free PMC article.
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