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5,934 results

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Page 1
N-Dealkylation of Amines.
Najmi AA, Bischoff R, Permentier HP. Najmi AA, et al. Molecules. 2022 May 20;27(10):3293. doi: 10.3390/molecules27103293. Molecules. 2022. PMID: 35630770 Free PMC article. Review.
N-dealkylation of amines is also an important in vivo metabolic pathway in the metabolism of xenobiotics. Identification and synthesis of drug metabolites such as N-dealkylated metabolites are necessary throughout all phases of drug development studies. ...
N-dealkylation of amines is also an important in vivo metabolic pathway in the metabolism of xenobiotics. Identification and synthesi …
Metabolic N-Dealkylation and N-Oxidation as Elucidators of the Role of Alkylamino Moieties in Drugs Acting at Various Receptors.
Eh-Haj BM. Eh-Haj BM. Molecules. 2021 Mar 29;26(7):1917. doi: 10.3390/molecules26071917. Molecules. 2021. PMID: 33805491 Free PMC article. Review.
Further, N-dealkylation has resulted in clinically used drugs, activation of prodrugs, change of receptor selectivity, and providing potential for developing fully-fledged drugs. While both secondary and tertiary alkylamino moieties (open chain aliphatic or heterocyclic) a …
Further, N-dealkylation has resulted in clinically used drugs, activation of prodrugs, change of receptor selectivity, and providing …
Oxidative dealkylation DNA repair mediated by the mononuclear non-heme iron AlkB proteins.
Mishina Y, He C. Mishina Y, et al. J Inorg Biochem. 2006 Apr;100(4):670-8. doi: 10.1016/j.jinorgbio.2005.12.018. Epub 2006 Feb 15. J Inorg Biochem. 2006. PMID: 16469386 Free PMC article. Review.
These proteins activate dioxygen and perform an unprecedented oxidative dealkylation of the alkyl adducts on DNA heteroatoms. This review summarizes the discovery of this activity and the recent research advances in studying this unique DNA repair pathway. ...
These proteins activate dioxygen and perform an unprecedented oxidative dealkylation of the alkyl adducts on DNA heteroatoms. This re …
Oxidative N-dealkylation.
FISH MS, JOHNSON NM, LAWRENCE EP, HORNING EC. FISH MS, et al. Biochim Biophys Acta. 1955 Dec;18(4):564-5. doi: 10.1016/0006-3002(55)90150-5. Biochim Biophys Acta. 1955. PMID: 13304041 No abstract available.
N-dealkylation of arylpiperazine derivatives: disposition and metabolism of the 1-aryl-piperazines formed.
Caccia S. Caccia S. Curr Drug Metab. 2007 Aug;8(6):612-22. doi: 10.2174/138920007781368908. Curr Drug Metab. 2007. PMID: 17691920 Review.
Most of them undergo extensive pre-systemic and systemic metabolism including CYP3A4-dependent N-dealkylation to 1-aryl-piperazines. These metabolites are best known for the variety of serotonin receptor-related effects they cause in man and animals, although some have aff …
Most of them undergo extensive pre-systemic and systemic metabolism including CYP3A4-dependent N-dealkylation to 1-aryl-piperazines. …
Radical cation intermediates in N-dealkylation reactions.
Guengerich FP, Okazaki O, Seto Y, Macdonald TL. Guengerich FP, et al. Xenobiotica. 1995 Jul;25(7):689-709. doi: 10.3109/00498259509061886. Xenobiotica. 1995. PMID: 7483667 Review.
A number of mechanistic possibilities exist for P450-catalysed N-dealkylation and have been considered over the years, including C- and N-hydroxylation and sequential electron transfer (SET). ...Even in the oxidation of N,N-dialkylanilines, a finite rate of N-oxidation is …
A number of mechanistic possibilities exist for P450-catalysed N-dealkylation and have been considered over the years, including C- a …
Involvement of CYP2D6, CYP3A4, and other cytochrome P-450 isozymes in N-dealkylation reactions.
Coutts RT, Su P, Baker GB. Coutts RT, et al. J Pharmacol Toxicol Methods. 1994 Aug;31(4):177-86. doi: 10.1016/1056-8719(94)90001-9. J Pharmacol Toxicol Methods. 1994. PMID: 7949373 Review.
Metabolic N-dealkylation is a commonly observed biotransformation with tertiary and secondary amine drugs and related N-alkylated amides, but surprisingly little is known about the cytochrome P-450 isozymes involved in these dealkylation reactions. ...Although CYP2D …
Metabolic N-dealkylation is a commonly observed biotransformation with tertiary and secondary amine drugs and related N-alkylated ami …
Dealkylation metabolites of Atrazine: A previously Neglected Contributor to soybean phytotoxicity within atrazine residue.
Wang N, Liang Y, Zhai W, Zhao F, Zheng L, Wang P, Zhou Z, Liu X, Liu D. Wang N, et al. Environ Int. 2025 May;199:109498. doi: 10.1016/j.envint.2025.109498. Epub 2025 Apr 25. Environ Int. 2025. PMID: 40300498 Free article.
In this study, the contributions and mechanisms underlying phytotoxicity of the atrazine and its metabolites (DEA and DIA) were systematically investigated in soybean seedlings. Two dealkylation metabolites DEA and DIA caused growth suppression, inhibited photosynthesis, a …
In this study, the contributions and mechanisms underlying phytotoxicity of the atrazine and its metabolites (DEA and DIA) were systematical …
Mild and Functional Group-Tolerant Aerobic N-Dealkylation of Tertiary Amines Promoted by Photoredox Catalysis.
Yilmaz O, Emmert MH. Yilmaz O, et al. J Org Chem. 2023 Jul 7;88(13):8874-8881. doi: 10.1021/acs.joc.3c00656. Epub 2023 Jun 9. J Org Chem. 2023. PMID: 37294553 Free PMC article.
This article describes the development of a mild method for the N-dealkylation of tertiary amines via photoredox catalysis and its application in late-stage functionalization. ...Interestingly, alpha-oxidation to imines was observed in several cyclic substructures instead …
This article describes the development of a mild method for the N-dealkylation of tertiary amines via photoredox catalysis and its ap …
5,934 results