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10,854 results

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Page 1
Death domain of p75 neurotrophin receptor: a structural perspective on an intracellular signalling hub.
Yuan W, Ibáñez CF, Lin Z. Yuan W, et al. Biol Rev Camb Philos Soc. 2019 Aug;94(4):1282-1293. doi: 10.1111/brv.12502. Epub 2019 Feb 14. Biol Rev Camb Philos Soc. 2019. PMID: 30762293 Review.
The death domain (DD) is a globular protein motif with a signature feature of an all-helical Greek-key motif. ...DDs exist in a wide range of signalling proteins including p75 neurotrophin receptor (p75(NTR) ), a member of the tumour necrosis factor recept …
The death domain (DD) is a globular protein motif with a signature feature of an all-helical Greek-key motif. ...DDs exist in …
Roles of the adaptor protein tumor necrosis factor receptor type 1-associated death domain protein (TRADD) in human diseases.
Chen Y, Gu Y, Xiong X, Zheng Y, Liu X, Wang W, Meng G. Chen Y, et al. Biomed Pharmacother. 2022 Sep;153:113467. doi: 10.1016/j.biopha.2022.113467. Epub 2022 Jul 28. Biomed Pharmacother. 2022. PMID: 36076575 Free article. Review.
TRADD contains an N terminal tumor necrosis factor receptor-associated factor 2 (TRAF2) binding domain and a C terminal death domain (DD) for interacting with multiple DD-containing proteins. Following activation of specific receptors, such as t …
TRADD contains an N terminal tumor necrosis factor receptor-associated factor 2 (TRAF2) binding domain and a C terminal dea …
Activation of apoptosis signalling pathways by reactive oxygen species.
Redza-Dutordoir M, Averill-Bates DA. Redza-Dutordoir M, et al. Biochim Biophys Acta. 2016 Dec;1863(12):2977-2992. doi: 10.1016/j.bbamcr.2016.09.012. Epub 2016 Sep 17. Biochim Biophys Acta. 2016. PMID: 27646922 Free article. Review.
Excess cellular levels of ROS cause damage to proteins, nucleic acids, lipids, membranes and organelles, which can lead to activation of cell death processes such as apoptosis. Apoptosis is a highly regulated process that is essential for the development and survival of mu …
Excess cellular levels of ROS cause damage to proteins, nucleic acids, lipids, membranes and organelles, which can lead to activation of cel …
NK cells switch from granzyme B to death receptor-mediated cytotoxicity during serial killing.
Prager I, Liesche C, van Ooijen H, Urlaub D, Verron Q, Sandström N, Fasbender F, Claus M, Eils R, Beaudouin J, Önfelt B, Watzl C. Prager I, et al. J Exp Med. 2019 Sep 2;216(9):2113-2127. doi: 10.1084/jem.20181454. Epub 2019 Jul 3. J Exp Med. 2019. PMID: 31270246 Free PMC article.
We observed that NK cells switch from inducing a fast GrzB-mediated cell death in their first killing events to a slow death receptor-mediated killing during subsequent tumor cell encounters. ...This demonstrates that GrzB and death receptor-med …
We observed that NK cells switch from inducing a fast GrzB-mediated cell death in their first killing events to a slow death …
The RIPK1 death domain restrains ZBP1- and TRIF-mediated cell death and inflammation.
Imai T, Lin J, Kaya GG, Ju E, Kondylis V, Kelepouras K, Liccardi G, Kim C, Pasparakis M. Imai T, et al. Immunity. 2024 Jul 9;57(7):1497-1513.e6. doi: 10.1016/j.immuni.2024.04.016. Epub 2024 May 13. Immunity. 2024. PMID: 38744293 Free article.
RIPK1 is a multi-functional kinase that regulates cell death and inflammation and has been implicated in the pathogenesis of inflammatory diseases. ...Here, we show that a mutation (R588E) disrupting the RIPK1 death domain (DD) caused perinatal lethality indu …
RIPK1 is a multi-functional kinase that regulates cell death and inflammation and has been implicated in the pathogenesis of inflamma …
The Death Receptor Pathway of Apoptosis.
Green DR. Green DR. Cold Spring Harb Perspect Biol. 2022 Feb 1;14(2):a041053. doi: 10.1101/cshperspect.a041053. Cold Spring Harb Perspect Biol. 2022. PMID: 35105716 Free PMC article. Review. No abstract available.
Virus Infection and Death Receptor-Mediated Apoptosis.
Zhou X, Jiang W, Liu Z, Liu S, Liang X. Zhou X, et al. Viruses. 2017 Oct 27;9(11):316. doi: 10.3390/v9110316. Viruses. 2017. PMID: 29077026 Free PMC article. Review.
Many viruses have acquired the capability to subvert death receptor-mediated apoptosis and evade the host immune response, mainly by virally encoded gene products that suppress death receptor-mediated apoptosis. In this review, we summarize the current …
Many viruses have acquired the capability to subvert death receptor-mediated apoptosis and evade the host immune response, mai …
Death domain fold proteins in immune signaling and transcriptional regulation.
Huoh YS, Hur S. Huoh YS, et al. FEBS J. 2022 Jul;289(14):4082-4097. doi: 10.1111/febs.15901. Epub 2021 May 13. FEBS J. 2022. PMID: 33905163 Free PMC article. Review.
Death domain fold (DDF) superfamily comprises of the death domain (DD), death effector domain (DED), caspase activation recruitment domain (CARD), and pyrin domain (PYD). ...The unique ability of DDFs to self-oligomerize upo …
Death domain fold (DDF) superfamily comprises of the death domain (DD), death effector domain (DED …
Equilibrium between monomers and dimers of the death domain of the p75 neurotrophin receptor in solution.
Li Z, Duan Y, Mao W, Chen C, Yuan W, Jin X, Shi S, Su XC, Ibáñez CF, Lin Z. Li Z, et al. Int J Biol Macromol. 2023 Aug 15;246:125710. doi: 10.1016/j.ijbiomac.2023.125710. Epub 2023 Jul 4. Int J Biol Macromol. 2023. PMID: 37414319
p75 neurotrophin receptor (p75(NTR)) contains a C-terminal globular protein module known as the death domain (DD), which plays a central role in apoptotic and inflammatory signaling through the formation of oligomeric protein complexes. ...
p75 neurotrophin receptor (p75(NTR)) contains a C-terminal globular protein module known as the death domain (DD), whic …
10,854 results
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