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Page 1
Chronic adaptive deep brain stimulation versus conventional stimulation in Parkinson's disease: a blinded randomized feasibility trial.
Oehrn CR, Cernera S, Hammer LH, Shcherbakova M, Yao J, Hahn A, Wang S, Ostrem JL, Little S, Starr PA. Oehrn CR, et al. Nat Med. 2024 Nov;30(11):3345-3356. doi: 10.1038/s41591-024-03196-z. Epub 2024 Aug 19. Nat Med. 2024. PMID: 39160351 Free PMC article. Clinical Trial.
Deep brain stimulation (DBS) is a widely used therapy for Parkinson's disease (PD) but lacks dynamic responsiveness to changing clinical and neural states. ...Here we present the results of a blinded randomized cross-over pilot trial aime …
Deep brain stimulation (DBS) is a widely used therapy for Parkinson's disease (PD) but lacks dynamic resp …
Deep Brain Stimulation in Parkinson Disease: A Meta-analysis of the Long-term Neuropsychological Outcomes.
Bucur M, Papagno C. Bucur M, et al. Neuropsychol Rev. 2023 Jun;33(2):307-346. doi: 10.1007/s11065-022-09540-9. Epub 2022 Mar 23. Neuropsychol Rev. 2023. PMID: 35318587 Free PMC article.
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) or globus pallidum internus (GPi) improves motor functions in patients with Parkinson's disease (PD) but may cause a decline in specific cognitive domains. ...Medline and Web of Scien …
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) or globus pallidum internus (GPi) improves motor function …
Adaptive deep brain stimulation in advanced Parkinson disease.
Little S, Pogosyan A, Neal S, Zavala B, Zrinzo L, Hariz M, Foltynie T, Limousin P, Ashkan K, FitzGerald J, Green AL, Aziz TZ, Brown P. Little S, et al. Ann Neurol. 2013 Sep;74(3):449-57. doi: 10.1002/ana.23951. Epub 2013 Jul 12. Ann Neurol. 2013. PMID: 23852650 Free PMC article.
OBJECTIVE: Brain-computer interfaces (BCIs) could potentially be used to interact with pathological brain signals to intervene and ameliorate their effects in disease states. Here, we provide proof-of-principle of this approach by using a BCI to interpret pat …
OBJECTIVE: Brain-computer interfaces (BCIs) could potentially be used to interact with pathological brain signals to intervene …
A randomized trial of deep-brain stimulation for Parkinson's disease.
Deuschl G, Schade-Brittinger C, Krack P, Volkmann J, Schäfer H, Bötzel K, Daniels C, Deutschländer A, Dillmann U, Eisner W, Gruber D, Hamel W, Herzog J, Hilker R, Klebe S, Kloss M, Koy J, Krause M, Kupsch A, Lorenz D, Lorenzl S, Mehdorn HM, Moringlane JR, Oertel W, Pinsker MO, Reichmann H, Reuss A, Schneider GH, Schnitzler A, Steude U, Sturm V, Timmermann L, Tronnier V, Trottenberg T, Wojtecki L, Wolf E, Poewe W, Voges J; German Parkinson Study Group, Neurostimulation Section. Deuschl G, et al. N Engl J Med. 2006 Aug 31;355(9):896-908. doi: 10.1056/NEJMoa060281. N Engl J Med. 2006. PMID: 16943402 Free article. Clinical Trial.
METHODS: In this randomized-pairs trial, we enrolled 156 patients with advanced Parkinson's disease and severe motor symptoms. The primary end points were the changes from baseline to six months in the quality of life, as assessed by the Parkinson's …
METHODS: In this randomized-pairs trial, we enrolled 156 patients with advanced Parkinson's disease and severe motor sy …
Long-Term Personalized Adaptive Deep Brain Stimulation in Parkinson Disease: A Nonrandomized Clinical Trial.
Bronte-Stewart HM, Beudel M, Ostrem JL, Little S, Almeida L, Ramirez-Zamora A, Fasano A, Hassell T, Mitchell KT, Moro E, Gostkowski M, Chattree G, de Bie RMA, de Neeling M, Piña-Fuentes D, Swinnen B, Starr PA, Hammer LH, Foote KD, Richardson RM, Flaherty A, Boogers A, Sa'di Q, Meoni S, Castrioto A, Stanslaski S, Summers RLS, Tonder L, Tan Y, Berrier H, Goble TJ, Raike RS, Herrington TM; ADAPT-PD Investigators. Bronte-Stewart HM, et al. JAMA Neurol. 2025 Nov 1;82(11):1171-1180. doi: 10.1001/jamaneurol.2025.2781. JAMA Neurol. 2025. PMID: 40982287 Free PMC article. Clinical Trial.
IMPORTANCE: Adaptive deep brain stimulation (aDBS) automatically adjusts stimulation amplitude in response to changes in relevant neural activity in people with Parkinson disease (PD). ...TEED was reduced during ST-aDBS compared to cDBS ( …
IMPORTANCE: Adaptive deep brain stimulation (aDBS) automatically adjusts stimulation amplitude in response to ch …
Five-Year Outcomes from Deep Brain Stimulation of the Subthalamic Nucleus for Parkinson Disease.
Starr PA, Shivacharan RS, Goldberg E, Tröster AI, House PA, Giroux ML, Hebb AO, Whiting DM, Leichliter TA, Ostrem JL, Metman LV, Sani S, Karl JA, Siddiqui MS, Tatter SB, Haq IU, Machado AG, Gostkowski M, Tagliati M, Mamelak AN, Okun MS, Foote KD, Moguel-Cobos G, Ponce FA, Pahwa R, Lyons K, Buetefisch CM, Gross RE, Luca CC, Jagid JR, Revuelta GJ, Takacs I, Pourfar MH, Mogilner AY, Duker AP, Mandybur GT, Rosenow JM, Zadikoff C, Khandhar SM, Sedrak M, Phibbs FT, Neimat J, Durphy J, Ramirez-Zamora A, Pilitsis JG, Uitti RJ, Wharen R, Park MC, Vitek JL; INTREPID Study Group. Starr PA, et al. JAMA Neurol. 2025 Nov 1;82(11):1181-1190. doi: 10.1001/jamaneurol.2025.3373. JAMA Neurol. 2025. PMID: 40952750 Free PMC article. Clinical Trial.
IMPORTANCE: The Implantable Neurostimulator for the Treatment of Parkinson's Disease (INTREPID) trial was a randomized, double-blind, sham-controlled study of subthalamic nucleus (STN) deep brain stimulation (DBS) for the treatment of …
IMPORTANCE: The Implantable Neurostimulator for the Treatment of Parkinson's Disease (INTREPID) trial was a randomized, …
Transcranial Temporal Interference Stimulation of the Right Globus Pallidus in Parkinson's Disease.
Yang C, Xu Y, Feng X, Wang B, Du Y, Wang K, Lü J, Huang L, Qian Z, Wang Z, Chen N, Zhou J, Zhang C, Liu Y. Yang C, et al. Mov Disord. 2025 Jun;40(6):1061-1069. doi: 10.1002/mds.29967. Epub 2024 Aug 12. Mov Disord. 2025. PMID: 39133053 Free PMC article. Clinical Trial.
BACKGROUND: Invasive deep brain stimulation (DBS) has been shown to be effective in treating patients with Parkinson's disease (PD), yet its clinical use is limited to patients at the advanced stage of the disease. ...Before and immediate …
BACKGROUND: Invasive deep brain stimulation (DBS) has been shown to be effective in treating patients with Parkinson …
Update on Treatments for Parkinson's Disease Motor Fluctuations - An International Parkinson and Movement Disorder Society Evidence-Based Medicine Review.
de Bie RMA, Katzenschlager R, Swinnen BEKS, Peball M, Lim SY, Mestre TA, Perez Lloret S, Coelho M, Aquino C, Tan AH, Bruno V, Dijk JM, Heim B, Lin CH, Kauppila LA, Litvan I, Spijker R, Seppi K, Costa J, Sampaio C, Fox SH, Silverdale MA. de Bie RMA, et al. Mov Disord. 2025 May;40(5):776-794. doi: 10.1002/mds.30162. Epub 2025 Mar 8. Mov Disord. 2025. PMID: 40055961 Free PMC article. Review.
METHODS: On January 1, 2023, a literature search was conducted without date limit in the MEDLINE, Embase, and Cochrane databases using the following search terms: Parkinson disease, levodopa and, for the Embase database, randomized controlled trial (RCT). ... …
METHODS: On January 1, 2023, a literature search was conducted without date limit in the MEDLINE, Embase, and Cochrane databases using the f …
Subthalamic deep brain stimulation and levodopa in Parkinson's disease: a meta-analysis of combined effects.
Vizcarra JA, Situ-Kcomt M, Artusi CA, Duker AP, Lopiano L, Okun MS, Espay AJ, Merola A. Vizcarra JA, et al. J Neurol. 2019 Feb;266(2):289-297. doi: 10.1007/s00415-018-8936-2. Epub 2018 Jun 16. J Neurol. 2019. PMID: 29909467 Review.
INTRODUCTION: While subthalamic nucleus deep brain stimulation (STN-DBS) and levodopa improve motor symptoms in Parkinson disease (PD) to a similar magnitude, their combined effect remains unclear. ...Dyskinesia duration and ADL outcomes were si …
INTRODUCTION: While subthalamic nucleus deep brain stimulation (STN-DBS) and levodopa improve motor symptoms in Park …
How Does Deep Brain Stimulation Change the Course of Parkinson's Disease?
Mahlknecht P, Foltynie T, Limousin P, Poewe W. Mahlknecht P, et al. Mov Disord. 2022 Aug;37(8):1581-1592. doi: 10.1002/mds.29052. Epub 2022 May 12. Mov Disord. 2022. PMID: 35560443 Free PMC article. Review.
A robust body of evidence from randomized controlled trials has established the efficacy of deep brain stimulation (DBS) in reducing off time and dyskinesias in levodopa-treated patients with Parkinson's disease (PD). ...These observation …
A robust body of evidence from randomized controlled trials has established the efficacy of deep brain stimulation …
721 results