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The cannabinoid quinol VCE-004.8 alleviates bleomycin-induced scleroderma and exerts potent antifibrotic effects through peroxisome proliferator-activated receptor-γ and CB2 pathways.
del Río C, Navarrete C, Collado JA, Bellido ML, Gómez-Cañas M, Pazos MR, Fernández-Ruiz J, Pollastro F, Appendino G, Calzado MA, Cantarero I, Muñoz E. del Río C, et al. Sci Rep. 2016 Feb 18;6:21703. doi: 10.1038/srep21703. Sci Rep. 2016. PMID: 26887982 Free PMC article.
VCE-003.2, a novel cannabigerol derivative, enhances neuronal progenitor cell survival and alleviates symptomatology in murine models of Huntington's disease.
Díaz-Alonso J, Paraíso-Luna J, Navarrete C, Del Río C, Cantarero I, Palomares B, Aguareles J, Fernández-Ruiz J, Bellido ML, Pollastro F, Appendino G, Calzado MA, Galve-Roperh I, Muñoz E. Díaz-Alonso J, et al. Among authors: del rio c. Sci Rep. 2016 Jul 19;6:29789. doi: 10.1038/srep29789. Sci Rep. 2016. PMID: 27430371 Free PMC article.
Tetrahydrocannabinolic acid is a potent PPARγ agonist with neuroprotective activity.
Nadal X, Del Río C, Casano S, Palomares B, Ferreiro-Vera C, Navarrete C, Sánchez-Carnerero C, Cantarero I, Bellido ML, Meyer S, Morello G, Appendino G, Muñoz E. Nadal X, et al. Among authors: del rio c. Br J Pharmacol. 2017 Dec;174(23):4263-4276. doi: 10.1111/bph.14019. Epub 2017 Nov 2. Br J Pharmacol. 2017. PMID: 28853159 Free PMC article.
VCE-004.3, a cannabidiol aminoquinone derivative, prevents bleomycin-induced skin fibrosis and inflammation through PPARγ- and CB2 receptor-dependent pathways.
Del Rio C, Cantarero I, Palomares B, Gómez-Cañas M, Fernández-Ruiz J, Pavicic C, García-Martín A, Luz Bellido M, Ortega-Castro R, Pérez-Sánchez C, López-Pedrera C, Appendino G, Calzado MA, Muñoz E. Del Rio C, et al. Br J Pharmacol. 2018 Oct;175(19):3813-3831. doi: 10.1111/bph.14450. Epub 2018 Aug 23. Br J Pharmacol. 2018. PMID: 30033591 Free PMC article.
Neuroprotection with the cannabigerol quinone derivative VCE-003.2 and its analogs CBGA-Q and CBGA-Q-Salt in Parkinson's disease using 6-hydroxydopamine-lesioned mice.
Burgaz S, García C, Gómez-Cañas M, Navarrete C, García-Martín A, Rolland A, Del Río C, Casarejos MJ, Muñoz E, Gonzalo-Consuegra C, Muñoz E, Fernández-Ruiz J. Burgaz S, et al. Among authors: del rio c. Mol Cell Neurosci. 2021 Jan;110:103583. doi: 10.1016/j.mcn.2020.103583. Epub 2020 Dec 16. Mol Cell Neurosci. 2021. PMID: 33338634
Cannabidiol markedly alleviates skin and liver fibrosis.
Del Río C, Ruiz-Pino F, Prados ME, Fiebich BL, Tena-Sempere M, Muñoz E. Del Río C, et al. Front Pharmacol. 2022 Oct 19;13:981817. doi: 10.3389/fphar.2022.981817. eCollection 2022. Front Pharmacol. 2022. PMID: 36339540 Free PMC article.
Evaluation of Bioactive Effects of Five Plant Extracts with Different Phenolic Compositions against Different Therapeutic Targets.
Villegas-Aguilar MDC, Sánchez-Marzo N, Fernández-Ochoa Á, Del Río C, Montaner J, Micol V, Herranz-López M, Barrajón-Catalán E, Arráez-Román D, Cádiz-Gurrea ML, Segura-Carretero A. Villegas-Aguilar MDC, et al. Among authors: del rio c. Antioxidants (Basel). 2024 Feb 8;13(2):217. doi: 10.3390/antiox13020217. Antioxidants (Basel). 2024. PMID: 38397815 Free PMC article.
751 results