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Metabolic and endocrine effects of interleukin-1 in obese, diabetic Zucker fa/fa rats.
del Rey A, Monge-Arditi G, Klusman I, Besedovsky HO. del Rey A, et al. Exp Clin Endocrinol Diabetes. 1996;104(4):317-26. doi: 10.1055/s-0029-1211461. Exp Clin Endocrinol Diabetes. 1996. PMID: 8886749
IL-1, a cytokine produced predominantly by cell from the macrophage lineage, can affect multiple neuroendocrine and metabolic functions. ...Administration of a bolus injection of IL-1 normalized the response of diabetic fa/fa rats to a glucose load. These rat …
IL-1, a cytokine produced predominantly by cell from the macrophage lineage, can affect multiple neuroendocrine and metabolic functio …
Endocrine host responses during early and late phases of tumor development.
Besedovsky HO, Normann S, Schardt M, Del Rey A. Besedovsky HO, et al. Int J Cancer. 2000 May 15;86(4):457-61. doi: 10.1002/(sici)1097-0215(20000515)86:4<457::aid-ijc2>3.0.co;2-0. Int J Cancer. 2000. PMID: 10797255
The results showed that (i) in both models, an early reduction in plasma insulin and prolactin levels occurred, and in the case of insulin, this reduction was sustained for a prolong period prior to tumor detection, indicating that recognition by the host of emergent tumor …
The results showed that (i) in both models, an early reduction in plasma insulin and prolactin levels occurred, and in the case of insulin, …
Selective depletion of macrophages prevents pituitary-adrenal activation in response to subpyrogenic, but not to pyrogenic, doses of bacterial endotoxin in rats.
Derijk R, Van Rooijen N, Tilders FJ, Besedovsky HO, Del Rey A, Berkenbosch F. Derijk R, et al. Endocrinology. 1991 Jul;129(1):330-8. doi: 10.1210/endo-129-1-330. Endocrinology. 1991. PMID: 1647300
Plasma IL-1 concentrations could only be detected in response to a pyrogenic (2.5 mg/kg, iv) and not to a subpyrogenic (0.025 mg/kg, ip) dose of LPS. ...These data demonstrate that activation of the HPAA by a subpyrogenic dose of LPS is macrophage dependent. …
Plasma IL-1 concentrations could only be detected in response to a pyrogenic (2.5 mg/kg, iv) and not to a subpyrogenic (0.025 …
Interleukin-1 stimulates aldosterone secretion: involvement of renin, ACTH, and prostaglandins.
Bataillard A, del Rey A, Klusman I, Arditi GM, Besedovsky HO. Bataillard A, et al. Am J Physiol. 1992 Oct;263(4 Pt 2):R840-4. doi: 10.1152/ajpregu.1992.263.4.R840. Am J Physiol. 1992. PMID: 1329566
Interleukin-1 (IL-1), a cytokine produced during infection and inflammation, mediates some of the endocrinological alterations that parallel these processes. ...We observed that intravenous administration of hrIL-1 into conscious unrestrained rats elicited a marked …
Interleukin-1 (IL-1), a cytokine produced during infection and inflammation, mediates some of the endocrinological alterations that p …
Neuroendocrine and metabolic responses induced by interleukin-1.
Besedovsky H, del Rey A. Besedovsky H, et al. J Neurosci Res. 1987;18(1):172-8. doi: 10.1002/jnr.490180124. J Neurosci Res. 1987. PMID: 2824799
We have previously demonstrated that Interleukin-1 (IL-1), a cytokine mainly produced by activated monocytes, stimulates the pituitary-adrenal axis and affects glucose homeostasis. ...A marked reduction in blood glucose levels occurred in these animals. This effect …
We have previously demonstrated that Interleukin-1 (IL-1), a cytokine mainly produced by activated monocytes, stimulates the pituitar …
Antidiabetic effects of interleukin 1.
del Rey A, Besedovsky H. del Rey A, et al. Proc Natl Acad Sci U S A. 1989 Aug;86(15):5943-7. doi: 10.1073/pnas.86.15.5943. Proc Natl Acad Sci U S A. 1989. PMID: 2668949 Free PMC article.
In these animal models, a single injection of a low dose of human recombinant IL-1 normalized glucose blood levels for several hours. ...Although the final mechanism of action is at present unknown, the results showed that IL-1 is a hormone with powerful anti …
In these animal models, a single injection of a low dose of human recombinant IL-1 normalized glucose blood levels for several …
Metabolic and endocrine actions of interleukin-1. Effects on insulin-resistant animals.
Besedovsky HO, Del Rey A. Besedovsky HO, et al. Ann N Y Acad Sci. 1990;594:214-21. doi: 10.1111/j.1749-6632.1990.tb40481.x. Ann N Y Acad Sci. 1990. PMID: 2198839 No abstract available.
Metabolic and neuroendocrine effects of pro-inflammatory cytokines.
Del Rey A, Besedovsky HO. Del Rey A, et al. Eur J Clin Invest. 1992 Oct;22 Suppl 1:10-5. Eur J Clin Invest. 1992. PMID: 1333964
Pro-inflammatory cytokines such as IL-1, IL-6 and TNF alpha play a role in mediating these interactions. Although all three cytokines can stimulate ACTH and glucocorticoid output, IL-1 has the highest potency. ...However, administration of low doses of lipopolysaccharide ( …
Pro-inflammatory cytokines such as IL-1, IL-6 and TNF alpha play a role in mediating these interactions. Although all three cytokines …
An adverse immune-endocrine profile in patients with tuberculosis and type 2 diabetes.
Fernández R, Díaz A, D'Attilio L, Bongiovanni B, Santucci N, Bertola D, Besedovsky H, Del Rey A, Bay ML, Bottasso O. Fernández R, et al. Tuberculosis (Edinb). 2016 Dec;101:95-101. doi: 10.1016/j.tube.2016.09.001. Epub 2016 Sep 12. Tuberculosis (Edinb). 2016. PMID: 27865406
Diabetes is a risk factor for the development of pulmonary tuberculosis (TB) and both diseases present endocrine alterations likely to play a role in certain immuno-endocrine-metabolic associated disorders. ...All patients had higher levels of cortisol with a
Diabetes is a risk factor for the development of pulmonary tuberculosis (TB) and both diseases present endocrine alterations likely t …
Intranasal delivery of dexamethasone efficiently controls LPS-induced murine neuroinflammation.
Meneses G, Gevorkian G, Florentino A, Bautista MA, Espinosa A, Acero G, Díaz G, Fleury A, Pérez Osorio IN, Del Rey A, Fragoso G, Sciutto E, Besedovsky H. Meneses G, et al. Clin Exp Immunol. 2017 Dec;190(3):304-314. doi: 10.1111/cei.13018. Epub 2017 Sep 7. Clin Exp Immunol. 2017. PMID: 28752628 Free PMC article.
A delayed diffusion of GCs molecules and the high systemic doses required for brain-specific targeting lead to severe undesirable effects, particularly when lifelong treatment is required. ...Altogether, these results indicate that IN-DX administration may offer a m
A delayed diffusion of GCs molecules and the high systemic doses required for brain-specific targeting lead to severe undesirable eff
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