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1980 1
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1988 1
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1999 2
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2002 5
2003 5
2004 2
2005 1
2006 2
2007 3
2008 4
2009 10
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2011 5
2012 5
2013 5
2014 3
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2016 6
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97 results

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Page 1
Regulation of energy metabolism by long-chain fatty acids.
Nakamura MT, Yudell BE, Loor JJ. Nakamura MT, et al. Prog Lipid Res. 2014 Jan;53:124-44. doi: 10.1016/j.plipres.2013.12.001. Epub 2013 Dec 18. Prog Lipid Res. 2014. PMID: 24362249 Review.
This review mainly focuses on the role of long chain fatty acids (LCFAs) in regulating energy metabolism as ligands of peroxisome proliferator-activated receptors (PPARs). ...PPAR-delta is highly expressed in skeletal muscle and induces genes for LCFA oxidation during fast …
This review mainly focuses on the role of long chain fatty acids (LCFAs) in regulating energy metabolism as ligands of peroxisome pro …
STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses.
Vila IK, Chamma H, Steer A, Saccas M, Taffoni C, Turtoi E, Reinert LS, Hussain S, Marines J, Jin L, Bonnefont X, Hubert M, Schwartz O, Paludan SR, Van Simaeys G, Doumont G, Sobhian B, Vlachakis D, Turtoi A, Laguette N. Vila IK, et al. Cell Metab. 2022 Jan 4;34(1):125-139.e8. doi: 10.1016/j.cmet.2021.12.007. Cell Metab. 2022. PMID: 34986331 Free PMC article.
We reveal that the STING (stimulator of interferon genes) protein regulates metabolic homeostasis through inhibition of the fatty acid desaturase 2 (FADS2) rate-limiting enzyme in polyunsaturated fatty acid (PUFA) desaturation. ...PUFAs in turn inhibited STING, ther …
We reveal that the STING (stimulator of interferon genes) protein regulates metabolic homeostasis through inhibition of the fatty aci …
Regulation of human delta-6 desaturase gene transcription: identification of a functional direct repeat-1 element.
Tang C, Cho HP, Nakamura MT, Clarke SD. Tang C, et al. J Lipid Res. 2003 Apr;44(4):686-95. doi: 10.1194/jlr.M200195-JLR200. Epub 2003 Jan 16. J Lipid Res. 2003. PMID: 12562861 Free article.
The WY 14,643 induction of the human Delta-6 desaturase promoter activity was dependent upon the expression of PPARalpha. ...The -385/-373 sequence also interacted with a mixture of in vitro translated PPARalpha-retinoic acid receptor X (RXR)alpha, but …
The WY 14,643 induction of the human Delta-6 desaturase promoter activity was dependent upon the expression of P …
FADS2 genotype regulates delta-6 desaturase activity and inflammation in human adipose tissue.
Vaittinen M, Walle P, Kuosmanen E, Männistö V, Käkelä P, Ågren J, Schwab U, Pihlajamäki J. Vaittinen M, et al. J Lipid Res. 2016 Jan;57(1):56-65. doi: 10.1194/jlr.M059113. Epub 2015 Nov 25. J Lipid Res. 2016. PMID: 26609056 Free PMC article.
We investigated the association of surgery-induced weight loss and FA desaturase (FADS)1/2 genotypes with serum and AT FA profile and with AT inflammation, measured as interleukin (IL)-1beta and NFkappaB pathway gene expression, in order to find potential gene-environment …
We investigated the association of surgery-induced weight loss and FA desaturase (FADS)1/2 genotypes with serum and AT FA profile and …
Expression of human delta-6-desaturase is associated with aggressiveness of human breast cancer.
Lane J, Mansel RE, Jiang WG. Lane J, et al. Int J Mol Med. 2003 Aug;12(2):253-7. Int J Mol Med. 2003. PMID: 12851727
Highly unsaturated fatty acids (HUFAs) are cyto-toxic to cancer cells and generated in the body by desaturation from essential fatty acids, primarily involving delta-6-desaturase. This study, for the first time, examined the level of expression of human …
Highly unsaturated fatty acids (HUFAs) are cyto-toxic to cancer cells and generated in the body by desaturation from essential fatty acids, …
Cloning, expression, and nutritional regulation of the mammalian Delta-6 desaturase.
Cho HP, Nakamura MT, Clarke SD. Cho HP, et al. J Biol Chem. 1999 Jan 1;274(1):471-7. doi: 10.1074/jbc.274.1.471. J Biol Chem. 1999. PMID: 9867867 Free article.
In this report, we describe the cloning, characterization, and expression of a mammalian Delta-6 desaturase. The open reading frames for mouse and human Delta-6 desaturase each encode a 444-amino acid peptide, and the two peptides …
In this report, we describe the cloning, characterization, and expression of a mammalian Delta-6 desaturase. The open r …
Delta-6 desaturase FADS2 is a tumor-promoting factor in cholangiocarcinoma.
Hasegawa K, Fujimori H, Nakatani K, Takahashi M, Izumi Y, Bamba T, Nakamura-Shima M, Shibuya-Takahashi R, Mochizuki M, Wakui Y, Abue M, Iwai W, Fukushi D, Satoh K, Yamaguchi K, Shindo N, Yasuda J, Asano N, Imai T, Asada Y, Katori Y, Tamai K. Hasegawa K, et al. Cancer Sci. 2024 Oct;115(10):3346-3357. doi: 10.1111/cas.16306. Epub 2024 Aug 7. Cancer Sci. 2024. PMID: 39113435 Free PMC article.
We screened genes required for cholangiocarcinoma tumorigenicity and identified FADS2, a delta-6 desaturase. FADS2 depletion reduced in vivo tumorigenicity and cell proliferation. ...
We screened genes required for cholangiocarcinoma tumorigenicity and identified FADS2, a delta-6 desaturase. FADS2 depl …
Cloning, expression, and fatty acid regulation of the human delta-5 desaturase.
Cho HP, Nakamura M, Clarke SD. Cho HP, et al. J Biol Chem. 1999 Dec 24;274(52):37335-9. doi: 10.1074/jbc.274.52.37335. J Biol Chem. 1999. PMID: 10601301 Free article.
The open reading frame of the human Delta-5 desaturase encodes a 444-amino acid peptide which is identical in size to the Delta-6 desaturase and which shares 61% identity with the human Delta-6 desaturase. ...Finally, …
The open reading frame of the human Delta-5 desaturase encodes a 444-amino acid peptide which is identical in size to the D …
Troglitazone downregulates delta-6 desaturase gene expression in human skeletal muscle cell cultures.
Wahl HG, Kausch C, Machicao F, Rett K, Stumvoll M, Häring HU. Wahl HG, et al. Diabetes. 2002 Apr;51(4):1060-5. doi: 10.2337/diabetes.51.4.1060. Diabetes. 2002. PMID: 11916926
Recently, it has been shown that human Delta-6 desaturase is expressed not only in liver but in a variety of human tissues, including muscle. ...We examined the effects of troglitazone on the regulation of Delta-6 desatur …
Recently, it has been shown that human Delta-6 desaturase is expressed not only in liver but in a variety of …
Association of Delta-6-Desaturase Expression with Aggressiveness of Cancer, Diabetes Mellitus, and Multiple Sclerosis: A Narrative Review.
Arshad Z, Rezapour-Firouzi S, Ebrahimifar M, Mosavi Jarrahi A, Mohammadian M. Arshad Z, et al. Asian Pac J Cancer Prev. 2019 Apr 29;20(4):1005-1018. doi: 10.31557/APJCP.2019.20.4.1005. Asian Pac J Cancer Prev. 2019. PMID: 31030467 Free PMC article. Review.
PUFAs are produced in the body by desaturases and elongases from dietary essential fatty acids (EFAs), primarily involving delta-6-desaturase (D6D). D6D is a rate-limiting enzyme for maintaining many aspects of lipid homeostasis and normal health. D6D is impo …
PUFAs are produced in the body by desaturases and elongases from dietary essential fatty acids (EFAs), primarily involving delta-6 …
97 results