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2012 4781
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146,494 results

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Page 1
Immune-mediated demyelination.
Hartung HP. Hartung HP. Ann Neurol. 1993 Jun;33(6):563-7. doi: 10.1002/ana.410330602. Ann Neurol. 1993. PMID: 8498835 Review.
TNF-alpha released from autoreactive T cells, macrophages, or microglia may contribute to inflammatory demyelinative processes by upregulating the expression of recognition molecules on antigen-presenting cells; by cytotoxic damage to endothelium; by stimulating the secret …
TNF-alpha released from autoreactive T cells, macrophages, or microglia may contribute to inflammatory demyelinative processes by upr …
Chronic demyelination-induced seizures.
Lapato AS, Szu JI, Hasselmann JPC, Khalaj AJ, Binder DK, Tiwari-Woodruff SK. Lapato AS, et al. Neuroscience. 2017 Mar 27;346:409-422. doi: 10.1016/j.neuroscience.2017.01.035. Epub 2017 Jan 30. Neuroscience. 2017. PMID: 28153692 Free PMC article.
Here, we report that cuprizone-mediated chronically demyelinated (9-12weeks) mice exhibit marked changes to dorsal hippocampal electroencephalography (EEG) and evidence of overt seizure activity. ...Our results suggest that chronically demyelinated mice are a valuab …
Here, we report that cuprizone-mediated chronically demyelinated (9-12weeks) mice exhibit marked changes to dorsal hippocampal electr …
Remyelination protects neurons from DLK-mediated neurodegeneration.
Duncan GJ, Ingram SD, Emberley K, Hill J, Cordano C, Abdelhak A, McCane M, Jenks JE, Jabassini N, Ananth K, Ferrara SJ, Stedelin B, Sivyer B, Aicher SA, Scanlan TS, Watkins TA, Mishra A, Nelson JW, Green AJ, Emery B. Duncan GJ, et al. Nat Commun. 2024 Oct 23;15(1):9148. doi: 10.1038/s41467-024-53429-5. Nat Commun. 2024. PMID: 39443516 Free PMC article.
Chronic demyelination and oligodendrocyte loss deprive neurons of crucial support. It is the degeneration of neurons and their connections that drives progressive disability in demyelinating disease. However, whether chronic demyelination triggers neurodegene …
Chronic demyelination and oligodendrocyte loss deprive neurons of crucial support. It is the degeneration of neurons and their connec …
Neuronal hibernation following hippocampal demyelination.
Baltan S, Jawaid SS, Chomyk AM, Kidd GJ, Chen J, Battapady HD, Chan R, Dutta R, Trapp BD. Baltan S, et al. Acta Neuropathol Commun. 2021 Mar 1;9(1):34. doi: 10.1186/s40478-021-01130-9. Acta Neuropathol Commun. 2021. PMID: 33648591 Free PMC article.
Cellular and molecular mechanisms responsible for neuronal dysfunction in demyelinated hippocampi are not fully understood. Here we investigate a mouse model of hippocampal demyelination where twelve weeks of treatment with the oligodendrocyte toxin, cuprizone, d …
Cellular and molecular mechanisms responsible for neuronal dysfunction in demyelinated hippocampi are not fully understood. Here we i …
Demyelination in spinal cord injury.
Waxman SG. Waxman SG. J Neurol Sci. 1989 Jun;91(1-2):1-14. doi: 10.1016/0022-510x(89)90072-5. J Neurol Sci. 1989. PMID: 2664092 Review.
Alternatively, conduction of action potentials can occur in the absence of remyelination, but this requires plasticity of the demyelinated axon. The biophysics of conduction favors recovery of electrogenesis after demyelination of small diameter axons. This may acco …
Alternatively, conduction of action potentials can occur in the absence of remyelination, but this requires plasticity of the demyelinate …
A hypothesis for the role of axon demyelination in seizure generation.
de Curtis M, Garbelli R, Uva L. de Curtis M, et al. Epilepsia. 2021 Mar;62(3):583-595. doi: 10.1111/epi.16824. Epub 2021 Jan 25. Epilepsia. 2021. PMID: 33493363 Review.
Moreover, seizures are a frequent symptom in demyelinating diseases, such as multiple sclerosis, and in animal models of demyelination and oligodendrocyte dysfunction. ...This process could facilitate the triggering of recurrent spontaneous seizures in areas …
Moreover, seizures are a frequent symptom in demyelinating diseases, such as multiple sclerosis, and in animal models of de …
Spatial lipidomics reveals demyelination and remyelination dynamics in the mouse brain.
Opielka M, Urbanowicz K, Konieczna-Wolska K, Müller E, Krajewski O, Feucherolles M, Zhou Q, Bienkowski M, Frache G, Hopf C, Schirmer L, Rutkowska A, Smolenski RT. Opielka M, et al. J Lipid Res. 2025 Nov;66(11):100912. doi: 10.1016/j.jlr.2025.100912. Epub 2025 Sep 23. J Lipid Res. 2025. PMID: 40998034 Free PMC article.
Myelin pathology in demyelinating diseases is accompanied by lipid remodeling that remains challenging to characterize at the spatial level using traditional mass spectrometry. ...Long-chain ceramides (Cer) and hexosylceramides (HexCer) were reduced in demyelinat …
Myelin pathology in demyelinating diseases is accompanied by lipid remodeling that remains challenging to characterize at the …
Demyelination in spinal cord injury and multiple sclerosis: what can we do to enhance functional recovery?
Waxman SG. Waxman SG. J Neurotrauma. 1992 Mar;9 Suppl 1:S105-17. J Neurotrauma. 1992. PMID: 1588601 Review.
Demyelination in white matter tracts has been observed in experimental and human spinal cord injury. ...The low density of sodium channels in the internodal axon membrane will impede conduction after demyelination. Moreover, "unmasked" potassium channels will tend t …
Demyelination in white matter tracts has been observed in experimental and human spinal cord injury. ...The low density of sodium cha …
Butyrate suppresses demyelination and enhances remyelination.
Chen T, Noto D, Hoshino Y, Mizuno M, Miyake S. Chen T, et al. J Neuroinflammation. 2019 Aug 9;16(1):165. doi: 10.1186/s12974-019-1552-y. J Neuroinflammation. 2019. PMID: 31399117 Free PMC article.
METHODS: To investigate the relationship between demyelination and gut microbiota, we administered a mixture of non-absorbing antibiotics or SCFAs to mice with cuprizone-induced demyelination and evaluated demyelination and the accumulation of microglia. ...R …
METHODS: To investigate the relationship between demyelination and gut microbiota, we administered a mixture of non-absorbing antibio …
Activated microglia drive demyelination via CSF1R signaling.
Marzan DE, Brügger-Verdon V, West BL, Liddelow S, Samanta J, Salzer JL. Marzan DE, et al. Glia. 2021 Jun;69(6):1583-1604. doi: 10.1002/glia.23980. Epub 2021 Feb 23. Glia. 2021. PMID: 33620118 Free PMC article.
Microgliosis is a prominent pathological feature in many neurological diseases including multiple sclerosis (MS), a progressive auto-immune demyelinating disorder. ...Direct injection of CSF1 into CNS white matter induces focal microgliosis and demyelination …
Microgliosis is a prominent pathological feature in many neurological diseases including multiple sclerosis (MS), a progressive auto- …
146,494 results
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