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Angelman syndrome without detectable chromosome 15q11-13 anomaly: clinical study of familial and isolated cases.
Laan LA, Halley DJ, den Boer AT, Hennekam RC, Renier WO, Brouwer OF. Laan LA, et al. Among authors: den boer at. Am J Med Genet. 1998 Mar 19;76(3):262-8. Am J Med Genet. 1998. PMID: 9508247 Review.
Loss of CBP acetyltransferase activity by PHD finger mutations in Rubinstein-Taybi syndrome.
Kalkhoven E, Roelfsema JH, Teunissen H, den Boer A, Ariyurek Y, Zantema A, Breuning MH, Hennekam RC, Peters DJ. Kalkhoven E, et al. Hum Mol Genet. 2003 Feb 15;12(4):441-50. doi: 10.1093/hmg/ddg039. Hum Mol Genet. 2003. PMID: 12566391
Angelman syndrome in adulthood.
Laan LA, den Boer AT, Hennekam RC, Renier WO, Brouwer OF. Laan LA, et al. Among authors: den boer at. Am J Med Genet. 1996 Dec 18;66(3):356-60. doi: 10.1002/(SICI)1096-8628(19961218)66:3<356::AID-AJMG21>3.0.CO;2-K. Am J Med Genet. 1996. PMID: 9072912
The tumoricidal activity of memory CD8+ T cells is hampered by persistent systemic antigen, but full functional capacity is regained in an antigen-free environment.
den Boer AT, van Mierlo GJ, Fransen MF, Melief CJ, Offringa R, Toes RE. den Boer AT, et al. J Immunol. 2004 May 15;172(10):6074-9. doi: 10.4049/jimmunol.172.10.6074. J Immunol. 2004. PMID: 15128791 Free article.
The role of CD40 in peripheral T cell tolerance and immunity.
Diehl L, Den Boer AT, van der Voort EI, Melief CJ, Offringa R, Toes RE. Diehl L, et al. Among authors: den boer at. J Mol Med (Berl). 2000;78(7):363-71. doi: 10.1007/s001090000126. J Mol Med (Berl). 2000. PMID: 11043379 Review.
Longevity of antigen presentation and activation status of APC are decisive factors in the balance between CTL immunity versus tolerance.
den Boer AT, Diehl L, van Mierlo GJ, van der Voort EI, Fransen MF, Krimpenfort P, Melief CJ, Offringa R, Toes RE. den Boer AT, et al. J Immunol. 2001 Sep 1;167(5):2522-8. doi: 10.4049/jimmunol.167.5.2522. J Immunol. 2001. PMID: 11509591
Successful immunotherapy of an intraocular tumor in mice.
Schurmans LR, den Boer AT, Diehl L, van der Voort EI, Kast WM, Melief CJ, Toes RE, Jager MJ. Schurmans LR, et al. Among authors: den boer at. Cancer Res. 1999 Oct 15;59(20):5250-4. Cancer Res. 1999. PMID: 10537305
Rejection of intraocular tumors by CD4(+) T cells without induction of phthisis.
Schurmans LR, Diehl L, den Boer AT, Sutmuller RP, Boonman ZF, Medema JP, van der Voort EI, Laman J, Melief CJ, Jager MJ, Toes RE. Schurmans LR, et al. Among authors: den boer at. J Immunol. 2001 Nov 15;167(10):5832-7. doi: 10.4049/jimmunol.167.10.5832. J Immunol. 2001. PMID: 11698457 Free article.
CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy.
Diehl L, den Boer AT, Schoenberger SP, van der Voort EI, Schumacher TN, Melief CJ, Offringa R, Toes RE. Diehl L, et al. Among authors: den boer at. Nat Med. 1999 Jul;5(7):774-9. doi: 10.1038/10495. Nat Med. 1999. PMID: 10395322
CD4+ T cells are able to promote tumor growth through inhibition of tumor-specific CD8+ T-cell responses in tumor-bearing hosts.
den Boer AT, van Mierlo GJ, Fransen MF, Melief CJ, Offringa R, Toes RE. den Boer AT, et al. Cancer Res. 2005 Aug 1;65(15):6984-9. doi: 10.1158/0008-5472.CAN-04-3344. Cancer Res. 2005. PMID: 16061684 Free article.
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