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Targeted BCL2 inhibition effectively inhibits neuroblastoma tumour growth.
Lamers F, Schild L, den Hartog IJ, Ebus ME, Westerhout EM, Ora I, Koster J, Versteeg R, Caron HN, Molenaar JJ. Lamers F, et al. Among authors: den hartog ij. Eur J Cancer. 2012 Nov;48(16):3093-103. doi: 10.1016/j.ejca.2012.01.037. Epub 2012 Feb 25. Eur J Cancer. 2012. PMID: 22366560 Free article.
Cyclin-Dependent Kinase Inhibitor AT7519 as a Potential Drug for MYCN-Dependent Neuroblastoma.
Dolman ME, Poon E, Ebus ME, den Hartog IJ, van Noesel CJ, Jamin Y, Hallsworth A, Robinson SP, Petrie K, Sparidans RW, Kok RJ, Versteeg R, Caron HN, Chesler L, Molenaar JJ. Dolman ME, et al. Among authors: den hartog ij. Clin Cancer Res. 2015 Nov 15;21(22):5100-9. doi: 10.1158/1078-0432.CCR-15-0313. Epub 2015 Jul 22. Clin Cancer Res. 2015. PMID: 26202950 Free PMC article.
High efficacy of the BCL-2 inhibitor ABT199 (venetoclax) in BCL-2 high-expressing neuroblastoma cell lines and xenografts and rational for combination with MCL-1 inhibition.
Bate-Eya LT, den Hartog IJ, van der Ploeg I, Schild L, Koster J, Santo EE, Westerhout EM, Versteeg R, Caron HN, Molenaar JJ, Dolman ME. Bate-Eya LT, et al. Among authors: den hartog ij. Oncotarget. 2016 May 10;7(19):27946-58. doi: 10.18632/oncotarget.8547. Oncotarget. 2016. PMID: 27056887 Free PMC article.
GRK2: a novel cell-specific regulator of severity and duration of inflammatory pain.
Eijkelkamp N, Heijnen CJ, Willemen HL, Deumens R, Joosten EA, Kleibeuker W, den Hartog IJ, van Velthoven CT, Nijboer C, Nassar MA, Dorn GW 2nd, Wood JN, Kavelaars A. Eijkelkamp N, et al. Among authors: den hartog ij. J Neurosci. 2010 Feb 10;30(6):2138-49. doi: 10.1523/JNEUROSCI.5752-09.2010. J Neurosci. 2010. PMID: 20147541 Free PMC article.
12 results