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1879 1
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1914 1
1916 2
1917 2
1921 2
1922 1
1924 3
1926 1
1927 1
1928 1
1929 5
1930 2
1931 1
1932 1
1933 3
1934 2
1935 2
1936 3
1937 4
1938 3
1939 3
1940 3
1941 2
1942 6
1943 5
1944 5
1945 13
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1947 29
1948 39
1949 26
1950 23
1951 41
1952 33
1953 42
1954 27
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1967 163
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1972 297
1973 377
1974 398
1975 1129
1976 1140
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1978 1180
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1980 1423
1981 1640
1982 1768
1983 2116
1984 2414
1985 2571
1986 2737
1987 2935
1988 2903
1989 3312
1990 3333
1991 3426
1992 3496
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1994 3763
1995 3741
1996 3838
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1998 3791
1999 3753
2000 4049
2001 4160
2002 4407
2003 4669
2004 4977
2005 5652
2006 6278
2007 6576
2008 6952
2009 7218
2010 7725
2011 8234
2012 8666
2013 9211
2014 9392
2015 9779
2016 9800
2017 9869
2018 10027
2019 10482
2020 11632
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2023 11582
2024 11024
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Ego depletion and the strength model of self-control: a meta-analysis.
Hagger MS, Wood C, Stiff C, Chatzisarantis NL. Hagger MS, et al. Psychol Bull. 2010 Jul;136(4):495-525. doi: 10.1037/a0019486. Psychol Bull. 2010. PMID: 20565167
Results revealed a significant effect of ego depletion on self-control task performance. Significant effect sizes were found for ego depletion on effort, perceived difficulty, negative affect, subjective fatigue, and blood glucose levels. ...Motivational incentives, …
Results revealed a significant effect of ego depletion on self-control task performance. Significant effect sizes were found for ego …
Differential expression of CCR8 in tumors versus normal tissue allows specific depletion of tumor-infiltrating T regulatory cells by GS-1811, a novel Fc-optimized anti-CCR8 antibody.
Weaver JD, Stack EC, Buggé JA, Hu C, McGrath L, Mueller A, Wong M, Klebanov B, Rahman T, Kaufman R, Fregeau C, Spaulding V, Priess M, Legendre K, Jaffe S, Upadhyay D, Singh A, Xu CA, Krukenberg K, Zhang Y, Ezzyat Y, Saddier Axe D, Kuhne MR, Meehl MA, Shaffer DR, Weist BM, Wiederschain D, Depis F, Gostissa M. Weaver JD, et al. Oncoimmunology. 2022 Nov 4;11(1):2141007. doi: 10.1080/2162402X.2022.2141007. eCollection 2022. Oncoimmunology. 2022. PMID: 36352891 Free PMC article.
However, identifying Treg-specific targets to drive such selective depletion is challenging. CCR8 has recently emerged as one of these potential targets. Here, we describe GS-1811, a novel therapeutic monoclonal antibody that specifically binds to human CCR8 and is designe …
However, identifying Treg-specific targets to drive such selective depletion is challenging. CCR8 has recently emerged as one of thes …
Depletion of Treg by the Diphtheria Toxin System.
Hanakawa S, Chow Z, Kabashima K. Hanakawa S, et al. Methods Mol Biol. 2023;2559:31-39. doi: 10.1007/978-1-0716-2647-4_3. Methods Mol Biol. 2023. PMID: 36180624
In this chapter, we describe the methods of depleting regulatory T cells (Tregs) systemically or selectively in the skin. Since it has been difficult to conclude the importance of tissue-residing Tregs with systemic Treg ablation, we sought to selectively deplete cu …
In this chapter, we describe the methods of depleting regulatory T cells (Tregs) systemically or selectively in the skin. Since it ha …
Antibody-mediated depletion of programmed death 1-positive (PD-1(+)) cells.
Zhai Y, Dong S, Li H, Zhang Y, Shami P, Chen M. Zhai Y, et al. J Control Release. 2022 Sep;349:425-433. doi: 10.1016/j.jconrel.2022.07.010. Epub 2022 Jul 15. J Control Release. 2022. PMID: 35820540 Free PMC article.
One definite approach to elucidate their roles is to deplete these cells in disease settings and examine how the depletion impacts disease progression and treatments. To execute the depletion, we designed and generated the first depleting antibody (D-a …
One definite approach to elucidate their roles is to deplete these cells in disease settings and examine how the depletion imp …
Depletion of Extracellular Chemokines by Aspergillus Melanin.
Graf KT, Liu H, Filler SG, Bruno VM. Graf KT, et al. mBio. 2023 Jun 27;14(3):e0019423. doi: 10.1128/mbio.00194-23. Epub 2023 Apr 17. mBio. 2023. PMID: 37067432 Free PMC article.
Melanin is both necessary and sufficient for this chemokine-depleting activity because a dihydroxynaphthalene (DHN)-melanin-deficient strain of A. fumigatus is defective in depleting chemokines and purified melanin ghosts retain potent depletion activity. We …
Melanin is both necessary and sufficient for this chemokine-depleting activity because a dihydroxynaphthalene (DHN)-melanin-deficient …
Depleting Macrophages In Vivo with Clodronate-Liposomes.
Moreno SG. Moreno SG. Methods Mol Biol. 2018;1784:259-262. doi: 10.1007/978-1-4939-7837-3_23. Methods Mol Biol. 2018. PMID: 29761405
In order to decipher the role of macrophages in vivo, it could be necessary to establish a model of macrophage depletion in the whole animal. One method to obtain animal models efficiently depleted in macrophages in different tissues (bone marrow, spleen, liver, lun …
In order to decipher the role of macrophages in vivo, it could be necessary to establish a model of macrophage depletion in the whole …
Polyamine Depletion Abrogates Enterovirus Cellular Attachment.
Kicmal TM, Tate PM, Dial CN, Esin JJ, Mounce BC. Kicmal TM, et al. J Virol. 2019 Sep 30;93(20):e01054-19. doi: 10.1128/JVI.01054-19. Print 2019 Oct 15. J Virol. 2019. PMID: 31341056 Free PMC article.
Passaging CVB3 in polyamine-depleted cells generated a mutation in capsid protein VP3 at residue 234. We show that this mutation confers resistance to polyamine depletion. ...Furthermore, the capsid mutant rescues this inhibition in polyamine-depleted cells. …
Passaging CVB3 in polyamine-depleted cells generated a mutation in capsid protein VP3 at residue 234. We show that this mutation conf …
Integrated ozone depletion as a metric for ozone recovery.
Pyle JA, Keeble J, Abraham NL, Chipperfield MP, Griffiths PT. Pyle JA, et al. Nature. 2022 Aug;608(7924):719-723. doi: 10.1038/s41586-022-04968-8. Epub 2022 Aug 24. Nature. 2022. PMID: 36002489
Ozone depletion potentials(2-4), relative measures of compounds' abilities to deplete stratospheric ozone, have been a key regulatory component of the Protocol in successfully guiding the phasing out in the manufacture of the most highly depleting substances. …
Ozone depletion potentials(2-4), relative measures of compounds' abilities to deplete stratospheric ozone, have been a key reg …
Liposomal Clodronate-mediated Macrophage Depletion in the Zebrafish Model.
Yang L, Rojas AM, Shiau CE. Yang L, et al. Bio Protoc. 2021 Mar 20;11(6):e3951. doi: 10.21769/BioProtoc.3951. eCollection 2021 Mar 20. Bio Protoc. 2021. PMID: 33855113 Free PMC article.
Multiple methods to deplete macrophages in zebrafish are available, including genetic (such as an irf8 knockout), chemogenetic (such as the nitroreductase/metronidazole system), and toxin-based depletions (such as using clodronate liposomes). ...Graphical abstract: …
Multiple methods to deplete macrophages in zebrafish are available, including genetic (such as an irf8 knockout), chemogenetic (such …
Effective, Long-Term, Neutrophil Depletion Using a Murinized Anti-Ly-6G 1A8 Antibody.
Olofsen PA, Stip MC, Jansen JHM, Chan C, Nederend M, Tieland RG, Tsioumpekou M, Leusen JHW. Olofsen PA, et al. Cells. 2022 Oct 27;11(21):3406. doi: 10.3390/cells11213406. Cells. 2022. PMID: 36359801 Free PMC article.
To study the function of neutrophils in vivo, these cells are often depleted using Ly-6G or Gr-1 depleting antibodies or genetic "knockout" models. However, these methods have several limitations, being only partially effective, effective for a short term, and lacki …
To study the function of neutrophils in vivo, these cells are often depleted using Ly-6G or Gr-1 depleting antibodies or genet …
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