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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 1
2002 5
2003 2
2004 3
2005 2
2006 2
2007 5
2008 4
2009 7
2010 8
2011 15
2012 13
2013 21
2014 21
2015 32
2016 44
2017 54
2018 68
2019 99
2020 71
2021 1
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410 results
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Clinical and metabolic response to probiotic administration in patients with major depressive disorder: A randomized, double-blind, placebo-controlled trial.
Akkasheh G, Kashani-Poor Z, Tajabadi-Ebrahimi M, Jafari P, Akbari H, Taghizadeh M, Memarzadeh MR, Asemi Z, Esmaillzadeh A. Akkasheh G, et al. Nutrition. 2016 Mar;32(3):315-20. doi: 10.1016/j.nut.2015.09.003. Epub 2015 Sep 28. Nutrition. 2016. PMID: 26706022 Clinical Trial.
OBJECTIVE: We are aware of no study examining the effects of probiotic supplementation on symptoms of depression, metabolic profiles, serum high-sensitivity C-reactive protein (hs-CRP), and biomarkers of oxidative stress in patients with major depressive d
OBJECTIVE: We are aware of no study examining the effects of probiotic supplementation on symptoms of depression, metabolic pr …
Probiotic Bifidobacterium longum NCC3001 Reduces Depression Scores and Alters Brain Activity: A Pilot Study in Patients With Irritable Bowel Syndrome.
Pinto-Sanchez MI, Hall GB, Ghajar K, Nardelli A, Bolino C, Lau JT, Martin FP, Cominetti O, Welsh C, Rieder A, Traynor J, Gregory C, De Palma G, Pigrau M, Ford AC, Macri J, Berger B, Bergonzelli G, Surette MG, Collins SM, Moayyedi P, Bercik P. Pinto-Sanchez MI, et al. Gastroenterology. 2017 Aug;153(2):448-459.e8. doi: 10.1053/j.gastro.2017.05.003. Epub 2017 May 5. Gastroenterology. 2017. PMID: 28483500 Free article. Clinical Trial.
BACKGROUND & AIMS: Probiotics can reduce symptoms of irritable bowel syndrome (IBS), but little is known about their effects on psychiatric comorbidities. ...At week 10, depression scores were reduced in patients given BL vs placebo. CONCLUSION: In a placebo-con …
BACKGROUND & AIMS: Probiotics can reduce symptoms of irritable bowel syndrome (IBS), but little is known about their effects on p …
The gut microbiome and diet in psychiatry: focus on depression.
Dash S, Clarke G, Berk M, Jacka FN. Dash S, et al. Curr Opin Psychiatry. 2015 Jan;28(1):1-6. doi: 10.1097/YCO.0000000000000117. Curr Opin Psychiatry. 2015. PMID: 25415497 Review.
Similarly, unhealthy diet has recently emerged as a significant correlate of and risk factor for depression. This review provides evidence for the gut microbiota as a key factor mediating the link between diet and depressive illness. ...New interventions are also su …
Similarly, unhealthy diet has recently emerged as a significant correlate of and risk factor for depression. This review provides evi …
Gut microbiota in autism and mood disorders.
Mangiola F, Ianiro G, Franceschi F, Fagiuoli S, Gasbarrini G, Gasbarrini A. Mangiola F, et al. World J Gastroenterol. 2016 Jan 7;22(1):361-8. doi: 10.3748/wjg.v22.i1.361. World J Gastroenterol. 2016. PMID: 26755882 Free PMC article. Review.
In the last few years, the importance of gut microbiota impairment in the etiopathogenesis of pathology such as autism, dementia and mood disorder, has been raised. The evidence of the inflammatory state alteration, highlighted in disorders such as schizophrenia, major …
In the last few years, the importance of gut microbiota impairment in the etiopathogenesis of pathology such as autism, dementia and mood …
Probiotic supplementation can positively affect anxiety and depressive symptoms: a systematic review of randomized controlled trials.
Pirbaglou M, Katz J, de Souza RJ, Stearns JC, Motamed M, Ritvo P. Pirbaglou M, et al. Nutr Res. 2016 Sep;36(9):889-898. doi: 10.1016/j.nutres.2016.06.009. Epub 2016 Jun 21. Nutr Res. 2016. PMID: 27632908 Review.
Thus, the purpose of this paper was to systematically evaluate current literature on the impact of probiotic supplementation on anxiety and depression symptoms in humans. ...Search results led to a total of 10 randomized controlled trials (4 in clinically diagnosed …
Thus, the purpose of this paper was to systematically evaluate current literature on the impact of probiotic supplementation on anxie …
Probiotic treatment reduces depressive-like behaviour in rats independently of diet.
Abildgaard A, Elfving B, Hokland M, Wegener G, Lund S. Abildgaard A, et al. Psychoneuroendocrinology. 2017 May;79:40-48. doi: 10.1016/j.psyneuen.2017.02.014. Epub 2017 Feb 16. Psychoneuroendocrinology. 2017. PMID: 28259042
The gut microbiota has recently emerged as an important regulator of brain physiology and behaviour in animals, and ingestion of certain bacteria (probiotics) therefore appear to be a potential treatment for major depressive disorder (MDD). ...Importantly, ou …
The gut microbiota has recently emerged as an important regulator of brain physiology and behaviour in animals, and ingestion of certain bac …
The study evaluating the effect of probiotic supplementation on the mental status, inflammation, and intestinal barrier in major depressive disorder patients using gluten-free or gluten-containing diet (SANGUT study): a 12-week, randomized, double-blind, and placebo-controlled clinical study protocol.
Karakula-Juchnowicz H, Rog J, Juchnowicz D, Łoniewski I, Skonieczna-Żydecka K, Krukow P, Futyma-Jedrzejewska M, Kaczmarczyk M. Karakula-Juchnowicz H, et al. Nutr J. 2019 Aug 31;18(1):50. doi: 10.1186/s12937-019-0475-x. Nutr J. 2019. PMID: 31472678 Free PMC article. Clinical Trial.
BACKGROUND: Current treatment of major depressive disorder (MDD) often does not achieve full remission of symptoms. Therefore, new forms of treatment and/or adjunct therapy are needed. ...Probiotics may restore the eubiosis within the gut while a gluten-free …
BACKGROUND: Current treatment of major depressive disorder (MDD) often does not achieve full remission of symptoms. Therefore, …
Effect of Probiotics on Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Huang R, Wang K, Hu J. Huang R, et al. Nutrients. 2016 Aug 6;8(8):483. doi: 10.3390/nu8080483. Nutrients. 2016. PMID: 27509521 Free PMC article. Review.
Probiotics may be essential to people with depression, which remains a global health challenge, as depression is a metabolic brain disorder. ...The meta-analysis showed that probiotics significantly decreased the depression scale score (M
Probiotics may be essential to people with depression, which remains a global health challenge, as depression is a meta
Effect of probiotic interventions on depressive symptoms: A narrative review evaluating systematic reviews.
Nadeem I, Rahman MZ, Ad-Dab'bagh Y, Akhtar M. Nadeem I, et al. Psychiatry Clin Neurosci. 2019 Apr;73(4):154-162. doi: 10.1111/pcn.12804. Epub 2019 Jan 6. Psychiatry Clin Neurosci. 2019. PMID: 30499231 Free article. Review.
Three of these reviews conducted meta-analyses, out of which, two concluded that probiotics improved depressive symptoms in the sample population. ...Due to the differences in clinical trials, a definitive effect of probiotics on depressive symptoms ca …
Three of these reviews conducted meta-analyses, out of which, two concluded that probiotics improved depressive symptoms in th …
Effect of probiotic and prebiotic vs placebo on psychological outcomes in patients with major depressive disorder: A randomized clinical trial.
Kazemi A, Noorbala AA, Azam K, Eskandari MH, Djafarian K. Kazemi A, et al. Clin Nutr. 2019 Apr;38(2):522-528. doi: 10.1016/j.clnu.2018.04.010. Epub 2018 Apr 24. Clin Nutr. 2019. PMID: 29731182 Clinical Trial.
BACKGROUND: Disturbance in the equilibrium of the gut microbiota has been involved in the pathophysiology of depression. Probiotics have the potential to healthfully modulate the gut microbiome. ...OBJECTIVE: The aim of this double blind clinical trial, was to compa …
BACKGROUND: Disturbance in the equilibrium of the gut microbiota has been involved in the pathophysiology of depression. Probiotic
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