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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1796 1
1797 2
1799 1
1801 2
1807 1
1819 1
1827 1
1831 1
1836 1
1838 1
1839 1
1841 1
1842 2
1844 1
1845 5
1846 1
1848 1
1850 3
1851 5
1852 2
1853 1
1859 1
1861 1
1866 1
1868 1
1870 2
1871 1
1874 9
1879 1
1880 2
1881 2
1891 1
1892 1
1893 1
1894 1
1895 2
1896 4
1897 6
1898 5
1899 2
1901 3
1902 2
1903 1
1904 1
1905 3
1907 4
1908 4
1909 6
1910 4
1911 10
1912 10
1913 13
1914 4
1915 14
1916 10
1917 14
1918 9
1919 10
1920 10
1921 7
1922 15
1923 16
1924 10
1925 20
1926 29
1927 19
1928 32
1929 20
1930 18
1931 21
1932 29
1933 27
1934 28
1935 24
1936 24
1937 29
1938 20
1939 21
1940 26
1941 21
1942 22
1943 15
1944 14
1945 141
1946 554
1947 645
1948 1088
1949 922
1950 912
1951 1117
1952 1492
1953 1899
1954 2212
1955 2521
1956 2822
1957 2771
1958 2905
1959 2889
1960 2598
1961 2732
1962 2659
1963 1813
1964 2085
1965 1786
1966 1493
1967 1753
1968 1835
1969 1871
1970 1969
1971 2114
1972 2319
1973 2429
1974 4841
1975 10145
1976 10455
1977 10682
1978 10517
1979 11483
1980 12980
1981 14760
1982 16470
1983 18420
1984 20631
1985 21516
1986 22559
1987 23092
1988 23892
1989 26114
1990 27422
1991 28250
1992 29436
1993 30313
1994 32155
1995 32970
1996 33299
1997 33430
1998 34224
1999 35403
2000 39512
2001 41875
2002 43608
2003 46648
2004 50285
2005 55828
2006 59345
2007 62530
2008 65589
2009 67937
2010 74306
2011 80038
2012 85799
2013 89600
2014 91472
2015 92343
2016 91329
2017 92913
2018 94735
2019 97259
2020 105756
2021 111469
2022 108364
2023 106201
2024 117853
2025 140001
2026 80937
2027 1

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2,585,393 results

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Page 1
Bypassing lantibiotic resistance by an effective nisin derivative.
Zaschke-Kriesche J, Behrmann LV, Reiners J, Lagedroste M, Gröner Y, Kalscheuer R, Smits SHJ. Zaschke-Kriesche J, et al. Bioorg Med Chem. 2019 Aug 1;27(15):3454-3462. doi: 10.1016/j.bmc.2019.06.031. Epub 2019 Jun 20. Bioorg Med Chem. 2019. PMID: 31253534
This study presents a highly potent, pore forming nisin variant as an alternative lantibiotic which bypasses the SaNSR protein. It is shown that this nisin derivate nisin(C28P) keeps its nanomolar antibacterial activity against L. lactis NZ9000 cells but is not recognized …
This study presents a highly potent, pore forming nisin variant as an alternative lantibiotic which bypasses the SaNSR protein. It is shown …
A novel antibacterial tyroscherin derivative with a natural unprecedented morpholine-2, 3-dione structural unit from the fungus Pseudallescheria boydii.
Chen R, Li Z, Qin C, Lu P, Lin J, Zheng W, Xiong Y, Li C. Chen R, et al. Nat Prod Res. 2022 Dec;36(23):5977-5983. doi: 10.1080/14786419.2022.2050228. Epub 2022 Mar 12. Nat Prod Res. 2022. PMID: 35285355
A novel tyroscherin derivative named pseudallecin A (1) with a natural unprecedented morpholine-2, 3-dione structural unit, and a new biogenic synthesis related organic acid named pseudallecin B (2) were purified from a symbiotic fungus Pseudallescheria boydii derived …
A novel tyroscherin derivative named pseudallecin A (1) with a natural unprecedented morpholine-2, 3-dione structural unit, and a new …
A novel hydroxytyrosol derivative HT-3 enhances antioxidant and neuroprotective activity through efficient molecular conjugation.
Zhang L, Wei H, Han T, Shi S, Zhang X, Shi X, Zhang H, Zhang B. Zhang L, et al. Bioorg Chem. 2025 Jul 1;161:108484. doi: 10.1016/j.bioorg.2025.108484. Epub 2025 Apr 23. Bioorg Chem. 2025. PMID: 40300447
Our previous studies demonstrated that hydroxytyrosol (HT) provides excellent neuroprotection in PC12 cells, which is derived from olive oil, and now widely used as a natural food additive. In this study, we rationally designed and synthesized a string of HT derivations …
Our previous studies demonstrated that hydroxytyrosol (HT) provides excellent neuroprotection in PC12 cells, which is derived from ol …
[A cellulose derivative with a potential to become an active pharmaceutical substance as well as an auxiliary substance].
Gajdziok J, Bajerová M, Chalupová Z, Masteiková R. Gajdziok J, et al. Ceska Slov Farm. 2007 Dec;56(6):259-63. Ceska Slov Farm. 2007. PMID: 18257415 Review. Czech.
The review article is focused on one of the wide range of pharmaceutically and medicinally employed cellulose derivates--oxycellulose. This substance, prepared by oxidation of cellulose, in contrast to cellulose esters and ethers, has not been not employed in practice in a …
The review article is focused on one of the wide range of pharmaceutically and medicinally employed cellulose derivates--oxycellulose …
Cytoprotective Effect of Epigallocatechin Gallate (EGCG)-5'-O-alpha-Glucopyranoside, a Novel EGCG Derivative.
Han SY, Kim E, Hwang K, Ratan ZA, Hwang H, Kim EM, Kim D, Park J, Cho JY. Han SY, et al. Int J Mol Sci. 2018 May 15;19(5):1466. doi: 10.3390/ijms19051466. Int J Mol Sci. 2018. PMID: 29762498 Free PMC article.
Since EGCG has low solubility and stability, many researchers have modified EGCG residues to ameliorate these problems. A novel EGCG derivative, EGCG-5'-O-alpha-glucopyranoside (EGCG-5'Glu), was synthesized, and its characteristics were investigated. EGCG-5'Glu showed anti …
Since EGCG has low solubility and stability, many researchers have modified EGCG residues to ameliorate these problems. A novel EGCG deri …
[Advances on the profiling of 5-hydroxymethylcytosine].
Fang K, Zhang KX, Wang J, Fu ZM, Zhao XH. Fang K, et al. Yi Chuan. 2016 Mar;38(3):206-16. doi: 10.16288/j.yczz.15-480. Yi Chuan. 2016. PMID: 27001475 Review. Chinese.
Compared to another well-known cytosine methylation derivate, 5-methylcytosine (5mC), the detection of 5hmC is difficult for its lower lever existing in most tissues. To distinguish 5hmC from other cytosine derivates, the methods using chemical or enzymatic DNA trea …
Compared to another well-known cytosine methylation derivate, 5-methylcytosine (5mC), the detection of 5hmC is difficult for its lowe …
[Prostacyclin derivatives].
Nagaya N. Nagaya N. Nihon Rinsho. 2008 Nov;66(11):2145-50. Nihon Rinsho. 2008. PMID: 19051734 Review. Japanese.
Subcutaneous administration of ONO-1301 markedly attenuated monocrotaline-induced pulmonary hypertension and improved survival in rats. These prostacycline derivates may be promising for the treatment of pulmonary arterial hypertension....
Subcutaneous administration of ONO-1301 markedly attenuated monocrotaline-induced pulmonary hypertension and improved survival in rats. Thes …
Stability studies on florfenicol using developed derivative spectrophotometric methods.
Elimam MM, Shantier SW, Gadkariem EA, Mohamed MA, Osman Z. Elimam MM, et al. Ann Pharm Fr. 2017 Jan;75(1):40-44. doi: 10.1016/j.pharma.2016.07.003. Epub 2016 Aug 24. Ann Pharm Fr. 2017. PMID: 27567357
OBJECTIVES: This study aims to investigate the stability of florfenicol using previously developed derivative spectrophotometric methods (D(1) and D(2)). METHODS: The studied stability-indicating pararmeters included alkali (NaOH, 1M), acid (HCl, 1M), pH changes (buffer pH …
OBJECTIVES: This study aims to investigate the stability of florfenicol using previously developed derivative spectrophotometric meth …
In vitro and in vivo anti-tumor activities of a gemcitabine derivative carried by nanoparticles.
Sloat BR, Sandoval MA, Li D, Chung WG, Lansakara-P DS, Proteau PJ, Kiguchi K, DiGiovanni J, Cui Z. Sloat BR, et al. Int J Pharm. 2011 May 16;409(1-2):278-88. doi: 10.1016/j.ijpharm.2011.02.037. Epub 2011 Mar 1. Int J Pharm. 2011. PMID: 21371545 Free PMC article.
In the present study, a new gemcitabine nanoparticle formulation was developed by incorporating a previously reported stearic acid amide derivative of gemcitabine into nanoparticles prepared from lecithin/glyceryl monostearate-in-water emulsions. ...It is concluded that fo …
In the present study, a new gemcitabine nanoparticle formulation was developed by incorporating a previously reported stearic acid amide …
Rational design of DXd derivatives for liposomal drug delivery: Towards safer and more effective cancer treatments.
Li J, Yu J, Zhang B, Song J, Huang R, Li N, Zhang Y, Zhou S, Li X, He Z, Liu H, Wang Y. Li J, et al. Int J Pharm. 2025 Jun 10;678:125688. doi: 10.1016/j.ijpharm.2025.125688. Epub 2025 May 8. Int J Pharm. 2025. PMID: 40339629
DXd (Exatecan derivative), a novel TOPO-I inhibitor, exhibits high membrane permeability and an efficient bystander effect, serving as a critical cytotoxic drug component in antibody-drug conjugates (ADCs). ...In this study, DXd was used as a model compound to design and s …
DXd (Exatecan derivative), a novel TOPO-I inhibitor, exhibits high membrane permeability and an efficient bystander effect, serving a …
2,585,393 results
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