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Page 1
Menopause and the Skin: Old Favorites and New Innovations in Cosmeceuticals for Estrogen-Deficient Skin.
Lephart ED, Naftolin F. Lephart ED, et al. Dermatol Ther (Heidelb). 2021 Feb;11(1):53-69. doi: 10.1007/s13555-020-00468-7. Epub 2020 Nov 26. Dermatol Ther (Heidelb). 2021. PMID: 33242128 Free PMC article. Review.
The changes include loss of collagen, elastin, fibroblast function, vascularity, and increased matrix metalloproteinase(s) enzymatic activities, resulting in cellular and extracellular degradation that leads to dryness, wrinkles, atrophy, impaired wound healing/barr …
The changes include loss of collagen, elastin, fibroblast function, vascularity, and increased matrix metalloproteinase(s) enz …
Taurine Prevents Impairments in Skin Barrier Function and Dermal Collagen Synthesis Triggered by Sleep Deprivation-Induced Estrogen Circadian Rhythm Disruption.
Shao Q, Wang Z, Li Y, Tang X, Li Z, Xia H, Wu Q, Chang R, Wu C, Meng T, Fan Y, Huang Y, Yang Y. Shao Q, et al. Cells. 2025 May 16;14(10):727. doi: 10.3390/cells14100727. Cells. 2025. PMID: 40422230 Free PMC article.
These disruptions can impair skin barrier functionality and decrease dermal collagen synthesis. In this study, our results demonstrate that topical taurine supplementation promotes the expression of tight junction (TJ)-related proteins and enhances collagen p …
These disruptions can impair skin barrier functionality and decrease dermal collagen synthesis. In this study, our results dem …
The role of cytokines in skin aging.
Borg M, Brincat S, Camilleri G, Schembri-Wismayer P, Brincat M, Calleja-Agius J. Borg M, et al. Climacteric. 2013 Oct;16(5):514-21. doi: 10.3109/13697137.2013.802303. Epub 2013 May 31. Climacteric. 2013. PMID: 23659624 Review.
Skin aging is mainly affected by three factors: chronological aging, decreased levels of estrogen after menopause, and environmental factors. ...Deranged levels of several interleukins and interferons also affect the aging process. The high level of CC …
Skin aging is mainly affected by three factors: chronological aging, decreased levels of estrogen after menopause, and …
Phytoestrogens as Natural Anti-Aging Solutions for Enhanced Collagen Synthesis in Skin.
Amini N, Osterlund C, Curpen J, Lafon-Kolb V, Richard T, Visdal-Johnsen L. Amini N, et al. J Cosmet Dermatol. 2025 Feb;24(2):e16719. doi: 10.1111/jocd.16719. Epub 2024 Dec 9. J Cosmet Dermatol. 2025. PMID: 39654355 Free PMC article.
Post-menopause, declining estrogen levels lead to a significant reduction in skin health, notably a 30% decrease in collagen types I and III within 5 years. ...Liquorice rhizome (G. uralensis), used in traditional Chinese medicine, is rich in phytoestrogens like liq …
Post-menopause, declining estrogen levels lead to a significant reduction in skin health, notably a 30% decrease in collagen t …
Development of an in vitro model of menopause using primary human dermal fibroblasts.
Remoué N, Molinari J, Andres E, Lago JC, Barrichello C, Moreira PL. Remoué N, et al. Int J Cosmet Sci. 2013 Dec;35(6):546-54. doi: 10.1111/ics.12075. Epub 2013 Jul 15. Int J Cosmet Sci. 2013. PMID: 23802717
METHODS: Human dermal fibroblasts were incubated with media containing 17beta-oestradiol, progesterone, dehydroepiandrosterone, growth hormone and insulin-like growth factor-1 at concentrations corresponding to those of non-menopausal women's sera and then of …
METHODS: Human dermal fibroblasts were incubated with media containing 17beta-oestradiol, progesterone, dehydroepiandrosterone …
[Hormone replacement treatment and skin aging].
Vaillant L, Callens A. Vaillant L, et al. Therapie. 1996 Jan-Feb;51(1):67-70. Therapie. 1996. PMID: 8762222 Review. French.
In some experimental studies oestrogens increase the activity of fibroblasts and water, hyaluronic acid and collagen dermal contents. Some studies have demonstrated that oestrogen treatment increases skin thickness, mitotic activity of keratinocytes, and d …
In some experimental studies oestrogens increase the activity of fibroblasts and water, hyaluronic acid and collagen dermal …
Topical estradiol does not interfere with the expression of the metalloproteinase-1 enzyme in photo exposed skin cells.
Neder L, Medeiros SF. Neder L, et al. An Bras Dermatol. 2012 Jan-Feb;87(1):70-5. doi: 10.1590/s0365-05962012000100008. An Bras Dermatol. 2012. PMID: 22481653 Free article.
BACKGROUND: In postmenopausal women there is a rapid destruction of dermal collagen, resulting in accelerated skin ageing, which is manifested by cutaneous atrophy, increased number and depth of wrinkles and sagging. This accelerated catabolism of the coll …
BACKGROUND: In postmenopausal women there is a rapid destruction of dermal collagen, resulting in accelerated skin ageing …
The role of hyaluronic acid and amino acid against the aging of the human skin: A clinical and histological study.
Scarano A, Sbarbati A, Amore R, Iorio EL, Ferraro G, Marchetti M, Amuso D. Scarano A, et al. J Cosmet Dermatol. 2021 Jul;20(7):2296-2304. doi: 10.1111/jocd.13811. Epub 2020 Nov 9. J Cosmet Dermatol. 2021. Retraction in: J Cosmet Dermatol. 2023 Dec;22(12):3527. doi: 10.1111/jocd.15857. PMID: 33090687 Retracted.
BACKGROUND: In esthetic medicine, different techniques have been used against the aging of the human skin especially in the facial area. Hyaluronic acid is used for improving the quantity of water and extracellular matrix molecule. ...RESULTS: The clinical results of the p …
BACKGROUND: In esthetic medicine, different techniques have been used against the aging of the human skin especially in the facial ar …
17beta-estradiol protects human skin fibroblasts and keratinocytes against oxidative damage.
Bottai G, Mancina R, Muratori M, Di Gennaro P, Lotti T. Bottai G, et al. J Eur Acad Dermatol Venereol. 2013 Oct;27(10):1236-43. doi: 10.1111/j.1468-3083.2012.04697.x. Epub 2012 Sep 18. J Eur Acad Dermatol Venereol. 2013. PMID: 22988828
Accumulation of these molecular changes apparently constitutes the basis of cell ageing. 17b-estradiol (E2) has a key role in skin ageing homeostasis as evidenced by the accelerated decline in skin appearance seen in the perimenopausal years. ...DISCUSSION: In this …
Accumulation of these molecular changes apparently constitutes the basis of cell ageing. 17b-estradiol (E2) has a key role in skin …
A Double-Blind Randomized Pilot Study Evaluating the Safety and Efficacy of Topical MEP in the Facial Appearance Improvement of Estrogen Deficient Females.
Draelos ZD. Draelos ZD. J Drugs Dermatol. 2018 Nov 1;17(11):1186 - 1189. J Drugs Dermatol. 2018. PMID: 30500138 Clinical Trial.
Facial skin aging is accelerated in postmenopausal females due to decreased collagen, reduced hydration, and loss of skin elasticity constituting the characteristics of estrogen deficient skin (EDS). The presence of estrogen receptors on dermal fibroblasts …
Facial skin aging is accelerated in postmenopausal females due to decreased collagen, reduced hydration, and loss of skin elas …