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Year Number of Results
1984 3
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1988 4
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1991 1
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Page 1
Efficacy of desciclovir in the treatment of Epstein-Barr virus infection in oral hairy leukoplakia.
Greenspan D, De Souza YG, Conant MA, Hollander H, Chapman SK, Lennette ET, Petersen V, Greenspan JS. Greenspan D, et al. J Acquir Immune Defic Syndr (1988). 1990;3(6):571-8. J Acquir Immune Defic Syndr (1988). 1990. PMID: 2159990 Clinical Trial.
The histological features of HL were significantly diminished in patients on desciclovir, and cytochemical, in situ hybridization, and ultrastructural studies showed that EBV infection was eliminated or dramatically reduced in the desciclovir group only. Four patien …
The histological features of HL were significantly diminished in patients on desciclovir, and cytochemical, in situ hybridization, an …
Desciclovir permeation of the human erythrocyte membrane by nonfacilitated diffusion.
Domin BA, Mahony WB, Zimmerman TP. Domin BA, et al. Biochem Pharmacol. 1991 Jun 21;42(1):147-52. doi: 10.1016/0006-2952(91)90693-y. Biochem Pharmacol. 1991. PMID: 2069588
The mechanism of transport of desciclovir (DCV)--a structural analogue and prodrug of acyclovir (ACV) which provides an improved oral bioavailability of ACV--was investigated in human erythrocytes with a "papaverine-stop" assay. ...
The mechanism of transport of desciclovir (DCV)--a structural analogue and prodrug of acyclovir (ACV) which provides an improved oral …
Pharmacokinetics and tolerance of desciclovir, a prodrug of acyclovir, in healthy human volunteers.
Petty BG, Whitley RJ, Liao S, Krasny HC, Rocco LE, Davis LG, Lietman PS. Petty BG, et al. Antimicrob Agents Chemother. 1987 Sep;31(9):1317-22. doi: 10.1128/AAC.31.9.1317. Antimicrob Agents Chemother. 1987. PMID: 3674844 Free PMC article.
Because of the incomplete absorption of acyclovir (ACV) when given orally in humans, efforts have been made to develop a prodrug of ACV that would be better absorbed from the gastrointestinal tract and then converted in vivo to ACV. One such compound, desciclovir (DCV), is …
Because of the incomplete absorption of acyclovir (ACV) when given orally in humans, efforts have been made to develop a prodrug of ACV that …
Acyclovir transport into human erythrocytes.
Mahony WB, Domin BA, McConnell RT, Zimmerman TP. Mahony WB, et al. J Biol Chem. 1988 Jul 5;263(19):9285-91. J Biol Chem. 1988. PMID: 3379070 Free article.
Conversely, ACV was a competitive inhibitor (Ki = 240-280 microM) of the transport of adenine (Km = 13 microM), guanine (Km = 37 microM), and hypoxanthine (Km = 180 microM). Desciclovir and ganciclovir, two compounds related structurally to ACV, were also found to be compe …
Conversely, ACV was a competitive inhibitor (Ki = 240-280 microM) of the transport of adenine (Km = 13 microM), guanine (Km = 37 microM), an …
Radioimmunoassay for desciclovir, 2-[(2-amino-9H-purin-9-yl)methoxy]ethanol, a prodrug for the antiviral acyclovir.
Quinn RP, Gerald L, Tadepalli S. Quinn RP, et al. J Immunoassay. 1987;8(2-3):247-65. doi: 10.1080/15321818708057025. J Immunoassay. 1987. PMID: 3624496
A direct radioimmunoassay for the detection of desciclovir (DCV)(2) in biological fluids has been developed. The radioimmunoassay was validated by comparing results obtained from human plasma samples analyzed by both this RIA and a gas chromatographic method. ...
A direct radioimmunoassay for the detection of desciclovir (DCV)(2) in biological fluids has been developed. The radioimmunoassay was …
Open study of 2-amino-9-(hydroxyethoxymethyl)-9H-purine (desciclovir) in the treatment of herpes zoster.
Peterslund NA, Esmann V, Geil JP, Petersen CM, Mogensen CE. Peterslund NA, et al. J Antimicrob Chemother. 1987 Nov;20(5):743-51. doi: 10.1093/jac/20.5.743. J Antimicrob Chemother. 1987. PMID: 3429375
An oral pro-drug of acyclovir, 2-amino-9-(2-hydroxyethoxymethyl)-9H-purine (desciclovir) was evaluated in an open study comprising of 20 patients with herpes zoster. ...The finding of possible impaired conversion of desciclovir to acyclovir in one patient was unexpl …
An oral pro-drug of acyclovir, 2-amino-9-(2-hydroxyethoxymethyl)-9H-purine (desciclovir) was evaluated in an open study comprising of …
Metabolism of desciclovir, a prodrug of acyclovir, in humans after multiple oral dosing.
Krasny HC, Petty BG. Krasny HC, et al. J Clin Pharmacol. 1987 Jan;27(1):74-7. doi: 10.1177/009127008702700112. J Clin Pharmacol. 1987. PMID: 3680558
Desciclovir (DCV), a prodrug of the antiherpetic agent acyclovir (ACV), is converted in humans to ACV, presumably by xanthine oxidase. ...
Desciclovir (DCV), a prodrug of the antiherpetic agent acyclovir (ACV), is converted in humans to ACV, presumably by xanthine oxidase …
Antivirals for the treatment of herpesvirus infections.
De Clercq E. De Clercq E. J Antimicrob Chemother. 1993 Jul;32 Suppl A:121-32. doi: 10.1093/jac/32.suppl_a.121. J Antimicrob Chemother. 1993. PMID: 8407694 Review.
Other antiviral agents considered for use in herpesvirus infections include brovavir, penciclovir (and its prodrug famciclovir), desciclovir (a prodrug of acyclovir), bishydroxymethylcyclobutylguanine (BHCG) and, in particular, 1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosi …
Other antiviral agents considered for use in herpesvirus infections include brovavir, penciclovir (and its prodrug famciclovir), desciclo …
Management of oral lesions in HIV-positive patients.
Baccaglini L, Atkinson JC, Patton LL, Glick M, Ficarra G, Peterson DE. Baccaglini L, et al. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Mar;103 Suppl:S50.e1-23. doi: 10.1016/j.tripleo.2006.11.002. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007. PMID: 17379155
There were no double blind, placebo-controlled randomized clinical trials (RCT) for topical treatment of OHL, and only one RCT for systemic treatment of the lesion with desciclovir. Systemic thalidomide was the only drug tested in RCT for treatment or prevention of RAU. .. …
There were no double blind, placebo-controlled randomized clinical trials (RCT) for topical treatment of OHL, and only one RCT for systemic …
32 results