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Page 1
Comparative Effectiveness of Levothyroxine, Desiccated Thyroid Extract, and Levothyroxine+Liothyronine in Hypothyroidism.
Shakir MKM, Brooks DI, McAninch EA, Fonseca TL, Mai VQ, Bianco AC, Hoang TD. Shakir MKM, et al. J Clin Endocrinol Metab. 2021 Oct 21;106(11):e4400-e4413. doi: 10.1210/clinem/dgab478. J Clin Endocrinol Metab. 2021. PMID: 34185829 Free PMC article. Clinical Trial.
INTRODUCTION: Studies comparing levothyroxine (LT4) therapy with LT4 + liothyronine (LT3) or desiccated thyroid extract (DTE) did not detect consistent superiority of either treatment. ...The primary outcomes were posttreatment scores on the 36-point thyro …
INTRODUCTION: Studies comparing levothyroxine (LT4) therapy with LT4 + liothyronine (LT3) or desiccated thyroid extract …
Hypothyroidism.
Taylor PN, Medici MM, Hubalewska-Dydejczyk A, Boelaert K. Taylor PN, et al. Lancet. 2024 Oct 5;404(10460):1347-1364. doi: 10.1016/S0140-6736(24)01614-3. Lancet. 2024. PMID: 39368843 Review.
However, 10% of patients have persistent symptoms of ill health despite normalisation of thyroid function tests biochemically and a substantial proportion of patients on levothyroxine have thyroid-stimulating hormone concentrations outside the reference range. Ongoi …
However, 10% of patients have persistent symptoms of ill health despite normalisation of thyroid function tests biochemically and a s …
Liothyronine and Desiccated Thyroid Extract in the Treatment of Hypothyroidism.
Idrees T, Palmer S, Maciel RMB, Bianco AC. Idrees T, et al. Thyroid. 2020 Oct;30(10):1399-1413. doi: 10.1089/thy.2020.0153. Epub 2020 May 12. Thyroid. 2020. PMID: 32279609 Free PMC article. Review.
An observational study of 400 patients with a mean follow-up of 9 years did not indicate increased mortality or morbidity risk due to cardiovascular disease, atrial fibrillation, or fractures after adjusting for age when compared with patients taking only LT4. Desiccated …
An observational study of 400 patients with a mean follow-up of 9 years did not indicate increased mortality or morbidity risk due to cardi …
Primary hypothyroidism and quality of life.
Hegedüs L, Bianco AC, Jonklaas J, Pearce SH, Weetman AP, Perros P. Hegedüs L, et al. Nat Rev Endocrinol. 2022 Apr;18(4):230-242. doi: 10.1038/s41574-021-00625-8. Epub 2022 Jan 18. Nat Rev Endocrinol. 2022. PMID: 35042968 Free PMC article. Review.
In the 1970s, treatment with thyroid extract was superseded by levothyroxine, a synthetic L form of tetraiodothyronine. ...However, neither studies combining levothyroxine and liothyronine (the synthetic form of tri-iodothyronine) nor the use of desiccated …
In the 1970s, treatment with thyroid extract was superseded by levothyroxine, a synthetic L form of tetraiodothyronine. ...How …
Potential Risks and Benefits of Desiccated Thyroid Extract for the Treatment of Hypothyroidism: A Systematic Review.
Riis KR, Larsen CB, Bonnema SJ. Riis KR, et al. Thyroid. 2024 Jun;34(6):687-701. doi: 10.1089/thy.2023.0649. Epub 2024 Apr 11. Thyroid. 2024. PMID: 38526391
Background: Desiccated thyroid extract (DTE) is no longer recommended for the treatment of hypothyroidism but is still in use. ...The primary outcome was quality of life (QoL), and the secondary outcomes included symptoms, treatment preference, adverse effect …
Background: Desiccated thyroid extract (DTE) is no longer recommended for the treatment of hypothyroidism but is still …
Treatment Preferences in Patients With Hypothyroidism.
de Lima Beltrão FE, Carvalhal G, de Almeida Beltrão DC, de Lima Beltrão FE, Ribeiro MO, Ettleson MD, Ramos HE, Bianco AC. de Lima Beltrão FE, et al. J Clin Endocrinol Metab. 2025 Feb 18;110(3):887-900. doi: 10.1210/clinem/dgae651. J Clin Endocrinol Metab. 2025. PMID: 39290156 Free PMC article.
A minority of L-T4-treated patients remain symptomatic and report better outcomes with combination therapy that contains liothyronine (L-T3) or with desiccated thyroid extract (DTE). OBJECTIVE: This work aimed to assess patient preferences in the treatment of …
A minority of L-T4-treated patients remain symptomatic and report better outcomes with combination therapy that contains liothyronine (L-T3) …
Thyroid.
[No authors listed] [No authors listed] 2026 Jun 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. 2026 Jun 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. PMID: 30000798 Free Books & Documents. Review.
Thyroid is an animal-derived mixture of levothyroxine (T4) and liothyronine (T3), which are normal components of human milk. Limited data on exogenous replacement doses of levothyroxine during breastfeeding indicate no adverse effects in infants. If the mother requires …
Thyroid is an animal-derived mixture of levothyroxine (T4) and liothyronine (T3), which are normal components of human milk. Limited …
Thyroid extract.
Fowler PB. Fowler PB. Br Med J. 1978 Oct 14;2(6144):1089. doi: 10.1136/bmj.2.6144.1089. Br Med J. 1978. PMID: 709243 Free PMC article. No abstract available.
Thyroid extract.
TAYLOR S. TAYLOR S. Lancet. 1961 Feb 11;1(7172):332-3. doi: 10.1016/s0140-6736(61)91499-4. Lancet. 1961. PMID: 13775648 No abstract available.
Socioeconomic influence on treatment with liothyronine and desiccated thyroid extract in Denmark.
la Cour JL, Møllehave LT, Medici BR, Jensen CZ, Bjerregaard AA, Nygaard B. la Cour JL, et al. Eur Thyroid J. 2022 Oct 20;11(6):e220149. doi: 10.1530/ETJ-22-0149. Print 2022 Dec 1. Eur Thyroid J. 2022. PMID: 36165837 Free PMC article.
INTRODUCTION: High compared with low educational level increases the odds of starting levothyroxine (L-T4) with a normal thyroid-stimulating hormone - the mechanism is most likely patient request. The use of liothyronine (L-T3) and desiccated thyroid extra …
INTRODUCTION: High compared with low educational level increases the odds of starting levothyroxine (L-T4) with a normal thyroid-stim …
750 results