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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1991 9
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1994 6
1995 2
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1999 5
2000 3
2001 6
2002 3
2003 7
2004 13
2005 11
2006 25
2007 21
2008 43
2009 41
2010 49
2011 43
2012 72
2013 117
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2015 154
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2,381 results

Results by year

Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Dexmedetomidine for analgesia and sedation in newborn infants receiving mechanical ventilation.
Lim JY, Ker CJ, Lai NM, Romantsik O, Fiander M, Tan K. Lim JY, et al. Cochrane Database Syst Rev. 2024 May 2;5(5):CD012361. doi: 10.1002/14651858.CD012361.pub2. Cochrane Database Syst Rev. 2024. PMID: 38695625 Free PMC article.
BACKGROUND: Dexmedetomidine is a selective alpha-2 agonist with minimal impact on the haemodynamic profile. ...One study will compare dexmedetomidine with morphine in asphyxiated newborns undergoing hypothermia, and the other (mixed population, age up to three years …
BACKGROUND: Dexmedetomidine is a selective alpha-2 agonist with minimal impact on the haemodynamic profile. ...One study will compare …
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Jakob SM, Ruokonen E, Grounds RM, Sarapohja T, Garratt C, Pocock SJ, Bratty JR, Takala J; Dexmedetomidine for Long-Term Sedation Investigators. Jakob SM, et al. JAMA. 2012 Mar 21;307(11):1151-60. doi: 10.1001/jama.2012.304. JAMA. 2012. PMID: 22436955 Clinical Trial.
The MIDEX trial compared midazolam with dexmedetomidine in ICUs of 44 centers in 9 European countries; the PRODEX trial compared propofol with dexmedetomidine in 31 centers in 6 European countries and 2 centers in Russia. ...Time at target sedation was analyzed in p …
The MIDEX trial compared midazolam with dexmedetomidine in ICUs of 44 centers in 9 European countries; the PRODEX trial compared prop …
The effect of dexmedetomidine on delirium and agitation in patients in intensive care: systematic review and meta-analysis with trial sequential analysis.
Ng KT, Shubash CJ, Chong JS. Ng KT, et al. Anaesthesia. 2019 Mar;74(3):380-392. doi: 10.1111/anae.14472. Epub 2018 Oct 27. Anaesthesia. 2019. PMID: 30367689 Free article.
The primary aim of this review was to examine whether dexmedetomidine reduces the incidence of delirium and agitation in intensive care patients. ...In summary, this meta-analysis suggests that dexmedetomidine reduces the incidence of delirium and agitation in inten …
The primary aim of this review was to examine whether dexmedetomidine reduces the incidence of delirium and agitation in intensive ca …
Dexmedetomidine for Reducing Mortality in Patients With Septic Shock: A Randomized Controlled Trial (DecatSepsis).
Ezz Al-Regal AR, Ramzy EA, Atia AAA, Emara MM. Ezz Al-Regal AR, et al. Chest. 2024 Dec;166(6):1394-1405. doi: 10.1016/j.chest.2024.06.3794. Epub 2024 Jul 14. Chest. 2024. PMID: 39004217 Clinical Trial.
Dexmedetomidine reduced the epinephrine infusion rescue (relative risk reduction, 0.6; 95% CI, 0.06-0.93; P = .025). ...INTERPRETATION: The study was underpowered to detect a reduction in in-hospital mortality or norepinephrine equivalent dose in patients with septic shock …
Dexmedetomidine reduced the epinephrine infusion rescue (relative risk reduction, 0.6; 95% CI, 0.06-0.93; P = .025). ...INTERPRETATIO …
Dexmedetomidine for awake craniotomy: Systematic review and meta-analysis.
Akavipat P, Sookplung P, Lekprasert V, Kasemsiri C, Lerdsirisophon S. Akavipat P, et al. J Clin Neurosci. 2024 Sep;127:110765. doi: 10.1016/j.jocn.2024.110765. Epub 2024 Jul 29. J Clin Neurosci. 2024. PMID: 39079421
Therefore, the systematic review and meta-analysis was done to compare the clinical profile, surgical outcomes, and anesthesia-related complications between dexmedetomidine-based and non-dexmedetomidine regimens during monitored anesthesia care (MAC) for this proced …
Therefore, the systematic review and meta-analysis was done to compare the clinical profile, surgical outcomes, and anesthesia-related compl …
Dexmedetomidine to Reduce Vasopressor Resistance in Refractory Septic Shock: alpha2 Agonist Dexmedetomidine for REfractory Septic Shock (ADRESS): A Double-Blind Randomized Controlled Pilot Trial.
Dargent A, Bourredjem A, Jacquier M, Bohe J, Argaud L, Levy B, Fournel I, Cransac A, Badie J, Quintin L, Quenot JP. Dargent A, et al. Crit Care Med. 2025 Apr 1;53(4):e884-e896. doi: 10.1097/CCM.0000000000006608. Epub 2025 Feb 28. Crit Care Med. 2025. PMID: 40019329 Free PMC article. Clinical Trial.
The alpha2 Agonist Dexmedetomidine for REfractory Septic Shock (ADRESS) pilot study aimed to evaluate the effect of dexmedetomidine on the vasopressor response in patients with refractory septic shock. ...However, heart rate was not decreased in the dexmedetomidi …
The alpha2 Agonist Dexmedetomidine for REfractory Septic Shock (ADRESS) pilot study aimed to evaluate the effect of dexmedetomidin …
Mini-dose esketamine-dexmedetomidine combination to supplement analgesia for patients after scoliosis correction surgery: a double-blind randomised trial.
Zhang Y, Cui F, Ma JH, Wang DX. Zhang Y, et al. Br J Anaesth. 2023 Aug;131(2):385-396. doi: 10.1016/j.bja.2023.05.001. Epub 2023 Jun 9. Br J Anaesth. 2023. PMID: 37302963 Free article. Clinical Trial.
BACKGROUND: Patients often experience severe pain after scoliosis correction surgery. Esketamine and dexmedetomidine each improves analgesia but can produce side-effects. We therefore tested the hypothesis that a mini-dose esketamine-dexmedetomidine combination safe …
BACKGROUND: Patients often experience severe pain after scoliosis correction surgery. Esketamine and dexmedetomidine each improves an …
Intranasal dexmedetomidine for sedation in children; a review.
Lewis J, Bailey CR. Lewis J, et al. J Perioper Pract. 2020 Jun;30(6):170-175. doi: 10.1177/1750458919854885. Epub 2019 Jun 27. J Perioper Pract. 2020. PMID: 31246159
Dexmedetomidine is an alpha2 adrenoreceptor agonist that may be administered by the intranasal route as a sole sedative agent in children. ...Intranasal dexmedetomidine was administered in a dose range of 1-4 g.kg(-1) and was compared with various other sedatives. . …
Dexmedetomidine is an alpha2 adrenoreceptor agonist that may be administered by the intranasal route as a sole sedative agent in chil …
Dexmedetomidine as a Promising Neuroprotective Sedoanalgesic in Neonatal Therapeutic Hypothermia: A Systematic Review and Meta-Analysis.
Cocchi E, Shabani J, Aceti A, Ancora G, Corvaglia L, Marchetti F. Cocchi E, et al. Neonatology. 2025;122(4):495-504. doi: 10.1159/000546017. Epub 2025 May 2. Neonatology. 2025. PMID: 40319876 Free article.
Therapeutic hypothermia (TH) is the standard of care, but optimized sedoanalgesic strategies remain critical. Dexmedetomidine shows promise as an alternative to traditional sedatives, but its role in this context remains systematically under-explored. ...Studies focusing o …
Therapeutic hypothermia (TH) is the standard of care, but optimized sedoanalgesic strategies remain critical. Dexmedetomidine shows p …
Effect of Dexmedetomidine on Mortality and Ventilator-Free Days in Patients Requiring Mechanical Ventilation With Sepsis: A Randomized Clinical Trial.
Kawazoe Y, Miyamoto K, Morimoto T, Yamamoto T, Fuke A, Hashimoto A, Koami H, Beppu S, Katayama Y, Itoh M, Ohta Y, Yamamura H; Dexmedetomidine for Sepsis in Intensive Care Unit Randomized Evaluation (DESIRE) Trial Investigators. Kawazoe Y, et al. JAMA. 2017 Apr 4;317(13):1321-1328. doi: 10.1001/jama.2017.2088. JAMA. 2017. PMID: 28322414 Free PMC article. Clinical Trial.
INTERVENTIONS: Patients were randomized to receive either sedation with dexmedetomidine (n = 100) or sedation without dexmedetomidine (control group; n = 101). Other agents used in both groups were fentanyl, propofol, and midazolam. ...Adverse events occurred in 8 ( …
INTERVENTIONS: Patients were randomized to receive either sedation with dexmedetomidine (n = 100) or sedation without dexmedetomid …
2,381 results