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Oral and Topical Administration of a Standardized Saw Palmetto Oil Reduces Hair Fall and Improves the Hair Growth in Androgenetic Alopecia Subjects - A 16-Week Randomized, Placebo-Controlled Study.
Sudeep HV, Rashmi S, Jestin TV, Richards A, Gouthamchandra K, Shyamprasad K. Sudeep HV, et al. Clin Cosmet Investig Dermatol. 2023 Nov 11;16:3251-3266. doi: 10.2147/CCID.S435795. eCollection 2023. Clin Cosmet Investig Dermatol. 2023. PMID: 38021422 Free PMC article. Clinical Trial.
This study aimed to assess the safety and efficacy of VISPO(TM), a standardized saw palmetto oil (2-3% beta-sitosterol), in subjects with mild-to-moderate AGA. METHODS: In a double-blind, placebo-controlled, four-arm clinical study, 80 healthy male and female subjec …
This study aimed to assess the safety and efficacy of VISPO(TM), a standardized saw palmetto oil (2-3% beta-sitosterol), in su …
Exploring the Inhibitory Potential of Phytosterols beta-Sitosterol, Stigmasterol, and Campesterol on 5-Alpha Reductase Activity in the Human Prostate: An In Vitro and In Silico Approach.
Buț MG, Tero-Vescan A, Pușcaș A, Jîtcă G, Marc G. Buț MG, et al. Plants (Basel). 2024 Nov 8;13(22):3146. doi: 10.3390/plants13223146. Plants (Basel). 2024. PMID: 39599355 Free PMC article.
This study evaluates the inhibitory effects of three PSs (beta-sitosterol, stigmasterol, and campesterol) on S5alphaR2 activity using a combined in vitro and in silico approach. ...The in vitro tests indicated significantly higher IC(50) values (beta-sitos …
This study evaluates the inhibitory effects of three PSs (beta-sitosterol, stigmasterol, and campesterol) on S5alphaR2 activit …
Pharmacological Effects of the Lipidosterolic Extract from Kigelia africana Fruits in Experimental Benign Prostatic Hyperplasia Induced by Testosterone in Sprague Dawley Rats.
Occhiuto C, Santoro G, Tranchida PQ, Bono G, Occhiuto F. Occhiuto C, et al. J Exp Pharmacol. 2023 Feb 5;15:41-50. doi: 10.2147/JEP.S383699. eCollection 2023. J Exp Pharmacol. 2023. PMID: 36776546 Free PMC article.
METHODS: BPH was induced in experimental groups by daily subcutaneous injections of testosterone propionate (TP) for four weeks. beta-sitosterol (beta-s) was used as positive control. On day 28, the animals were sacrificed by cervical dislocation after anesth …
METHODS: BPH was induced in experimental groups by daily subcutaneous injections of testosterone propionate (TP) for four weeks. beta …
Administration of Caesalpinia bonduc Seed Extracts Ameliorates Testosterone-Induced Benign Prostatic Hyperplasia (BPH) in Male Wistar Rats.
Sasidharan S, Kp S, Bhaumik A, Kanti Das S, Nair J H. Sasidharan S, et al. Res Rep Urol. 2022 May 26;14:225-239. doi: 10.2147/RRU.S365598. eCollection 2022. Res Rep Urol. 2022. PMID: 35651598 Free PMC article.
The seed extracts exhibited a potent inhibitory effect on dihydrotestosterone (DHT) in serum and prostate. In addition, the PSA level in the serum showed a noteworthy decrease in comparison with the BPH group. ...Finally, liquid chromatography quadrupole time-of-flight mas …
The seed extracts exhibited a potent inhibitory effect on dihydrotestosterone (DHT) in serum and prostate. In addition, the PSA level …
A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia.
Prager N, Bickett K, French N, Marcovici G. Prager N, et al. J Altern Complement Med. 2002 Apr;8(2):143-52. doi: 10.1089/acm.2002.8.143. J Altern Complement Med. 2002. PMID: 12006122 Clinical Trial.
Biochemically, one contributing factor of this disorder is the conversion of testosterone (T) to dihydrotestosterone (DHT) via the enzyme 5-alpha reductase (5AR). This metabolism is also key to the onset and progression of benign prostatic hyperplasia (BPH). ...OBJECTIVES: …
Biochemically, one contributing factor of this disorder is the conversion of testosterone (T) to dihydrotestosterone (DHT) via the en …