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The anti-CD20 antibody rituximab reduces the Th17 cell response.
van de Veerdonk FL, Lauwerys B, Marijnissen RJ, Timmermans K, Di Padova F, Koenders MI, Gutierrez-Roelens I, Durez P, Netea MG, van der Meer JW, van den Berg WB, Joosten LA. van de Veerdonk FL, et al. Arthritis Rheum. 2011 Jun;63(6):1507-16. doi: 10.1002/art.30314. Arthritis Rheum. 2011. PMID: 21400475 Free article. Clinical Trial.
Blocking of interleukin-17 during reactivation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and interleukin-1.
Koenders MI, Lubberts E, Oppers-Walgreen B, van den Bersselaar L, Helsen MM, Di Padova FE, Boots AM, Gram H, Joosten LA, van den Berg WB. Koenders MI, et al. Among authors: di padova fe. Am J Pathol. 2005 Jul;167(1):141-9. doi: 10.1016/S0002-9440(10)62961-6. Am J Pathol. 2005. PMID: 15972960 Free PMC article.
Interleukin-17 acts independently of TNF-alpha under arthritic conditions.
Koenders MI, Lubberts E, van de Loo FA, Oppers-Walgreen B, van den Bersselaar L, Helsen MM, Kolls JK, Di Padova FE, Joosten LA, van den Berg WB. Koenders MI, et al. Among authors: di padova fe. J Immunol. 2006 May 15;176(10):6262-9. doi: 10.4049/jimmunol.176.10.6262. J Immunol. 2006. PMID: 16670337
T cell lessons from the rheumatoid arthritis synovium SCID mouse model: CD3-rich synovium lacks response to CTLA-4Ig but is successfully treated by interleukin-17 neutralization.
Koenders MI, Marijnissen RJ, Joosten LA, Abdollahi-Roodsaz S, Di Padova FE, van de Loo FA, Dulos J, van den Berg WB, Boots AM. Koenders MI, et al. Among authors: di padova fe. Arthritis Rheum. 2012 Jun;64(6):1762-70. doi: 10.1002/art.34352. Epub 2011 Dec 27. Arthritis Rheum. 2012. PMID: 22213107 Free article.
Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis.
Hueber W, Patel DD, Dryja T, Wright AM, Koroleva I, Bruin G, Antoni C, Draelos Z, Gold MH; Psoriasis Study Group; Durez P, Tak PP, Gomez-Reino JJ; Rheumatoid Arthritis Study Group; Foster CS, Kim RY, Samson CM, Falk NS, Chu DS, Callanan D, Nguyen QD; Uveitis Study Group; Rose K, Haider A, Di Padova F. Hueber W, et al. Sci Transl Med. 2010 Oct 6;2(52):52ra72. doi: 10.1126/scitranslmed.3001107. Sci Transl Med. 2010. PMID: 20926833 Clinical Trial.
93 results