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A yeast-based assay identifies drugs active against human mitochondrial disorders.
Couplan E, Aiyar RS, Kucharczyk R, Kabala A, Ezkurdia N, Gagneur J, St Onge RP, Salin B, Soubigou F, Le Cann M, Steinmetz LM, di Rago JP, Blondel M. Couplan E, et al. Among authors: di rago jp. Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):11989-94. doi: 10.1073/pnas.1101478108. Epub 2011 Jun 29. Proc Natl Acad Sci U S A. 2011. PMID: 21715656 Free PMC article.
Failure to assemble the alpha 3 beta 3 subcomplex of the ATP synthase leads to accumulation of the alpha and beta subunits within inclusion bodies and the loss of mitochondrial cristae in Saccharomyces cerevisiae.
Lefebvre-Legendre L, Salin B, Schaëffer J, Brèthes D, Dautant A, Ackerman SH, di Rago JP. Lefebvre-Legendre L, et al. Among authors: di rago jp. J Biol Chem. 2005 May 6;280(18):18386-92. doi: 10.1074/jbc.M410789200. Epub 2005 Feb 16. J Biol Chem. 2005. PMID: 15716275 Free article.
82 results