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2005 1
2006 2
2008 1
2010 1
2011 2
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Metabolic therapy for patients with diabetes mellitus and coronary artery disease.
Rosano GM, Vitale C, Fragasso G. Rosano GM, et al. Am J Cardiol. 2006 Sep 4;98(5A):14J-18J. doi: 10.1016/j.amjcard.2006.07.004. Epub 2006 Jul 24. Am J Cardiol. 2006. PMID: 16931201 Review.
Patients with diabetes mellitus and ischemic heart disease more frequently develop heart failure and have a greater amount of myocardial ischemia, often silent, compared with patients without diabetes. Furthermore, patients with corona
Patients with diabetes mellitus and ischemic heart disease more frequently develop heart failure and have a greater amo …
Early administration of trimetazidine may prevent or ameliorate diabetic cardiomyopathy.
Wenmeng W, Qizhu T. Wenmeng W, et al. Med Hypotheses. 2011 Feb;76(2):181-3. doi: 10.1016/j.mehy.2010.09.012. Epub 2010 Oct 6. Med Hypotheses. 2011. PMID: 20932648
It clinically manifests initially as asymptomatic diastolic dysfunction and then progresses to symptomatic heart failure. Two major contributors to the development of diabetic cardiomyopathy, which are unique to diabetes, are hyperglycemia and diabetes-relate …
It clinically manifests initially as asymptomatic diastolic dysfunction and then progresses to symptomatic heart failure. Two major contribu …
Trimetazidine improves exercise tolerance in patients with ischemic heart disease : A meta-analysis.
Zhao Y, Peng L, Luo Y, Li S, Zheng Z, Dong R, Zhu J, Liu J. Zhao Y, et al. Herz. 2016 Sep;41(6):514-22. doi: 10.1007/s00059-015-4392-2. Epub 2015 Dec 14. Herz. 2016. PMID: 26668006 Review. English.
AIM: This study aimed to evaluate the effect of trimetazidine (TMZ) in addition to standard treatment on exercise tolerance in patients with ischemic heart disease (IHD). ...However, there is insufficient evidence to show that TMZ has beneficial effects in participa …
AIM: This study aimed to evaluate the effect of trimetazidine (TMZ) in addition to standard treatment on exercise tolerance in patien …
The effect of trimetazidine treatment in patients with type 2 diabetes undergoing percutaneous coronary intervention for AMI.
Li R, Tang X, Jing Q, Wang Q, Yang M, Han X, Zhao J, Yu X. Li R, et al. Am J Emerg Med. 2017 Nov;35(11):1657-1661. doi: 10.1016/j.ajem.2017.05.024. Epub 2017 May 23. Am J Emerg Med. 2017. PMID: 28587952 Clinical Trial.
PURPOSE: Trimetazidine (TMZ) improves clinical outcomes in patients with chronic heart failure and stable coronary artery disease. No study has yet evaluated the efficacy of TMZ in type 2 diabetes patients with acute myocardial infarction …
PURPOSE: Trimetazidine (TMZ) improves clinical outcomes in patients with chronic heart failure and stable coronary artery
Evaluation of trimetazidine in angina pectoris by echocardiography and radionuclide angiography: a meta-analysis of randomized, controlled trials.
Hu B, Li W, Xu T, Chen T, Guo J. Hu B, et al. Clin Cardiol. 2011 Jun;34(6):395-400. doi: 10.1002/clc.20888. Epub 2011 Apr 27. Clin Cardiol. 2011. PMID: 21538382 Free PMC article. Review.
BACKGROUND: The objective of this meta-analysis was to evaluate the efficacy of the metabolic agent trimetazidine (TMZ) as monotherapy in the treatment of stable angina pectoris, from echocardiography and radionuclide angiography data. ...In both the long term and t …
BACKGROUND: The objective of this meta-analysis was to evaluate the efficacy of the metabolic agent trimetazidine (TMZ) as mon …
Clinical benefits of a metabolic approach in the cardiac rehabilitation of patients with coronary artery disease.
Belardinelli R, Lacalaprice F, Faccenda E, Volpe L. Belardinelli R, et al. Am J Cardiol. 2006 Sep 4;98(5A):25J-33J. doi: 10.1016/j.amjcard.2006.07.006. Epub 2006 Jul 24. Am J Cardiol. 2006. PMID: 16931203 Review.
There is evidence that trimetazidine improves left ventricular (LV) function in patients with ischemic and diabetic cardiomyopathy by shifting the cellular energy substrate reference from fatty acids to glucose oxidation, and that this effect is associated with a be …
There is evidence that trimetazidine improves left ventricular (LV) function in patients with ischemic and diabetic cardiomyop …
Trimetazidine potentiates the effects of exercise training in patients with ischemic cardiomyopathy referred for cardiac rehabilitation.
Belardinelli R, Lacalaprice F, Faccenda E, Volpe L. Belardinelli R, et al. Eur J Cardiovasc Prev Rehabil. 2008 Oct;15(5):533-40. doi: 10.1097/HJR.0b013e328304feec. Eur J Cardiovasc Prev Rehabil. 2008. PMID: 18797405 Clinical Trial.
METHODS: We studied 116 patients (97 men and 19 women, mean age 58+/-9 years) with ischemic heart disease and left ventricular dysfunction who were referred for cardiac rehabilitation. Coronary risk factors were present in 82 patients (diabetes in 28 patients …
METHODS: We studied 116 patients (97 men and 19 women, mean age 58+/-9 years) with ischemic heart disease and left ventricular dysfun …
[Anti-ischemic efficacy of combination of trimetazidine with enalapril in patients with stable effort angina and metabolic syndrome].
Petelina TI, Gapon LI, Bakhmatova IuA, Zhevagina IA, Kalinina VA, Todosiĭchuk VV, Kuznetsov VA. Petelina TI, et al. Kardiologiia. 2005;45(8):17-22. Kardiologiia. 2005. PMID: 16091635 Clinical Trial. Russian.
Efficacy of combination of trimetazidine (60 mg/day) and enalapril in patients with stable effort angina and metabolic syndrome was assessed in a randomized placebo controlled study of 64 patients. Anti-ischemic activity of trimetazidine was found to be signi …
Efficacy of combination of trimetazidine (60 mg/day) and enalapril in patients with stable effort angina and metabolic syndrom …