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2000 1
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2019 259
2020 330
2021 242
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1,622 results
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Activation of Nrf2 signaling by natural products-can it alleviate diabetes?
Matzinger M, Fischhuber K, Heiss EH. Matzinger M, et al. Biotechnol Adv. 2018 Nov 1;36(6):1738-1767. doi: 10.1016/j.biotechadv.2017.12.015. Epub 2017 Dec 28. Biotechnol Adv. 2018. PMID: 29289692 Free PMC article. Review.
Type 2 diabetes mellitus (DM) has reached pandemic proportions and effective prevention strategies are wanted. ...We summarize function, regulation and exogenous activation of Nrf2, as well as diabetes-linked and Nrf2-susceptible forms of cellul …
Type 2 diabetes mellitus (DM) has reached pandemic proportions and effective prevention strategies are wanted. ...We summarize …
Unfolding Nrf2 in diabetes mellitus.
Behl T, Kaur I, Sehgal A, Sharma E, Kumar A, Grover M, Bungau S. Behl T, et al. Mol Biol Rep. 2021 Jan;48(1):927-939. doi: 10.1007/s11033-020-06081-3. Epub 2021 Jan 3. Mol Biol Rep. 2021. PMID: 33389540 Review.
In spite of much awareness, diabetes mellitus continues to remain one of major reasons for mortality and morbidity rate all over the globe. Free radicals cause oxidative stress which is responsible for causing diabetes. The recent advancements in elucidation …
In spite of much awareness, diabetes mellitus continues to remain one of major reasons for mortality and morbidity rate all ov …
Protective role of NRF2 in macrovascular complications of diabetes.
Wu J, Sun X, Jiang Z, Jiang J, Xu L, Tian A, Sun X, Meng H, Li Y, Huang W, Jia Y, Wu H. Wu J, et al. J Cell Mol Med. 2020 Aug;24(16):8903-8917. doi: 10.1111/jcmm.15583. Epub 2020 Jul 6. J Cell Mol Med. 2020. PMID: 32628815 Free PMC article. Review.
It is therefore important to develop effective approaches to prevent or slow down the pathogenesis and progression of macrovascular complications of diabetes (MCD). Oxidative stress is a major contributor to MCD. Nuclear factor (erythroid-derived 2)-like 2 (NRF2) go …
It is therefore important to develop effective approaches to prevent or slow down the pathogenesis and progression of macrovascular complica …
HDAC3 inhibition prevents blood-brain barrier permeability through Nrf2 activation in type 2 diabetes male mice.
Zhao Q, Zhang F, Yu Z, Guo S, Liu N, Jiang Y, Lo EH, Xu Y, Wang X. Zhao Q, et al. J Neuroinflammation. 2019 May 17;16(1):103. doi: 10.1186/s12974-019-1495-3. J Neuroinflammation. 2019. PMID: 31101061 Free PMC article.
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a chronic metabolic dysfunction characterized by progressive insulin resistance and hyperglycaemia. ...HDAC3 expression and activity, Nrf2 activation, and BBB permeability and junction protein expression were exa …
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a chronic metabolic dysfunction characterized by progressive insulin resistance …
Protection of diabetes-induced kidney injury by phosphocreatine via the regulation of ERK/Nrf2/HO-1 signaling pathway.
Shopit A, Niu M, Wang H, Tang Z, Li X, Tesfaldet T, Ai J, Ahmad N, Al-Azab M, Tang Z. Shopit A, et al. Life Sci. 2020 Feb 1;242:117248. doi: 10.1016/j.lfs.2019.117248. Epub 2019 Dec 31. Life Sci. 2020. PMID: 31899224
Diabetic nephropathy is the most common long-term complication of diabetes mellitus. ...The aim of our present study is to examine the potential role of phosphocreatine (PCr) as a molecule protects against diabetes-induced Kidney Injury in-vitro and in
Diabetic nephropathy is the most common long-term complication of diabetes mellitus. ...The aim of our present study is
Diabetes and ageing-induced vascular inflammation.
Assar ME, Angulo J, Rodríguez-Mañas L. Assar ME, et al. J Physiol. 2016 Apr 15;594(8):2125-46. doi: 10.1113/JP270841. Epub 2015 Nov 2. J Physiol. 2016. PMID: 26435167 Free PMC article. Review.
Since incidence of diabetes increases as people get older, the diabetic older adults represent the largest population of diabetic subjects. ...In contrast, there are scarce data regarding the interaction of these mechanisms when ageing and diabetes co- …
Since incidence of diabetes increases as people get older, the diabetic older adults represent the largest population of di
Natural Nrf2 activators in diabetes.
Jiménez-Osorio AS, González-Reyes S, Pedraza-Chaverri J. Jiménez-Osorio AS, et al. Clin Chim Acta. 2015 Aug 25;448:182-92. doi: 10.1016/j.cca.2015.07.009. Epub 2015 Jul 9. Clin Chim Acta. 2015. PMID: 26165427 Review.
Prediabetes and diabetes are rising worldwide. Control of blood glucose is crucial to prevent or delay diabetic complications that frequently result in increased morbidity and mortality. ...The role of some natural Nrf2 activators and its effect in diabete
Prediabetes and diabetes are rising worldwide. Control of blood glucose is crucial to prevent or delay diabetic complications …
The Keap1-Nrf2 system and diabetes mellitus.
Uruno A, Yagishita Y, Yamamoto M. Uruno A, et al. Arch Biochem Biophys. 2015 Jan 15;566:76-84. doi: 10.1016/j.abb.2014.12.012. Epub 2014 Dec 17. Arch Biochem Biophys. 2015. PMID: 25528168 Review.
Keap1 also acts as an E3 ubiquitin ligase substrate-recognition subunit that specifically targets Nrf2. Keap1 causes Nrf2 to be degraded through the ubiquitin-proteasome pathway and thus ensures that Nrf2 is constitutively suppressed under unstressed conditio …
Keap1 also acts as an E3 ubiquitin ligase substrate-recognition subunit that specifically targets Nrf2. Keap1 causes Nrf2 to b …
Nrf2, a novel molecular target to reduce type 1 diabetes associated secondary complications: The basic considerations.
Negi CK, Jena G. Negi CK, et al. Eur J Pharmacol. 2019 Jan 15;843:12-26. doi: 10.1016/j.ejphar.2018.10.026. Epub 2018 Oct 23. Eur J Pharmacol. 2019. PMID: 30359563 Review.
Whereas, deletion of the transcription factor Nrf2 amplifies tissue level pathogenic alterations. In addition, Nrf2 also regulates the expression of numerous cellular defensive genes and protects against oxidative stress-mediated injuries in diabetes. The pre …
Whereas, deletion of the transcription factor Nrf2 amplifies tissue level pathogenic alterations. In addition, Nrf2 also regul …
Nrf2 activation protects against lithium-induced nephrogenic diabetes insipidus.
Jobbagy S, Vitturi DA, Salvatore SR, Pires MF, Rowart P, Emlet DR, Ross M, Hahn S, St Croix C, Wendell SG, Subramanya AR, Straub AC, Tan RJ, Schopfer FJ. Jobbagy S, et al. JCI Insight. 2020 Jan 16;5(1):e128578. doi: 10.1172/jci.insight.128578. JCI Insight. 2020. PMID: 31941842 Free PMC article.
Its efficacious use is complicated by acute and chronic renal side effects, including nephrogenic diabetes insipidus (NDI) and progression to chronic kidney disease (CKD). ...In addition, Nrf2 reduces cyclooxygenase expression and vasoactive prostaglandin bio …
Its efficacious use is complicated by acute and chronic renal side effects, including nephrogenic diabetes insipidus (NDI) and …
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