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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1961 1
1964 1
1965 1
1968 1
1971 2
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1976 2
1978 1
1979 1
1980 2
1981 1
1982 1
1983 5
1985 2
1986 6
1987 1
1988 2
1989 2
1990 2
1991 3
1992 1
1993 3
1994 3
1995 2
1996 2
1997 4
1998 2
2000 3
2001 1
2002 3
2004 4
2005 1
2006 3
2007 8
2008 2
2009 6
2010 7
2011 1
2012 5
2013 2
2014 7
2015 1
2016 3
2017 4
2018 10
2019 4
2020 5
2021 7
2022 9
2023 13
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2025 14
2026 6

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184 results

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Page 1
Diamine oxidase deficiency implications for health, current management, and future directions in the treatment of histamine intolerance: A review.
Alemany-Fornés M, Bori J, Muguerza B, Suárez M. Alemany-Fornés M, et al. Int J Biol Macromol. 2025 Oct;327(Pt 1):147130. doi: 10.1016/j.ijbiomac.2025.147130. Epub 2025 Aug 26. Int J Biol Macromol. 2025. PMID: 40865824 Free article. Review.
Diamine oxidase (DAO) is a key enzyme responsible for the metabolism of histamine, preventing its excessive accumulation and thereby maintaining physiological homeostasis. ...By synthesising current evidence, this review aims to offer insights that guide future rese …
Diamine oxidase (DAO) is a key enzyme responsible for the metabolism of histamine, preventing its excessive accumulation and t …
Histamine Intolerance: Symptoms, Diagnosis, and Beyond.
Jochum C. Jochum C. Nutrients. 2024 Apr 19;16(8):1219. doi: 10.3390/nu16081219. Nutrients. 2024. PMID: 38674909 Free PMC article. Review.
Researchers have attributed several reasons to this condition, such as genetic factors, alcohol, and dietary deficiencies, among other elements. Symptoms of histamine intolerance have been found to extend beyond the gastrointestinal tract and to the whole body, with these …
Researchers have attributed several reasons to this condition, such as genetic factors, alcohol, and dietary deficiencies, among othe …
Histamine Intolerance: The Current State of the Art.
Comas-Basté O, Sánchez-Pérez S, Veciana-Nogués MT, Latorre-Moratalla M, Vidal-Carou MDC. Comas-Basté O, et al. Biomolecules. 2020 Aug 14;10(8):1181. doi: 10.3390/biom10081181. Biomolecules. 2020. PMID: 32824107 Free PMC article. Review.
Histamine and histamine intolerance.
Maintz L, Novak N. Maintz L, et al. Am J Clin Nutr. 2007 May;85(5):1185-96. doi: 10.1093/ajcn/85.5.1185. Am J Clin Nutr. 2007. PMID: 17490952 Free article. Review.
Histamine intolerance results from a disequilibrium of accumulated histamine and the capacity for histamine degradation. Histamine is a biogenic amine that occurs to various degrees in many foods. In healthy persons, dietary histamine can be rapidly detoxified by amine …
Histamine intolerance results from a disequilibrium of accumulated histamine and the capacity for histamine degradation. Histamine is a biog …
Personalized Medicine: Unraveling the Potential of Diamine Oxidase Deficiency.
Blasco-Fontecilla H. Blasco-Fontecilla H. J Clin Med. 2024 Nov 12;13(22):6797. doi: 10.3390/jcm13226797. J Clin Med. 2024. PMID: 39597941 Free PMC article.
The Special Issue Diamine Oxidase Deficiency: Prevalence, consequences, and solutions brings together a series of groundbreaking studies that explore the role of four single-nucleotide polymorphisms (SNPs) (rs10156191, rs1049742, rs1049793, and rs2052129) of …
The Special Issue Diamine Oxidase Deficiency: Prevalence, consequences, and solutions brings together a series of groun …
Histamine Intolerance Originates in the Gut.
Schnedl WJ, Enko D. Schnedl WJ, et al. Nutrients. 2021 Apr 12;13(4):1262. doi: 10.3390/nu13041262. Nutrients. 2021. PMID: 33921522 Free PMC article. Review.
Histamine intolerance (HIT) is assumed to be due to a deficiency of the gastrointestinal (GI) enzyme diamine oxidase (DAO) and, therefore, the food component histamine not being degraded and/or absorbed properly within the GI tract. ...
Histamine intolerance (HIT) is assumed to be due to a deficiency of the gastrointestinal (GI) enzyme diamine oxidase (D …
Histamine Intolerance-The More We Know the Less We Know. A Review.
Hrubisko M, Danis R, Huorka M, Wawruch M. Hrubisko M, et al. Nutrients. 2021 Jun 29;13(7):2228. doi: 10.3390/nu13072228. Nutrients. 2021. PMID: 34209583 Free PMC article. Review.
Alongside the dietary measures, DAO supplementation supporting the degradation of ingested histamine may be considered as subsidiary treatment for individuals with intestinal DAO deficiency. If antihistamines are indicated, the treatment should be conscious and time-limite …
Alongside the dietary measures, DAO supplementation supporting the degradation of ingested histamine may be considered as subsidiary treatme …
Prevalence of Diamine Oxidase Enzyme (DAO) Deficiency in Subjects with Insomnia-Related Symptoms.
López García R, Ferrer-Garcia J, Sansalvador A, Quera-Salva MA. López García R, et al. J Clin Med. 2024 Aug 6;13(16):4583. doi: 10.3390/jcm13164583. J Clin Med. 2024. PMID: 39200725 Free PMC article.
Background: To assess the prevalence of diamine oxidase (DAO) enzyme deficiency caused by single nucleotide polymorphisms (SNPs) of the AOC1 gene in a sample of patients with symptoms of insomnia. ...Conclusions: This preliminary real-world study presents nov …
Background: To assess the prevalence of diamine oxidase (DAO) enzyme deficiency caused by single nucleotide polymorphis …
Prevalence of Genetic Diamine Oxidase (DAO) Deficiency in Female Patients with Fibromyalgia in Spain.
Okutan G, Ruiz Casares E, Perucho Alcalde T, Sánchez Niño GM, Penadés BF, Terrén Lora A, Torrente Estríngana L, López Oliva S, San Mauro Martín I. Okutan G, et al. Biomedicines. 2023 Feb 22;11(3):660. doi: 10.3390/biomedicines11030660. Biomedicines. 2023. PMID: 36979637 Free PMC article.
Diamine oxidase (DAO) is an enzyme that metabolizes intestinal histamine. Single nucleotide polymorphisms (SNPs) of the Amine Oxidase Copper Containing 1 (AOC1) gene can lead to low enzymatic activity or functionality in histamine metabol …
Diamine oxidase (DAO) is an enzyme that metabolizes intestinal histamine. Single nucleotide polymorphisms (SNPs) of the Ami …
Diamine oxidase (DAO) supplement reduces headache in episodic migraine patients with DAO deficiency: A randomized double-blind trial.
Izquierdo-Casas J, Comas-Basté O, Latorre-Moratalla ML, Lorente-Gascón M, Duelo A, Soler-Singla L, Vidal-Carou MC. Izquierdo-Casas J, et al. Clin Nutr. 2019 Feb;38(1):152-158. doi: 10.1016/j.clnu.2018.01.013. Epub 2018 Feb 15. Clin Nutr. 2019. PMID: 29475774 Clinical Trial.
BACKGROUND & AIMS: Histamine intolerance is a disorder in the homeostasis of histamine due to a reduced intestinal degradation of this amine, mainly caused by a deficiency in the enzyme diamine oxidase (DAO). Among histamine related symptoms, heada …
BACKGROUND & AIMS: Histamine intolerance is a disorder in the homeostasis of histamine due to a reduced intestinal degradation of this …
184 results