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597 results

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Page 1
[Anti-cancer properties of dichloroacetate].
Latocha M, Żyrek L. Latocha M, et al. Pol Merkur Lekarski. 2022 Apr 19;50(296):145-147. Pol Merkur Lekarski. 2022. PMID: 35436282 Review. Polish.
One of the hallmarks of cancer cells is aerobic glycolysis (the Warburg effect). The effect of dichloroacetate (DCA) is to switch glucose metabolism (cellular respiration) to a more efficient process involving oxygen, reduce the production of lactic acid, activate t …
One of the hallmarks of cancer cells is aerobic glycolysis (the Warburg effect). The effect of dichloroacetate (DCA) is to swi …
Dichloroacetate (DCA) and Cancer: An Overview towards Clinical Applications.
Tataranni T, Piccoli C. Tataranni T, et al. Oxid Med Cell Longev. 2019 Nov 14;2019:8201079. doi: 10.1155/2019/8201079. eCollection 2019. Oxid Med Cell Longev. 2019. PMID: 31827705 Free PMC article. Review.
An extensive body of literature describes anticancer property of dichloroacetate (DCA), but its effective clinical administration in cancer therapy is still limited to clinical trials. ...Interestingly, DCA could significantly affect cancer stem cell fraction …
An extensive body of literature describes anticancer property of dichloroacetate (DCA), but its effective clinical administration in …
Dichloroacetate for Cancer Treatment: Some Facts and Many Doubts.
Koltai T, Fliegel L. Koltai T, et al. Pharmaceuticals (Basel). 2024 Jun 6;17(6):744. doi: 10.3390/ph17060744. Pharmaceuticals (Basel). 2024. PMID: 38931411 Free PMC article. Review.
However, the main controversies started in 2008 when DCA was found to have anti-cancer effects on experimental animals. These publications showed contradictory results in vivo and in vitro such that a thorough consideration of this compound's in cancer is merited. . …
However, the main controversies started in 2008 when DCA was found to have anti-cancer effects on experimental animals. These publica …
Use of sodium dichloroacetate for cancer treatment: a scoping review.
Bianchi C, Martinelli RP, Rozados VR, Scharovsky OG. Bianchi C, et al. Medicina (B Aires). 2024;84(2):313-323. Medicina (B Aires). 2024. PMID: 38683516 Free article. English.
In recent years, drug repurposing (DR) has gained significant attention as a promising strategy for identifying new therapeutic uses of existing drugs. One potential candidate for DR in cancer treatment is sodium dichloroacetate (DCA), which has been shown to alter …
In recent years, drug repurposing (DR) has gained significant attention as a promising strategy for identifying new therapeutic uses of exis …
Dichloroacetate and cancer: new home for an orphan drug?
Kankotia S, Stacpoole PW. Kankotia S, et al. Biochim Biophys Acta. 2014 Dec;1846(2):617-29. doi: 10.1016/j.bbcan.2014.08.005. Epub 2014 Aug 23. Biochim Biophys Acta. 2014. PMID: 25157892 Review.
We reviewed the anti-cancer effects of DCA, an orphan drug long used as an investigational treatment for various acquired and congenital disorders of mitochondrial intermediary metabolism. ...These effects have been replicated in both human cancer cell lines and in …
We reviewed the anti-cancer effects of DCA, an orphan drug long used as an investigational treatment for various acquired and congeni …
Novel strategies to reverse chemoresistance in colorectal cancer.
Ma SC, Zhang JQ, Yan TH, Miao MX, Cao YM, Cao YB, Zhang LC, Li L. Ma SC, et al. Cancer Med. 2023 May;12(10):11073-11096. doi: 10.1002/cam4.5594. Epub 2023 Jan 16. Cancer Med. 2023. PMID: 36645225 Free PMC article. Review.
Colorectal cancer (CRC) is a common gastrointestinal malignancy with high morbidity and fatality. ...Here, we review the common and novel measures to combat the resistance, including drug repurposing (nonsteroidal anti-inflammatory drugs, metformin, dichloroacetate, …
Colorectal cancer (CRC) is a common gastrointestinal malignancy with high morbidity and fatality. ...Here, we review the common and n …
Dichloroacetate Radiosensitizes Hypoxic Breast Cancer Cells.
de Mey S, Dufait I, Jiang H, Corbet C, Wang H, Van De Gucht M, Kerkhove L, Law KL, Vandenplas H, Gevaert T, Feron O, De Ridder M. de Mey S, et al. Int J Mol Sci. 2020 Dec 9;21(24):9367. doi: 10.3390/ijms21249367. Int J Mol Sci. 2020. PMID: 33316932 Free PMC article.
Mitochondrial metabolism is an attractive target for cancer therapy. Reprogramming metabolic pathways can potentially sensitize tumors with limited treatment options, such as triple-negative breast cancer (TNBC), to chemo- and/or radiotherapy. ...This study therefor …
Mitochondrial metabolism is an attractive target for cancer therapy. Reprogramming metabolic pathways can potentially sensitize tumor …
Dichloroacetate and Salinomycin as Therapeutic Agents in Cancer.
Hunt S, Thyagarajan A, Sahu RP. Hunt S, et al. Med Sci (Basel). 2025 Apr 23;13(2):47. doi: 10.3390/medsci13020047. Med Sci (Basel). 2025. PMID: 40407542 Free PMC article. Review.
Cancer is the second leading cause of mortality worldwide. Despite the available treatment options, a majority of cancer patients develop drug resistance, indicating the need for alternative approaches. ...We used the following searches and selection criteria. (1) B …
Cancer is the second leading cause of mortality worldwide. Despite the available treatment options, a majority of cancer patie …
Targeting Glucose Metabolism of Cancer Cells with Dichloroacetate to Radiosensitize High-Grade Gliomas.
Cook KM, Shen H, McKelvey KJ, Gee HE, Hau E. Cook KM, et al. Int J Mol Sci. 2021 Jul 6;22(14):7265. doi: 10.3390/ijms22147265. Int J Mol Sci. 2021. PMID: 34298883 Free PMC article. Review.
Several metabolic drugs have been used as a novel approach to improve the radiosensitivity of HGGs, including dichloroacetate (DCA), a small molecule used to treat children with congenital mitochondrial disorders. ...
Several metabolic drugs have been used as a novel approach to improve the radiosensitivity of HGGs, including dichloroacetate (DCA), …
Targeting glucose metabolism to suppress cancer progression: prospective of anti-glycolytic cancer therapy.
Abdel-Wahab AF, Mahmoud W, Al-Harizy RM. Abdel-Wahab AF, et al. Pharmacol Res. 2019 Dec;150:104511. doi: 10.1016/j.phrs.2019.104511. Epub 2019 Oct 31. Pharmacol Res. 2019. PMID: 31678210 Review.
The cellular metabolic reprogramming in cancer is regulated by several oncogenic proteins and tumor suppressors such as hypoxia-inducible factor (HIF-1), Myc, p53, and PI3K/Akt/mTOR pathway. ...These metabolic antiglycolytic agents could be more effective if used in drug c …
The cellular metabolic reprogramming in cancer is regulated by several oncogenic proteins and tumor suppressors such as hypoxia-induc …
597 results

Searches related to "dichloroacetate cancer"