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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 1
1980 2
1981 2
1982 1
1983 1
1984 2
1985 1
1986 3
1987 1
1989 2
1990 3
1991 6
1992 2
1993 4
1994 1
1995 7
1996 6
1997 7
1998 6
1999 4
2000 10
2001 4
2002 4
2003 3
2004 6
2005 3
2006 3
2007 10
2008 12
2009 11
2010 22
2011 24
2012 28
2013 37
2014 40
2015 56
2016 44
2017 28
2018 38
2019 44
2020 45
2021 32
2022 29
2023 27
2024 9

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570 results

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Page 1
[Anti-cancer properties of dichloroacetate].
Latocha M, Żyrek L. Latocha M, et al. Pol Merkur Lekarski. 2022 Apr 19;50(296):145-147. Pol Merkur Lekarski. 2022. PMID: 35436282 Review. Polish.
One of the hallmarks of cancer cells is aerobic glycolysis (the Warburg effect). The effect of dichloroacetate (DCA) is to switch glucose metabolism (cellular respiration) to a more efficient process involving oxygen, reduce the production of lactic acid, activate t …
One of the hallmarks of cancer cells is aerobic glycolysis (the Warburg effect). The effect of dichloroacetate (DCA) is to swi …
Dichloroacetate (DCA) and Cancer: An Overview towards Clinical Applications.
Tataranni T, Piccoli C. Tataranni T, et al. Oxid Med Cell Longev. 2019 Nov 14;2019:8201079. doi: 10.1155/2019/8201079. eCollection 2019. Oxid Med Cell Longev. 2019. PMID: 31827705 Free PMC article. Review.
An extensive body of literature describes anticancer property of dichloroacetate (DCA), but its effective clinical administration in cancer therapy is still limited to clinical trials. ...Interestingly, DCA could significantly affect cancer stem cell fraction …
An extensive body of literature describes anticancer property of dichloroacetate (DCA), but its effective clinical administration in …
Dichloroacetate as a novel pharmaceutical treatment for cancer-related fatigue in melanoma.
Zhang X, Lee WD, Leitner BP, Zhu W, Fosam A, Li Z, Gaspar RC, Halberstam AA, Robles B, Rabinowitz JD, Perry RJ. Zhang X, et al. Am J Physiol Endocrinol Metab. 2023 Oct 1;325(4):E363-E375. doi: 10.1152/ajpendo.00105.2023. Epub 2023 Aug 30. Am J Physiol Endocrinol Metab. 2023. PMID: 37646579
Cancer-related fatigue (CRF) is one of the most common complications in patients with multiple cancer types and severely affects patients' quality of life. ...In all, this study provides evidence for DCA as a novel pharmaceutical treatment to maintain physical funct
Cancer-related fatigue (CRF) is one of the most common complications in patients with multiple cancer types and severely affec
Use of sodium dichloroacetate for cancer treatment: a scoping review.
Bianchi C, Martinelli RP, Rozados VR, Scharovsky OG. Bianchi C, et al. Medicina (B Aires). 2024;84(2):313-323. Medicina (B Aires). 2024. PMID: 38683516 Free article. Review. English.
In recent years, drug repurposing (DR) has gained significant attention as a promising strategy for identifying new therapeutic uses of existing drugs. One potential candidate for DR in cancer treatment is sodium dichloroacetate (DCA), which has been shown to alter …
In recent years, drug repurposing (DR) has gained significant attention as a promising strategy for identifying new therapeutic uses of exis …
Novel strategies to reverse chemoresistance in colorectal cancer.
Ma SC, Zhang JQ, Yan TH, Miao MX, Cao YM, Cao YB, Zhang LC, Li L. Ma SC, et al. Cancer Med. 2023 May;12(10):11073-11096. doi: 10.1002/cam4.5594. Epub 2023 Jan 16. Cancer Med. 2023. PMID: 36645225 Free PMC article. Review.
Colorectal cancer (CRC) is a common gastrointestinal malignancy with high morbidity and fatality. ...Here, we review the common and novel measures to combat the resistance, including drug repurposing (nonsteroidal anti-inflammatory drugs, metformin, dichloroacetate, …
Colorectal cancer (CRC) is a common gastrointestinal malignancy with high morbidity and fatality. ...Here, we review the common and n …
Dichloroacetate Radiosensitizes Hypoxic Breast Cancer Cells.
de Mey S, Dufait I, Jiang H, Corbet C, Wang H, Van De Gucht M, Kerkhove L, Law KL, Vandenplas H, Gevaert T, Feron O, De Ridder M. de Mey S, et al. Int J Mol Sci. 2020 Dec 9;21(24):9367. doi: 10.3390/ijms21249367. Int J Mol Sci. 2020. PMID: 33316932 Free PMC article.
Mitochondrial metabolism is an attractive target for cancer therapy. Reprogramming metabolic pathways can potentially sensitize tumors with limited treatment options, such as triple-negative breast cancer (TNBC), to chemo- and/or radiotherapy. ...This study therefor …
Mitochondrial metabolism is an attractive target for cancer therapy. Reprogramming metabolic pathways can potentially sensitize tumor …
Dichloroacetate and cancer: new home for an orphan drug?
Kankotia S, Stacpoole PW. Kankotia S, et al. Biochim Biophys Acta. 2014 Dec;1846(2):617-29. doi: 10.1016/j.bbcan.2014.08.005. Epub 2014 Aug 23. Biochim Biophys Acta. 2014. PMID: 25157892 Review.
We reviewed the anti-cancer effects of DCA, an orphan drug long used as an investigational treatment for various acquired and congenital disorders of mitochondrial intermediary metabolism. ...At least two fundamental changes in tumor metabolism are induced by DCA that anta …
We reviewed the anti-cancer effects of DCA, an orphan drug long used as an investigational treatment for various acquired and congeni …
Targeting Glucose Metabolism of Cancer Cells with Dichloroacetate to Radiosensitize High-Grade Gliomas.
Cook KM, Shen H, McKelvey KJ, Gee HE, Hau E. Cook KM, et al. Int J Mol Sci. 2021 Jul 6;22(14):7265. doi: 10.3390/ijms22147265. Int J Mol Sci. 2021. PMID: 34298883 Free PMC article. Review.
Several metabolic drugs have been used as a novel approach to improve the radiosensitivity of HGGs, including dichloroacetate (DCA), a small molecule used to treat children with congenital mitochondrial disorders. ...
Several metabolic drugs have been used as a novel approach to improve the radiosensitivity of HGGs, including dichloroacetate (DCA), …
Targeting glucose metabolism to suppress cancer progression: prospective of anti-glycolytic cancer therapy.
Abdel-Wahab AF, Mahmoud W, Al-Harizy RM. Abdel-Wahab AF, et al. Pharmacol Res. 2019 Dec;150:104511. doi: 10.1016/j.phrs.2019.104511. Epub 2019 Oct 31. Pharmacol Res. 2019. PMID: 31678210 Review.
The cellular metabolic reprogramming in cancer is regulated by several oncogenic proteins and tumor suppressors such as hypoxia-inducible factor (HIF-1), Myc, p53, and PI3K/Akt/mTOR pathway. ...These metabolic antiglycolytic agents could be more effective if used in drug c …
The cellular metabolic reprogramming in cancer is regulated by several oncogenic proteins and tumor suppressors such as hypoxia-induc …
In-vivo magnetic resonance spectroscopy of lactate as a non-invasive biomarker of dichloroacetate activity in cancer and non-cancer central nervous system disorders.
Kamson DO, Chinnasamy V, Grossman SA, Bettegowda C, Barker PB, Stacpoole PW, Oeltzschner G. Kamson DO, et al. Front Oncol. 2023 Mar 17;13:1077461. doi: 10.3389/fonc.2023.1077461. eCollection 2023. Front Oncol. 2023. PMID: 37007074 Free PMC article. Review.
The adverse effects of lactic acidosis in the cancer microenvironment have been increasingly recognized. Dichloroacetate (DCA) is an orally bioavailable, blood brain barrier penetrable drug that has been extensively studied in the treatment of mitochondrial neurolog …
The adverse effects of lactic acidosis in the cancer microenvironment have been increasingly recognized. Dichloroacetate (DCA) …
570 results