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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1992 3
1993 8
1994 13
1995 24
1996 31
1997 22
1998 33
1999 29
2000 23
2001 14
2002 21
2003 15
2004 14
2005 22
2006 17
2007 16
2008 8
2009 5
2010 10
2011 9
2012 4
2013 3
2014 6
2015 3
2017 1
2020 1
2021 1
2022 1
2023 1
2026 0

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351 results

Results by year

Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Zidovudine, didanosine, and zalcitabine in the treatment of HIV infection: meta-analyses of the randomised evidence. HIV Trialists' Collaborative Group.
[No authors listed] [No authors listed] Lancet. 1999 Jun 12;353(9169):2014-25. Lancet. 1999. PMID: 10376616
The addition of didanosine to zidovudine delayed both progression (rate ratio 0.74 [0.67-0.82], p<0.0001) and death (0.72 [0.64-0.82], p<0.0001). ...Five of the six trials involved randomised comparisons of zidovudine plus didanosine versus zidovudine plus zal …
The addition of didanosine to zidovudine delayed both progression (rate ratio 0.74 [0.67-0.82], p<0.0001) and death (0.72 [0.64-0. …
Meta-analysis of five randomized controlled trials comparing continuation of zidovudine versus switching to didanosine in HIV-infected individuals.
Raboud JM, Montaner JS, Rae S, Kahn J, Hammer SM, Katzenstein DA, Pavia A, Dolin R, Hughes MD, Cross A, Beltangady M, Gatell J, Dunkle L, Smaldone L. Raboud JM, et al. Antivir Ther. 1997 Dec;2(4):237-47. Antivir Ther. 1997. PMID: 11327443
After stratification by study and adjusting for baseline CD4 count and presence of an AIDS diagnosis prior to baseline, the relative risks of death associated with switching from zidovudine to high-dose didanosine or to didanosine were 0.94 (P = 0.64) and 0.77 (P = …
After stratification by study and adjusting for baseline CD4 count and presence of an AIDS diagnosis prior to baseline, the relative risks o …
Relation of peripheral neuropathy to HIV treatment in four randomized clinical trials including didanosine.
Kelleher T, Cross A, Dunkle L. Kelleher T, et al. Clin Ther. 1999 Jul;21(7):1182-92. doi: 10.1016/S0149-2918(00)80021-1. Clin Ther. 1999. PMID: 10463516 Clinical Trial.
Peripheral neuropathy has been recognized as a dose-limiting adverse effect in Phase I studies of didanosine (ddI) therapy for HIV infection. To study the effect of the currently recommended lower dose of ddI, the databases of 4 randomized, controlled trials were used to a …
Peripheral neuropathy has been recognized as a dose-limiting adverse effect in Phase I studies of didanosine (ddI) therapy for HIV in …
Meta-analysis of two randomized controlled trials comparing combined zidovudine and didanosine therapy with combined zidovudine, didanosine, and nevirapine therapy in patients with HIV. INCAS study team.
Raboud JM, Rae S, Vella S, Harrigan PR, Bucciardini R, Fragola V, Ricciardulli D, Montaner JS. Raboud JM, et al. J Acquir Immune Defic Syndr. 1999 Nov 1;22(3):260-6. doi: 10.1097/00126334-199911010-00007. J Acquir Immune Defic Syndr. 1999. PMID: 10770346 Clinical Trial.
METHODS: A meta-analysis was conducted of the original individual patient data from two randomized controlled trials comparing zidovudine (ZDV)/didanosine (ddI) with ZDV/ddI/nevirapine (NVP). RESULTS: In total, 87 patients received ZDV/ddI and 83 received ZDV/ddI/NVP. ...
METHODS: A meta-analysis was conducted of the original individual patient data from two randomized controlled trials comparing zidovudine (Z …
Nucleoside combinations for antiretroviral therapy: efficacy of stavudine in combination with either didanosine or lamivudine.
Fisher M. Fisher M. AIDS. 1998;12 Suppl 3:S9-16. AIDS. 1998. PMID: 15168718
The latter two studies directly compared d4T plus didanosine (ddI) or lamivudine (3TC) versus zidovudine (ZDV) plus each of these two nucleosides. ...
The latter two studies directly compared d4T plus didanosine (ddI) or lamivudine (3TC) versus zidovudine (ZDV) plus each of these two …
Didanosine compared with continued zidovudine therapy for HIV-infected patients with 200 to 500 CD4 cells/mm3. A double-blind, randomized, controlled trial. Canadian HIV Trials Network Protocol 002 Study Group.
Montaner JS, Schechter MT, Rachlis A, Gill J, Beaulieu R, Tsoukas C, Raboud J, Cameron B, Salomon H, Dunkle L, Smaldone L, Wainberg MA. Montaner JS, et al. Ann Intern Med. 1995 Oct 15;123(8):561-71. doi: 10.7326/0003-4819-123-8-199510150-00001. Ann Intern Med. 1995. PMID: 7677296 Clinical Trial.
RESULTS: 245 of 246 patients were eligible (118 receiving didanosine and 127 receiving zidovudine). Sixty-six percent were asymptomatic, 30% had AIDS-related complex, and 4% had AIDS. ...Abdominal pain, leukopenia, and neutropenia were more frequent in the zidovudine group …
RESULTS: 245 of 246 patients were eligible (118 receiving didanosine and 127 receiving zidovudine). Sixty-six percent were asymptomat …
Improving patient adherence with antiretroviral therapy: evaluation of once-daily administration of didanosine.
Gathe JC. Gathe JC. AIDS. 1998;12 Suppl 3:S23-6. AIDS. 1998. PMID: 15168720
One important goal of antiretroviral therapy should be simplification of treatment regimens whenever possible, in order to enhance adherence and potentially improve treatment outcome. While the nucleoside didanosine (ddI) has generally been dosed twice daily in clinical tr …
One important goal of antiretroviral therapy should be simplification of treatment regimens whenever possible, in order to enhance adherence …
Zidovudine, didanosine, or both as the initial treatment for symptomatic HIV-infected children. AIDS Clinical Trials Group (ACTG) Study 152 Team.
Englund JA, Baker CJ, Raskino C, McKinney RE, Petrie B, Fowler MG, Pearson D, Gershon A, McSherry GD, Abrams EJ, Schliozberg J, Sullivan JL. Englund JA, et al. N Engl J Med. 1997 Jun 12;336(24):1704-12. doi: 10.1056/NEJM199706123362403. N Engl J Med. 1997. PMID: 9182213 Free article. Clinical Trial.
This trial was designed to assess the efficacy and safety of treatment with zidovudine alone as compared with either didanosine alone or combination therapy with zidovudine plus didanosine. METHODS: In this multicenter, double-blind study, symptomatic HIV-infected c …
This trial was designed to assess the efficacy and safety of treatment with zidovudine alone as compared with either didanosine alone …
Effects of the antacids in didanosine tablets on dapsone pharmacokinetics.
Sahai J, Garber G, Gallicano K, Oliveras L, Cameron DW. Sahai J, et al. Ann Intern Med. 1995 Oct 15;123(8):584-7. doi: 10.7326/0003-4819-123-8-199510150-00003. Ann Intern Med. 1995. PMID: 7677298 Clinical Trial.
OBJECTIVE: To investigate 1) the effects of the magnesium-aluminum antacids in didanosine tablets on dapsone absorption in healthy volunteers and 2) the effects of the antacid formulation of active didanosine tablets on dapsone pharmacokinetics in patients seroposit …
OBJECTIVE: To investigate 1) the effects of the magnesium-aluminum antacids in didanosine tablets on dapsone absorption in healthy vo …
Zidovudine compared with didanosine in patients with advanced HIV type 1 infection and little or no previous experience with zidovudine. AIDS Clinical Trials Group.
Dolin R, Amato DA, Fischl MA, Pettinelli C, Beltangady M, Liou SH, Brown MJ, Cross AP, Hirsch MS, Hardy WD, et al. Dolin R, et al. Arch Intern Med. 1995 May 8;155(9):961-74. Arch Intern Med. 1995. PMID: 7726705 Clinical Trial.
However, there was a strong interaction between the relative efficacies of zidovudine and didanosine and previous experience with zidovudine. Among 380 patients with no previous zidovudine therapy, zidovudine was more effective than 750 mg/d of didanosine (RR, 1.43; …
However, there was a strong interaction between the relative efficacies of zidovudine and didanosine and previous experience with zid …
351 results