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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1968 1
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1973 4
1974 9
1975 7
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1977 8
1978 12
1979 9
1980 12
1981 7
1982 10
1983 12
1984 21
1985 15
1986 15
1987 14
1988 19
1989 30
1990 25
1991 26
1992 23
1993 26
1994 30
1995 31
1996 26
1997 30
1998 27
1999 23
2000 27
2001 25
2002 27
2003 33
2004 18
2005 15
2006 15
2007 16
2008 16
2009 13
2010 17
2011 9
2012 16
2013 23
2014 21
2015 16
2016 14
2017 13
2018 18
2019 4
2020 5
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860 results

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Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
The effect of digoxin on mortality and morbidity in patients with heart failure.
Digitalis Investigation Group. Digitalis Investigation Group. N Engl J Med. 1997 Feb 20;336(8):525-33. doi: 10.1056/NEJM199702203360801. N Engl J Med. 1997. PMID: 9036306 Free article. Clinical Trial.
In an ancillary trial of patients with ejection fractions greater than 0.45, 492 patients were randomly assigned to digoxin and 496 to placebo. RESULTS: In the main trial, mortality was unaffected. There were 1181 deaths (34.8 percent) with digoxin and 1194 deaths ( …
In an ancillary trial of patients with ejection fractions greater than 0.45, 492 patients were randomly assigned to digoxin and 496 t …
Effect of Digoxin vs Bisoprolol for Heart Rate Control in Atrial Fibrillation on Patient-Reported Quality of Life: The RATE-AF Randomized Clinical Trial.
Kotecha D, Bunting KV, Gill SK, Mehta S, Stanbury M, Jones JC, Haynes S, Calvert MJ, Deeks JJ, Steeds RP, Strauss VY, Rahimi K, Camm AJ, Griffith M, Lip GYH, Townend JN, Kirchhof P; Rate Control Therapy Evaluation in Permanent Atrial Fibrillation (RATE-AF) Team. Kotecha D, et al. JAMA. 2020 Dec 22;324(24):2497-2508. doi: 10.1001/jama.2020.23138. JAMA. 2020. PMID: 33351042 Free PMC article. Clinical Trial.
At 12 months, 8 of 20 outcomes were significantly different (all favoring digoxin), with a median NT-proBNP level of 960 pg/mL (interquartile range, 626 to 1531 pg/mL) in the digoxin group vs 1250 pg/mL (interquartile range, 847 to 1890 pg/mL) in the bisoprolol grou …
At 12 months, 8 of 20 outcomes were significantly different (all favoring digoxin), with a median NT-proBNP level of 960 pg/mL (inter …
Digoxin-mortality: randomized vs. observational comparison in the DIG trial.
Aguirre Dávila L, Weber K, Bavendiek U, Bauersachs J, Wittes J, Yusuf S, Koch A. Aguirre Dávila L, et al. Eur Heart J. 2019 Oct 21;40(40):3336-3341. doi: 10.1093/eurheartj/ehz395. Eur Heart J. 2019. PMID: 31211324 Free PMC article.
METHODS AND RESULTS: Forty-four percent of the 6800 patients in the DIG trial had been treated with digoxin before randomization, and half of them were randomly withdrawn from digoxin treatment. ...The higher risks for both outcomes in those who had previously recei …
METHODS AND RESULTS: Forty-four percent of the 6800 patients in the DIG trial had been treated with digoxin before randomization, and …
Digoxin and Outcomes in Patients with Heart Failure and Preserved Ejection Fraction (HFpEF) Patients: A Systematic Review and Meta- Analysis.
Hashemi-Shahri SH, Aghajanloo A, Ghavami V, Arasteh O, Mohammadpour AH, Reiner Ž, Sahebkar A. Hashemi-Shahri SH, et al. Curr Drug Targets. 2023;24(2):191-200. doi: 10.2174/1389450123666220906093058. Curr Drug Targets. 2023. PMID: 36065922
BACKGROUND: One of the major indications for digoxin use is the treatment of heart failure (HF). Although the clinical application of digoxin in long-term outcomes in patients with HF and reduced ejection fraction (HFrEF) patients is well explained, the association …
BACKGROUND: One of the major indications for digoxin use is the treatment of heart failure (HF). Although the clinical application of …
Digoxin therapy in chronic heart failure.
Gheorghiade M. Gheorghiade M. Cardiovasc Drugs Ther. 1997 May;11 Suppl 1:279-83. doi: 10.1023/a:1007743930938. Cardiovasc Drugs Ther. 1997. PMID: 9211021 Review.
Discontinuation of digoxin in patients with chronic heart failure resulted in hemodynamic deterioration, which was reversed when the drug was readministered. ...In the only large-scale, placebo-controlled mortality study reported thus for (DIG Trial), 7788 patients receive …
Discontinuation of digoxin in patients with chronic heart failure resulted in hemodynamic deterioration, which was reversed when the …
Digoxin for atrial fibrillation and atrial flutter: A systematic review with meta-analysis and trial sequential analysis of randomised clinical trials.
Sethi NJ, Nielsen EE, Safi S, Feinberg J, Gluud C, Jakobsen JC. Sethi NJ, et al. PLoS One. 2018 Mar 8;13(3):e0193924. doi: 10.1371/journal.pone.0193924. eCollection 2018. PLoS One. 2018. PMID: 29518134 Free PMC article.
BACKGROUND: During recent years, systematic reviews of observational studies have compared digoxin to no digoxin in patients with atrial fibrillation or atrial flutter, and the results of these reviews suggested that digoxin seems to increase the risk of all- …
BACKGROUND: During recent years, systematic reviews of observational studies have compared digoxin to no digoxin in patients w …
Digoxin-associated mortality: a systematic review and meta-analysis of the literature.
Vamos M, Erath JW, Hohnloser SH. Vamos M, et al. Eur Heart J. 2015 Jul 21;36(28):1831-8. doi: 10.1093/eurheartj/ehv143. Epub 2015 May 4. Eur Heart J. 2015. PMID: 25939649
There are conflicting data regarding the effect of digoxin use on mortality in patients with atrial fibrillation (AF) or with congestive heart failure (CHF). ...Among 91.379 heart failure patients, digoxin-associated mortality risk increased by 14% (HR 1.14, 95% CI, …
There are conflicting data regarding the effect of digoxin use on mortality in patients with atrial fibrillation (AF) or with congest …
Effect of digoxin on all-cause and cardiovascular mortality in patients with atrial fibrillation with and without heart failure: an umbrella review of systematic reviews and 12 meta-analyses.
Gazzaniga G, Menichelli D, Scaglione F, Farcomeni A, Pani A, Pastori D. Gazzaniga G, et al. Eur J Clin Pharmacol. 2023 Apr;79(4):473-483. doi: 10.1007/s00228-023-03470-y. Epub 2023 Mar 6. Eur J Clin Pharmacol. 2023. PMID: 36872367 Free PMC article.
PURPOSE: To perform a systematic umbrella review with meta-analysis to evaluate the certainty of evidence on mortality risk associated with digoxin use in patients with atrial fibrillation (AF) with or without heart failure (HF). ...Subgroup analysis showed that digoxin …
PURPOSE: To perform a systematic umbrella review with meta-analysis to evaluate the certainty of evidence on mortality risk associated with …
Digoxin for preventing or treating neonatal respiratory distress syndrome.
Soll R, Ozek E. Soll R, et al. Cochrane Database Syst Rev. 2011 Jan 19;2011(1):CD001080. doi: 10.1002/14651858.CD001080.pub2. Cochrane Database Syst Rev. 2011. PMID: 21249645 Free PMC article.
MAIN RESULTS: Two randomized controlled trials have studied the effects of digoxin in the prevention and treatment of RDS. No improvement in respiratory status or mortality was noted. Meta-analysis of the effect of digoxin given to infants at risk of or with RDS on …
MAIN RESULTS: Two randomized controlled trials have studied the effects of digoxin in the prevention and treatment of RDS. No improve …
Digoxin Is Associated With Increased All-cause Mortality in Patients With Atrial Fibrillation Regardless of Concomitant Heart Failure: A Meta-analysis.
Wang ZQ, Zhang R, Chen MT, Wang QS, Zhang Y, Huang XH, Wang J, Yan JH, Li YG. Wang ZQ, et al. J Cardiovasc Pharmacol. 2015 Sep;66(3):270-5. doi: 10.1097/FJC.0000000000000274. J Cardiovasc Pharmacol. 2015. PMID: 26348825
For decades, digoxin has been widely used to control ventricular rate in atrial fibrillation (AF). However, it remains controversial as to whether digoxin is associated with increased mortality in AF. ...We suggest that digoxin should not be preferentially us …
For decades, digoxin has been widely used to control ventricular rate in atrial fibrillation (AF). However, it remains controversial …
860 results