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686 results

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3,3'-Diindolylmethane and indole-3-carbinol: potential therapeutic molecules for cancer chemoprevention and treatment via regulating cellular signaling pathways.
Reyes-Hernández OD, Figueroa-González G, Quintas-Granados LI, Gutiérrez-Ruíz SC, Hernández-Parra H, Romero-Montero A, Del Prado-Audelo ML, Bernal-Chavez SA, Cortés H, Peña-Corona SI, Kiyekbayeva L, Ateşşahin DA, Goloshvili T, Leyva-Gómez G, Sharifi-Rad J. Reyes-Hernández OD, et al. Cancer Cell Int. 2023 Aug 26;23(1):180. doi: 10.1186/s12935-023-03031-4. Cancer Cell Int. 2023. PMID: 37633886 Free PMC article. Review.
Dietary compounds in cancer prevention have gained significant consideration as a viable method. Indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM) are heterocyclic and bioactive chemicals found in cruciferous vegetables like broccoli, cauliflower, cabba …
Dietary compounds in cancer prevention have gained significant consideration as a viable method. Indole-3-carbinol (I3C) and 3,3
3,3'-Diindolylmethane and its derivatives: nature-inspired strategies tackling drug resistant tumors by regulation of signal transduction, transcription factors and microRNAs.
Biersack B. Biersack B. Cancer Drug Resist. 2020 Oct 12;3(4):867-878. doi: 10.20517/cdr.2020.53. eCollection 2020. Cancer Drug Resist. 2020. PMID: 35582221 Free PMC article. Review.
Indoles of cruciferous vegetables are promising anti-tumor agents. Studies with indole-3-carbinol and its dimeric product, 3,3'-diindolylmethane (DIM), suggest that these compounds have the ability to deregulate multiple cellular signaling pathways that are e …
Indoles of cruciferous vegetables are promising anti-tumor agents. Studies with indole-3-carbinol and its dimeric product, 3,3
3, 3'-diindolylmethane enhances macrophage efferocytosis and subsequently relieves visceral pain via the AhR/Nrf2/Arg-1-mediated arginine metabolism pathway.
Yang L, Zheng C, Xia YF, Dai Y, Wei ZF. Yang L, et al. Phytomedicine. 2023 Jul 25;116:154874. doi: 10.1016/j.phymed.2023.154874. Epub 2023 May 13. Phytomedicine. 2023. PMID: 37216760
BACKGROUND: 3, 3'-diindolylmethane (DIM), a classical aryl hydrocarbon receptor (AhR) agonist, has been shown to relieve neuropathic pain, but few studies have reported the efficacy of DIM in visceral pain under colitis condition. ...
BACKGROUND: 3, 3'-diindolylmethane (DIM), a classical aryl hydrocarbon receptor (AhR) agonist, has been shown to reliev …
Indoles Derived From Glucobrassicin: Cancer Chemoprevention by Indole-3-Carbinol and 3,3'-Diindolylmethane.
Williams DE. Williams DE. Front Nutr. 2021 Oct 1;8:734334. doi: 10.3389/fnut.2021.734334. eCollection 2021. Front Nutr. 2021. PMID: 34660663 Free PMC article. Review.
Hydrolysis of glucobrassicin by plant or bacterial myrosinase produces multiple indoles predominantly indole-3-carbinol (I3C). I3C and its major in vivo product, 3,3'-diindolylmethane (DIM), are effective cancer chemopreventive agents in pre-clinical models a …
Hydrolysis of glucobrassicin by plant or bacterial myrosinase produces multiple indoles predominantly indole-3-carbinol (I3C). I3C and its m …
Indole-3-Carbinol: Occurrence, Health-Beneficial Properties, and Cellular/Molecular Mechanisms.
Amarakoon D, Lee WJ, Tamia G, Lee SH. Amarakoon D, et al. Annu Rev Food Sci Technol. 2023 Mar 27;14:347-366. doi: 10.1146/annurev-food-060721-025531. Annu Rev Food Sci Technol. 2023. PMID: 36972159 Free article. Review.
Indole-3-carbinol (I3C) is a bioactive phytochemical abundant in cruciferous vegetables. One of its main in vivo metabolites is 3,3'-diindolylmethane (DIM), formed by the condensation of two molecules of I3C. ...
Indole-3-carbinol (I3C) is a bioactive phytochemical abundant in cruciferous vegetables. One of its main in vivo metabolites is 3, …
Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction.
Chen S, Henderson A, Petriello MC, Romano KA, Gearing M, Miao J, Schell M, Sandoval-Espinola WJ, Tao J, Sha B, Graham M, Crooke R, Kleinridders A, Balskus EP, Rey FE, Morris AJ, Biddinger SB. Chen S, et al. Cell Metab. 2019 Dec 3;30(6):1141-1151.e5. doi: 10.1016/j.cmet.2019.08.021. Epub 2019 Sep 19. Cell Metab. 2019. PMID: 31543404 Free article.
Cellular and Molecular Mechanisms of 3,3'-Diindolylmethane in Gastrointestinal Cancer.
Kim SM. Kim SM. Int J Mol Sci. 2016 Jul 19;17(7):1155. doi: 10.3390/ijms17071155. Int J Mol Sci. 2016. PMID: 27447608 Free PMC article. Review.
Studies in humans have shown that 3,3'-diindolylmethane (DIM), which is found in cruciferous vegetables, such as cabbage and broccoli, is effective in the attenuation of gastrointestinal cancers. ...
Studies in humans have shown that 3,3'-diindolylmethane (DIM), which is found in cruciferous vegetables, such as cabbag …
3, 3'-diindolylmethane, a natural aryl hydrocarbon receptor agonist, alleviates ulcerative colitis by enhancing "glycolysis-lactate-STAT3" and TIP60 signals-mediated Treg differentiation.
Liu S, Yan W, Lv Q, Yang L, Miao Y, Hu Y, Wei Z. Liu S, et al. Mol Immunol. 2023 Nov;163:147-162. doi: 10.1016/j.molimm.2023.09.009. Epub 2023 Oct 2. Mol Immunol. 2023. PMID: 37793204
BACKGROUND: Aryl hydrocarbon receptor (AhR) plays an important role in the occurrence and development of ulcerative colitis (UC). In this study, the effect and mechanism of 3, 3'-diindolylmethane (DIM), the classical AhR agonist, on UC was investigated from t …
BACKGROUND: Aryl hydrocarbon receptor (AhR) plays an important role in the occurrence and development of ulcerative colitis (UC). In this st …
3,3'-Diindolylmethane induces apoptosis and autophagy in fission yeast.
Emami P, Ueno M. Emami P, et al. PLoS One. 2021 Dec 10;16(12):e0255758. doi: 10.1371/journal.pone.0255758. eCollection 2021. PLoS One. 2021. PMID: 34890395 Free PMC article.
3,3'-Diindolylmethane (DIM) is a compound derived from the digestion of indole-3-carbinol, found in the broccoli family. ...
3,3'-Diindolylmethane (DIM) is a compound derived from the digestion of indole-3-carbinol, found in the broccoli family
Chemopreventive properties of 3,3'-diindolylmethane in breast cancer: evidence from experimental and human studies.
Thomson CA, Ho E, Strom MB. Thomson CA, et al. Nutr Rev. 2016 Jul;74(7):432-43. doi: 10.1093/nutrit/nuw010. Epub 2016 May 31. Nutr Rev. 2016. PMID: 27261275 Free PMC article. Review.
The role of bioactive compounds of food origin, including those found in cruciferous vegetables, is an active area of research in cancer chemoprevention. This review focuses on 3,3'-diindolylmethane (DIM), the major bioactive indole in crucifers. ...
The role of bioactive compounds of food origin, including those found in cruciferous vegetables, is an active area of research in cancer che …
686 results