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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 1
1957 1
1962 2
1965 1
1966 1
1975 2
1976 1
1978 2
1987 2
1989 1
1991 1
1992 2
1993 2
1994 1
1995 5
1996 3
1998 3
1999 7
2000 3
2001 9
2002 7
2003 12
2004 17
2005 24
2006 24
2007 21
2008 24
2009 38
2010 31
2011 32
2012 42
2013 46
2014 39
2015 51
2016 49
2017 50
2018 38
2019 33
2020 30
2021 28
2022 33
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648 results
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Indoles Derived From Glucobrassicin: Cancer Chemoprevention by Indole-3-Carbinol and 3,3'-Diindolylmethane.
Williams DE. Williams DE. Front Nutr. 2021 Oct 1;8:734334. doi: 10.3389/fnut.2021.734334. eCollection 2021. Front Nutr. 2021. PMID: 34660663 Free PMC article. Review.
Hydrolysis of glucobrassicin by plant or bacterial myrosinase produces multiple indoles predominantly indole-3-carbinol (I3C). I3C and its major in vivo product, 3,3'-diindolylmethane (DIM), are effective cancer chemopreventive agents in pre-clinical m …
Hydrolysis of glucobrassicin by plant or bacterial myrosinase produces multiple indoles predominantly indole-3-carbinol (I3C). I3C an …
3,3'-Diindolylmethane Exhibits Significant Metabolism after Oral Dosing in Humans.
Vermillion Maier ML, Siddens LK, Uesugi SL, Choi J, Leonard SW, Pennington JM, Tilton SC, Smith JN, Ho E, Chow HHS, Nguyen BD, Kolluri SK, Williams DE. Vermillion Maier ML, et al. Drug Metab Dispos. 2021 Aug;49(8):694-705. doi: 10.1124/dmd.120.000346. Epub 2021 May 25. Drug Metab Dispos. 2021. PMID: 34035125 Free PMC article.
3,3'-Diindolylmethane (DIM), a major phytochemical derived from ingestion of cruciferous vegetables, is also a dietary supplement. ...In addition to competitive phytochemical-drug adverse reactions, additional metabolites may exhibit pharmacological activity
3,3'-Diindolylmethane (DIM), a major phytochemical derived from ingestion of cruciferous vegetables, is also a dietary
3,3'-Diindolylmethane and its derivatives: nature-inspired strategies tackling drug resistant tumors by regulation of signal transduction, transcription factors and microRNAs.
Biersack B. Biersack B. Cancer Drug Resist. 2020 Oct 12;3(4):867-878. doi: 10.20517/cdr.2020.53. eCollection 2020. Cancer Drug Resist. 2020. PMID: 35582221 Free PMC article. Review.
Indoles of cruciferous vegetables are promising anti-tumor agents. Studies with indole-3-carbinol and its dimeric product, 3,3'-diindolylmethane (DIM), suggest that these compounds have the ability to deregulate multiple cellular signaling pathways tha …
Indoles of cruciferous vegetables are promising anti-tumor agents. Studies with indole-3-carbinol and its dimeric product, 3, …
3,3-Diindolylmethane (DIM): a nutritional intervention and its impact on breast density in healthy BRCA carriers. A prospective clinical trial.
Yerushalmi R, Bargil S, Ber Y, Ozlavo R, Sivan T, Rapson Y, Pomerantz A, Tsoref D, Sharon E, Caspi O, Grubsrein A, Margel D. Yerushalmi R, et al. Carcinogenesis. 2020 Oct 15;41(10):1395-1401. doi: 10.1093/carcin/bgaa050. Carcinogenesis. 2020. PMID: 32458980 Free PMC article. Clinical Trial.
Women who carry the BRCA mutation are at high lifetime risk of breast cancer, but there is no consensus regarding an effective and safe chemoprevention strategy. A large body of evidence suggests that 3,3-diindolylmethane (DIM), a dimer of indole-3-car …
Women who carry the BRCA mutation are at high lifetime risk of breast cancer, but there is no consensus regarding an effective and safe chem …
Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction.
Chen S, Henderson A, Petriello MC, Romano KA, Gearing M, Miao J, Schell M, Sandoval-Espinola WJ, Tao J, Sha B, Graham M, Crooke R, Kleinridders A, Balskus EP, Rey FE, Morris AJ, Biddinger SB. Chen S, et al. Cell Metab. 2019 Dec 3;30(6):1141-1151.e5. doi: 10.1016/j.cmet.2019.08.021. Epub 2019 Sep 19. Cell Metab. 2019. PMID: 31543404 Free article.
Furthermore, interventions to reduce TMAO, either by manipulation of the gut microbiota or by inhibition of the TMAO synthesizing enzyme, flavin-containing monooxygenase 3, can reduce PERK activation and FoxO1 levels in the liver. Taken together, these data suggest TMAO an …
Furthermore, interventions to reduce TMAO, either by manipulation of the gut microbiota or by inhibition of the TMAO synthesizing enzyme, fl …
3,3'-Diindolylmethane induces apoptosis and autophagy in fission yeast.
Emami P, Ueno M. Emami P, et al. PLoS One. 2021 Dec 10;16(12):e0255758. doi: 10.1371/journal.pone.0255758. eCollection 2021. PLoS One. 2021. PMID: 34890395 Free PMC article.
3,3'-Diindolylmethane (DIM) is a compound derived from the digestion of indole-3-carbinol, found in the broccoli family. ...
3,3'-Diindolylmethane (DIM) is a compound derived from the digestion of indole-3-carbinol, found in the broccoli
3,3'-Diindolylmethane induces gastric cancer cells death via STIM1 mediated store-operated calcium entry.
Ye Y, Li X, Wang Z, Ye F, Xu W, Lu R, Shen H, Miao S. Ye Y, et al. Int J Biol Sci. 2021 Mar 19;17(5):1217-1233. doi: 10.7150/ijbs.56833. eCollection 2021. Int J Biol Sci. 2021. PMID: 33867841 Free PMC article.
3,3'-Diindolylmethane (DIM), a natural phytochemicals isolated from cruciferous vegetables, has been reported to inhibit human gastric cancer cells proliferation and induce cells apoptosis as well as autophagy, but its mechanisms are still unclear. ...
3,3'-Diindolylmethane (DIM), a natural phytochemicals isolated from cruciferous vegetables, has been reported to inhibi
Cellular and Molecular Mechanisms of 3,3'-Diindolylmethane in Gastrointestinal Cancer.
Kim SM. Kim SM. Int J Mol Sci. 2016 Jul 19;17(7):1155. doi: 10.3390/ijms17071155. Int J Mol Sci. 2016. PMID: 27447608 Free PMC article. Review.
Studies in humans have shown that 3,3'-diindolylmethane (DIM), which is found in cruciferous vegetables, such as cabbage and broccoli, is effective in the attenuation of gastrointestinal cancers. ...
Studies in humans have shown that 3,3'-diindolylmethane (DIM), which is found in cruciferous vegetables, such as cabbag …
648 results