Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 1
1957 1
1962 2
1965 1
1966 1
1975 2
1976 1
1978 2
1987 2
1989 1
1991 1
1992 2
1993 2
1994 1
1995 5
1996 3
1998 3
1999 7
2000 3
2001 9
2002 7
2003 12
2004 17
2005 24
2006 24
2007 21
2008 24
2009 38
2010 31
2011 32
2012 42
2013 46
2014 39
2015 51
2016 49
2017 50
2018 38
2019 33
2020 30
2021 28
2022 37
2023 32
2024 27
2025 13

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

712 results

Results by year

Filters applied: . Clear all
Page 1
3,3'-Diindolylmethane and indole-3-carbinol: potential therapeutic molecules for cancer chemoprevention and treatment via regulating cellular signaling pathways.
Reyes-Hernández OD, Figueroa-González G, Quintas-Granados LI, Gutiérrez-Ruíz SC, Hernández-Parra H, Romero-Montero A, Del Prado-Audelo ML, Bernal-Chavez SA, Cortés H, Peña-Corona SI, Kiyekbayeva L, Ateşşahin DA, Goloshvili T, Leyva-Gómez G, Sharifi-Rad J. Reyes-Hernández OD, et al. Cancer Cell Int. 2023 Aug 26;23(1):180. doi: 10.1186/s12935-023-03031-4. Cancer Cell Int. 2023. PMID: 37633886 Free PMC article. Review.
Dietary compounds in cancer prevention have gained significant consideration as a viable method. Indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM) are heterocyclic and bioactive chemicals found in cruciferous vegetables like broccoli, cauliflower, cabba …
Dietary compounds in cancer prevention have gained significant consideration as a viable method. Indole-3-carbinol (I3C) and 3,3 …
3, 3'-diindolylmethane enhances macrophage efferocytosis and subsequently relieves visceral pain via the AhR/Nrf2/Arg-1-mediated arginine metabolism pathway.
Yang L, Zheng C, Xia YF, Dai Y, Wei ZF. Yang L, et al. Phytomedicine. 2023 Jul 25;116:154874. doi: 10.1016/j.phymed.2023.154874. Epub 2023 May 13. Phytomedicine. 2023. PMID: 37216760
BACKGROUND: 3, 3'-diindolylmethane (DIM), a classical aryl hydrocarbon receptor (AhR) agonist, has been shown to relieve neuropathic pain, but few studies have reported the efficacy of DIM in visceral pain under colitis condition. ...
BACKGROUND: 3, 3'-diindolylmethane (DIM), a classical aryl hydrocarbon receptor (AhR) agonist, has been shown to reliev …
3,3'-Diindolylmethane and its derivatives: nature-inspired strategies tackling drug resistant tumors by regulation of signal transduction, transcription factors and microRNAs.
Biersack B. Biersack B. Cancer Drug Resist. 2020 Oct 12;3(4):867-878. doi: 10.20517/cdr.2020.53. eCollection 2020. Cancer Drug Resist. 2020. PMID: 35582221 Free PMC article. Review.
Studies with indole-3-carbinol and its dimeric product, 3,3'-diindolylmethane (DIM), suggest that these compounds have the ability to deregulate multiple cellular signaling pathways that are essential for tumor growth and spread. ...
Studies with indole-3-carbinol and its dimeric product, 3,3'-diindolylmethane (DIM), suggest that these compounds have …
Indole-3-Carbinol: Occurrence, Health-Beneficial Properties, and Cellular/Molecular Mechanisms.
Amarakoon D, Lee WJ, Tamia G, Lee SH. Amarakoon D, et al. Annu Rev Food Sci Technol. 2023 Mar 27;14:347-366. doi: 10.1146/annurev-food-060721-025531. Annu Rev Food Sci Technol. 2023. PMID: 36972159 Free article. Review.
Indole-3-carbinol (I3C) is a bioactive phytochemical abundant in cruciferous vegetables. One of its main in vivo metabolites is 3,3'-diindolylmethane (DIM), formed by the condensation of two molecules of I3C. Both I3C and DIM alter multiple signaling pathways …
Indole-3-carbinol (I3C) is a bioactive phytochemical abundant in cruciferous vegetables. One of its main in vivo metabolites is 3, …
3, 3'-diindolylmethane, a natural aryl hydrocarbon receptor agonist, alleviates ulcerative colitis by enhancing "glycolysis-lactate-STAT3" and TIP60 signals-mediated Treg differentiation.
Liu S, Yan W, Lv Q, Yang L, Miao Y, Hu Y, Wei Z. Liu S, et al. Mol Immunol. 2023 Nov;163:147-162. doi: 10.1016/j.molimm.2023.09.009. Epub 2023 Oct 2. Mol Immunol. 2023. PMID: 37793204
In this study, the effect and mechanism of 3, 3'-diindolylmethane (DIM), the classical AhR agonist, on UC was investigated from the angle of recovering the balance of Th17/Treg. ...
In this study, the effect and mechanism of 3, 3'-diindolylmethane (DIM), the classical AhR agonist, on UC was investiga …
Indoles Derived From Glucobrassicin: Cancer Chemoprevention by Indole-3-Carbinol and 3,3'-Diindolylmethane.
Williams DE. Williams DE. Front Nutr. 2021 Oct 1;8:734334. doi: 10.3389/fnut.2021.734334. eCollection 2021. Front Nutr. 2021. PMID: 34660663 Free PMC article. Review.
Hydrolysis of glucobrassicin by plant or bacterial myrosinase produces multiple indoles predominantly indole-3-carbinol (I3C). I3C and its major in vivo product, 3,3'-diindolylmethane (DIM), are effective cancer chemopreventive agents in pre-clinical models a …
Hydrolysis of glucobrassicin by plant or bacterial myrosinase produces multiple indoles predominantly indole-3-carbinol (I3C). I3C and its m …
3,3'-Diindolylmethane induces apoptosis and autophagy in fission yeast.
Emami P, Ueno M. Emami P, et al. PLoS One. 2021 Dec 10;16(12):e0255758. doi: 10.1371/journal.pone.0255758. eCollection 2021. PLoS One. 2021. PMID: 34890395 Free PMC article.
3,3'-Diindolylmethane (DIM) is a compound derived from the digestion of indole-3-carbinol, found in the broccoli family. ...
3,3'-Diindolylmethane (DIM) is a compound derived from the digestion of indole-3-carbinol, found in the broccoli family …
Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction.
Chen S, Henderson A, Petriello MC, Romano KA, Gearing M, Miao J, Schell M, Sandoval-Espinola WJ, Tao J, Sha B, Graham M, Crooke R, Kleinridders A, Balskus EP, Rey FE, Morris AJ, Biddinger SB. Chen S, et al. Cell Metab. 2019 Dec 3;30(6):1141-1151.e5. doi: 10.1016/j.cmet.2019.08.021. Epub 2019 Sep 19. Cell Metab. 2019. PMID: 31543404 Free article.
Cellular and Molecular Mechanisms of 3,3'-Diindolylmethane in Gastrointestinal Cancer.
Kim SM. Kim SM. Int J Mol Sci. 2016 Jul 19;17(7):1155. doi: 10.3390/ijms17071155. Int J Mol Sci. 2016. PMID: 27447608 Free PMC article. Review.
Studies in humans have shown that 3,3'-diindolylmethane (DIM), which is found in cruciferous vegetables, such as cabbage and broccoli, is effective in the attenuation of gastrointestinal cancers. ...
Studies in humans have shown that 3,3'-diindolylmethane (DIM), which is found in cruciferous vegetables, such as cabbag …
3,3'-Diindolylmethane (DIM): A Potential Therapeutic Agent against Cariogenic Streptococcus mutans Biofilm.
Baruch Y, Golberg K, Sun Q, Yew-Hoong Gin K, Marks RS, Kushmaro A. Baruch Y, et al. Antibiotics (Basel). 2023 Jun 6;12(6):1017. doi: 10.3390/antibiotics12061017. Antibiotics (Basel). 2023. PMID: 37370336 Free PMC article.
In this study, we test the effect of a natural bis-indole, 3,3'-Diindolylmethane (DIM), in mitigating the pathogenicity of the oral biofilm inhabiting bacterium Streptococcus mutans, a bacterium that is considered to be a principal etiological agent in dental …
In this study, we test the effect of a natural bis-indole, 3,3'-Diindolylmethane (DIM), in mitigating the pathogenicity …
712 results

Searches related to "diindolylmethane"