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11 results

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Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Effectiveness of 3,3'-Diindolylmethane Supplements on Favoring the Benign Estrogen Metabolism Pathway and Decreasing Body Fat in Premenopausal Women.
Godínez-Martínez E, Santillán R, Sámano R, Chico-Barba G, Tolentino MC, Hernández-Pineda J. Godínez-Martínez E, et al. Nutr Cancer. 2023;75(2):510-519. doi: 10.1080/01635581.2022.2123535. Epub 2022 Sep 15. Nutr Cancer. 2023. PMID: 36111381 Clinical Trial.
The Estrogen Metabolites (2-hydroxyestrogens: 16alpha-hydroxyestrone) Urine Ratio (EMUR) has been negatively associated with breast cancer; Mexican women have a lower EMUR than other populations. We evaluated the effectiveness of 3,3'-diindolylmethane (DIM) s …
The Estrogen Metabolites (2-hydroxyestrogens: 16alpha-hydroxyestrone) Urine Ratio (EMUR) has been negatively associated with breast cancer; …
Oral diindolylmethane (DIM): pilot evaluation of a nonsurgical treatment for cervical dysplasia.
Del Priore G, Gudipudi DK, Montemarano N, Restivo AM, Malanowska-Stega J, Arslan AA. Del Priore G, et al. Gynecol Oncol. 2010 Mar;116(3):464-7. doi: 10.1016/j.ygyno.2009.10.060. Epub 2009 Nov 24. Gynecol Oncol. 2010. PMID: 19939441 Clinical Trial.
METHODS: Patients with biopsy-proven cervical intraepithelial neoplasia (CIN) 2 or 3 scheduled for loop electrosurgical excision procedure (LEEP) were randomized 2:1 to receive diindolylmethane (DIM) (BioResponse-DIM, BioResponse, Boulder, CO) orally at approximately 2 mg/ …
METHODS: Patients with biopsy-proven cervical intraepithelial neoplasia (CIN) 2 or 3 scheduled for loop electrosurgical excision procedure ( …
Urinary 3,3'-diindolylmethane: a biomarker of glucobrassicin exposure and indole-3-carbinol uptake in humans.
Fujioka N, Ainslie-Waldman CE, Upadhyaya P, Carmella SG, Fritz VA, Rohwer C, Fan Y, Rauch D, Le C, Hatsukami DK, Hecht SS. Fujioka N, et al. Cancer Epidemiol Biomarkers Prev. 2014 Feb;23(2):282-7. doi: 10.1158/1055-9965.EPI-13-0645. Epub 2013 Dec 19. Cancer Epidemiol Biomarkers Prev. 2014. PMID: 24357105 Free PMC article. Clinical Trial.
METHODS: We conducted a randomized, crossover trial to test whether 3,3'-diindolylmethane (DIM, a metabolite of I3C) excreted in the urine after consumption of raw Brassica vegetables with divergent glucobrassicin concentrations is a marker of I3C uptake from …
METHODS: We conducted a randomized, crossover trial to test whether 3,3'-diindolylmethane (DIM, a metabolite of I3C) ex …
Effect of diindolylmethane supplementation on low-grade cervical cytological abnormalities: double-blind, randomised, controlled trial.
Castañon A, Tristram A, Mesher D, Powell N, Beer H, Ashman S, Rieck G, Fielder H, Fiander A, Sasieni P. Castañon A, et al. Br J Cancer. 2012 Jan 3;106(1):45-52. doi: 10.1038/bjc.2011.496. Epub 2011 Nov 10. Br J Cancer. 2012. PMID: 22075942 Free PMC article. Clinical Trial.
In vitro and in vivo studies have shown that diindolylmethane (DIM) could potentially halt (cervical) carcinogenesis. We report on a randomised controlled trial of the effect of DIM in women with low-grade cervical cytological abnormalities. ...Of those HPV-positive at bas …
In vitro and in vivo studies have shown that diindolylmethane (DIM) could potentially halt (cervical) carcinogenesis. We report on a …
A randomized, placebo-controlled trial of diindolylmethane for breast cancer biomarker modulation in patients taking tamoxifen.
Thomson CA, Chow HHS, Wertheim BC, Roe DJ, Stopeck A, Maskarinec G, Altbach M, Chalasani P, Huang C, Strom MB, Galons JP, Thompson PA. Thomson CA, et al. Breast Cancer Res Treat. 2017 Aug;165(1):97-107. doi: 10.1007/s10549-017-4292-7. Epub 2017 May 30. Breast Cancer Res Treat. 2017. PMID: 28560655 Free PMC article. Clinical Trial.
PURPOSE: Diindolylmethane (DIM), a bioactive metabolite of indole-3-carbinol found in cruciferous vegetables, has proposed cancer chemoprevention activity in the breast. ...
PURPOSE: Diindolylmethane (DIM), a bioactive metabolite of indole-3-carbinol found in cruciferous vegetables, has proposed cancer che …
Comparison of dienogest effects upon 3,3'-diindolylmethane supplementation in models of endometriosis and clinical cases.
Morales-Prieto DM, Herrmann J, Osterwald H, Kochhar PS, Schleussner E, Markert UR, Oettel M. Morales-Prieto DM, et al. Reprod Biol. 2018 Sep;18(3):252-258. doi: 10.1016/j.repbio.2018.07.002. Epub 2018 Jul 9. Reprod Biol. 2018. PMID: 30001982 Clinical Trial.
In this study, addition of the phytochemical 3,3'-diindolylmethane (DIM) to DNG therapy has been investigated in in vitro and ex vivo models for endometriosis and in a small cohort of women with endometriosis. ...
In this study, addition of the phytochemical 3,3'-diindolylmethane (DIM) to DNG therapy has been investigated in in vit …
Single-dose pharmacokinetics and tolerability of absorption-enhanced 3,3'-diindolylmethane in healthy subjects.
Reed GA, Sunega JM, Sullivan DK, Gray JC, Mayo MS, Crowell JA, Hurwitz A. Reed GA, et al. Cancer Epidemiol Biomarkers Prev. 2008 Oct;17(10):2619-24. doi: 10.1158/1055-9965.EPI-08-0520. Cancer Epidemiol Biomarkers Prev. 2008. PMID: 18843002 Free PMC article. Clinical Trial.
We have completed a single ascending dose clinical study of the proposed chemopreventive agent 3,3'-diindolylmethane (DIM). The study agent was nutritional-grade, absorption-enhanced BioResponse 3,3'-diindolylmethane (BR-DIM). ...
We have completed a single ascending dose clinical study of the proposed chemopreventive agent 3,3'-diindolylmethane (D …
Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer.
Dalessandri KM, Firestone GL, Fitch MD, Bradlow HL, Bjeldanes LF. Dalessandri KM, et al. Nutr Cancer. 2004;50(2):161-7. doi: 10.1207/s15327914nc5002_5. Nutr Cancer. 2004. PMID: 15623462 Clinical Trial.
Dietary indoles, present in Brassica plants such as cabbage, broccoli, and Brussels sprouts, have been shown to provide potential protection against hormone-dependent cancers. 3,3'-Diindolylmethane (DIM) is under study as one of the main protective indole met …
Dietary indoles, present in Brassica plants such as cabbage, broccoli, and Brussels sprouts, have been shown to provide potential protection …
Phase Ib placebo-controlled, tissue biomarker trial of diindolylmethane (BR-DIMNG) in patients with prostate cancer who are undergoing prostatectomy.
Gee JR, Saltzstein DR, Messing E, Kim K, Kolesar J, Huang W, Havighurst TC, Harris L, Wollmer BW, Jarrard D, House M, Parnes H, Bailey HH. Gee JR, et al. Eur J Cancer Prev. 2016 Jul;25(4):312-20. doi: 10.1097/CEJ.0000000000000189. Eur J Cancer Prev. 2016. PMID: 26313229 Clinical Trial.
Epidemiologic, preclinical, and early phase I studies of the cruciferous vegetable bioactive metabolite, 3,3'-diindolylmethane (DIM), support its potential prostate cancer chemopreventive ability. ...
Epidemiologic, preclinical, and early phase I studies of the cruciferous vegetable bioactive metabolite, 3,3'-diindolylmeth …
Harnessing the Power of Cruciferous Vegetables: Developing a Biomarker for Brassica Vegetable Consumption Using Urinary 3,3'-Diindolylmethane.
Fujioka N, Ransom BW, Carmella SG, Upadhyaya P, Lindgren BR, Roper-Batker A, Hatsukami DK, Fritz VA, Rohwer C, Hecht SS. Fujioka N, et al. Cancer Prev Res (Phila). 2016 Oct;9(10):788-793. doi: 10.1158/1940-6207.CAPR-16-0136. Epub 2016 Aug 18. Cancer Prev Res (Phila). 2016. PMID: 27538743 Free PMC article. Clinical Trial.
We previously showed that the urinary metabolite 3,3'-diindolylmethane (DIM) could discriminate between volunteers fed high and low doses of Brassica vegetables. ...
We previously showed that the urinary metabolite 3,3'-diindolylmethane (DIM) could discriminate between volunteers fed …
11 results