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Year Number of Results
1996 1
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2002 5
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2004 5
2005 6
2006 7
2007 5
2008 6
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2011 5
2012 5
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127 results

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Page 1
Targeting cancer stem cells and signaling pathways by phytochemicals: Novel approach for breast cancer therapy.
Dandawate PR, Subramaniam D, Jensen RA, Anant S. Dandawate PR, et al. Semin Cancer Biol. 2016 Oct;40-41:192-208. doi: 10.1016/j.semcancer.2016.09.001. Epub 2016 Sep 5. Semin Cancer Biol. 2016. PMID: 27609747 Free PMC article. Review.
In addition, CSCs are believed to be responsible for cancer recurrence, anticancer drug resistance, and metastasis. Hence, compounds targeting breast CSCs may be better therapeutic agents for treating breast cancer and control recurrence and metastasis. ...Therefore …
In addition, CSCs are believed to be responsible for cancer recurrence, anticancer drug resistance, and metastasis. Hence, compounds targeti …
Chemopreventive properties of 3,3'-diindolylmethane in breast cancer: evidence from experimental and human studies.
Thomson CA, Ho E, Strom MB. Thomson CA, et al. Nutr Rev. 2016 Jul;74(7):432-43. doi: 10.1093/nutrit/nuw010. Epub 2016 May 31. Nutr Rev. 2016. PMID: 27261275 Free PMC article. Review.
This review focuses on 3,3'-diindolylmethane (DIM), the major bioactive indole in crucifers. ...Bioactive DIM has demonstrated chemopreventive activity in all stages of breast cancer carcinogenesis. This review describes current evidence related to the …
This review focuses on 3,3'-diindolylmethane (DIM), the major bioactive indole in crucifers. ...Bioactive DIM has demon …
Dietary bioactive diindolylmethane enhances the therapeutic efficacy of centchroman in breast cancer cells by regulating ABCB1/P-gp efflux transporter.
Penta D, Mondal P, Natesh J, Meeran SM. Penta D, et al. J Nutr Biochem. 2021 Aug;94:108749. doi: 10.1016/j.jnutbio.2021.108749. Epub 2021 Apr 25. J Nutr Biochem. 2021. PMID: 33910062
Here for the first time, we investigated the ability of diindolylmethane (DIM), a dietary bioactive rich in cruciferous vegetables, in enhancing the efficacy of Centchroman (CC) by modulating the drug efflux transporters in human breast cancer cells. CC is a selecti …
Here for the first time, we investigated the ability of diindolylmethane (DIM), a dietary bioactive rich in cruciferous vegetables, i …
Dietary Diindolylmethane Enhances the Therapeutic Effect of Centchroman in Breast Cancer by Inhibiting Neoangiogenesis.
Penta D, Natesh J, Mondal P, Meeran SM. Penta D, et al. Nutr Cancer. 2023;75(2):734-749. doi: 10.1080/01635581.2022.2143825. Epub 2022 Nov 12. Nutr Cancer. 2023. PMID: 36370104
Tumor angiogenesis is primarily regulated by vascular endothelial growth factor and its receptor (VEGF-VEGFR) communication, which is involved in cancer cell growth, progression, and metastasis. Diindolylmethane (DIM), a dietary bioactive from cruciferous vegetables, has b …
Tumor angiogenesis is primarily regulated by vascular endothelial growth factor and its receptor (VEGF-VEGFR) communication, which is involv …
3,3'-Diindolylmethane Enhances Paclitaxel Sensitivity by Suppressing DNMT1-Mediated KLF4 Methylation in Breast Cancer.
Xiang F, Zhu Z, Zhang M, Wang J, Chen Z, Li X, Zhang T, Gu Q, Wu R, Kang X. Xiang F, et al. Front Oncol. 2021 Jun 3;11:627856. doi: 10.3389/fonc.2021.627856. eCollection 2021. Front Oncol. 2021. PMID: 34150611 Free PMC article.
Paclitaxel (PTX) is a first-line chemotherapeutic drug for the treatment of breast cancer, but drug resistance seriously limits its clinical use. The aim of the present work was to explore the effect of 3,3'-diindolylmethane (DIM) on PTX sensitivity an …
Paclitaxel (PTX) is a first-line chemotherapeutic drug for the treatment of breast cancer, but drug resistance seriously limits its c …
AKT inhibitor AZD5363 suppresses stemness and promotes anti-cancer activity of 3,3'-diindolylmethane in human breast cancer cells.
Zhu K, Liu X, Liu C, Xu Y, Fu Y, Dong W, Yan Y, Wang W, Qian C. Zhu K, et al. Toxicol Appl Pharmacol. 2021 Oct 15;429:115700. doi: 10.1016/j.taap.2021.115700. Epub 2021 Aug 28. Toxicol Appl Pharmacol. 2021. PMID: 34464674
3,3'-diindolylmethane (DIM) is a dimer compound converted from Indoly-3-carbinol that had been studied as promising chemo-preventive agent against breast cancer. ...Taken together, the above observations suggested that the combination of AZD5363 …
3,3'-diindolylmethane (DIM) is a dimer compound converted from Indoly-3-carbinol that had been studied as promis …
Studies on the mode of action of synthetic diindolylmethane derivatives against triple negative breast cancer cells.
Shilpa G, Lakshmi S, Jamsheena V, Lankalapalli RS, Prakash V, Anbumani S, Priya S. Shilpa G, et al. Basic Clin Pharmacol Toxicol. 2022 Oct;131(4):224-240. doi: 10.1111/bcpt.13767. Epub 2022 Jul 8. Basic Clin Pharmacol Toxicol. 2022. PMID: 35750657 Free article.
Diindolylmethane (DIM) is a metabolic product of indole-3-carbinol (I3C), the major phytochemicals present in cruciferous vegetables, which can modulate multiple signalling pathways in cancer. ...Immunofluorescence studies revealed the reduced expression of EGFR and …
Diindolylmethane (DIM) is a metabolic product of indole-3-carbinol (I3C), the major phytochemicals present in cruciferous vege …
3,3-Diindolylmethane (DIM): a nutritional intervention and its impact on breast density in healthy BRCA carriers. A prospective clinical trial.
Yerushalmi R, Bargil S, Ber Y, Ozlavo R, Sivan T, Rapson Y, Pomerantz A, Tsoref D, Sharon E, Caspi O, Grubsrein A, Margel D. Yerushalmi R, et al. Carcinogenesis. 2020 Oct 15;41(10):1395-1401. doi: 10.1093/carcin/bgaa050. Carcinogenesis. 2020. PMID: 32458980 Free PMC article. Clinical Trial.
A large body of evidence suggests that 3,3-diindolylmethane (DIM), a dimer of indole-3-carbinol found in cruciferous vegetables, can potentially prevent carcinogenesis and tumor development. The primary aim of this prospective single-arm study was to i …
A large body of evidence suggests that 3,3-diindolylmethane (DIM), a dimer of indole-3-carbinol found in crucife …
Indole compounds against breast cancer: recent developments.
Biersack B, Schobert R. Biersack B, et al. Curr Drug Targets. 2012 Dec;13(14):1705-19. doi: 10.2174/138945012804545551. Curr Drug Targets. 2012. PMID: 23140282 Review.
Breast cancer is still the leading cause of cancer deaths among women worldwide and new therapies and drugs are continuously being conceived and explored to better control or even cure this disease. Among the most efficacious low-molecular drugs for the treatment of bre …
Breast cancer is still the leading cause of cancer deaths among women worldwide and new therapies and drugs are continuously being co …
Advising Women Undergoing Treatment for Breast Cancer: A Narrative Review.
Lemanne D, Maizes V. Lemanne D, et al. J Altern Complement Med. 2018 Sep/Oct;24(9-10):902-909. doi: 10.1089/acm.2018.0150. J Altern Complement Med. 2018. PMID: 30247957 Review.
A majority of women undergoing conventional treatment for breast cancer also undertake complementary and integrative approaches. ...Specific food recommendations include avoidance or limitation of alcohol, and liberal culinary use of cruciferous vegetables, coffee, green t …
A majority of women undergoing conventional treatment for breast cancer also undertake complementary and integrative approaches. ...S …
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