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1996 1
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1999 4
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2002 5
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2004 5
2005 6
2006 7
2007 5
2008 6
2009 9
2010 6
2011 5
2012 5
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2017 6
2018 7
2019 4
2020 4
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Chemopreventive properties of 3,3'-diindolylmethane in breast cancer: evidence from experimental and human studies.
Thomson CA, Ho E, Strom MB. Thomson CA, et al. Nutr Rev. 2016 Jul;74(7):432-43. doi: 10.1093/nutrit/nuw010. Epub 2016 May 31. Nutr Rev. 2016. PMID: 27261275 Free PMC article. Review.
This review focuses on 3,3'-diindolylmethane (DIM), the major bioactive indole in crucifers. ...Bioactive DIM has demonstrated chemopreventive activity in all stages of breast cancer carcinogenesis. This review describes current evidence related to the …
This review focuses on 3,3'-diindolylmethane (DIM), the major bioactive indole in crucifers. ...Bioactive DIM has demon …
Advising Women Undergoing Treatment for Breast Cancer: A Narrative Review.
Lemanne D, Maizes V. Lemanne D, et al. J Altern Complement Med. 2018 Sep/Oct;24(9-10):902-909. doi: 10.1089/acm.2018.0150. J Altern Complement Med. 2018. PMID: 30247957 Review.
A majority of women undergoing conventional treatment for breast cancer also undertake complementary and integrative approaches. ...Specific food recommendations include avoidance or limitation of alcohol, and liberal culinary use of cruciferous vegetables, coffee, green t …
A majority of women undergoing conventional treatment for breast cancer also undertake complementary and integrative approaches. ...S …
A randomized, placebo-controlled trial of diindolylmethane for breast cancer biomarker modulation in patients taking tamoxifen.
Thomson CA, Chow HHS, Wertheim BC, Roe DJ, Stopeck A, Maskarinec G, Altbach M, Chalasani P, Huang C, Strom MB, Galons JP, Thompson PA. Thomson CA, et al. Breast Cancer Res Treat. 2017 Aug;165(1):97-107. doi: 10.1007/s10549-017-4292-7. Epub 2017 May 30. Breast Cancer Res Treat. 2017. PMID: 28560655 Free PMC article. Clinical Trial.
PURPOSE: Diindolylmethane (DIM), a bioactive metabolite of indole-3-carbinol found in cruciferous vegetables, has proposed cancer chemoprevention activity in the breast. ...BR-DIM increased the 2/16alpha-OHE1 ratio (+3.2 [0.8, 8.4]) compared to placebo …
PURPOSE: Diindolylmethane (DIM), a bioactive metabolite of indole-3-carbinol found in cruciferous vegetables, has proposed can …
Targeting cancer stem cells and signaling pathways by phytochemicals: Novel approach for breast cancer therapy.
Dandawate PR, Subramaniam D, Jensen RA, Anant S. Dandawate PR, et al. Semin Cancer Biol. 2016 Oct;40-41:192-208. doi: 10.1016/j.semcancer.2016.09.001. Epub 2016 Sep 5. Semin Cancer Biol. 2016. PMID: 27609747 Free PMC article. Review.
In addition, CSCs are believed to be responsible for cancer recurrence, anticancer drug resistance, and metastasis. Hence, compounds targeting breast CSCs may be better therapeutic agents for treating breast cancer and control recurrence and metastasis. ...Therefore …
In addition, CSCs are believed to be responsible for cancer recurrence, anticancer drug resistance, and metastasis. Hence, compounds targeti …
3,3'-Diindolylmethane Inhibits TNF-alpha- and TGF-beta-Induced Epithelial-Mesenchymal Transition in Breast Cancer Cells.
Lee J. Lee J. Nutr Cancer. 2019;71(6):992-1006. doi: 10.1080/01635581.2019.1577979. Epub 2019 Apr 29. Nutr Cancer. 2019. PMID: 31032639
The phytochemicals have been reported to have inhibitory activity against the EMT process in breast cancers, but the mechanism behind this effect has not been fully elucidated. 3,3'-Diindolylmethane (DIM) is a major indole derived from bioactive compou …
The phytochemicals have been reported to have inhibitory activity against the EMT process in breast cancers, but the mechanism behind …
Retraction: "Down-regulation of uPA and uPAR by 3,3'-diindolylmethane contributes to the inhibition of cell growth and migration of breast cancer cells" by Ahmad et al.
[No authors listed] [No authors listed] J Cell Biochem. 2016 Aug;117(8):1959. doi: 10.1002/jcb.25583. J Cell Biochem. 2016. PMID: 27301886 Free PMC article.
The above article, published online on August 19, 2009 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor in Chief, Gary S. Stein, and Wiley Periodicals, Inc. The retraction has been agreed following an investigatio …
The above article, published online on August 19, 2009 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement bet …
3,3'-Diindolylmethane enhances apoptosis in docetaxel-treated breast cancer cells by generation of reactive oxygen species.
Lanza-Jacoby S, Cheng G. Lanza-Jacoby S, et al. Pharm Biol. 2018 Dec;56(1):407-414. doi: 10.1080/13880209.2018.1495747. Pharm Biol. 2018. PMID: 30301388 Free PMC article.
The use of plant compounds to overcome resistance and prevent toxicity is a potential strategy for treatment. OBJECTIVE: We evaluated whether 3,3'-diindolylmethane (DIM) enhanced the sensitivity of breast cancer cells to docetaxel (DOC). ...ROS product …
The use of plant compounds to overcome resistance and prevent toxicity is a potential strategy for treatment. OBJECTIVE: We evaluated whethe …
Inhibitory effects of 3,3'-diindolylmethane on epithelial-mesenchymal transition induced by endocrine disrupting chemicals in cellular and xenograft mouse models of breast cancer.
Lee GA, Hwang KA, Choi KC. Lee GA, et al. Food Chem Toxicol. 2017 Nov;109(Pt 1):284-295. doi: 10.1016/j.fct.2017.08.037. Epub 2017 Aug 24. Food Chem Toxicol. 2017. PMID: 28844962
As a phytoestrogen, 3,3'-diindolylmethane (DIM) plays a chemopreventive role by inhibiting cancer progression. ...These in vitro effects of E2, TCS, BPA, and DIM were also identified in a xenografted mouse model transplanted with MCF-7 breast cancer ce …
As a phytoestrogen, 3,3'-diindolylmethane (DIM) plays a chemopreventive role by inhibiting cancer progression. ...These …
3,3'-Diindolylmethane: A Promising Sensitizer of gamma-Irradiation.
Wang W, Lv M, Huangfu C, Wang F, Zhang J. Wang W, et al. Biomed Res Int. 2015;2015:465105. doi: 10.1155/2015/465105. Epub 2015 Oct 22. Biomed Res Int. 2015. PMID: 26579534 Free PMC article.
PURPOSE: Radiotherapy is an effective treatment modality in the clinical treatment of breast cancer. The present work investigated the effect of 3,3'-diindolylmethane (DIM) on gamma-irradiation sensitizing human breast carcinoma. ...
PURPOSE: Radiotherapy is an effective treatment modality in the clinical treatment of breast cancer. The present work investigated th …
Indole-3-carbinol and 3-3'-diindolylmethane antiproliferative signaling pathways control cell-cycle gene transcription in human breast cancer cells by regulating promoter-Sp1 transcription factor interactions.
Firestone GL, Bjeldanes LF. Firestone GL, et al. J Nutr. 2003 Jul;133(7 Suppl):2448S-2455S. doi: 10.1093/jn/133.7.2448S. J Nutr. 2003. PMID: 12840223 Review.
Indole-3-carbinol (I3C), a compound that occurs naturally in Brassica vegetables such as cabbage and broccoli, can induce a G1 cell-cycle arrest of human MCF-7 breast cancer cells that is accompanied by the selective inhibition of cyclin-dependent kinase 6 (Cdk6) ex …
Indole-3-carbinol (I3C), a compound that occurs naturally in Brassica vegetables such as cabbage and broccoli, can induce a G1 cell-c …
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