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Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction.
Chen S, Henderson A, Petriello MC, Romano KA, Gearing M, Miao J, Schell M, Sandoval-Espinola WJ, Tao J, Sha B, Graham M, Crooke R, Kleinridders A, Balskus EP, Rey FE, Morris AJ, Biddinger SB. Chen S, et al. Cell Metab. 2019 Dec 3;30(6):1141-1151.e5. doi: 10.1016/j.cmet.2019.08.021. Epub 2019 Sep 19. Cell Metab. 2019. PMID: 31543404 Free article.
The gut-microbe-derived metabolite trimethylamine N-oxide (TMAO) is increased by insulin resistance and associated with several sequelae of metabolic syndrome in humans, including cardiovascular, renal, and neurodegenerative disease. The mechanism by which TMAO promotes di …
The gut-microbe-derived metabolite trimethylamine N-oxide (TMAO) is increased by insulin resistance and associated with several sequelae of …
Indole-3-Carbinol and Its Role in Chronic Diseases.
Licznerska B, Baer-Dubowska W. Licznerska B, et al. Adv Exp Med Biol. 2016;928:131-154. doi: 10.1007/978-3-319-41334-1_6. Adv Exp Med Biol. 2016. PMID: 27671815 Review.
Indole-3-carbinol (I3C), a common phytochemical in cruciferous vegetables, and its condensation product, 3,3'-diindolylmethane (DIM) exert several biological activities on cellular and molecular levels, which contribute to their well-recognized chemopr …
Indole-3-carbinol (I3C), a common phytochemical in cruciferous vegetables, and its condensation product, 3,3'-diindo
MPP+ induces necrostatin-1- and ferrostatin-1-sensitive necrotic death of neuronal SH-SY5Y cells.
Ito K, Eguchi Y, Imagawa Y, Akai S, Mochizuki H, Tsujimoto Y. Ito K, et al. Cell Death Discov. 2017 Feb 27;3:17013. doi: 10.1038/cddiscovery.2017.13. eCollection 2017. Cell Death Discov. 2017. PMID: 28250973 Free PMC article.
This cell death was strongly inhibited by necrostatin-1 (Nec-1), a necroptosis inhibitor, and by an indole-containing compound (3,3'-diindolylmethane: DIM). However, it occurred independently of receptor-interacting serine/threonine-protein kinase 1/3
This cell death was strongly inhibited by necrostatin-1 (Nec-1), a necroptosis inhibitor, and by an indole-containing compound (3, …
3,3'-Diindolylmethane protects cardiomyocytes from LPS-induced inflammatory response and apoptosis.
Luo Q, Yang A, Cao Q, Guan H. Luo Q, et al. BMC Pharmacol Toxicol. 2018 Nov 9;19(1):71. doi: 10.1186/s40360-018-0262-x. BMC Pharmacol Toxicol. 2018. PMID: 30413180 Free PMC article.
BACKGROUND: 3,3'-Diindolylmethane (DIM) has been extensively studied as a potential therapeutic drug with free radical scavenging, antioxidant and anti-angiogenic effects. ...
BACKGROUND: 3,3'-Diindolylmethane (DIM) has been extensively studied as a potential therapeutic drug with free radical …
3,3'-Diindolylmethane attenuates cardiomyocyte hypoxia by modulating autophagy in H9c2 cells.
Liang K, Qian WH, Zong J. Liang K, et al. Mol Med Rep. 2017 Dec;16(6):9553-9560. doi: 10.3892/mmr.2017.7788. Epub 2017 Oct 13. Mol Med Rep. 2017. PMID: 29039568
Autophagy is activated in the ischemic heart and is a process that is essential for survival, differentiation, development and homeostasis. 3,3'-Diindolylmethane (DIM) is a natural product of the acid-catalyzed condensation of indole-3-carbinol in cruc …
Autophagy is activated in the ischemic heart and is a process that is essential for survival, differentiation, development and homeostasis. …
Molecular Simulation Studies of 3,3'-Diindolylmethane as a Potent MicroRNA-21 Antagonist.
Junaid M, Dash R, Islam N, Chowdhury J, Alam MJ, Nath SD, Shakil MAS, Azam A, Quader SM, Zahid Hosen SM. Junaid M, et al. J Pharm Bioallied Sci. 2017 Oct-Dec;9(4):259-265. doi: 10.4103/jpbs.JPBS_266_16. J Pharm Bioallied Sci. 2017. PMID: 29456377 Free PMC article.
OBJECTIVE: In recent decades, the overexpression of microRNA-21 (miR-21) is found to be progressively linked with many diseases such as different types of cancers, cardiovascular diseases, and inflammation. Thereby, it has become an attractive target for pharmacological an …
OBJECTIVE: In recent decades, the overexpression of microRNA-21 (miR-21) is found to be progressively linked with many diseases such as diff …
3,3'-Diindolylmethane attenuates cardiac H9c2 cell hypertrophy through 5'-adenosine monophosphate-activated protein kinase-alpha.
Zong J, Wu QQ, Zhou H, Zhang JY, Yuan Y, Bian ZY, Deng W, Dai J, Li FF, Xu M, Fang Y, Tang QZ. Zong J, et al. Mol Med Rep. 2015 Jul;12(1):1247-52. doi: 10.3892/mmr.2015.3523. Epub 2015 Mar 20. Mol Med Rep. 2015. PMID: 25816057
3,3'-Diindolylmethane (DIM) is the major product of the acid-catalyzed condensation of indole-3-carbinol (I3C), a component of extracts of Brassica food plants. ...
3,3'-Diindolylmethane (DIM) is the major product of the acid-catalyzed condensation of indole-3-carbinol (I3C),
3,3'-Diindolylmethane improves myocardial energy metabolism imbalance induced by pressure overload via AMPKalpha in mice.
Deng W, Zong J, Wei L, Guo H, Cheng Z, Zhang R, Lin Y, Tang Q. Deng W, et al. Int J Cardiol. 2014 Nov 15;177(1):235-7. doi: 10.1016/j.ijcard.2014.09.037. Epub 2014 Sep 28. Int J Cardiol. 2014. PMID: 25499385 No abstract available.
3,3'-Diindolylmethane decreases VCAM-1 expression and alleviates experimental colitis via a BRCA1-dependent antioxidant pathway.
Huang Z, Zuo L, Zhang Z, Liu J, Chen J, Dong L, Zhang J. Huang Z, et al. Free Radic Biol Med. 2011 Jan 15;50(2):228-36. doi: 10.1016/j.freeradbiomed.2010.10.703. Epub 2010 Oct 26. Free Radic Biol Med. 2011. PMID: 21034812
Reactive oxygen species (ROS) exhibit a key role in the pathogenesis of inflammatory bowel disease (IBD). 3,3'-Diindolylmethane (DIM) can protect against oxidative stress in a breast cancer susceptibility gene 1 (BRCA1)-dependent manner. ...
Reactive oxygen species (ROS) exhibit a key role in the pathogenesis of inflammatory bowel disease (IBD). 3,3'-Diindolylmet
3,3'Diindolylmethane suppresses vascular smooth muscle cell phenotypic modulation and inhibits neointima formation after carotid injury.
Guan H, Zhu L, Fu M, Yang D, Tian S, Guo Y, Cui C, Wang L, Jiang H. Guan H, et al. PLoS One. 2012;7(4):e34957. doi: 10.1371/journal.pone.0034957. Epub 2012 Apr 10. PLoS One. 2012. PMID: 22506059 Free PMC article.
BACKGROUND: 3,3'Diindolylmethane (DIM), a natural phytochemical, has shown inhibitory effects on the growth and migration of a variety of cancer cells; however, whether DIM has similar effects on vascular smooth muscle cells (VSMCs) remains unknown. ...Mechan …
BACKGROUND: 3,3'Diindolylmethane (DIM), a natural phytochemical, has shown inhibitory effects on the growth and migrati …
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