3,3'-Diindolylmethane inhibits patient-derived xenograft colon tumor growth by targeting COX1/2 and ERK1/2.
Tian X, Liu K, Zu X, Ma F, Li Z, Lee M, Chen H, Li Y, Zhao Y, Liu F, Oi N, Bode AM, Dong Z, Kim DJ.
Tian X, et al.
Cancer Lett. 2019 Apr 28;448:20-30. doi: 10.1016/j.canlet.2019.01.031. Epub 2019 Feb 1.
Cancer Lett. 2019.
PMID: 30716361
3,3'-Diindolymethane (DIM) is a dimeric condensation product of indole-3-carbinol (I3C) that is found in broccoli and cabbage. ...Notably, oral administration of DIM suppressed patient-derived xenograft colon tumor growth in an in vivo mouse model. Ove …
3,3'-Diindolymethane (DIM) is a dimeric condensation product of indole-3-carbinol (I3C) that is found in broccoli and c …