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3,3'-Diindolylmethane inhibits patient-derived xenograft colon tumor growth by targeting COX1/2 and ERK1/2.
Tian X, Liu K, Zu X, Ma F, Li Z, Lee M, Chen H, Li Y, Zhao Y, Liu F, Oi N, Bode AM, Dong Z, Kim DJ. Tian X, et al. Cancer Lett. 2019 Apr 28;448:20-30. doi: 10.1016/j.canlet.2019.01.031. Epub 2019 Feb 1. Cancer Lett. 2019. PMID: 30716361
3,3'-Diindolymethane (DIM) is a dimeric condensation product of indole-3-carbinol (I3C) that is found in broccoli and cabbage. ...Notably, oral administration of DIM suppressed patient-derived xenograft colon tumor growth in an in vivo mouse model. Ove …
3,3'-Diindolymethane (DIM) is a dimeric condensation product of indole-3-carbinol (I3C) that is found in broccoli and c …
Diindolylmethane Derivatives: New Selective Blockers for T-Type Calcium Channels.
Wang D, Neupane P, Ragnarsson L, Capon RJ, Lewis RJ. Wang D, et al. Membranes (Basel). 2022 Jul 30;12(8):749. doi: 10.3390/membranes12080749. Membranes (Basel). 2022. PMID: 36005664 Free PMC article.
The natural product indole-3-carbinol (I3C) and its major digestive product 3,3'-diindolylmethane (DIM) have shown clinical promise in multiple forms of cancer including breast cancer. ...For the first time, DIM, DIM-one and analog IX were identified a …
The natural product indole-3-carbinol (I3C) and its major digestive product 3,3'-diindolylmethane (DIM) have sho …
3,3'-diindolylmethane enhances the efficacy of butyrate in colon cancer prevention through down-regulation of survivin.
Bhatnagar N, Li X, Chen Y, Zhou X, Garrett SH, Guo B. Bhatnagar N, et al. Cancer Prev Res (Phila). 2009 Jun;2(6):581-9. doi: 10.1158/1940-6207.CAPR-08-0142. Epub 2009 May 26. Cancer Prev Res (Phila). 2009. PMID: 19470789 Free PMC article.
Butyrate is an inhibitor of histone deacetylase (HDAC) and has been extensively evaluated as a chemoprevention agent for colon cancer. We recently showed that mutations in the adenomatous polyposis coli (APC) gene confer resistance to HDAC inhibitor-induced apoptosis in …
Butyrate is an inhibitor of histone deacetylase (HDAC) and has been extensively evaluated as a chemoprevention agent for colon cancer …
Diindolylmethane analogs bind NR4A1 and are NR4A1 antagonists in colon cancer cells.
Lee SO, Li X, Hedrick E, Jin UH, Tjalkens RB, Backos DS, Li L, Zhang Y, Wu Q, Safe S. Lee SO, et al. Mol Endocrinol. 2014 Oct;28(10):1729-39. doi: 10.1210/me.2014-1102. Epub 2014 Aug 6. Mol Endocrinol. 2014. PMID: 25099012 Free PMC article.
Computational-based molecular modeling studies showed high-affinity interactions of DIM-C-pPhOH and related compounds within the ligand binding pocket of NR4A1, and these same compounds decreased NR4A1-dependent transactivation in colon cancer cells transfected with a cons …
Computational-based molecular modeling studies showed high-affinity interactions of DIM-C-pPhOH and related compounds within the ligand bind …
Genome-wide transcriptome analysis reveals inactivation of Wnt/β-catenin by 3,3'-diindolylmethane inhibiting proliferation of colon cancer cells.
Leem SH, Li XJ, Park MH, Park BH, Kim SM. Leem SH, et al. Int J Oncol. 2015 Sep;47(3):918-26. doi: 10.3892/ijo.2015.3089. Epub 2015 Jul 17. Int J Oncol. 2015. PMID: 26203047
Multiple genetic and signaling pathway alterations underlie the development of colon cancer. We utilized genome-wide transcriptome analysis to identify important gene expression patterns following treatment with 3,3'-diindolylmethane (DIM), a natural c …
Multiple genetic and signaling pathway alterations underlie the development of colon cancer. We utilized genome-wide transcriptome an …
Regulation of YAP through an Akt-dependent process by 3, 3'-diindolylmethane in human colon cancer cells.
Li XJ, Leem SH, Park MH, Kim SM. Li XJ, et al. Int J Oncol. 2013 Dec;43(6):1992-8. doi: 10.3892/ijo.2013.2121. Epub 2013 Oct 3. Int J Oncol. 2013. PMID: 24100865
The Hippo and PI3K/Akt pathways have been shown to play a critical role in controlling tissue growth involved in the regulation of cell proliferation. 3, 3'-diindolylmethane (DIM) is a natural compound that selectively kills cancer cells without causing toxic …
The Hippo and PI3K/Akt pathways have been shown to play a critical role in controlling tissue growth involved in the regulation of cell prol …
The indolic diet-derivative, 3,3'-diindolylmethane, induced apoptosis in human colon cancer cells through upregulation of NDRG1.
Lerner A, Grafi-Cohen M, Napso T, Azzam N, Fares F. Lerner A, et al. J Biomed Biotechnol. 2012;2012:256178. doi: 10.1155/2012/256178. Epub 2011 Nov 13. J Biomed Biotechnol. 2012. PMID: 22187533 Free PMC article.
In the present study, we analyzed the expression pattern of N-myc downstream regulated gene-1 following treatment of human colonic cancer cell lines; HCT-116 (well differentiated with wild-type p53 gene) and Colo-320 (poorly differentiated with mutant p53 gene), with 3 …
In the present study, we analyzed the expression pattern of N-myc downstream regulated gene-1 following treatment of human colonic ca …
Sulindac, 3,3'-diindolylmethane and curcumin reduce carcinogenesis in the Pirc rat, an Apc-driven model of colon carcinogenesis.
Femia AP, Soares PV, Luceri C, Lodovici M, Giannini A, Caderni G. Femia AP, et al. BMC Cancer. 2015 Sep 3;15:611. doi: 10.1186/s12885-015-1627-9. BMC Cancer. 2015. PMID: 26335331 Free PMC article.
Moreover, since side effects of SU hamper its chronic use and a combination of drugs could be more effective and less toxic than single agents, we also studied whether two natural compounds, 3,3'-diindolylmethane (DIM; 250 ppm) and curcumin (CUR; 2000 ppm), w …
Moreover, since side effects of SU hamper its chronic use and a combination of drugs could be more effective and less toxic than single agen …
Quantitative combination effects between sulforaphane and 3,3'-diindolylmethane on proliferation of human colon cancer cells in vitro.
Pappa G, Strathmann J, Löwinger M, Bartsch H, Gerhäuser C. Pappa G, et al. Carcinogenesis. 2007 Jul;28(7):1471-7. doi: 10.1093/carcin/bgm044. Epub 2007 Feb 28. Carcinogenesis. 2007. PMID: 17331956
ITCs like sulforaphane (SFN) are cytotoxic, whereas indoles including indole-3-carbinol or its condensation product 3,3'-diindolylmethane (DIM) are acting by cytostatic mechanisms in human colon cancer cell lines. In the present study, we have i …
ITCs like sulforaphane (SFN) are cytotoxic, whereas indoles including indole-3-carbinol or its condensation product 3,3 …
Activation of caspase-8 contributes to 3,3'-Diindolylmethane-induced apoptosis in colon cancer cells.
Kim EJ, Park SY, Shin HK, Kwon DY, Surh YJ, Park JH. Kim EJ, et al. J Nutr. 2007 Jan;137(1):31-6. doi: 10.1093/jn/137.1.31. J Nutr. 2007. PMID: 17182797 Free article.
3,3'-Diindolylmethane (DIM) is the major in vivo product of acid-catalyzed oligomerization of indole-3-carbinol, which is a promising anticancer agent present in cruciferous vegetables and has itself been reported to have anticarcinogenic properties. . …
3,3'-Diindolylmethane (DIM) is the major in vivo product of acid-catalyzed oligomerization of indole-3-carbinol, …
41 results