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3,3'-Diindolylmethane increases serum interferon-gamma levels in the K14-HPV16 transgenic mouse model for cervical cancer.
Sepkovic DW, Raucci L, Stein J, Carlisle AD, Auborn K, Ksieski HB, Nyirenda T, Bradlow HL. Sepkovic DW, et al. In Vivo. 2012 Mar-Apr;26(2):207-11. In Vivo. 2012. PMID: 22351660
Human papilloma viral infection causes cervical neoplasia (CIN). 3,3'-Diindolylmethane (DIM) prevents or inhibits the progression from cervical dysplasia to cancer. ...MATERIALS AND METHODS: Five doses of DIM in food were administered to the mouse model for 2 …
Human papilloma viral infection causes cervical neoplasia (CIN). 3,3'-Diindolylmethane (DIM) prevents or inhibits the p …
Activation and potentiation of interferon-gamma signaling by 3,3'-diindolylmethane in MCF-7 breast cancer cells.
Riby JE, Xue L, Chatterji U, Bjeldanes EL, Firestone GL, Bjeldanes LF. Riby JE, et al. Mol Pharmacol. 2006 Feb;69(2):430-9. doi: 10.1124/mol.105.017053. Epub 2005 Nov 2. Mol Pharmacol. 2006. PMID: 16267208
3,3'-Diindolylmethane (DIM), a natural autolytic product in plants of the Brassica genus, including broccoli, cauliflower, and Brussels sprouts, exhibits promising cancer protective activities, especially against mammary neoplasia in animal models. ...We show
3,3'-Diindolylmethane (DIM), a natural autolytic product in plants of the Brassica genus, including broccoli, cauliflow
3,3'-Diindolylmethane stimulates murine immune function in vitro and in vivo.
Xue L, Pestka JJ, Li M, Firestone GL, Bjeldanes LF. Xue L, et al. J Nutr Biochem. 2008 May;19(5):336-44. doi: 10.1016/j.jnutbio.2007.05.004. Epub 2007 Aug 17. J Nutr Biochem. 2008. PMID: 17707631 Free PMC article.
3,3'-Diindolylmethane (DIM), a major condensation product of indole-3-carbinol, exhibits chemopreventive properties in animal models of cancer. Recent studies have shown that DIM stimulates interferon-gamma (IFN-gamma) production a
3,3'-Diindolylmethane (DIM), a major condensation product of indole-3-carbinol, exhibits chemopreventive propert
3,39-Diindolylmethane Ameliorates Staphylococcal Enterotoxin B-Induced Acute Lung Injury through Alterations in the Expression of MicroRNA that Target Apoptosis and Cell-Cycle Arrest in Activated T Cells.
Elliott DM, Nagarkatti M, Nagarkatti PS. Elliott DM, et al. J Pharmacol Exp Ther. 2016 Apr;357(1):177-87. doi: 10.1124/jpet.115.226563. J Pharmacol Exp Ther. 2016. PMID: 26818958 Free PMC article.
3,39-Diindolylmethane (DIM), a natural indole found in cruciferous vegetables, has significant anti-cancer and anti-inflammatory properties. ...
3,39-Diindolylmethane (DIM), a natural indole found in cruciferous vegetables, has significant anti-cancer and anti-inflammato
DIM stimulates IFNgamma gene expression in human breast cancer cells via the specific activation of JNK and p38 pathways.
Xue L, Firestone GL, Bjeldanes LF. Xue L, et al. Oncogene. 2005 Mar 31;24(14):2343-53. doi: 10.1038/sj.onc.1208434. Oncogene. 2005. PMID: 15735741 Free article.
3,3'-Diindolylmethane (DIM) is a promising anticancer agent derived from Brassica vegetables, but the mechanisms of DIM action are largely unknown. We have shown that DIM can upregulate the expression and stimulate the secretion of interferon-gamma
3,3'-Diindolylmethane (DIM) is a promising anticancer agent derived from Brassica vegetables, but the mechanisms of DIM
Diindolylmethane inhibits cervical dysplasia, alters estrogen metabolism, and enhances immune response in the K14-HPV16 transgenic mouse model.
Sepkovic DW, Stein J, Carlisle AD, Ksieski HB, Auborn K, Bradlow HL. Sepkovic DW, et al. Cancer Epidemiol Biomarkers Prev. 2009 Nov;18(11):2957-64. doi: 10.1158/1055-9965.EPI-09-0698. Epub 2009 Oct 27. Cancer Epidemiol Biomarkers Prev. 2009. PMID: 19861518 Free PMC article.
This study was designed to establish whether 3,3'-diindolylmethane (DIM) can inhibit cervical lesions, alter estrogen metabolism in favor of C-2 hydroxylation, and enhance immune function in the K14-HPV16 transgenic mouse model. ...Estradiol C-2 hydroxylation …
This study was designed to establish whether 3,3'-diindolylmethane (DIM) can inhibit cervical lesions, alter estrogen m …
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