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2018 2
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3,3'-Diindolylmethane mitigates lipopolysaccharide-induced acute kidney injury in mice by inhibiting NOX-mediated oxidative stress and the apoptosis of renal tubular epithelial cells.
He J, Huang T, Zhao L. He J, et al. Mol Med Rep. 2019 Jun;19(6):5115-5122. doi: 10.3892/mmr.2019.10178. Epub 2019 Apr 22. Mol Med Rep. 2019. PMID: 31059037 Free PMC article.
3,3'-Diindolylmethane (DIM) is a naturally derived indole compound found in the Brassica family of vegetables. ...The results indicated that DIM significantly mitigated histopathological changes in the kidneys and improved the levels of blood urea nitr
3,3'-Diindolylmethane (DIM) is a naturally derived indole compound found in the Brassica family of vegetables. ...The r
Relations between approved platinum drugs and non-coding RNAs in mesothelioma.
Biersack B. Biersack B. Noncoding RNA Res. 2018 Aug 30;3(4):161-173. doi: 10.1016/j.ncrna.2018.08.001. eCollection 2018 Dec. Noncoding RNA Res. 2018. PMID: 30809599 Free PMC article. Review.
Amelioration of Hyperglycemia-Induced Nephropathy by 3,3'-Diindolylmethane in Diabetic Mice.
Choi KM, Yoo HS. Choi KM, et al. Molecules. 2019 Dec 6;24(24):4474. doi: 10.3390/molecules24244474. Molecules. 2019. PMID: 31817632 Free PMC article.
Diabetic nephropathy is a major complication of hyperglycemia. 3,3'-diindolylmethane (DIM)-a natural compound produced from indole-3-carbinol, found in cruciferous vegetables-enhances glucose uptake by increasing the activation of the insulin signaling …
Diabetic nephropathy is a major complication of hyperglycemia. 3,3'-diindolylmethane (DIM)-a natural compound produced …
3,3'-Diindolylmethane ameliorates renal fibrosis through the inhibition of renal fibroblast activation in vivo and in vitro.
Xia ZE, Xi JL, Shi L. Xia ZE, et al. Ren Fail. 2018 Nov;40(1):447-454. doi: 10.1080/0886022X.2018.1490322. Ren Fail. 2018. PMID: 30101622 Free PMC article.
3,3'-Diindolylmethane (DIM), a natural acid condensation extracted from cruciferous plants, exhibits anti-fibrotic effects in hepatic and cardiac fibrosis models. ...In addition, DIM significantly inhibited the TGF-beta1-induced proliferation of NRK49F cells
3,3'-Diindolylmethane (DIM), a natural acid condensation extracted from cruciferous plants, exhibits anti-fibrotic effe
Development and validation of an HPLC method for the simultaneous quantification of indole-3-carbinol acetate, indole-3-carbinol, and 3,3'-diindolylmethane in mouse plasma, liver, and kidney tissues.
Moussata J, Wang Z, Wang J. Moussata J, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 May 1;958:1-9. doi: 10.1016/j.jchromb.2014.02.026. Epub 2014 Mar 12. J Chromatogr B Analyt Technol Biomed Life Sci. 2014. PMID: 24686233
A novel Indole-3-carbinol derivative (I3C) prodrug, indole-3-carbinol acetate (I3CA), was synthesized and a rapid high-performance liquid chromatography (HPLC) method for the quantification of I3CA, I3C, and the major metabolite of I3C, diindolylmethane (DIM) …
A novel Indole-3-carbinol derivative (I3C) prodrug, indole-3-carbinol acetate (I3CA), was synthesized and a rapid high-perform …
Inhibitory effect of the low-toxic exogenous aryl hydrocarbon receptor modulator 3'3-diindolylmethane on gastric cancer in mice.
Su M, Qian C, Hu Y, Lu W, Huang R, Chen M, Chen J. Su M, et al. Oncol Lett. 2017 Dec;14(6):8100-8105. doi: 10.3892/ol.2017.7185. Epub 2017 Oct 16. Oncol Lett. 2017. PMID: 29344254 Free PMC article.
3'3-Diindolylmethane (DIM) has been proved to exhibit anticancer properties in many solid tumors. ...Blood tests also indicated that DIM showed no toxic effect on animal weight or liver and kidney function. These results indicated that DIM agent could
3'3-Diindolylmethane (DIM) has been proved to exhibit anticancer properties in many solid tumors. ...Blood tests also i
In vivo and in vitro study on the role of 3,3'-diindolylmethane in treatment and prevention of nasopharyngeal carcinoma.
Chen C, Chen SM, Xu B, Chen Z, Wang F, Ren J, Xu Y, Wang Y, Xiao BK, Tao ZZ. Chen C, et al. Carcinogenesis. 2013 Aug;34(8):1815-21. doi: 10.1093/carcin/bgt122. Epub 2013 Apr 8. Carcinogenesis. 2013. PMID: 23568953
There were in vitro and in vivo preclinical evidences to support chemotherapeutic and chemopreventive effects of 3,3'-diindolylmethane (DIM), which was a natural compound extracted from cruciferous plants. ...Intake of DIM had no toxic effects on vital organs …
There were in vitro and in vivo preclinical evidences to support chemotherapeutic and chemopreventive effects of 3,3'-diind
A controlled safety study of diindolylmethane in the immature rat model.
Elackattu AP, Feng L, Wang Z. Elackattu AP, et al. Laryngoscope. 2009 Sep;119(9):1803-8. doi: 10.1002/lary.20526. Laryngoscope. 2009. PMID: 19544380 Free PMC article.
OBJECTIVES/HYPOTHESIS: Diindolylmethane (DIM), a natural product from cruciferous vegetables, has been shown to be a dietary component that has inhibitory effects on some tumors (e.g., laryngeal papilloma). ...RESULTS: Although our numbers do not allow for statistical sign …
OBJECTIVES/HYPOTHESIS: Diindolylmethane (DIM), a natural product from cruciferous vegetables, has been shown to be a dietary componen …
Effect of diindolylmethane on Ca(2+) homeostasis and viability in MDCK renal tubular cells.
Fang YC, Chou CT, Chi CC, Lin KL, Li YD, Cheng HH, Lu YC, Cheng JS, Kuo CC, Jan CR. Fang YC, et al. Hum Exp Toxicol. 2013 Apr;32(4):344-53. doi: 10.1177/0960327112462727. Hum Exp Toxicol. 2013. PMID: 23613483
The effect of the natural product diindolylmethane (DIM) on cytosolic Ca(2+) concentrations ([Ca(2+)]i) and viability in MDCK renal tubular cells was explored. ...
The effect of the natural product diindolylmethane (DIM) on cytosolic Ca(2+) concentrations ([Ca(2+)]i) and viability in MDCK renal t …
Evaluation of chronic dietary exposure to indole-3-carbinol and absorption-enhanced 3,3'-diindolylmethane in sprague-dawley rats.
Leibelt DA, Hedstrom OR, Fischer KA, Pereira CB, Williams DE. Leibelt DA, et al. Toxicol Sci. 2003 Jul;74(1):10-21. doi: 10.1093/toxsci/kfg103. Epub 2003 May 2. Toxicol Sci. 2003. PMID: 12730619 Review.
Indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM) are naturally occurring dietary components found in cruciferous vegetables. ...Results at 3 or 12 months were similar in most respects. No significant differences between groups were found …
Indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM) are naturally occurring dietary components found in cruc …
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