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2002 1
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2018 6
2019 2
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Retraction: Down-regulation of Androgen Receptor by 3,3'-Diindolylmethane Contributes to Inhibition of Cell Proliferation and Induction of Apoptosis in Both Hormone-Sensitive LNCaP and Insensitive C4-2B Prostate Cancer Cells.
[No authors listed] [No authors listed] Cancer Res. 2018 Sep 15;78(18):5473. doi: 10.1158/0008-5472.CAN-18-1167. Cancer Res. 2018. PMID: 30217883 Free article. No abstract available.
Retraction: Inhibition of Angiogenesis and Invasion by 3,3'-Diindolylmethane Is Mediated by the Nuclear Factor-kappaB Downstream Target Genes MMP-9 and uPA that Regulated Bioavailability of Vascular Endothelial Growth Factor in Prostate Cancer.
[No authors listed] [No authors listed] Cancer Res. 2018 Sep 15;78(18):5471. doi: 10.1158/0008-5472.CAN-18-1170. Cancer Res. 2018. PMID: 30217881 Free article. No abstract available.
Role of BioResponse 3,3'-Diindolylmethane in the Treatment of Human Prostate Cancer: Clinical Experience.
Li Y, Sarkar FH. Li Y, et al. Med Princ Pract. 2016;25 Suppl 2(Suppl 2):11-7. doi: 10.1159/000439307. Epub 2015 Oct 27. Med Princ Pract. 2016. PMID: 26501150 Free PMC article. Review.
In our recent study, we found that resistance to enzalutamide was partly due to deregulated expression of microRNAs such as miR-34a, miR-124, miR-27b, miR-320 and let-7, which play important roles in regulating AR and stem cell marker gene expression that appears to be linked wit …
In our recent study, we found that resistance to enzalutamide was partly due to deregulated expression of microRNAs such as miR-34a, miR-124 …
Diindolylmethane and its halogenated derivatives induce protective autophagy in human prostate cancer cells via induction of the oncogenic protein AEG-1 and activation of AMP-activated protein kinase (AMPK).
Draz H, Goldberg AA, Titorenko VI, Tomlinson Guns ES, Safe SH, Sanderson JT. Draz H, et al. Cell Signal. 2017 Dec;40:172-182. doi: 10.1016/j.cellsig.2017.09.006. Epub 2017 Sep 18. Cell Signal. 2017. PMID: 28923415
3,3'-Diindolylmethane (DIM) and its synthetic halogenated derivatives 4,4'-Br(2)- and 7,7'-Cl(2)DIM (ring-DIMs) have recently been shown to induce protective autophagy in human prostate cancer cells. ...Our findings could facilitate the development of
3,3'-Diindolylmethane (DIM) and its synthetic halogenated derivatives 4,4'-Br(2)- and 7,7'-Cl(2)DIM (ring-DIMs) have re
Phase Ib placebo-controlled, tissue biomarker trial of diindolylmethane (BR-DIMNG) in patients with prostate cancer who are undergoing prostatectomy.
Gee JR, Saltzstein DR, Messing E, Kim K, Kolesar J, Huang W, Havighurst TC, Harris L, Wollmer BW, Jarrard D, House M, Parnes H, Bailey HH. Gee JR, et al. Eur J Cancer Prev. 2016 Jul;25(4):312-20. doi: 10.1097/CEJ.0000000000000189. Eur J Cancer Prev. 2016. PMID: 26313229 Clinical Trial.
Epidemiologic, preclinical, and early phase I studies of the cruciferous vegetable bioactive metabolite, 3,3'-diindolylmethane (DIM), support its potential prostate cancer chemopreventive ability. ...Prostate tissue levels of DIM were the primar …
Epidemiologic, preclinical, and early phase I studies of the cruciferous vegetable bioactive metabolite, 3,3'-diindolylmeth
Effects of sulforaphane and 3,3'-diindolylmethane on genome-wide promoter methylation in normal prostate epithelial cells and prostate cancer cells.
Wong CP, Hsu A, Buchanan A, Palomera-Sanchez Z, Beaver LM, Houseman EA, Williams DE, Dashwood RH, Ho E. Wong CP, et al. PLoS One. 2014 Jan 22;9(1):e86787. doi: 10.1371/journal.pone.0086787. eCollection 2014. PLoS One. 2014. PMID: 24466240 Free PMC article.
Epigenetic changes, including aberrant DNA methylation, result in altered gene expression and play an important role in carcinogenesis. Phytochemicals such as sulforaphane (SFN) and 3,3'-diindolylmethane (DIM) are promising chemopreventive agents for the trea …
Epigenetic changes, including aberrant DNA methylation, result in altered gene expression and play an important role in carcinogenesis. Phyt …
Aryl hydrocarbon receptor enhances the expression of miR-150-5p to suppress in prostate cancer progression by regulating MAP3K12.
Yu J, Feng Y, Wang Y, An R. Yu J, et al. Arch Biochem Biophys. 2018 Sep 15;654:47-54. doi: 10.1016/j.abb.2018.07.010. Epub 2018 Jul 18. Arch Biochem Biophys. 2018. PMID: 30009782
Next, the inhibitory effects of Tetrachlorodibenzo-p-dioxin (TCDD) and 3,3'-Diindolylmethane (DIM) on the proliferation and invasion of prostate cancer cells were demonstrated. ...The expression level of CYP1A1 also was measured to confirm that Ahr was …
Next, the inhibitory effects of Tetrachlorodibenzo-p-dioxin (TCDD) and 3,3'-Diindolylmethane (DIM) on the proliferation …
3,3'-Diindolylmethane inhibits prostate cancer development in the transgenic adenocarcinoma mouse prostate model.
Cho HJ, Park SY, Kim EJ, Kim JK, Park JH. Cho HJ, et al. Mol Carcinog. 2011 Feb;50(2):100-12. doi: 10.1002/mc.20698. Epub 2010 Nov 8. Mol Carcinog. 2011. PMID: 21229607
3,3'-Diindolylmethane (DIM) is a major in vivo derivative of indole-3-carbinol, which is present in cruciferous vegetables and has been reported to possess anti-carcinogenic properties. In the present study, we examined whether DIM inhibits the develop
3,3'-Diindolylmethane (DIM) is a major in vivo derivative of indole-3-carbinol, which is present in cruciferous
The phytochemical 3,3'-diindolylmethane decreases expression of AR-controlled DNA damage repair genes through repressive chromatin modifications and is associated with DNA damage in prostate cancer cells.
Palomera-Sanchez Z, Watson GW, Wong CP, Beaver LM, Williams DE, Dashwood RH, Ho E. Palomera-Sanchez Z, et al. J Nutr Biochem. 2017 Sep;47:113-119. doi: 10.1016/j.jnutbio.2017.05.005. Epub 2017 May 25. J Nutr Biochem. 2017. PMID: 28582660 Free PMC article.
Androgen receptor (AR) is a transcription factor involved in normal prostate physiology and prostate cancer (PCa) development. 3,3'-Diindolylmethane (DIM) is a promising phytochemical agent against PCa that affects AR activity and epigenetic reg …
Androgen receptor (AR) is a transcription factor involved in normal prostate physiology and prostate cancer (PCa) development. …
Anti-androgenic activity of absorption-enhanced 3, 3'-diindolylmethane in prostatectomy patients.
Hwang C, Sethi S, Heilbrun LK, Gupta NS, Chitale DA, Sakr WA, Menon M, Peabody JO, Smith DW, Sarkar FH, Heath EI. Hwang C, et al. Am J Transl Res. 2016 Jan 15;8(1):166-76. eCollection 2016. Am J Transl Res. 2016. PMID: 27069550 Free PMC article.
Consumption of cruciferous vegetables is associated with a decreased risk of developing prostate cancer. Antineoplastic effects of cruciferous vegetables are attributable to bioactive indoles, most prominently, 3, 3'-diindolylmethane (DIM). In addition …
Consumption of cruciferous vegetables is associated with a decreased risk of developing prostate cancer. Antineoplastic effects of cr …
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