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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2002 1
2003 3
2004 4
2005 4
2006 6
2007 4
2008 5
2009 5
2010 5
2011 5
2012 9
2013 5
2014 9
2015 4
2016 7
2017 3
2018 6
2019 2
2021 4
2023 4
2024 0

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83 results

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Page 1
Role of BioResponse 3,3'-Diindolylmethane in the Treatment of Human Prostate Cancer: Clinical Experience.
Li Y, Sarkar FH. Li Y, et al. Med Princ Pract. 2016;25 Suppl 2(Suppl 2):11-7. doi: 10.1159/000439307. Epub 2015 Oct 27. Med Princ Pract. 2016. PMID: 26501150 Free PMC article. Review.
In our recent study, we found that resistance to enzalutamide was partly due to deregulated expression of microRNAs such as miR-34a, miR-124, miR-27b, miR-320 and let-7, which play important roles in regulating AR and stem cell marker gene expression that appears to be linked wit …
In our recent study, we found that resistance to enzalutamide was partly due to deregulated expression of microRNAs such as miR-34a, miR-124 …
The Plant Derived 3-3'-Diindolylmethane (DIM) Behaves as CB(2) Receptor Agonist in Prostate Cancer Cellular Models.
Tucci P, Brown I, Bewick GS, Pertwee RG, Marini P. Tucci P, et al. Int J Mol Sci. 2023 Feb 11;24(4):3620. doi: 10.3390/ijms24043620. Int J Mol Sci. 2023. PMID: 36835033 Free PMC article.
3-3'-Diindolylmethane (DIM) is a biologically active dimer derived from the endogenous conversion of indole-3-carbinol (I3C), a naturally occurring glucosinolate found in many cruciferous vegetables (i.e., Brassicaceae). ...In this context, by considering the
3-3'-Diindolylmethane (DIM) is a biologically active dimer derived from the endogenous conversion of indole-3-carbinol
Indole-3-carbinol and prostate cancer.
Sarkar FH, Li Y. Sarkar FH, et al. J Nutr. 2004 Dec;134(12 Suppl):3493S-3498S. doi: 10.1093/jn/134.12.3493S. J Nutr. 2004. PMID: 15570059 Free article. Review.
Epidemiological and dietary studies have revealed an association between high dietary intake of cruciferous vegetables and decreased prostate cancer risk. Our studies have shown that indole-3-carbinol (I3C), a common phytochemical in cruciferous vegetables, and its in vivo …
Epidemiological and dietary studies have revealed an association between high dietary intake of cruciferous vegetables and decreased pros
Regulation of carcinogenesis and mediation through Wnt/beta-catenin signaling by 3,3'-diindolylmethane in an enzalutamide-resistant prostate cancer cell line.
Tsao CW, Li JS, Lin YW, Wu ST, Cha TL, Liu CY. Tsao CW, et al. Sci Rep. 2021 Jan 13;11(1):1239. doi: 10.1038/s41598-020-80519-3. Sci Rep. 2021. PMID: 33441906 Free PMC article.
Enzalutamide (ENZ) is an important drug used to treat castration-resistant prostate cancer (CRPC), which inhibits androgen receptor (AR) signaling. Previous study showed that 3,3'-diindolylmethane (DIM) is an AR antagonist that also inhibits Wnt signal …
Enzalutamide (ENZ) is an important drug used to treat castration-resistant prostate cancer (CRPC), which inhibits androgen receptor ( …
3,3'-Diindolylmethane and indole-3-carbinol: potential therapeutic molecules for cancer chemoprevention and treatment via regulating cellular signaling pathways.
Reyes-Hernández OD, Figueroa-González G, Quintas-Granados LI, Gutiérrez-Ruíz SC, Hernández-Parra H, Romero-Montero A, Del Prado-Audelo ML, Bernal-Chavez SA, Cortés H, Peña-Corona SI, Kiyekbayeva L, Ateşşahin DA, Goloshvili T, Leyva-Gómez G, Sharifi-Rad J. Reyes-Hernández OD, et al. Cancer Cell Int. 2023 Aug 26;23(1):180. doi: 10.1186/s12935-023-03031-4. Cancer Cell Int. 2023. PMID: 37633886 Free PMC article. Review.
Dietary compounds in cancer prevention have gained significant consideration as a viable method. Indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM) are heterocyclic and bioactive chemicals found in cruciferous vegetables like broccoli, cauliflower, cabba …
Dietary compounds in cancer prevention have gained significant consideration as a viable method. Indole-3-carbinol (I3C) and 3,3
Effect of diindolylmethane on Ca2+ homeostasis and viability in PC3 human prostate cancer cells.
Tsai JY, Chou CT, Liu SI, Liang WZ, Kuo CC, Liao WC, Lin KL, Hsu SS, Lu YC, Huang JK, Jan CR. Tsai JY, et al. J Recept Signal Transduct Res. 2012 Oct;32(5):271-8. doi: 10.3109/10799893.2012.707212. Epub 2012 Jul 31. J Recept Signal Transduct Res. 2012. PMID: 22845469
The effect of the natural product diindolylmethane on cytosolic Ca(2+) concentrations ([Ca(2+)](i)) and viability in PC3 human prostate cancer cells was explored. ...Diindolylmethane caused cell death in which apoptosis may participate....
The effect of the natural product diindolylmethane on cytosolic Ca(2+) concentrations ([Ca(2+)](i)) and viability in PC3 human pro
Recent progress on nutraceutical research in prostate cancer.
Li Y, Ahmad A, Kong D, Bao B, Sarkar FH. Li Y, et al. Cancer Metastasis Rev. 2014 Sep;33(2-3):629-40. doi: 10.1007/s10555-013-9478-9. Cancer Metastasis Rev. 2014. PMID: 24375392 Free PMC article. Review.
Several nutraceuticals including isoflavone, indole-3-carbinol, 3,3'-diindolylmethane, lycopene, (-)-epigallocatechin-3-gallate, and curcumin are known to downregulate the signal transductions in AR, Akt, NF-kappaB, and other signal transduction pathways whic …
Several nutraceuticals including isoflavone, indole-3-carbinol, 3,3'-diindolylmethane, lycopene, (-)-epigallocatechin-3 …
3,3'-Diindolylmethane enhances taxotere-induced apoptosis in hormone-refractory prostate cancer cells through survivin down-regulation.
Rahman KM, Banerjee S, Ali S, Ahmad A, Wang Z, Kong D, Sakr WA. Rahman KM, et al. Cancer Res. 2009 May 15;69(10):4468-75. doi: 10.1158/0008-5472.CAN-08-4423. Epub 2009 May 12. Cancer Res. 2009. PMID: 19435906
Survivin, a member of inhibitor of apoptosis family, is associated with both prostate cancer progression and drug resistance. Therefore, we hypothesized that survivin may play a potentially important role in hormone-refractory prostate cancer (HRPC) and bone metasta …
Survivin, a member of inhibitor of apoptosis family, is associated with both prostate cancer progression and drug resistance. Therefo …
Effects of sulforaphane and 3,3'-diindolylmethane on genome-wide promoter methylation in normal prostate epithelial cells and prostate cancer cells.
Wong CP, Hsu A, Buchanan A, Palomera-Sanchez Z, Beaver LM, Houseman EA, Williams DE, Dashwood RH, Ho E. Wong CP, et al. PLoS One. 2014 Jan 22;9(1):e86787. doi: 10.1371/journal.pone.0086787. eCollection 2014. PLoS One. 2014. PMID: 24466240 Free PMC article.
Epigenetic changes, including aberrant DNA methylation, result in altered gene expression and play an important role in carcinogenesis. Phytochemicals such as sulforaphane (SFN) and 3,3'-diindolylmethane (DIM) are promising chemopreventive agents for the trea …
Epigenetic changes, including aberrant DNA methylation, result in altered gene expression and play an important role in carcinogenesis. Phyt …
3,3'-Diindolylmethane inhibits prostate cancer development in the transgenic adenocarcinoma mouse prostate model.
Cho HJ, Park SY, Kim EJ, Kim JK, Park JH. Cho HJ, et al. Mol Carcinog. 2011 Feb;50(2):100-12. doi: 10.1002/mc.20698. Epub 2010 Nov 8. Mol Carcinog. 2011. PMID: 21229607
3,3'-Diindolylmethane (DIM) is a major in vivo derivative of indole-3-carbinol, which is present in cruciferous vegetables and has been reported to possess anti-carcinogenic properties. In the present study, we examined whether DIM inhibits the development of
3,3'-Diindolylmethane (DIM) is a major in vivo derivative of indole-3-carbinol, which is present in cruciferous vegetab
83 results