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Page 1
Yam-derived exosome-like nanovesicles stimulate osteoblast formation and prevent osteoporosis in mice.
Hwang JH, Park YS, Kim HS, Kim DH, Lee SH, Lee CH, Lee SH, Kim JE, Lee S, Kim HM, Kim HW, Kim J, Seo W, Kwon HJ, Song BJ, Kim DK, Baek MC, Cho YE. Hwang JH, et al. J Control Release. 2023 Mar;355:184-198. doi: 10.1016/j.jconrel.2023.01.071. Epub 2023 Feb 6. J Control Release. 2023. PMID: 36736431
Substances extracted from yams have been reported to promote osteoblast growth in bone regeneration, which prevent weak and brittle bones in osteoporosis. Herein, we describe the beneficial effects of yam-derived exosome-like nanovesicles (YNVs) on promoting differentiatio …
Substances extracted from yams have been reported to promote osteoblast growth in bone regeneration, which prevent weak and brittle b …
Low-molecular-weight estrogenic phytoprotein suppresses osteoporosis development through positive modulation of skeletal estrogen receptors.
Kubi JA, Brah AS, Cheung KMC, Chen ACH, Lee YL, Lee KF, Qiao W, Feng Y, Yeung KWK. Kubi JA, et al. Bioact Mater. 2024 Sep 4;42:299-315. doi: 10.1016/j.bioactmat.2024.08.045. eCollection 2024 Dec. Bioact Mater. 2024. PMID: 39290337 Free PMC article.
We recently discovered a low-molecular-weight biocompatible and osteoanabolic phytoprotein, called HKUOT-S2 protein (32 kDa), from Dioscorea opposita Thunb that can accelerate bone defect healing. Here, we demonstrated that the HKUOT-S2 protein treatment can enhance ost …
We recently discovered a low-molecular-weight biocompatible and osteoanabolic phytoprotein, called HKUOT-S2 protein (32 kDa), from Diosco …
Yam polysaccharide promoted bone differentiation of MC3T3-E1 cells through targeted Inhibition of CASP3 activation.
Yu Q, Liu L, Jiang T, Guan Z, Liu Z. Yu Q, et al. J Orthop Surg Res. 2025 Aug 7;20(1):745. doi: 10.1186/s13018-025-06141-z. J Orthop Surg Res. 2025. PMID: 40775331 Free PMC article.
Yam polysaccharide (YP) is a natural active component extracted from Dioscorea opposita, which has anti-inflammatory, antioxidant and immunomodulatory effects, but its role and mechanism in bone differentiation remain unclear. ...
Yam polysaccharide (YP) is a natural active component extracted from Dioscorea opposita, which has anti-inflammatory, antioxidant and …
Dioscin reduces ovariectomy-induced bone loss by enhancing osteoblastogenesis and inhibiting osteoclastogenesis.
Tao X, Qi Y, Xu L, Yin L, Han X, Xu Y, Wang C, Sun H, Peng J. Tao X, et al. Pharmacol Res. 2016 Jun;108:90-101. doi: 10.1016/j.phrs.2016.05.003. Epub 2016 May 4. Pharmacol Res. 2016. PMID: 27155058
Our previous studies showed that dioscin can promote osteoblasts proliferation and differentiation in vitro, but its anti-osteoporosis effect in vivo and the underlying mechanisms remain unclear. In the present work, the results showed that dioscin significantly increased …
Our previous studies showed that dioscin can promote osteoblasts proliferation and differentiation in vitro, but its anti-osteoporosi …
A new osteogenic protein isolated from Dioscorea opposita Thunb accelerates bone defect healing through the mTOR signaling axis.
Kubi JA, Brah AS, Cheung KMC, Lee YL, Lee KF, Sze SCW, Qiao W, Yeung KW. Kubi JA, et al. Bioact Mater. 2023 Apr 23;27:429-446. doi: 10.1016/j.bioactmat.2023.04.018. eCollection 2023 Sep. Bioact Mater. 2023. PMID: 37152710 Free PMC article.
Here, we have identified one new osteogenic protein, named 'HKUOT-S2' protein, from Dioscorea opposita Thunb. Using the bone defect model, we have shown that the HKUOT-S2 protein can accelerate bone defect repair by activating the mTOR signaling axis of MSCs-derived ost …
Here, we have identified one new osteogenic protein, named 'HKUOT-S2' protein, from Dioscorea opposita Thunb. Using the bone defect m …
A Traditional Chinese Medicine Plant Extract Prevents Alcohol-Induced Osteopenia.
Qian D, Zhou H, Fan P, Yu T, Patel A, O'Brien M, Wang Z, Lu S, Tong G, Shan Y, Wang L, Gao Y, Xiong Y, Zhang L, Wang X, Liu Y, Zhou S. Qian D, et al. Front Pharmacol. 2021 Dec 15;12:754088. doi: 10.3389/fphar.2021.754088. eCollection 2021. Front Pharmacol. 2021. PMID: 35002697 Free PMC article.
TCM herbal extracts (Jing extracts) were prepared from nine Chinese herbal medicines, a combinative herbal formula for antifatigue and immune regulation, including Astragalus, Cistanche deserticola, Dioscorea polystachya, Lycium barbarum, Epimedium, Cinnamomum cassia, Syzy …
TCM herbal extracts (Jing extracts) were prepared from nine Chinese herbal medicines, a combinative herbal formula for antifatigue and immun …
Antiosteoporotic activity of the water extract of Dioscorea spongiosa.
Yin J, Tezuka Y, Kouda K, Tran QL, Miyahara T, Chen Y, Kadota S. Yin J, et al. Biol Pharm Bull. 2004 Apr;27(4):583-6. doi: 10.1248/bpb.27.583. Biol Pharm Bull. 2004. PMID: 15056872 Free article.
After 60 MeOH and water extracts of natural crude drugs were screened for their ability to stimulate osteoblast proliferation, four MeOH extracts (Cynomorium songaricum, Drynaria fortunei, Lycium chinense, Rehmannia glutinosa) and seven water extracts (Cornus officinalis, …
After 60 MeOH and water extracts of natural crude drugs were screened for their ability to stimulate osteoblast proliferation, four M …
The in vitro anti-osteoporotic activity of some diarylheptanoids and lignans from the rhizomes of Dioscorea spongiosa.
Yin J, Han N, Liu Z, Xu X, Zhang B, Kadota S. Yin J, et al. Planta Med. 2008 Oct;74(12):1451-3. doi: 10.1055/s-2008-1081340. Epub 2008 Aug 5. Planta Med. 2008. PMID: 18683123
Three diarylheptanoids and three lignans from the 90 % ethanol fraction of the rhizomes of DIOSCOREA SPONGIOSA were isolated and subjected to IN VITRO experiments to investigate their activity on osteoblasts and osteoclasts. Diarylheptanoid 1 and furofuran lignan 6 …
Three diarylheptanoids and three lignans from the 90 % ethanol fraction of the rhizomes of DIOSCOREA SPONGIOSA were isolated and subj …
Diosgenin induces hypoxia-inducible factor-1 activation and angiogenesis through estrogen receptor-related phosphatidylinositol 3-kinase/Akt and p38 mitogen-activated protein kinase pathways in osteoblasts.
Yen ML, Su JL, Chien CL, Tseng KW, Yang CY, Chen WF, Chang CC, Kuo ML. Yen ML, et al. Mol Pharmacol. 2005 Oct;68(4):1061-73. doi: 10.1124/mol.104.010082. Epub 2005 Jul 5. Mol Pharmacol. 2005. PMID: 15998873
Diosgenin, extracted from the root of wild yam (Dioscorea villosa), has been reported to demonstrate an opportunity for medical application. ...In this study, we examine whether diosgenin is able to induce VEGF-A expression and to promote angiogenesis in osteobla …
Diosgenin, extracted from the root of wild yam (Dioscorea villosa), has been reported to demonstrate an opportunity for medica …
Effect of diosgenin, a steroidal sapogenin, on the rat skeletal system.
Folwarczna J, Zych M, Nowińska B, Pytlik M, Bialik M, Jagusiak A, Lipecka-Karcz M, Matysiak M. Folwarczna J, et al. Acta Biochim Pol. 2016;63(2):287-95. doi: 10.18388/abp.2015_1095. Epub 2016 Apr 26. Acta Biochim Pol. 2016. PMID: 27119728 Free article.
Diosgenin is a steroidal sapogenin present in fenugreek and Dioscorea spp. as glycosides (saponins). Diosgenin has already been reported to inhibit osteoclastogenesis and to stimulate osteogenic activity of osteoblastic cells in vitro, and to exert some antiosteopor …
Diosgenin is a steroidal sapogenin present in fenugreek and Dioscorea spp. as glycosides (saponins). Diosgenin has already been repor …
19 results