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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 1
1946 1
1948 2
1949 1
1950 3
1951 1
1952 2
1953 4
1955 2
1956 3
1957 1
1958 4
1959 2
1960 2
1961 4
1962 6
1963 5
1964 5
1965 4
1966 6
1967 8
1968 9
1969 5
1970 4
1971 7
1972 8
1973 10
1974 9
1975 5
1976 13
1977 5
1978 6
1979 10
1980 5
1981 3
1982 6
1983 11
1984 12
1985 13
1986 5
1987 5
1988 6
1989 7
1990 8
1991 8
1992 14
1993 9
1994 7
1995 12
1996 13
1997 7
1998 7
1999 11
2000 12
2001 23
2002 27
2003 37
2004 34
2005 34
2006 45
2007 45
2008 33
2009 52
2010 65
2011 65
2012 77
2013 80
2014 98
2015 102
2016 111
2017 106
2018 117
2019 119
2020 139
2021 157
2022 50
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1,745 results
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Diosgenin a steroidal compound: An emerging way to cancer management.
Arya P, Kumar P. Arya P, et al. J Food Biochem. 2021 Dec;45(12):e14005. doi: 10.1111/jfbc.14005. Epub 2021 Nov 19. J Food Biochem. 2021. PMID: 34799857 Review.
Fenugreek is an excellent source of various bioactive compounds especially diosgenin. Diosgenin is steroidal sapogenin that cures various health issues including cancers. ...Cancer cure with diosgenin is providing a new base to the pharmaceutical and medical …
Fenugreek is an excellent source of various bioactive compounds especially diosgenin. Diosgenin is steroidal sapogenin that cu …
[Research on anti-tumor natural product diosgenin].
Zhang SQ, Song YX, Zhang WX, Chen MJ, Man SL. Zhang SQ, et al. Zhongguo Zhong Yao Za Zhi. 2021 Sep;46(17):4360-4366. doi: 10.19540/j.cnki.cjcmm.20210610.701. Zhongguo Zhong Yao Za Zhi. 2021. PMID: 34581038 Review. Chinese.
However, problems like low yield and bioavailability frequently exist in natural diosgenin. This review introduced methods such as structural modification, dosage form optimization and combination medication to improve the yield and anti-tumor activity of diosgenin. …
However, problems like low yield and bioavailability frequently exist in natural diosgenin. This review introduced methods such as st …
Effects of diosgenin and its derivatives on atherosclerosis.
Wu FC, Jiang JG. Wu FC, et al. Food Funct. 2019 Nov 1;10(11):7022-7036. doi: 10.1039/c9fo00749k. Epub 2019 Nov 5. Food Funct. 2019. PMID: 31687707 Review.
At present, it is an important topic for researchers to develop safe and effective drugs from natural products to prevent and treat cardiovascular diseases. Diosgenin (DSG) is a plant sterol saponin mainly found in natural medicinal plants such as fenugreek seeds and wild …
At present, it is an important topic for researchers to develop safe and effective drugs from natural products to prevent and treat cardiova …
Dioscin and diosgenin: Insights into their potential protective effects in cardiac diseases.
Li X, Liu S, Qu L, Chen Y, Yuan C, Qin A, Liang J, Huang Q, Jiang M, Zou W. Li X, et al. J Ethnopharmacol. 2021 Jun 28;274:114018. doi: 10.1016/j.jep.2021.114018. Epub 2021 Mar 11. J Ethnopharmacol. 2021. PMID: 33716083 Review.
BACKGROUND AND ETHNOPHARMACOLOGICAL RELEVANCE: Dioscin and diosgenin derived from plants of the genus Dioscoreaceae such as D. nipponica and D. panthaica Prain et Burk. ...But the bioavailability of dioscin and diosgenin may be too low as a result of poor absorption …
BACKGROUND AND ETHNOPHARMACOLOGICAL RELEVANCE: Dioscin and diosgenin derived from plants of the genus Dioscoreaceae such as D. nippon …
[Pathway design and key enzyme analysis of diosgenin biosynthesis].
Sun Z, Zhao P, Ge X, Tian P. Sun Z, et al. Sheng Wu Gong Cheng Xue Bao. 2021 Apr 25;37(4):1178-1188. doi: 10.13345/j.cjb.200389. Sheng Wu Gong Cheng Xue Bao. 2021. PMID: 33973434 Free article. Review. Chinese.
Currently, industrial production of diosgenin relies primarily on chemical extraction from plant materials. ...In particular, we suggest heterologous biosynthesis of diosgenin in Saccharomyces cerevisiae. Overall, this review aims to provide valuable insights for fu …
Currently, industrial production of diosgenin relies primarily on chemical extraction from plant materials. ...In particular, we sugg …
Diosgenin, a steroidal saponin, and its analogs: Effective therapies against different chronic diseases.
Parama D, Boruah M, Yachna K, Rana V, Banik K, Harsha C, Thakur KK, Dutta U, Arya A, Mao X, Ahn KS, Kunnumakkara AB. Parama D, et al. Life Sci. 2020 Nov 1;260:118182. doi: 10.1016/j.lfs.2020.118182. Epub 2020 Aug 8. Life Sci. 2020. PMID: 32781063 Review.
AIM: To evaluate the literature available on the potential of diosgenin and its analogs in modulating different molecular targets leading to the prevention and treatment of chronic diseases. METHOD: A detailed literature search has been carried out on PubMed for gathering …
AIM: To evaluate the literature available on the potential of diosgenin and its analogs in modulating different molecular targets lea …
Biotechnological strategies for the sustainable production of diosgenin from Dioscorea spp.
Nazir R, Kumar V, Gupta S, Dwivedi P, Pandey DK, Dey A. Nazir R, et al. Appl Microbiol Biotechnol. 2021 Jan;105(2):569-585. doi: 10.1007/s00253-020-11055-3. Epub 2021 Jan 6. Appl Microbiol Biotechnol. 2021. PMID: 33404834 Review.
Diosgenin is a plant-derived secondary metabolite mainly present in the members of the plant family Dioscoreaceae. ...KEY POINTS: Critical and updated assessment on sustainable production of diosgenin from Dioscorea spp. In vitro propagation of Dioscorea spp. and el
Diosgenin is a plant-derived secondary metabolite mainly present in the members of the plant family Dioscoreaceae. ...KEY POINTS: Cri
Diosgenin via NMDA Receptor Exerted Anxiolytic-like Effect on Maternally Separated Mice.
Boroujeni SN, Lorigooini Z, Boldaji FR, Amini-Khoei H. Boroujeni SN, et al. Curr Pharm Des. 2021;27(3):440-445. doi: 10.2174/1381612826666200717083211. Curr Pharm Des. 2021. PMID: 32679011
MATERIALS AND METHODS: Maternal separation (MS) paradigm was performed daily (3 h) from postnatal day (PND) 2-14. Male mice were treated with different doses of diosgenin to find effective and sub-effective doses. In the next step, mice were treated with an effective dose …
MATERIALS AND METHODS: Maternal separation (MS) paradigm was performed daily (3 h) from postnatal day (PND) 2-14. Male mice were treated wit …
Diosgenin ameliorates cellular and molecular changes in multiple sclerosis in C57BL/6 mice.
Zeinali H, Baluchnejadmojarad T, Roghani M. Zeinali H, et al. Mult Scler Relat Disord. 2021 Oct;55:103211. doi: 10.1016/j.msard.2021.103211. Epub 2021 Aug 10. Mult Scler Relat Disord. 2021. PMID: 34425463

Inflammation, demyelination and axonal loss scores also decreased significantly in the diosgenin treatment group compared to the EAE group (p < 0.05). Serum and spinal cord tissue level of TNFalpha and tissue level of MMP-9 considerably decreased in the diosgenin

Inflammation, demyelination and axonal loss scores also decreased significantly in the diosgenin treatment group compared to the EAE …
Therapeutic Potential of Diosgenin and Its Major Derivatives against Neurological Diseases: Recent Advances.
Cai B, Zhang Y, Wang Z, Xu D, Jia Y, Guan Y, Liao A, Liu G, Chun C, Li J. Cai B, et al. Oxid Med Cell Longev. 2020 Mar 6;2020:3153082. doi: 10.1155/2020/3153082. eCollection 2020. Oxid Med Cell Longev. 2020. PMID: 32215172 Free PMC article. Review.
Diosgenin (DG), a well-known steroidal sapogenin, is present abundantly in medicinal herbs such as Dioscorea rhizome, Dioscorea villosa, Trigonella foenum-graecum, Smilax China, and Rhizoma polgonati. ...
Diosgenin (DG), a well-known steroidal sapogenin, is present abundantly in medicinal herbs such as Dioscorea rhizome, Dioscorea villo
1,745 results