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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 1
1946 1
1948 2
1949 1
1950 3
1951 1
1952 2
1953 4
1955 2
1956 3
1957 1
1958 4
1959 2
1960 2
1961 4
1962 6
1963 5
1964 5
1965 4
1966 6
1967 8
1968 9
1969 5
1970 4
1971 7
1972 8
1973 10
1974 9
1975 5
1976 13
1977 5
1978 6
1979 10
1980 5
1981 3
1982 6
1983 11
1984 12
1985 13
1986 5
1987 5
1988 6
1989 7
1990 8
1991 8
1992 14
1993 9
1994 7
1995 12
1996 13
1997 7
1998 7
1999 11
2000 12
2001 23
2002 27
2003 37
2004 34
2005 34
2006 45
2007 45
2008 33
2009 52
2010 65
2011 65
2012 78
2013 80
2014 97
2015 102
2016 111
2017 106
2018 117
2019 110
2020 67
2021 1
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1,503 results
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Pro-Apoptotic and Anti-Cancer Properties of Diosgenin: A Comprehensive and Critical Review.
Sethi G, Shanmugam MK, Warrier S, Merarchi M, Arfuso F, Kumar AP, Bishayee A. Sethi G, et al. Nutrients. 2018 May 19;10(5):645. doi: 10.3390/nu10050645. Nutrients. 2018. PMID: 29783752 Free PMC article. Review.
Diosgenin has a unique structural similarity to estrogen. Several preclinical studies have reported on the pro-apoptotic and anti-cancer properties of diosgenin against a variety of cancers, both in in vitro and in vivo. ...Remarkably, diosgenin has also been
Diosgenin has a unique structural similarity to estrogen. Several preclinical studies have reported on the pro-apoptotic and anti-can
Effects of diosgenin and its derivatives on atherosclerosis.
Wu FC, Jiang JG. Wu FC, et al. Food Funct. 2019 Nov 1;10(11):7022-7036. doi: 10.1039/c9fo00749k. Epub 2019 Nov 5. Food Funct. 2019. PMID: 31687707 Review.
Diosgenin (DSG) is a plant sterol saponin mainly found in natural medicinal plants such as fenugreek seeds and wild yam tubers. ...Furthermore, diosgenin is also an important basic raw material for the preparation of steroids and contraceptives in the pharmaceutical
Diosgenin (DSG) is a plant sterol saponin mainly found in natural medicinal plants such as fenugreek seeds and wild yam tubers. ...Fu
Advances in the pharmacological activities and mechanisms of diosgenin.
Chen Y, Tang YM, Yu SL, Han YW, Kou JP, Liu BL, Yu BY. Chen Y, et al. Chin J Nat Med. 2015 Aug;13(8):578-87. doi: 10.1016/S1875-5364(15)30053-4. Chin J Nat Med. 2015. PMID: 26253490 Review.
Diosgenin, a well-known steroid sapogenin derived from plants, has been used as a starting material for production of steroidal hormones. The present review will summarize published literature concerning pharmacological potential of diosgenin, and the underlying mec
Diosgenin, a well-known steroid sapogenin derived from plants, has been used as a starting material for production of steroidal hormo
Diosgenin Glucoside Protects against Spinal Cord Injury by Regulating Autophagy and Alleviating Apoptosis.
Chen XB, Wang ZL, Yang QY, Zhao FY, Qin XL, Tang XE, Du JL, Chen ZH, Zhang K, Huang FJ. Chen XB, et al. Int J Mol Sci. 2018 Aug 2;19(8):2274. doi: 10.3390/ijms19082274. Int J Mol Sci. 2018. PMID: 30072674 Free PMC article.
Diosgenin glucoside (DG), a major bioactive ingredient of Trillium tschonoskii Max., possesses neuroprotective effects through its antioxidant and anti-apoptotic functions. ...
Diosgenin glucoside (DG), a major bioactive ingredient of Trillium tschonoskii Max., possesses neuroprotective effects through its an
HPTLC determination of diosgenin in fenugreek seeds.
Król-Kogus B, Lamine KM, Migas P, Boudjeniba M, Krauze-Baranowska M. Król-Kogus B, et al. Acta Pharm. 2018 Mar 1;68(1):97-107. doi: 10.2478/acph-2018-0002. Acta Pharm. 2018. PMID: 29453912
A new HPTLC-densitometric method for diosgenin determination in fenugreek seeds was established after optimization of the conditions for efficient saponin extraction and acid hydrolysis. ...The method was preliminarily validated and the determined amounts of diosgenin
A new HPTLC-densitometric method for diosgenin determination in fenugreek seeds was established after optimization of the conditions …
Validation of a method for diosgenin extraction from fenugreek (Trigonella foenum-graecum L.).
Chaudhary SA, Chaudhary PS, Syed BA, Misra R, Bagali PG, Vitalini S, Iriti M. Chaudhary SA, et al. Acta Sci Pol Technol Aliment. 2018 Oct-Dec;17(4):377-385. doi: 10.17306/J.AFS.0606. Acta Sci Pol Technol Aliment. 2018. PMID: 30558394 Free article.
BACKGROUND: Diosgenin is a very important plant secondary metabolite and raw material for the drug indus- try. Plant sources rich in diosgenin include yam (Dioscorea spp.) and fenugreek (Trigonella foenum-graecum L.). ...Diosgenin yield estimation and purity …
BACKGROUND: Diosgenin is a very important plant secondary metabolite and raw material for the drug indus- try. Plant sources rich in …
Diosgenin inhibited the expression of TAZ in hepatocellular carcinoma.
Chen Z, Xu J, Wu Y, Lei S, Liu H, Meng Q, Xia Z. Chen Z, et al. Biochem Biophys Res Commun. 2018 Sep 10;503(3):1181-1185. doi: 10.1016/j.bbrc.2018.07.022. Epub 2018 Jul 11. Biochem Biophys Res Commun. 2018. PMID: 30005871
In the current study, we aim to determine whether diosgenin could be an inhibitor of TAZ in liver cancer cells. We found that diosgenin inhibited the expression of TAZ in liver cancer cells. ...Our study provides the evidence to support that diosgenin could b …
In the current study, we aim to determine whether diosgenin could be an inhibitor of TAZ in liver cancer cells. We found that dios
Diosgenin induces genotoxic and mutagenic effects on HepG2 cells.
Cruz MS, Navoni JA, da Costa Xavier LA, Madalena Rocha Silva Teles M, Barbosa-Filho JM, Almeida-Lima J, de Oliveira Rocha HA, do Amaral VS. Cruz MS, et al. Food Chem Toxicol. 2018 Oct;120:98-103. doi: 10.1016/j.fct.2018.07.011. Epub 2018 Jul 5. Food Chem Toxicol. 2018. PMID: 29981786
A reduction on cell viability was observed due to diosgenin treatment at concentrations higher than 30 μM. A genotoxic effect was shown by comet assay and CBMN. ...Diosgenin elicited DNA damage on HepG2 cells which could not be efficiently repaired contributing to t …
A reduction on cell viability was observed due to diosgenin treatment at concentrations higher than 30 μM. A genotoxic effect was sho …
Diosgenin and Its Fenugreek Based Biological Matrix Affect Insulin Resistance and Anabolic Hormones in a Rat Based Insulin Resistance Model.
Kiss R, Pesti-Asbóth G, Szarvas MM, Stündl L, Cziáky Z, Hegedűs C, Kovács D, Badale A, Máthé E, Szilvássy Z, Remenyik J. Kiss R, et al. Biomed Res Int. 2019 Apr 4;2019:7213913. doi: 10.1155/2019/7213913. eCollection 2019. Biomed Res Int. 2019. PMID: 31080828 Free PMC article.
For the study of how diosgenin and fenugreek seeds modify insulin sensitivity, we used a rat insulin resistance model induced by high-fat diet. Diosgenin in three different doses (1mg/bwkg, 10mg/bwkg, and 50 mg/bwkg, respectively) and fenugreek seed (0.2 g/bwkg) wer …
For the study of how diosgenin and fenugreek seeds modify insulin sensitivity, we used a rat insulin resistance model induced by high …
Diosgenin-loaded niosome as an effective phytochemical nanocarrier: physicochemical characterization, loading efficiency, and cytotoxicity assay.
Hajizadeh MR, Parvaz N, Barani M, Khoshdel A, Fahmidehkar MA, Mahmoodi M, Torkzadeh-Mahani M. Hajizadeh MR, et al. Daru. 2019 Jun;27(1):329-339. doi: 10.1007/s40199-019-00277-0. Epub 2019 May 27. Daru. 2019. PMID: 31134490 Free PMC article.
METHODS: We loaded diosgenin into niosome to increase its solubility and hence efficiency. Diosgenin-niosome (diosgenin loaded into niosome) was prepared by thin-film hydration method and characterised by optical microscopy, dynamic light scattering (DLS), sc …
METHODS: We loaded diosgenin into niosome to increase its solubility and hence efficiency. Diosgenin-niosome (diosgenin
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