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Synthesis of dipeptide 4-nitroanilides containing non-proteinogenic amino acids.
Schutkowski M, Mrestani-Klaus C, Neubert K. Schutkowski M, et al. Int J Pept Protein Res. 1995 Mar;45(3):257-65. doi: 10.1111/j.1399-3011.1995.tb01487.x. Int J Pept Protein Res. 1995. PMID: 7775018
The resulting amino acid 4-nitroanilides were extended to corresponding dipeptide 4-nitroanilides with tert-butyloxycarbonyl-(S)-alanine. In the case of sterically hindered amino acid 4-nitroanilides the mixed anhydride procedure with diphenylphosphinyl chloride was …
The resulting amino acid 4-nitroanilides were extended to corresponding dipeptide 4-nitroanilides with tert-butyloxycarbonyl-( …
Ribosome-Mediated Incorporation of Dipeptides and Dipeptide Analogues into Proteins in Vitro.
Maini R, Dedkova LM, Paul R, Madathil MM, Chowdhury SR, Chen S, Hecht SM. Maini R, et al. J Am Chem Soc. 2015 Sep 9;137(35):11206-9. doi: 10.1021/jacs.5b03135. Epub 2015 Aug 31. J Am Chem Soc. 2015. PMID: 26301427 Free PMC article.
The four incorporated species included two dipeptides (Gly-Phe (2) and Phe-Gly (3)), as well as a thiolated dipeptide analogue (4) and a fluorescent oxazole (5) having amine and carboxyl groups approximately the same distance apart as in a normal dipeptide. A protein containing b …
The four incorporated species included two dipeptides (Gly-Phe (2) and Phe-Gly (3)), as well as a thiolated dipeptide analogue (4) and a flu …
Exercises in pyrrolidine chemistry: gram scale synthesis of a Pro-Pro dipeptide mimetic with a polyproline type II helix conformation.
Reuter C, Huy P, Neudörfl JM, Kühne R, Schmalz HG. Reuter C, et al. Chemistry. 2011 Oct 17;17(43):12037-44. doi: 10.1002/chem.201101704. Epub 2011 Sep 7. Chemistry. 2011. PMID: 21901773
The strategy is based on a Ru-catalyzed ring-closing metathesis of a dipeptide (4) prepared by PyBOP coupling of cis-5-vinylproline tert-butylester (2) and trans-N-Boc-3-vinylproline (rac-3) followed by chromatographic diastereomer separation. ...
The strategy is based on a Ru-catalyzed ring-closing metathesis of a dipeptide (4) prepared by PyBOP coupling of cis-5-vinylpr …
Antimicrobial compounds were isolated from the secondary metabolites of Gordonia, a resident of intestinal tract of Periplaneta americana.
Ma Y, Xu M, Liu H, Yu T, Guo P, Liu W, Jin X. Ma Y, et al. AMB Express. 2021 Jul 30;11(1):111. doi: 10.1186/s13568-021-01272-y. AMB Express. 2021. PMID: 34331149 Free PMC article.
Meanwhile, actinomycin D (1), actinomycin X2 (2), mojavensin A (3) and cyclic (leucine-leucne) dipeptide (4) were obtained from the EtOAc extract from the broth of WA 4-31. ...
Meanwhile, actinomycin D (1), actinomycin X2 (2), mojavensin A (3) and cyclic (leucine-leucne) dipeptide (4) were obtained fro …
Phytochemical Investigation of Bioactive Compounds from White Kidney Beans (Fruits of Phaseolus multiflorus var. Albus): Identification of Denatonium with Osteogenesis-Inducing Effect.
Lee YH, Hong JH, Park KH, Kim SH, Kim JC, Kim DH, Park YH, Lee KW, Kim JK, Kim KH. Lee YH, et al. Plants (Basel). 2021 Oct 17;10(10):2205. doi: 10.3390/plants10102205. Plants (Basel). 2021. PMID: 34686012 Free PMC article.
As part of our ongoing study to investigate novel bioactive components from various natural resources, a phytochemical investigation of the extract of P. multiflorus var. albus fruits resulted in the isolation of three phenolic compounds (1-3) and one dipeptide (4). …
As part of our ongoing study to investigate novel bioactive components from various natural resources, a phytochemical investigation of the …
Analogues of both Leu- and Met-enkephalin containing a constrained dipeptide isostere prepared from a Baylis-Hillman adduct.
Galeazzi R, Martelli G, Marcucci E, Orena M, Rinaldi S, Lattanzi R, Negri L. Galeazzi R, et al. Amino Acids. 2010 Apr;38(4):1057-65. doi: 10.1007/s00726-009-0314-z. Epub 2009 Jul 8. Amino Acids. 2010. PMID: 19585218
An efficient route was developed for the synthesis of the Fmoc-protected dipeptide 4, isostere of Gly-Gly containing an alpha-methylene beta-amino acid; the conformationally restricted analogues of Leu-enkephalin, 3a, and Met-enkephalin, 3b, respectively, were prepa …
An efficient route was developed for the synthesis of the Fmoc-protected dipeptide 4, isostere of Gly-Gly containing an alpha- …
Electrospray ionization mass spectrometry study on dipeptide 4-chlorobutyl ester produced from refluxing of amino acid with phosphoryl chloride in tetrahydrofuran.
Zhou GJ, Liu Z, Wang TJ, Xu PX, Tang G, Ye Y, Zhao YF. Zhou GJ, et al. J Mass Spectrom. 2005 Oct;40(10):1382-6. doi: 10.1002/jms.918. J Mass Spectrom. 2005. PMID: 16220467
ESI multistage tandem mass spectrometry was applied to trace the reaction and elucidate the product structures, dipeptide 4-chlorobutyl ester....
ESI multistage tandem mass spectrometry was applied to trace the reaction and elucidate the product structures, dipeptide 4-ch …
Influence of substituents on conformational preferences of helix foldamers of γ-dipeptides.
Kee Kang Y, Yoo IK. Kee Kang Y, et al. Biopolymers. 2014 Nov;101(11):1077-87. doi: 10.1002/bip.22507. Biopolymers. 2014. PMID: 24838173
There are only marginal changes in backbone structures and the distances and angles of H-bonds for all local minima by C(alpha) -ethyl and/or benzyl substitutions. Although vibrational frequencies and intensities of the dipeptide 4 calculated at both M06-2X/6-31 + G …
There are only marginal changes in backbone structures and the distances and angles of H-bonds for all local minima by C(alpha) -ethyl and/o …
Mechanism-based inhibition of human folylpolyglutamate synthetase: design, synthesis, and biochemical characterization of a phosphapeptide mimic of the tetrahedral intermediate.
Tsukamoto T, Haile WH, McGuire JJ, Coward JK. Tsukamoto T, et al. Arch Biochem Biophys. 1998 Jul 1;355(1):109-18. doi: 10.1006/abbi.1998.0703. Arch Biochem Biophys. 1998. PMID: 9647673
This intermediate would arise from direct attack of H2O on the dipeptide, 4-NH2-10-CH3-Pte-L-Glu-gamma-L-Glu. The fact that 4-NH2-10-CH3-Pte-L-Glu-gamma-[PsiP(O)(OH)-O]glutarate is not an inhibitor of gamma-GH strongly suggests that hydrolysis of poly-gamma-glutamat …
This intermediate would arise from direct attack of H2O on the dipeptide, 4-NH2-10-CH3-Pte-L-Glu-gamma-L-Glu. The fact that 4- …
Synthesis and NMR studies of malonyl-linked glycoconjugates of N-(2-aminoethyl)glycine. Building blocks for the construction of combinatorial glycopeptide libraries.
Nörrlinger M, Hafner S, Ziegler T. Nörrlinger M, et al. Beilstein J Org Chem. 2016 Aug 30;12:1939-1948. doi: 10.3762/bjoc.12.183. eCollection 2016. Beilstein J Org Chem. 2016. PMID: 27829900 Free PMC article.
The Fmoc group of compound 1c was removed and the intermediate amine 9 was condensed with 2a to afford the corresponding glycosylated AEG dipeptide 4 in 58% yield. All glycoconjugate building blocks showed the presence of cis and trans rotamers. ...
The Fmoc group of compound 1c was removed and the intermediate amine 9 was condensed with 2a to afford the corresponding glycosylated AEG …
14 results