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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 1
1968 1
1969 1
1971 2
1973 2
1974 1
1975 2
1976 1
1977 6
1978 1
1979 2
1980 1
1981 3
1982 2
1984 2
1985 5
1986 4
1987 6
1988 6
1989 7
1990 6
1991 13
1992 13
1993 13
1994 13
1995 13
1996 12
1997 11
1998 10
1999 11
2000 18
2001 11
2002 13
2003 11
2004 9
2005 10
2006 19
2007 14
2008 16
2009 8
2010 13
2011 11
2012 13
2013 10
2014 8
2015 10
2016 8
2017 14
2018 9
2019 14
2020 11
2021 11
2022 9
2023 6
2024 5
2025 2

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423 results

Results by year

Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Sio TT, Le-Rademacher JG, Leenstra JL, Loprinzi CL, Rine G, Curtis A, Singh AK, Martenson JA Jr, Novotny PJ, Tan AD, Qin R, Ko SJ, Reiter PL, Miller RC. Sio TT, et al. JAMA. 2019 Apr 16;321(15):1481-1490. doi: 10.1001/jama.2019.3504. JAMA. 2019. PMID: 30990550 Free PMC article. Clinical Trial.
In a randomized study, doxepin mouthwash was shown to reduce oral mucositis-related pain. A common mouthwash comprising diphenhydramine-lidocaine-antacid is also widely used. OBJECTIVE: To evaluate the effect of doxepin mouthwash or diphenhydramine-lidocaine-antacid …
In a randomized study, doxepin mouthwash was shown to reduce oral mucositis-related pain. A common mouthwash comprising diphenhydramine
Prophylactic Administration of Diphenhydramine to Reduce Neuroleptic Side Effects in the Acute Care Setting: A Systematic Review and Meta-Analysis.
Mokhtari A, Yip O, Alain J, Berthelot S. Mokhtari A, et al. J Emerg Med. 2021 Feb;60(2):165-174. doi: 10.1016/j.jemermed.2020.09.031. Epub 2020 Oct 31. J Emerg Med. 2021. PMID: 33131965
In subgroup analysis, diphenhydramine was associated with a significant decrease in extrapyramidal adverse effects compared with placebo (4 studies, n = 705; RR 0.61; 95% CI 0.41-0.90). ...CONCLUSIONS: When compared with placebo, diphenhydramine was associated with …
In subgroup analysis, diphenhydramine was associated with a significant decrease in extrapyramidal adverse effects compared with plac …
Honey for acute cough in children.
Oduwole O, Udoh EE, Oyo-Ita A, Meremikwu MM. Oduwole O, et al. Cochrane Database Syst Rev. 2018 Apr 10;4(4):CD007094. doi: 10.1002/14651858.CD007094.pub5. Cochrane Database Syst Rev. 2018. PMID: 29633783 Free PMC article. Review.
Honey may have a similar effect as dextromethorphan in reducing cough frequency (MD -0.07, 95% CI -1.07 to 0.94; I2 = 87%; 2 studies; 149 children; low-certainty evidence). Honey may be better than diphenhydramine in reducing cough frequency (MD -0.57, 95% CI -0.90 to -0.2 …
Honey may have a similar effect as dextromethorphan in reducing cough frequency (MD -0.07, 95% CI -1.07 to 0.94; I2 = 87%; 2 studies; 149 ch …
Standardized Extract of Valeriana officinalis Improves Overall Sleep Quality in Human Subjects with Sleep Complaints: A Randomized, Double-Blind, Placebo-Controlled, Clinical Study.
Chandra Shekhar H, Joshua L, Thomas JV. Chandra Shekhar H, et al. Adv Ther. 2024 Jan;41(1):246-261. doi: 10.1007/s12325-023-02708-6. Epub 2023 Oct 30. Adv Ther. 2024. PMID: 37899385 Free PMC article. Clinical Trial.
The treatments for sleep disturbances include melatonin and over-the-counter medicines like diphenhydramine and doxylamine, all of which have negative side effects. Valerian (Valeriana officinalis L.) is a traditional herb and the most preferred alternate sleep solution to …
The treatments for sleep disturbances include melatonin and over-the-counter medicines like diphenhydramine and doxylamine, all of wh …
Pharmacological interventions for antipsychotic-related sialorrhea: a systematic review and network meta-analysis of randomized trials.
Fornaro M, Caiazza C, Solini N, De Prisco M, Billeci M, Vannini M, Shorr R, Caiolo S, Lussignoli M, Siskind D, Pigato G, Barone A, Sambataro F, de Bartolomeis A, Correll CU, Solmi M. Fornaro M, et al. Mol Psychiatry. 2023 Sep;28(9):3648-3660. doi: 10.1038/s41380-023-02266-x. Epub 2023 Oct 11. Mol Psychiatry. 2023. PMID: 37821573
. = 1.65-3.77), propantheline (RR = 2.39, 95% C.I. = 1.97-2.90), diphenhydramine (RR = 2.32, 95% C.I. = 1.88-2.86), benzhexol (RR = 2.32, 95% C.I. = 1.59-3.38), doxepin (RR = 2.30, 95% C.I. = 1.85-2.88), amisulpride (RR = 2.23, 95% C.I. = 1.30-3.81), chlorpheniramine (RR = …
. = 1.65-3.77), propantheline (RR = 2.39, 95% C.I. = 1.97-2.90), diphenhydramine (RR = 2.32, 95% C.I. = 1.88-2.86), benzhexol (RR = 2 …
Randomized Study of Metoclopramide Plus Diphenhydramine for Acute Posttraumatic Headache.
Friedman BW, Irizarry E, Cain D, Caradonna A, Minen MT, Solorzano C, Zias E, Zybert D, McGregor M, Bijur PE, Gallagher EJ. Friedman BW, et al. Neurology. 2021 May 4;96(18):e2323-e2331. doi: 10.1212/WNL.0000000000011822. Epub 2021 Mar 24. Neurology. 2021. PMID: 33762421 Free PMC article. Clinical Trial.
OBJECTIVE: To determine whether IV metoclopramide 20 mg + diphenhydramine 25 mg (M + D) was more efficacious than IV placebo for acute moderate or severe posttraumatic headache in the emergency room. ...
OBJECTIVE: To determine whether IV metoclopramide 20 mg + diphenhydramine 25 mg (M + D) was more efficacious than IV placebo for acut …
Prophylactic diphenhydramine attenuates postoperative catheter-related bladder discomfort in patients undergoing gynecologic laparoscopic surgery: a randomized double-blind clinical study.
Li YY, Zeng YS, Chen JY, Wang KF, Hsing CH, Wu WJ, Wang JJ, Feng PH, Chu CC. Li YY, et al. J Anesth. 2020 Apr;34(2):232-237. doi: 10.1007/s00540-019-02724-3. Epub 2019 Dec 20. J Anesth. 2020. PMID: 31863189 Clinical Trial.
The control group received normal saline 2 ml, whereas the diphenhydramine group received diphenhydramine 30 mg intravenously after induction of general anesthesia. ...Diphenhydramine treatment also reduced the severity of CRBD at 6 h postoperatively (p = 0.0 …
The control group received normal saline 2 ml, whereas the diphenhydramine group received diphenhydramine 30 mg intravenously …
Prophylactic administration of diphenhydramine/paracetamol reduced emergence agitation and postoperative pain following maxillofacial surgeries: a randomized controlled trial.
Khajavi MR, Saffarian A, Majidi F, Moharari RS, Pourfakhr P, Parhiz SA. Khajavi MR, et al. Eur Arch Otorhinolaryngol. 2022 Mar;279(3):1467-1471. doi: 10.1007/s00405-021-06904-4. Epub 2021 May 27. Eur Arch Otorhinolaryngol. 2022. PMID: 34043064 Clinical Trial.
METHODS: Eighty-five patients undergoing maxillofacial surgery were randomized into two groups. The diphenhydramine group (Group D, n = 40) received diphenhydramine premedication 0.5 mg/kg before anesthesia induction, while the control group (Group C, n = 40) receiv …
METHODS: Eighty-five patients undergoing maxillofacial surgery were randomized into two groups. The diphenhydramine group (Group D, n …
Evaluation of diphenhydramine as a sedative for dogs.
Hofmeister EH, Egger CM. Hofmeister EH, et al. J Am Vet Med Assoc. 2005 Apr 1;226(7):1092-4. doi: 10.2460/javma.2005.226.1092. J Am Vet Med Assoc. 2005. PMID: 15825733 Free article. Clinical Trial.
RESULTS: Dogs in the acepromazine group had significantly higher sedation scores than did dogs in the saline solution or diphenhydramine groups at 30 minutes. Dogs in the diphenhydramine groups did not have significantly different sedation scores from dogs in the sa …
RESULTS: Dogs in the acepromazine group had significantly higher sedation scores than did dogs in the saline solution or diphenhydramine
423 results