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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 1
1968 1
1969 1
1971 2
1973 2
1974 1
1975 2
1976 1
1977 6
1978 1
1979 2
1980 1
1981 3
1982 2
1984 2
1985 5
1986 4
1987 6
1988 6
1989 7
1990 6
1991 13
1992 13
1993 13
1994 13
1995 13
1996 12
1997 11
1998 10
1999 11
2000 18
2001 11
2002 13
2003 11
2004 9
2005 10
2006 19
2007 14
2008 16
2009 8
2010 13
2011 11
2012 13
2013 10
2014 8
2015 10
2016 8
2017 14
2018 9
2019 15
2020 11
2021 11
2022 9
2023 6
2024 4

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Search Results

421 results

Results by year

Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Sio TT, Le-Rademacher JG, Leenstra JL, Loprinzi CL, Rine G, Curtis A, Singh AK, Martenson JA Jr, Novotny PJ, Tan AD, Qin R, Ko SJ, Reiter PL, Miller RC. Sio TT, et al. JAMA. 2019 Apr 16;321(15):1481-1490. doi: 10.1001/jama.2019.3504. JAMA. 2019. PMID: 30990550 Free PMC article. Clinical Trial.
In a randomized study, doxepin mouthwash was shown to reduce oral mucositis-related pain. A common mouthwash comprising diphenhydramine-lidocaine-antacid is also widely used. OBJECTIVE: To evaluate the effect of doxepin mouthwash or diphenhydramine-lidocaine-antacid …
In a randomized study, doxepin mouthwash was shown to reduce oral mucositis-related pain. A common mouthwash comprising diphenhydramine
Honey for acute cough in children.
Oduwole O, Udoh EE, Oyo-Ita A, Meremikwu MM. Oduwole O, et al. Cochrane Database Syst Rev. 2018 Apr 10;4(4):CD007094. doi: 10.1002/14651858.CD007094.pub5. Cochrane Database Syst Rev. 2018. PMID: 29633783 Free PMC article. Review.
Honey may have a similar effect as dextromethorphan in reducing cough frequency (MD -0.07, 95% CI -1.07 to 0.94; I2 = 87%; 2 studies; 149 children; low-certainty evidence). Honey may be better than diphenhydramine in reducing cough frequency (MD -0.57, 95% CI -0.90 to -0.2 …
Honey may have a similar effect as dextromethorphan in reducing cough frequency (MD -0.07, 95% CI -1.07 to 0.94; I2 = 87%; 2 studies; 149 ch …
Randomized Study of Metoclopramide Plus Diphenhydramine for Acute Posttraumatic Headache.
Friedman BW, Irizarry E, Cain D, Caradonna A, Minen MT, Solorzano C, Zias E, Zybert D, McGregor M, Bijur PE, Gallagher EJ. Friedman BW, et al. Neurology. 2021 May 4;96(18):e2323-e2331. doi: 10.1212/WNL.0000000000011822. Epub 2021 Mar 24. Neurology. 2021. PMID: 33762421 Free PMC article. Clinical Trial.
OBJECTIVE: To determine whether IV metoclopramide 20 mg + diphenhydramine 25 mg (M + D) was more efficacious than IV placebo for acute moderate or severe posttraumatic headache in the emergency room. ...
OBJECTIVE: To determine whether IV metoclopramide 20 mg + diphenhydramine 25 mg (M + D) was more efficacious than IV placebo for acut …
Prophylactic diphenhydramine attenuates postoperative catheter-related bladder discomfort in patients undergoing gynecologic laparoscopic surgery: a randomized double-blind clinical study.
Li YY, Zeng YS, Chen JY, Wang KF, Hsing CH, Wu WJ, Wang JJ, Feng PH, Chu CC. Li YY, et al. J Anesth. 2020 Apr;34(2):232-237. doi: 10.1007/s00540-019-02724-3. Epub 2019 Dec 20. J Anesth. 2020. PMID: 31863189 Clinical Trial.
The control group received normal saline 2 ml, whereas the diphenhydramine group received diphenhydramine 30 mg intravenously after induction of general anesthesia. ...Diphenhydramine treatment also reduced the severity of CRBD at 6 h postoperatively (p = 0.0 …
The control group received normal saline 2 ml, whereas the diphenhydramine group received diphenhydramine 30 mg intravenously …
Diphenhydramine as Adjuvant Therapy for Acute Migraine: An Emergency Department-Based Randomized Clinical Trial.
Friedman BW, Cabral L, Adewunmi V, Solorzano C, Esses D, Bijur PE, Gallagher EJ. Friedman BW, et al. Ann Emerg Med. 2016 Jan;67(1):32-39.e3. doi: 10.1016/j.annemergmed.2015.07.495. Epub 2015 Aug 29. Ann Emerg Med. 2016. PMID: 26320523 Free PMC article. Clinical Trial.
One hour after medication administration, patients randomized to diphenhydramine improved by a mean of 5.1 on the 0 to 10 scale versus 4.8 for those randomized to placebo (95% CI for difference of 0.3: -0.6 to 1.1). ...Median ED length of stay was 122 minutes (interquartil …
One hour after medication administration, patients randomized to diphenhydramine improved by a mean of 5.1 on the 0 to 10 scale versu …
Evaluation of diphenhydramine as a sedative for dogs.
Hofmeister EH, Egger CM. Hofmeister EH, et al. J Am Vet Med Assoc. 2005 Apr 1;226(7):1092-4. doi: 10.2460/javma.2005.226.1092. J Am Vet Med Assoc. 2005. PMID: 15825733 Free article. Clinical Trial.
CONCLUSIONS AND CLINICAL RELEVANCE: Diphenhydramine did not cause clinically appreciable sedation in healthy dogs. Diphenhydramine is not suitable as a sole sedative prior to general anesthesia in dogs....
CONCLUSIONS AND CLINICAL RELEVANCE: Diphenhydramine did not cause clinically appreciable sedation in healthy dogs. Diphenhydramine
Prophylactic administration of diphenhydramine/paracetamol reduced emergence agitation and postoperative pain following maxillofacial surgeries: a randomized controlled trial.
Khajavi MR, Saffarian A, Majidi F, Moharari RS, Pourfakhr P, Parhiz SA. Khajavi MR, et al. Eur Arch Otorhinolaryngol. 2022 Mar;279(3):1467-1471. doi: 10.1007/s00405-021-06904-4. Epub 2021 May 27. Eur Arch Otorhinolaryngol. 2022. PMID: 34043064 Clinical Trial.
In this study, we investigated the effects of preemptive administration of diphenhydramine on emergence agitation and quality of recovery after maxillofacial surgery in adult patients. METHODS: Eighty-five patients undergoing maxillofacial surgery were randomized into two …
In this study, we investigated the effects of preemptive administration of diphenhydramine on emergence agitation and quality of reco …
Prophylactic Administration of Diphenhydramine to Reduce Neuroleptic Side Effects in the Acute Care Setting: A Systematic Review and Meta-Analysis.
Mokhtari A, Yip O, Alain J, Berthelot S. Mokhtari A, et al. J Emerg Med. 2021 Feb;60(2):165-174. doi: 10.1016/j.jemermed.2020.09.031. Epub 2020 Oct 31. J Emerg Med. 2021. PMID: 33131965
., migraines) in the emergency department, but can cause serious adverse effects. Using diphenhydramine to prevent these adverse effects is very common but remains controversial. ...Dosage analysis yielded no further information. CONCLUSIONS: When compared with placebo, …
., migraines) in the emergency department, but can cause serious adverse effects. Using diphenhydramine to prevent these adverse effe …
Diphenhydramine as an adjunct to sedation for colonoscopy: a double-blind randomized, placebo-controlled study.
Tu RH, Grewall P, Leung JW, Suryaprasad AG, Sheykhzadeh PI, Doan C, Garcia JC, Zhang N, Prindiville T, Mann S, Trudeau W. Tu RH, et al. Gastrointest Endosc. 2006 Jan;63(1):87-94. doi: 10.1016/j.gie.2005.08.015. Gastrointest Endosc. 2006. PMID: 16377322 Clinical Trial.
RESULTS: Of 270 patients, data were analyzed for 258 patients, with 130 patients in the diphenhydramine group and 128 patients in the placebo group. There was a 10.1% reduction in meperidine usage and 13.7% reduction in midazolam usage in favor of the diphenhydramine
RESULTS: Of 270 patients, data were analyzed for 258 patients, with 130 patients in the diphenhydramine group and 128 patients in the …
421 results