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1995 2
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48 results

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Page 1
Escitalopram Induced Angioedema.
Conde SL, Nazha H, Simpkins C. Conde SL, et al. Cureus. 2022 Nov 17;14(11):e31600. doi: 10.7759/cureus.31600. eCollection 2022 Nov. Cureus. 2022. PMID: 36540519 Free PMC article.
We present the case report of a 28-year-old female with a history of generalized anxiety disorder (GAD), major depressive disorder (MDD), intravenous heroin use disorder, and prior tricuspid valve replacement who presented to the hospital with signs and symptoms of sepsis. She wa …
We present the case report of a 28-year-old female with a history of generalized anxiety disorder (GAD), major depressive disorder (MDD), in …
Cardiac actions of antihistamines.
Woosley RL. Woosley RL. Annu Rev Pharmacol Toxicol. 1996;36:233-52. doi: 10.1146/annurev.pa.36.040196.001313. Annu Rev Pharmacol Toxicol. 1996. PMID: 8725389 Review.
Two of the nonsedating antihistaminic drugs, terfenadine and astemizole, have recently been recognized in rare cases to induce the syndrome of torsades de pointes, i.e. QT interval prolongation and life-threatening ventricular tachycardia. ...Two agents recently mar …
Two of the nonsedating antihistaminic drugs, terfenadine and astemizole, have recently been recognized in rare cases to induce the syndrome …
Evaluation of the potential for QTc prolongation with avelumab.
Vugmeyster Y, Güzel G, Hennessy M, Loos AH, Dai H. Vugmeyster Y, et al. Cancer Chemother Pharmacol. 2019 Nov;84(5):1017-1026. doi: 10.1007/s00280-019-03925-z. Epub 2019 Sep 3. Cancer Chemother Pharmacol. 2019. PMID: 31478078 Free PMC article.
In addition, models including avelumab concentration and diphenhydramine premedication use did not show a clinically meaningful effect on the QT interval. ...Six patients (0.3%) were QTc outliers; all had either received concomitant medication known to cause QT …
In addition, models including avelumab concentration and diphenhydramine premedication use did not show a clinically meaningful effec …
QT interval prolongation and rhabdomyolysis associated with diphenhydramine toxicity: a case report.
Ali Z, Khan M, Ullah W, Kpehor AA, Cheema MA. Ali Z, et al. J Community Hosp Intern Med Perspect. 2020 May 21;10(2):151-153. doi: 10.1080/20009666.2020.1749511. J Community Hosp Intern Med Perspect. 2020. PMID: 32850053 Free PMC article.
Diphenhydramine is a widely available, over-the-counter medication used for allergies and as a sleeping aid. ...Overdose of the medication has been associated with dangerous and life-threatening outcomes. Our case describes diphenhydramine toxicity manifesting with …
Diphenhydramine is a widely available, over-the-counter medication used for allergies and as a sleeping aid. ...Overdose of the medic …
Diphenhydramine and QT prolongation - A rare cardiac side effect of a drug used in common practice.
Shah A, Yousuf T, Ziffra J, Zaidi A, Raghuvir R. Shah A, et al. J Cardiol Cases. 2015 Jul 3;12(4):126-129. doi: 10.1016/j.jccase.2015.06.002. eCollection 2015 Oct. J Cardiol Cases. 2015. PMID: 30546575 Free PMC article.
There have been few cases in recent times where QT interval prolongation has been studied with regards to the use of diphenhydramine. ...We describe a case of a patient who developed QT prolongation with a temporal association with diphenhydramine usag …
There have been few cases in recent times where QT interval prolongation has been studied with regards to the use of diphenhydrami …
Standard treatment: the role of antihistamines.
Merk HF. Merk HF. J Investig Dermatol Symp Proc. 2001 Nov;6(2):153-6. doi: 10.1046/j.0022-202x.2001.00032.x. J Investig Dermatol Symp Proc. 2001. PMID: 11764306 Free article. Review.
Major progress has been achieved in recent years both in the understanding of their ligands, the H1-histamine receptors, and therefore in the mechanisms of their pharmacologic effects, as well as in the development of safer antihistamines with low or no sedating effects and no in …
Major progress has been achieved in recent years both in the understanding of their ligands, the H1-histamine receptors, and therefore in th …
Death by paint thinner.
Collison I, Moorehead W. Collison I, et al. J Anal Toxicol. 2002 Oct;26(7):532-6. doi: 10.1093/jat/26.7.532. J Anal Toxicol. 2002. PMID: 12423013
Two rectangular cans of paint thinner, 1-qt and 1-gal sizes, were found in his vehicle at the top of the cliff. The autopsy report indicated that the decedent was normal except for the heart and myocardium, the lung parenchyma, and the gastric and esophageal mucosa. ...Tox …
Two rectangular cans of paint thinner, 1-qt and 1-gal sizes, were found in his vehicle at the top of the cliff. The autopsy report in …
Diphenhydramine induced QT prolongation and torsade de pointes: An uncommon effect of a common drug.
Husain Z, Hussain K, Nair R, Steinman R. Husain Z, et al. Cardiol J. 2010;17(5):509-11. Cardiol J. 2010. PMID: 20865683 Free article.
It inhibits the fast sodium channels and, at higher concentrations, the repolarising potassium channels, particularly Ikr which leads to prolongation of the action potential and the QT interval. The toxicity of diphenhydramine is dose-dependent, with a critical dose …
It inhibits the fast sodium channels and, at higher concentrations, the repolarising potassium channels, particularly Ikr which leads to pro …
Antiemetic therapy for nausea and vomiting in the emergency department.
Patanwala AE, Amini R, Hays DP, Rosen P. Patanwala AE, et al. J Emerg Med. 2010 Sep;39(3):330-6. doi: 10.1016/j.jemermed.2009.08.060. Epub 2009 Dec 21. J Emerg Med. 2010. PMID: 20022195 Review.
Droperidol was commonly used in the past, and is more effective than prochlorperazine or metoclopramide, but due to the US Food and Drug Administration black box warning regarding the potential for QT prolongation with this drug, its use is limited to refractory cases. Pro …
Droperidol was commonly used in the past, and is more effective than prochlorperazine or metoclopramide, but due to the US Food and Drug Adm …
Diphenhydramine dependence through deep intramuscular injection resulting in myonecrosis and prolonged QT interval.
Chen TY, Yeh YW, Kuo SC, Chen CY, Lin TP, Chang CC. Chen TY, et al. J Clin Pharm Ther. 2014 Jun;39(3):325-7. doi: 10.1111/jcpt.12142. Epub 2014 Mar 5. J Clin Pharm Ther. 2014. PMID: 24597640
WHAT IS KNOWN AND OBJECTIVE: Diphenhydramine (DPH) is a first-generation antihistamine, which is useful in treating allergic reaction, and is usually considered innocuous. ...She needed to receive psychiatric inpatient treatment because of depressive mood, serious myonecro …
WHAT IS KNOWN AND OBJECTIVE: Diphenhydramine (DPH) is a first-generation antihistamine, which is useful in treating allergic reaction …
48 results