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Year Number of Results
1911 3
1912 1
1918 1
1920 1
1925 1
1929 1
1934 1
1935 3
1936 1
1940 3
1941 1
1945 1
1948 1
1949 1
1950 3
1951 1
1952 1
1953 3
1954 4
1956 1
1957 6
1958 2
1959 2
1960 5
1961 5
1962 9
1963 12
1964 12
1965 14
1966 34
1967 37
1968 38
1969 46
1970 52
1971 55
1972 74
1973 96
1974 97
1975 395
1976 433
1977 356
1978 369
1979 417
1980 543
1981 555
1982 630
1983 744
1984 978
1985 973
1986 1033
1987 1157
1988 1237
1989 1483
1990 1628
1991 1823
1992 1910
1993 2113
1994 2277
1995 2397
1996 2750
1997 2671
1998 2769
1999 2823
2000 3313
2001 3351
2002 3622
2003 3748
2004 4221
2005 4446
2006 4661
2007 4937
2008 5155
2009 5422
2010 5938
2011 6354
2012 7032
2013 7477
2014 7758
2015 8209
2016 8193
2017 8957
2018 9291
2019 9506
2020 10649
2021 11755
2022 11644
2023 11609
2024 12496
2025 14250
2026 174

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209,734 results

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Page 1
Selective Sweeps.
Stephan W. Stephan W. Genetics. 2019 Jan;211(1):5-13. doi: 10.1534/genetics.118.301319. Genetics. 2019. PMID: 30626638 Free PMC article. Review.
For almost 20 years, many inference methods have been developed to detect selective sweeps and localize the targets of directional selection in the genome. These methods are based on population genetic models that describe the effect of a beneficial al …
For almost 20 years, many inference methods have been developed to detect selective sweeps and localize the targets of directional …
Laboratory-directed protein evolution.
Yuan L, Kurek I, English J, Keenan R. Yuan L, et al. Microbiol Mol Biol Rev. 2005 Sep;69(3):373-92. doi: 10.1128/MMBR.69.3.373-392.2005. Microbiol Mol Biol Rev. 2005. PMID: 16148303 Free PMC article. Review.
Systematic approaches to directed evolution of proteins have been documented since the 1970s. The ability to recruit new protein functions arises from the considerable substrate ambiguity of many proteins. ...When exploited in a laboratory under controlled mutagenesis and …
Systematic approaches to directed evolution of proteins have been documented since the 1970s. The ability to recruit new protein func …
Natural directed evolution in gut microbiota.
Paul BG, Mekalanos JJ. Paul BG, et al. Science. 2025 Oct 9;390(6769):129-130. doi: 10.1126/science.aeb8597. Epub 2025 Oct 9. Science. 2025. PMID: 41066587
Bacteria undergo rapid genetic changes that are selected by alterations in the human gut environment....
Bacteria undergo rapid genetic changes that are selected by alterations in the human gut environment....
Directed Evolution of Protein Catalysts.
Zeymer C, Hilvert D. Zeymer C, et al. Annu Rev Biochem. 2018 Jun 20;87:131-157. doi: 10.1146/annurev-biochem-062917-012034. Epub 2018 Mar 1. Annu Rev Biochem. 2018. PMID: 29494241 Review.
Directed evolution is a powerful technique for generating tailor-made enzymes for a wide range of biocatalytic applications. ...This review briefly surveys the experimental methods used to generate genetic diversity and screen or select for improved enzyme va …
Directed evolution is a powerful technique for generating tailor-made enzymes for a wide range of biocatalytic applications. ...This …
Directional selection coupled with kin selection favors the establishment of senescence.
Szilágyi A, Czárán T, Santos M, Szathmáry E. Szilágyi A, et al. BMC Biol. 2023 Oct 23;21(1):230. doi: 10.1186/s12915-023-01716-w. BMC Biol. 2023. PMID: 37867189 Free PMC article.
RESULTS: Here, we show by a spatially explicit, individual-based simulation model that aging can positively be selected for if a sufficient degree of kin selection complements directional selection. ...The applicability of our results depends on empiri …
RESULTS: Here, we show by a spatially explicit, individual-based simulation model that aging can positively be selected for if a suff …
The divergence of mean phenotypes under persistent directional selection.
Devi A, Speyer G, Lynch M. Devi A, et al. Genetics. 2023 Jul 6;224(3):iyad091. doi: 10.1093/genetics/iyad091. Genetics. 2023. PMID: 37200616 Free PMC article.
Numerous organismal traits, particularly at the cellular level, are likely to be under persistent directional selection across phylogenetic lineages. Unless all mutations affecting such traits have large enough effects to be efficiently selected in all specie …
Numerous organismal traits, particularly at the cellular level, are likely to be under persistent directional selection across …
Directional mutation pressure, selective constraints, and genetic equilibria.
Sueoka N. Sueoka N. J Mol Evol. 1992 Feb;34(2):95-114. doi: 10.1007/BF00182387. J Mol Evol. 1992. PMID: 1556753 Review.
In this article, first, a theory of the evolution of DNA G + C content is presented that is based on the equilibrium among three components: directional mutation pressure, DNA G + C content, and selective constraints. According to this theory, consideration of both …
In this article, first, a theory of the evolution of DNA G + C content is presented that is based on the equilibrium among three components: …
Are humans increasing bacterial evolvability?
Gillings MR, Stokes HW. Gillings MR, et al. Trends Ecol Evol. 2012 Jun;27(6):346-52. doi: 10.1016/j.tree.2012.02.006. Epub 2012 Mar 27. Trends Ecol Evol. 2012. PMID: 22459247 Review.
These processes are under selection, balancing genomic integrity against the advantages accrued by genetic innovation. Saturation of the environment with selective agents might cause directional selection for higher rates of mutation, recombinat …
These processes are under selection, balancing genomic integrity against the advantages accrued by genetic innovation. Saturat …
Directed evolution of metabolic pathways.
Chatterjee R, Yuan L. Chatterjee R, et al. Trends Biotechnol. 2006 Jan;24(1):28-38. doi: 10.1016/j.tibtech.2005.11.002. Epub 2005 Nov 18. Trends Biotechnol. 2006. PMID: 16298446 Review.
The modification of cellular metabolism is of biotechnological and commercial significance because naturally occurring metabolic pathways are the source of diverse compounds used in fields ranging from medicine to bioremediation. Directed evolution is the experimental impr …
The modification of cellular metabolism is of biotechnological and commercial significance because naturally occurring metabolic pathways ar …
The Role of Mutation Bias in Adaptive Evolution.
Svensson EI, Berger D. Svensson EI, et al. Trends Ecol Evol. 2019 May;34(5):422-434. doi: 10.1016/j.tree.2019.01.015. Trends Ecol Evol. 2019. PMID: 31003616 Review.
Mutational input is the ultimate source of genetic variation, but mutations are not thought to affect the direction of adaptive evolution. ...We further emphasize that natural selection can shape the phenotypic effects of mutations, giving the false impressio …
Mutational input is the ultimate source of genetic variation, but mutations are not thought to affect the direction of adaptiv …
209,734 results
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