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Year Number of Results
1792 1
1795 1
1797 1
1798 1
1799 7
1800 7
1801 2
1802 3
1803 2
1805 1
1806 2
1809 1
1814 3
1816 1
1818 1
1821 1
1822 1
1824 1
1829 1
1830 2
1834 1
1835 1
1837 3
1838 2
1839 3
1840 1
1842 1
1843 1
1845 1
1846 1
1847 4
1848 5
1849 4
1850 5
1851 4
1852 1
1853 2
1854 1
1855 5
1856 2
1857 2
1859 4
1862 1
1863 2
1865 2
1866 1
1868 2
1869 2
1870 2
1871 2
1874 1
1877 4
1879 1
1880 1
1881 12
1882 6
1883 6
1884 2
1885 4
1886 1
1887 7
1888 3
1889 8
1890 2
1891 13
1892 7
1893 7
1894 6
1895 5
1896 8
1897 4
1898 2
1899 1
1900 2
1901 1
1902 5
1903 4
1904 4
1905 4
1906 6
1907 1
1908 4
1910 1
1911 2
1912 4
1913 5
1914 2
1915 4
1916 4
1917 2
1918 1
1919 1
1920 4
1921 3
1922 4
1923 4
1924 6
1925 5
1926 5
1927 4
1928 6
1929 3
1930 5
1931 5
1932 12
1933 4
1934 4
1935 7
1936 3
1937 4
1938 5
1939 3
1940 3
1941 1
1942 4
1943 5
1944 2
1945 25
1946 50
1947 26
1948 33
1949 19
1950 56
1951 54
1952 57
1953 62
1954 46
1955 55
1956 49
1957 48
1958 36
1959 44
1960 53
1961 52
1962 48
1963 54
1964 80
1965 67
1966 59
1967 73
1968 90
1969 83
1970 80
1971 78
1972 101
1973 70
1974 86
1975 268
1976 287
1977 266
1978 281
1979 321
1980 305
1981 321
1982 354
1983 443
1984 433
1985 485
1986 509
1987 527
1988 536
1989 781
1990 800
1991 891
1992 982
1993 1167
1994 1320
1995 1537
1996 1599
1997 1875
1998 2241
1999 2738
2000 3243
2001 3659
2002 4177
2003 4739
2004 5544
2005 6392
2006 7197
2007 8120
2008 9108
2009 10737
2010 12308
2011 13912
2012 15165
2013 16630
2014 18712
2015 20939
2016 23153
2017 24222
2018 25796
2019 27981
2020 31858
2021 35482
2022 34801
2023 34424
2024 38177
2025 14910

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429,173 results

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Page 1
In silico methods and tools for drug discovery.
Shaker B, Ahmad S, Lee J, Jung C, Na D. Shaker B, et al. Comput Biol Med. 2021 Oct;137:104851. doi: 10.1016/j.compbiomed.2021.104851. Epub 2021 Sep 8. Comput Biol Med. 2021. PMID: 34520990 Review.
In this review, we briefly introduce computational drug discovery strategies and outline up-to-date tools to perform the strategies as well as available knowledge bases for those who develop their own computational models. Finally, we introduce successful examples of anti- …
In this review, we briefly introduce computational drug discovery strategies and outline up-to-date tools to perform the strategies a …
Transforming Academic Drug Discovery.
Meinke PT. Meinke PT. Chembiochem. 2022 Apr 20;23(8):e202100671. doi: 10.1002/cbic.202100671. Epub 2022 Feb 18. Chembiochem. 2022. PMID: 35181980 Review.
A drug accelerator that partners the creative power of academic scientists with drug discovery professionals to consistently advance groundbreaking biological discoveries would be transformational. One such model, the Tri-Institutional Therapeutics Discovery …
A drug accelerator that partners the creative power of academic scientists with drug discovery professionals to consistently advance …
Discovery in clinical and translational medicine.
Wang DC, Wang X. Wang DC, et al. Clin Transl Med. 2021 Oct;11(10):e568. doi: 10.1002/ctm2.568. Clin Transl Med. 2021. PMID: 34709762 Free PMC article.
The first priority of Clinical and Translational Discovery is to turn gene-, protein-, drug-, cell-, and interaction-based discoveries into health advancements. Clinical and Translational Discovery highly focuses on the discoveries of biological therap …
The first priority of Clinical and Translational Discovery is to turn gene-, protein-, drug-, cell-, and interaction-based discove …
Target discovery using biobanks and human genetics.
Hicks MA, Hou CYC, Iranmehr A, Marosi K, Kirkness E. Hicks MA, et al. Drug Discov Today. 2020 Feb;25(2):438-445. doi: 10.1016/j.drudis.2019.09.014. Epub 2019 Sep 25. Drug Discov Today. 2020. PMID: 31562982 Review.
Large-scale biobanks can yield unprecedented insights into our health and provide discoveries of new and potentially targetable biomarkers. Several protective loss-of-function alleles have been identified, including variants that protect against cardiovascular disease, obe …
Large-scale biobanks can yield unprecedented insights into our health and provide discoveries of new and potentially targetable bioma …
Autonomous Discovery in the Chemical Sciences Part II: Outlook.
Coley CW, Eyke NS, Jensen KF. Coley CW, et al. Angew Chem Int Ed Engl. 2020 Dec 21;59(52):23414-23436. doi: 10.1002/anie.201909989. Epub 2020 Jun 11. Angew Chem Int Ed Engl. 2020. PMID: 31553509 Review.
This two-part Review examines how automation has contributed to different aspects of discovery in the chemical sciences. In this second part, we reflect on a selection of exemplary studies. ...We must carefully consider how they have been and can be applied to future probl …
This two-part Review examines how automation has contributed to different aspects of discovery in the chemical sciences. In this seco …
Autonomous Discovery in the Chemical Sciences Part I: Progress.
Coley CW, Eyke NS, Jensen KF. Coley CW, et al. Angew Chem Int Ed Engl. 2020 Dec 14;59(51):22858-22893. doi: 10.1002/anie.201909987. Epub 2020 Jun 8. Angew Chem Int Ed Engl. 2020. PMID: 31553511 Review.
This two-part Review examines how automation has contributed to different aspects of discovery in the chemical sciences. In this first part, we describe a classification for discoveries of physical matter (molecules, materials, devices), processes, and models and ho …
This two-part Review examines how automation has contributed to different aspects of discovery in the chemical sciences. In this firs …
Stroke genetics: discovery, biology, and clinical applications.
Dichgans M, Pulit SL, Rosand J. Dichgans M, et al. Lancet Neurol. 2019 Jun;18(6):587-599. doi: 10.1016/S1474-4422(19)30043-2. Epub 2019 Apr 8. Lancet Neurol. 2019. PMID: 30975520 Review.
Stroke, a leading cause of long-term disability and death worldwide, has a heritable component. Recent gene discovery efforts have expanded the number of known single-gene disorders associated with stroke and have linked common variants at approximately 35 genetic loci to …
Stroke, a leading cause of long-term disability and death worldwide, has a heritable component. Recent gene discovery efforts have ex …
The Discovery of Insulin: An Important Milestone in the History of Medicine.
Vecchio I, Tornali C, Bragazzi NL, Martini M. Vecchio I, et al. Front Endocrinol (Lausanne). 2018 Oct 23;9:613. doi: 10.3389/fendo.2018.00613. eCollection 2018. Front Endocrinol (Lausanne). 2018. PMID: 30405529 Free PMC article. Review.
The discovery of insulin represents an authentic breakthrough, characterized, at the same time, by contrasts, controversies and disputes among scholars, as well as by great disappointments, failures and hopes. It is the story of famous, almost famous and little known peopl …
The discovery of insulin represents an authentic breakthrough, characterized, at the same time, by contrasts, controversies and dispu …
Of Flies and Men-The Discovery of TLRs.
Weiss HJ, O'Neill LAJ. Weiss HJ, et al. Cells. 2022 Oct 5;11(19):3127. doi: 10.3390/cells11193127. Cells. 2022. PMID: 36231089 Free PMC article. Review.
Today, Beutler and Hoffmann's research has not only resulted in the discovery of the role of multiple TLRs in innate immunity but also in a much broader understanding of the molecular components of the innate immune system. ...We will also discuss how these discoveries …
Today, Beutler and Hoffmann's research has not only resulted in the discovery of the role of multiple TLRs in innate immunity but als …
A Drosophila Based Cancer Drug Discovery Framework.
Bangi E. Bangi E. Adv Exp Med Biol. 2019;1167:237-248. doi: 10.1007/978-3-030-23629-8_14. Adv Exp Med Biol. 2019. PMID: 31520359 Review.
In recent years, there has been growing interest in using Drosophila for drug discovery as it provides a unique opportunity to screen small molecules against complex disease phenotypes in a whole animal setting. ...Here, I discuss how compound screening and testing approac …
In recent years, there has been growing interest in using Drosophila for drug discovery as it provides a unique opportunity to screen …
429,173 results
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