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1992 1
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2001 2
2002 4
2003 8
2004 3
2005 3
2006 5
2007 1
2008 4
2009 5
2010 7
2011 7
2012 5
2013 3
2014 7
2015 15
2016 8
2017 2
2018 5
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2020 5
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Page 1
Evaluation of N4-hydroxycytidine incorporation into nucleic acids of SARS-CoV-2-infected host cells by direct measurement with liquid chromatography-mass spectrometry.
Urbanowicz K, Opielka M, Stegmann KM, Dickmanns A, Dobbelstein M, Peters GJ, Smoleński RT. Urbanowicz K, et al. Among authors: dobbelstein m. Nucleosides Nucleotides Nucleic Acids. 2024 May 13:1-9. doi: 10.1080/15257770.2024.2346550. Online ahead of print. Nucleosides Nucleotides Nucleic Acids. 2024. PMID: 38741480
Multiple redox switches of the SARS-CoV-2 main protease in vitro provide opportunities for drug design.
Funk LM, Poschmann G, Rabe von Pappenheim F, Chari A, Stegmann KM, Dickmanns A, Wensien M, Eulig N, Paknia E, Heyne G, Penka E, Pearson AR, Berndt C, Fritz T, Bazzi S, Uranga J, Mata RA, Dobbelstein M, Hilgenfeld R, Curth U, Tittmann K. Funk LM, et al. Among authors: dobbelstein m. Nat Commun. 2024 Jan 9;15(1):411. doi: 10.1038/s41467-023-44621-0. Nat Commun. 2024. PMID: 38195625 Free PMC article.
Nanobodies to multiple spike variants and inhalation of nanobody-containing aerosols neutralize SARS-CoV-2 in cell culture and hamsters.
Aksu M, Kumar P, Güttler T, Taxer W, Gregor K, Mußil B, Rymarenko O, Stegmann KM, Dickmanns A, Gerber S, Reineking W, Schulz C, Henneck T, Mohamed A, Pohlmann G, Ramazanoglu M, Mese K, Groß U, Ben-Yedidia T, Ovadia O, Fischer DW, Kamensky M, Reichman A, Baumgärtner W, von Köckritz-Blickwede M, Dobbelstein M, Görlich D. Aksu M, et al. Among authors: dobbelstein m. Antiviral Res. 2024 Jan;221:105778. doi: 10.1016/j.antiviral.2023.105778. Epub 2023 Dec 7. Antiviral Res. 2024. PMID: 38065245 Free article.
N4-hydroxycytidine, the active compound of Molnupiravir, promotes SARS-CoV-2 mutagenesis and escape from a neutralizing nanobody.
Zibat A, Zhang X, Dickmanns A, Stegmann KM, Dobbelstein AW, Alachram H, Soliwoda R, Salinas G, Groß U, Görlich D, Kschischo M, Wollnik B, Dobbelstein M. Zibat A, et al. Among authors: dobbelstein m. iScience. 2023 Aug 30;26(10):107786. doi: 10.1016/j.isci.2023.107786. eCollection 2023 Oct 20. iScience. 2023. PMID: 37731621 Free PMC article.
The interplay of TARG1 and PARG protects against genomic instability.
Groslambert J, Prokhorova E, Wondisford AR, Tromans-Coia C, Giansanti C, Jansen J, Timinszky G, Dobbelstein M, Ahel D, O'Sullivan RJ, Ahel I. Groslambert J, et al. Among authors: dobbelstein m. Cell Rep. 2023 Sep 26;42(9):113113. doi: 10.1016/j.celrep.2023.113113. Epub 2023 Sep 6. Cell Rep. 2023. PMID: 37676774 Free PMC article.
MYC multimers shield stalled replication forks from RNA polymerase.
Solvie D, Baluapuri A, Uhl L, Fleischhauer D, Endres T, Papadopoulos D, Aziba A, Gaballa A, Mikicic I, Isaakova E, Giansanti C, Jansen J, Jungblut M, Klein T, Schülein-Völk C, Maric H, Doose S, Sauer M, Beli P, Rosenwald A, Dobbelstein M, Wolf E, Eilers M. Solvie D, et al. Among authors: dobbelstein m. Nature. 2022 Dec;612(7938):148-155. doi: 10.1038/s41586-022-05469-4. Epub 2022 Nov 23. Nature. 2022. PMID: 36424410
Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair.
Bolgi O, Silva-Garcia M, Ross B, Pilla E, Kari V, Killisch M, Spitzner M, Stark N, Lenz C, Weiss K, Donzelli L, Gorrell MD, Grade M, Riemer J, Urlaub H, Dobbelstein M, Huber R, Geiss-Friedlander R. Bolgi O, et al. Among authors: dobbelstein m. EMBO Rep. 2022 Oct 6;23(10):e54136. doi: 10.15252/embr.202154136. Epub 2022 Aug 1. EMBO Rep. 2022. PMID: 35912982 Free PMC article.
MDM2 binds and ubiquitinates PARP1 to enhance DNA replication fork progression.
Giansanti C, Manzini V, Dickmanns A, Dickmanns A, Palumbieri MD, Sanchi A, Kienle SM, Rieth S, Scheffner M, Lopes M, Dobbelstein M. Giansanti C, et al. Among authors: dobbelstein m. Cell Rep. 2022 May 31;39(9):110879. doi: 10.1016/j.celrep.2022.110879. Cell Rep. 2022. PMID: 35649362 Free article.
Inhibitors of dihydroorotate dehydrogenase cooperate with molnupiravir and N4-hydroxycytidine to suppress SARS-CoV-2 replication.
Stegmann KM, Dickmanns A, Heinen N, Blaurock C, Karrasch T, Breithaupt A, Klopfleisch R, Uhlig N, Eberlein V, Issmail L, Herrmann ST, Schreieck A, Peelen E, Kohlhof H, Sadeghi B, Riek A, Speakman JR, Groß U, Görlich D, Vitt D, Müller T, Grunwald T, Pfaender S, Balkema-Buschmann A, Dobbelstein M. Stegmann KM, et al. Among authors: dobbelstein m. iScience. 2022 May 20;25(5):104293. doi: 10.1016/j.isci.2022.104293. Epub 2022 Apr 25. iScience. 2022. PMID: 35492218 Free PMC article.
Therapeutische Nanobodies gegen SARS-CoV-2.
Güttler T, Dobbelstein M, Görlich D. Güttler T, et al. Among authors: dobbelstein m. Biospektrum (Heidelb). 2022;28(1):39-42. doi: 10.1007/s12268-022-1684-y. Epub 2022 Feb 13. Biospektrum (Heidelb). 2022. PMID: 35194331 Free PMC article. Review. German.
MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts.
Papadopoulos D, Solvie D, Baluapuri A, Endres T, Ha SA, Herold S, Kalb J, Giansanti C, Schülein-Völk C, Ade CP, Schneider C, Gaballa A, Vos S, Fischer U, Dobbelstein M, Wolf E, Eilers M. Papadopoulos D, et al. Among authors: dobbelstein m. Mol Cell. 2022 Jan 6;82(1):159-176.e12. doi: 10.1016/j.molcel.2021.11.002. Epub 2021 Nov 29. Mol Cell. 2022. PMID: 34847357 Free article.
Neutralization of SARS-CoV-2 by highly potent, hyperthermostable, and mutation-tolerant nanobodies.
Güttler T, Aksu M, Dickmanns A, Stegmann KM, Gregor K, Rees R, Taxer W, Rymarenko O, Schünemann J, Dienemann C, Gunkel P, Mussil B, Krull J, Teichmann U, Groß U, Cordes VC, Dobbelstein M, Görlich D. Güttler T, et al. Among authors: dobbelstein m. EMBO J. 2021 Oct 1;40(19):e107985. doi: 10.15252/embj.2021107985. Epub 2021 Aug 9. EMBO J. 2021. PMID: 34302370 Free PMC article.
The folate antagonist methotrexate diminishes replication of the coronavirus SARS-CoV-2 and enhances the antiviral efficacy of remdesivir in cell culture models.
Stegmann KM, Dickmanns A, Gerber S, Nikolova V, Klemke L, Manzini V, Schlösser D, Bierwirth C, Freund J, Sitte M, Lugert R, Salinas G, Meister TL, Pfaender S, Görlich D, Wollnik B, Groß U, Dobbelstein M. Stegmann KM, et al. Among authors: dobbelstein m. Virus Res. 2021 Sep;302:198469. doi: 10.1016/j.virusres.2021.198469. Epub 2021 Jun 6. Virus Res. 2021. PMID: 34090962 Free PMC article.
Combined inhibition of Aurora-A and ATR kinase results in regression of MYCN-amplified neuroblastoma.
Roeschert I, Poon E, Henssen AG, Garcia HD, Gatti M, Giansanti C, Jamin Y, Ade CP, Gallant P, Schülein-Völk C, Beli P, Richards M, Rosenfeldt M, Altmeyer M, Anderson J, Eggert A, Dobbelstein M, Bayliss R, Chesler L, Büchel G, Eilers M. Roeschert I, et al. Among authors: dobbelstein m. Nat Cancer. 2021 Mar;2(3):312-326. doi: 10.1038/s43018-020-00171-8. Epub 2021 Feb 11. Nat Cancer. 2021. PMID: 33768209 Free PMC article.
The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis.
Müller A, Dickmanns A, Resch C, Schäkel K, Hailfinger S, Dobbelstein M, Schulze-Osthoff K, Kramer D. Müller A, et al. Among authors: dobbelstein m. J Clin Invest. 2020 Nov 2;130(11):5765-5781. doi: 10.1172/JCI134217. J Clin Invest. 2020. PMID: 32701505 Free PMC article.
Mdm4 supports DNA replication in a p53-independent fashion.
Wohlberedt K, Klusmann I, Derevyanko PK, Henningsen K, Choo JAMY, Manzini V, Magerhans A, Giansanti C, Eischen CM, Jochemsen AG, Dobbelstein M. Wohlberedt K, et al. Among authors: dobbelstein m. Oncogene. 2020 Jun;39(25):4828-4843. doi: 10.1038/s41388-020-1325-1. Epub 2020 May 19. Oncogene. 2020. PMID: 32427989 Free PMC article.
Mdm2: Open questions.
Dobbelstein M, Levine AJ. Dobbelstein M, et al. Cancer Sci. 2020 Jul;111(7):2203-2211. doi: 10.1111/cas.14433. Epub 2020 Jun 11. Cancer Sci. 2020. PMID: 32335977 Free PMC article. Review.
Recruitment of BRCA1 limits MYCN-driven accumulation of stalled RNA polymerase.
Herold S, Kalb J, Büchel G, Ade CP, Baluapuri A, Xu J, Koster J, Solvie D, Carstensen A, Klotz C, Rodewald S, Schülein-Völk C, Dobbelstein M, Wolf E, Molenaar J, Versteeg R, Walz S, Eilers M. Herold S, et al. Among authors: dobbelstein m. Nature. 2019 Mar;567(7749):545-549. doi: 10.1038/s41586-019-1030-9. Epub 2019 Mar 20. Nature. 2019. PMID: 30894746 Free PMC article.
Chromatin modifiers Mdm2 and RNF2 prevent RNA:DNA hybrids that impair DNA replication.
Klusmann I, Wohlberedt K, Magerhans A, Teloni F, Korbel JO, Altmeyer M, Dobbelstein M. Klusmann I, et al. Among authors: dobbelstein m. Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):E11311-E11320. doi: 10.1073/pnas.1809592115. Epub 2018 Nov 9. Proc Natl Acad Sci U S A. 2018. PMID: 30413623 Free PMC article.
CDK4 inhibition diminishes p53 activation by MDM2 antagonists.
Sriraman A, Dickmanns A, Najafova Z, Johnsen SA, Dobbelstein M. Sriraman A, et al. Among authors: dobbelstein m. Cell Death Dis. 2018 Sep 11;9(9):918. doi: 10.1038/s41419-018-0968-0. Cell Death Dis. 2018. PMID: 30206211 Free PMC article.
Mdm2 as a chromatin modifier.
Wienken M, Moll UM, Dobbelstein M. Wienken M, et al. Among authors: dobbelstein m. J Mol Cell Biol. 2017 Feb 1;9(1):74-80. doi: 10.1093/jmcb/mjw046. J Mol Cell Biol. 2017. PMID: 27927750 Free PMC article. Review.
p53 Activity Results in DNA Replication Fork Processivity.
Klusmann I, Rodewald S, Müller L, Friedrich M, Wienken M, Li Y, Schulz-Heddergott R, Dobbelstein M. Klusmann I, et al. Among authors: dobbelstein m. Cell Rep. 2016 Nov 8;17(7):1845-1857. doi: 10.1016/j.celrep.2016.10.036. Cell Rep. 2016. PMID: 27829155 Free article.
Fortifying p53 - beyond Mdm2 inhibitors.
Sriraman A, Li Y, Dobbelstein M. Sriraman A, et al. Among authors: dobbelstein m. Aging (Albany NY). 2016 Sep 29;8(9):1836-1837. doi: 10.18632/aging.101073. Aging (Albany NY). 2016. PMID: 27688014 Free PMC article. No abstract available.
Cooperation of Nutlin-3a and a Wip1 inhibitor to induce p53 activity.
Sriraman A, Radovanovic M, Wienken M, Najafova Z, Li Y, Dobbelstein M. Sriraman A, et al. Among authors: dobbelstein m. Oncotarget. 2016 May 31;7(22):31623-38. doi: 10.18632/oncotarget.9302. Oncotarget. 2016. PMID: 27183917 Free PMC article.
MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53.
Wienken M, Dickmanns A, Nemajerova A, Kramer D, Najafova Z, Weiss M, Karpiuk O, Kassem M, Zhang Y, Lozano G, Johnsen SA, Moll UM, Zhang X, Dobbelstein M. Wienken M, et al. Among authors: dobbelstein m. Mol Cell. 2016 Jan 7;61(1):68-83. doi: 10.1016/j.molcel.2015.12.008. Epub 2015 Dec 31. Mol Cell. 2016. PMID: 26748827 Free PMC article.
Usp22 deficiency impairs intestinal epithelial lineage specification in vivo.
Kosinsky RL, Wegwitz F, Hellbach N, Dobbelstein M, Mansouri A, Vogel T, Begus-Nahrmann Y, Johnsen SA. Kosinsky RL, et al. Among authors: dobbelstein m. Oncotarget. 2015 Nov 10;6(35):37906-18. doi: 10.18632/oncotarget.5412. Oncotarget. 2015. PMID: 26431380 Free PMC article.
G2E3 attenuating replicative stress.
Schmidt F, Karnitz LM, Dobbelstein M. Schmidt F, et al. Among authors: dobbelstein m. Aging (Albany NY). 2015 Aug;7(8):527-8. doi: 10.18632/aging.100784. Aging (Albany NY). 2015. PMID: 26298869 Free PMC article. No abstract available.
MicroRNA-101 Suppresses Tumor Cell Proliferation by Acting as an Endogenous Proteasome Inhibitor via Targeting the Proteasome Assembly Factor POMP.
Zhang X, Schulz R, Edmunds S, Krüger E, Markert E, Gaedcke J, Cormet-Boyaka E, Ghadimi M, Beissbarth T, Levine AJ, Moll UM, Dobbelstein M. Zhang X, et al. Among authors: dobbelstein m. Mol Cell. 2015 Jul 16;59(2):243-57. doi: 10.1016/j.molcel.2015.05.036. Epub 2015 Jul 2. Mol Cell. 2015. PMID: 26145175 Free article.
Exploiting replicative stress to treat cancer.
Dobbelstein M, Sørensen CS. Dobbelstein M, et al. Nat Rev Drug Discov. 2015 Jun;14(6):405-23. doi: 10.1038/nrd4553. Epub 2015 May 8. Nat Rev Drug Discov. 2015. PMID: 25953507 Review.
Overcoming EMT-driven therapeutic resistance by BH3 mimetics.
Keitel U, Scheel C, Dobbelstein M. Keitel U, et al. Among authors: dobbelstein m. Oncoscience. 2014 Nov 5;1(11):706-8. doi: 10.18632/oncoscience.93. eCollection 2014. Oncoscience. 2014. PMID: 25593997 Free PMC article.
TAp73 is essential for germ cell adhesion and maturation in testis.
Holembowski L, Kramer D, Riedel D, Sordella R, Nemajerova A, Dobbelstein M, Moll UM. Holembowski L, et al. Among authors: dobbelstein m. J Cell Biol. 2014 Mar 31;204(7):1173-90. doi: 10.1083/jcb.201306066. Epub 2014 Mar 24. J Cell Biol. 2014. PMID: 24662569 Free PMC article.
Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity.
Köpper F, Bierwirth C, Schön M, Kunze M, Elvers I, Kranz D, Saini P, Menon MB, Walter D, Sørensen CS, Gaestel M, Helleday T, Schön MP, Dobbelstein M. Köpper F, et al. Among authors: dobbelstein m. Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):16856-61. doi: 10.1073/pnas.1304355110. Epub 2013 Sep 30. Proc Natl Acad Sci U S A. 2013. PMID: 24082115 Free PMC article.
Identification of a microRNA expression signature for chemoradiosensitivity of colorectal cancer cells, involving miRNAs-320a, -224, -132 and let7g.
Salendo J, Spitzner M, Kramer F, Zhang X, Jo P, Wolff HA, Kitz J, Kaulfuß S, Beißbarth T, Dobbelstein M, Ghadimi M, Grade M, Gaedcke J. Salendo J, et al. Among authors: dobbelstein m. Radiother Oncol. 2013 Sep;108(3):451-7. doi: 10.1016/j.radonc.2013.06.032. Epub 2013 Aug 7. Radiother Oncol. 2013. PMID: 23932154
MicroRNA-449 in cell fate determination.
Lizé M, Klimke A, Dobbelstein M. Lizé M, et al. Among authors: dobbelstein m. Cell Cycle. 2011 Sep 1;10(17):2874-82. doi: 10.4161/cc.10.17.17181. Epub 2011 Sep 1. Cell Cycle. 2011. PMID: 21857159 Review.
Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart.
Knöll R, Linke WA, Zou P, Miocic S, Kostin S, Buyandelger B, Ku CH, Neef S, Bug M, Schäfer K, Knöll G, Felkin LE, Wessels J, Toischer K, Hagn F, Kessler H, Didié M, Quentin T, Maier LS, Teucher N, Unsöld B, Schmidt A, Birks EJ, Gunkel S, Lang P, Granzier H, Zimmermann WH, Field LJ, Faulkner G, Dobbelstein M, Barton PJ, Sattler M, Wilmanns M, Chien KR. Knöll R, et al. Among authors: dobbelstein m. Circ Res. 2011 Sep 16;109(7):758-69. doi: 10.1161/CIRCRESAHA.111.245787. Epub 2011 Jul 28. Circ Res. 2011. PMID: 21799151 Free PMC article.
Brdm2 - an aberrant hypomorphic p63 allele.
Talos F, Wolff S, Beyer U, Dobbelstein M, Moll UM. Talos F, et al. Among authors: dobbelstein m. Cell Death Differ. 2010 Jan;17(1):184-186. doi: 10.1038/cdd.2009.158. Cell Death Differ. 2010. PMID: 20161489 Free PMC article. No abstract available.
p63 antagonizes Wnt-induced transcription.
Drewelus I, Göpfert C, Hippel C, Dickmanns A, Damianitsch K, Pieler T, Dobbelstein M. Drewelus I, et al. Among authors: dobbelstein m. Cell Cycle. 2010 Feb 1;9(3):580-87. doi: 10.4161/cc.9.3.10593. Cell Cycle. 2010. PMID: 20107313
Specific inhibition of Mdm2-mediated neddylation by Tip60.
Dohmesen C, Koeppel M, Dobbelstein M. Dohmesen C, et al. Among authors: dobbelstein m. Cell Cycle. 2008 Jan 15;7(2):222-31. doi: 10.4161/cc.7.2.5185. Epub 2007 Oct 16. Cell Cycle. 2008. PMID: 18264029
p73 and p63: why do we still need them?
Blandino G, Dobbelstein M. Blandino G, et al. Among authors: dobbelstein m. Cell Cycle. 2004 Jul;3(7):886-94. Epub 2004 Jul 2. Cell Cycle. 2004. PMID: 15254416 Review.
Replicating adenoviruses in cancer therapy.
Dobbelstein M. Dobbelstein M. Curr Top Microbiol Immunol. 2004;273:291-334. doi: 10.1007/978-3-662-05599-1_9. Curr Top Microbiol Immunol. 2004. PMID: 14674605 Review.
Differential regulation of p63 and p73 expression.
Waltermann A, Kartasheva NN, Dobbelstein M. Waltermann A, et al. Among authors: dobbelstein m. Oncogene. 2003 Aug 28;22(36):5686-93. doi: 10.1038/sj.onc.1206859. Oncogene. 2003. PMID: 12944917
p21/CDKN1A mediates negative regulation of transcription by p53.
Löhr K, Möritz C, Contente A, Dobbelstein M. Löhr K, et al. Among authors: dobbelstein m. J Biol Chem. 2003 Aug 29;278(35):32507-16. doi: 10.1074/jbc.M212517200. Epub 2003 May 13. J Biol Chem. 2003. PMID: 12748190 Free article.
Viruses in therapy--royal road or dead end?
Dobbelstein M. Dobbelstein M. Virus Res. 2003 Apr;92(2):219-21. doi: 10.1016/s0168-1702(02)00355-6. Virus Res. 2003. PMID: 12686433 Review.
YB-1 relocates to the nucleus in adenovirus-infected cells and facilitates viral replication by inducing E2 gene expression through the E2 late promoter.
Holm PS, Bergmann S, Jurchott K, Lage H, Brand K, Ladhoff A, Mantwill K, Curiel DT, Dobbelstein M, Dietel M, Gansbacher B, Royer HD. Holm PS, et al. Among authors: dobbelstein m. J Biol Chem. 2002 Mar 22;277(12):10427-34. doi: 10.1074/jbc.M106955200. Epub 2002 Jan 11. J Biol Chem. 2002. PMID: 11788582 Free article.