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Page 1
Complement MASP-1 Modifies Endothelial Wound Healing.
Németh Z, Demeter F, Dobó J, Gál P, Cervenak L. Németh Z, et al. Among authors: dobo j. Int J Mol Sci. 2024 Apr 5;25(7):4048. doi: 10.3390/ijms25074048. Int J Mol Sci. 2024. PMID: 38612857 Free PMC article.
Correction: Synergy of protease-binding sites within the ecotin homodimer is crucial for inhibition of MASP enzymes and for blocking lectin pathway activation.
Nagy ZA, Héja D, Bencze D, Kiss B, Boros E, Szakács D, Fodor K, Wilmanns M, Kocsis A, Dobó J, Gál P, Harmat V, Pál G. Nagy ZA, et al. Among authors: dobo j. J Biol Chem. 2023 Jan;299(1):102807. doi: 10.1016/j.jbc.2022.102807. Epub 2022 Dec 21. J Biol Chem. 2023. PMID: 36563463 Free PMC article. No abstract available.
Proprotein Convertases and the Complement System.
Dobó J, Kocsis A, Dani R, Gál P. Dobó J, et al. Front Immunol. 2022 Jul 6;13:958121. doi: 10.3389/fimmu.2022.958121. eCollection 2022. Front Immunol. 2022. PMID: 35874789 Free PMC article. Review.
Directed Evolution-Driven Increase of Structural Plasticity Is a Prerequisite for Binding the Complement Lectin Pathway Blocking MASP-Inhibitor Peptides.
Dürvanger Z, Boros E, Nagy ZA, Hegedüs R, Megyeri M, Dobó J, Gál P, Schlosser G, Ángyán AF, Gáspári Z, Perczel A, Harmat V, Mező G, Menyhárd DK, Pál G. Dürvanger Z, et al. Among authors: dobo j. ACS Chem Biol. 2022 Apr 15;17(4):969-986. doi: 10.1021/acschembio.2c00114. Epub 2022 Apr 4. ACS Chem Biol. 2022. PMID: 35378038 Free PMC article.
Fasciola hepatica is refractory to complement killing by preventing attachment of mannose binding lectin (MBL) and inhibiting MBL-associated serine proteases (MASPs) with serpins.
De Marco Verissimo C, Jewhurst HL, Dobó J, Gál P, Dalton JP, Cwiklinski K. De Marco Verissimo C, et al. Among authors: dobo j. PLoS Pathog. 2022 Jan 10;18(1):e1010226. doi: 10.1371/journal.ppat.1010226. eCollection 2022 Jan. PLoS Pathog. 2022. PMID: 35007288 Free PMC article.
ITIH4 acts as a protease inhibitor by a novel inhibitory mechanism.
Pihl R, Jensen RK, Poulsen EC, Jensen L, Hansen AG, Thøgersen IB, Dobó J, Gál P, Andersen GR, Enghild JJ, Thiel S. Pihl R, et al. Among authors: dobo j. Sci Adv. 2021 Jan 8;7(2):eaba7381. doi: 10.1126/sciadv.aba7381. Print 2021 Jan. Sci Adv. 2021. PMID: 33523981 Free PMC article.
Patterns of C1-Inhibitor/Plasma Serine Protease Complexes in Healthy Humans and in Hereditary Angioedema Patients.
Kajdácsi E, Jandrasics Z, Veszeli N, Makó V, Koncz A, Gulyás D, Köhalmi KV, Temesszentandrási G, Cervenak L, Gál P, Dobó J, de Maat S, Maas C, Farkas H, Varga L. Kajdácsi E, et al. Among authors: dobo j. Front Immunol. 2020 May 5;11:794. doi: 10.3389/fimmu.2020.00794. eCollection 2020. Front Immunol. 2020. PMID: 32431708 Free PMC article.
Key Components of the Complement Lectin Pathway Are Not Only Required for the Development of Inflammatory Arthritis but Also Regulate the Transcription of Factor D.
Holers VM, Borodovsky A, Scheinman RI, Ho N, Ramirez JR, Dobó J, Gál P, Lindenberger J, Hansen AG, Desai D, Pihl R, Thiel S, Banda NK. Holers VM, et al. Among authors: dobo j. Front Immunol. 2020 Feb 21;11:201. doi: 10.3389/fimmu.2020.00201. eCollection 2020. Front Immunol. 2020. PMID: 32153567 Free PMC article.
MASP-1 Increases Endothelial Permeability.
Debreczeni ML, Németh Z, Kajdácsi E, Schwaner E, Makó V, Masszi A, Doleschall Z, Rigó J, Walter FR, Deli MA, Pál G, Dobó J, Gál P, Cervenak L. Debreczeni ML, et al. Among authors: dobo j. Front Immunol. 2019 May 3;10:991. doi: 10.3389/fimmu.2019.00991. eCollection 2019. Front Immunol. 2019. PMID: 31130964 Free PMC article.
Structural plasticity of the Salmonella FliS flagellar export chaperone.
Sajó R, Tőke O, Hajdú I, Jankovics H, Micsonai A, Dobó J, Kardos J, Vonderviszt F. Sajó R, et al. Among authors: dobo j. FEBS Lett. 2016 Apr;590(8):1103-13. doi: 10.1002/1873-3468.12149. Epub 2016 Mar 31. FEBS Lett. 2016. PMID: 27003324 Free article.
MASP-1 and MASP-2 Do Not Activate Pro-Factor D in Resting Human Blood, whereas MASP-3 Is a Potential Activator: Kinetic Analysis Involving Specific MASP-1 and MASP-2 Inhibitors.
Oroszlán G, Kortvely E, Szakács D, Kocsis A, Dammeier S, Zeck A, Ueffing M, Závodszky P, Pál G, Gál P, Dobó J. Oroszlán G, et al. Among authors: dobo j. J Immunol. 2016 Jan 15;196(2):857-65. doi: 10.4049/jimmunol.1501717. Epub 2015 Dec 16. J Immunol. 2016. PMID: 26673137 Free article.
Serum MASP-1 in complex with MBL activates endothelial cells.
Megyeri M, Jani PK, Kajdácsi E, Dobó J, Schwaner E, Major B, Rigó J Jr, Závodszky P, Thiel S, Cervenak L, Gál P. Megyeri M, et al. Among authors: dobo j. Mol Immunol. 2014 May;59(1):39-45. doi: 10.1016/j.molimm.2014.01.001. Epub 2014 Jan 26. Mol Immunol. 2014. PMID: 24472859 Free article.
C1 inhibitor: quantification and purification.
Varga L, Dobó J. Varga L, et al. Among authors: dobo j. Methods Mol Biol. 2014;1100:189-205. doi: 10.1007/978-1-62703-724-2_16. Methods Mol Biol. 2014. PMID: 24218261
Quantitative characterization of the activation steps of mannan-binding lectin (MBL)-associated serine proteases (MASPs) points to the central role of MASP-1 in the initiation of the complement lectin pathway.
Megyeri M, Harmat V, Major B, Végh Á, Balczer J, Héja D, Szilágyi K, Datz D, Pál G, Závodszky P, Gál P, Dobó J. Megyeri M, et al. Among authors: dobo j. J Biol Chem. 2013 Mar 29;288(13):8922-34. doi: 10.1074/jbc.M112.446500. Epub 2013 Feb 5. J Biol Chem. 2013. PMID: 23386610 Free PMC article.
Structural basis for activation of the complement system by component C4 cleavage.
Kidmose RT, Laursen NS, Dobó J, Kjaer TR, Sirotkina S, Yatime L, Sottrup-Jensen L, Thiel S, Gál P, Andersen GR. Kidmose RT, et al. Among authors: dobo j. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15425-30. doi: 10.1073/pnas.1208031109. Epub 2012 Sep 4. Proc Natl Acad Sci U S A. 2012. PMID: 22949645 Free PMC article.
Mannan-binding lectin (MBL)-associated serine protease-1 (MASP-1), a serine protease associated with humoral pattern-recognition molecules: normal and acute-phase levels in serum and stoichiometry of lectin pathway components.
Thiel S, Jensen L, Degn SE, Nielsen HJ, Gál P, Dobó J, Jensenius JC. Thiel S, et al. Among authors: dobo j. Clin Exp Immunol. 2012 Jul;169(1):38-48. doi: 10.1111/j.1365-2249.2012.04584.x. Clin Exp Immunol. 2012. PMID: 22670777 Free PMC article.
Monospecific inhibitors show that both mannan-binding lectin-associated serine protease-1 (MASP-1) and -2 Are essential for lectin pathway activation and reveal structural plasticity of MASP-2.
Héja D, Harmat V, Fodor K, Wilmanns M, Dobó J, Kékesi KA, Závodszky P, Gál P, Pál G. Héja D, et al. Among authors: dobo j. J Biol Chem. 2012 Jun 8;287(24):20290-300. doi: 10.1074/jbc.M112.354332. Epub 2012 Apr 16. J Biol Chem. 2012. PMID: 22511776 Free PMC article.
Selective inhibition of the lectin pathway of complement with phage display selected peptides against mannose-binding lectin-associated serine protease (MASP)-1 and -2: significant contribution of MASP-1 to lectin pathway activation.
Kocsis A, Kékesi KA, Szász R, Végh BM, Balczer J, Dobó J, Závodszky P, Gál P, Pál G. Kocsis A, et al. Among authors: dobo j. J Immunol. 2010 Oct 1;185(7):4169-78. doi: 10.4049/jimmunol.1001819. Epub 2010 Sep 3. J Immunol. 2010. PMID: 20817870 Free article.