Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2006 1
2007 1
2008 1
2009 3
2012 2
2013 1
2014 2
2015 1
2016 2
2018 1
2019 5
2020 7
2021 8
2022 2
2023 4
2024 4
2025 3
2026 3

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

44 results

Results by year

Filters applied: . Clear all
Page 1
QT interval prolongation and Torsades de Pointes with donepezil, rivastigmine and galantamine.
Malone K, Hancox JC. Malone K, et al. Ther Adv Drug Saf. 2020 Aug 17;11:2042098620942416. doi: 10.1177/2042098620942416. eCollection 2020. Ther Adv Drug Saf. 2020. PMID: 32874532 Free PMC article.
Case reports were analysed using causality scales and a QT interval nomogram. RESULTS: A total of 13 case reports were found (10 for donepezil, 2 for galantamine and 1 for rivastigmine) with rate corrected QT interval (QT(c)) prolongation. ...CONCLUSIO …
Case reports were analysed using causality scales and a QT interval nomogram. RESULTS: A total of 13 case reports were found (10 for …
Cardiovascular pharmacodynamics of donepezil hydrochloride on the PR and QT intervals in patients with dementia.
Igeta H, Suzuki Y, Tajiri M, Someya T. Igeta H, et al. Hum Psychopharmacol. 2014 May;29(3):292-4. doi: 10.1002/hup.2398. Epub 2014 Mar 11. Hum Psychopharmacol. 2014. PMID: 24615803
We implemented a study of the impact of donepezil hydrochloride administration on PR, RR, and QT intervals. METHODS: The subjects were 18 patients who were diagnosed with either dementia or cognitive disorder (DSM-IV-TR) and were hospitalized between January 2011 an …
We implemented a study of the impact of donepezil hydrochloride administration on PR, RR, and QT intervals. METHODS: The subje …
Correlation Between Donepezil and QTc Prolongation and Torsades de Pointes: A Very Rare Phenomenon.
Malik BH, Hamid P, Khan S, Gupta D, Islam M. Malik BH, et al. Cureus. 2019 Dec 23;11(12):e6451. doi: 10.7759/cureus.6451. Cureus. 2019. PMID: 32025385 Free PMC article. Review.
Patients demonstrated associated atrioventricular (AV) block or ventricular premature contractions (VPC) or atrial fibrillation (AF) prior to developing torsades de pointes (TdP). Presenting complaints were either syncope or diarrhoea or accidental bradycardia. Mostly, the …
Patients demonstrated associated atrioventricular (AV) block or ventricular premature contractions (VPC) or atrial fibrillation (AF) prior t …
Long term use of donepezil and QTc prolongation.
Kho J, Ioannou A, Mandal AKJ, Cox A, Nasim A, Metaxa S, Missouris CG. Kho J, et al. Clin Toxicol (Phila). 2021 Mar;59(3):208-214. doi: 10.1080/15563650.2020.1788054. Epub 2020 Jul 1. Clin Toxicol (Phila). 2021. PMID: 32609550
OBJECTIVE: To investigate whether long-term donepezil therapy is associated with electrocardiographic (ECG) changes and in particular to assess its effects on the QT interval. ...CONCLUSION: Our results clearly demonstrate that long-term use of donepezil is a …
OBJECTIVE: To investigate whether long-term donepezil therapy is associated with electrocardiographic (ECG) changes and in particular …
Proarrhythmic major adverse cardiac events with donepezil: A systematic review with meta-analysis.
Nham T, Garcia MC, Tsang KJ, Silva JM, Schneider T, Deng J, Lohit S, Mbuagbaw L, Holbrook A. Nham T, et al. J Am Geriatr Soc. 2024 Aug;72(8):2552-2565. doi: 10.1111/jgs.18909. Epub 2024 Apr 5. J Am Geriatr Soc. 2024. PMID: 38580328
Of the three ChEIs approved for dementia, donepezil is among the most prescribed drugs in the United States with nearly 6 million prescriptions in 2020; however, it is classified as a "known risk" QT interval-prolonging medication (QTPmed). ...Subgroup analysis sugg …
Of the three ChEIs approved for dementia, donepezil is among the most prescribed drugs in the United States with nearly 6 million pre …
Lumacaftor and fexofenadine prevent donepezil-induced LQTS via PHE656-mediated hERG chaperoning.
Li Y, Li X, Ren J, Hong H, Sun J, Ma L, Li B. Li Y, et al. Biochem Pharmacol. 2026 Mar;245:117681. doi: 10.1016/j.bcp.2026.117681. Epub 2026 Jan 5. Biochem Pharmacol. 2026. PMID: 41500472 Free article.
Donepezil (DPZ), a first-line therapeutic agent for Alzheimer's disease, causes acquired long QT syndrome (LQTS) by inhibiting the hERG potassium channel. ...Finally, the reversal effects of FEX and LUM on DPZ-induced QT interval and action potential duration …
Donepezil (DPZ), a first-line therapeutic agent for Alzheimer's disease, causes acquired long QT syndrome (LQTS) by inhibiting …
Drug-induced Inhibition and Trafficking Disruption of ion Channels: Pathogenesis of QT Abnormalities and Drug-induced Fatal Arrhythmias.
Cubeddu LX. Cubeddu LX. Curr Cardiol Rev. 2016;12(2):141-54. doi: 10.2174/1573403x12666160301120217. Curr Cardiol Rev. 2016. PMID: 26926294 Free PMC article. Review.
Risk of severe and fatal ventricular arrhythmias, presenting as Torsade de Pointes (TdP), is increased in congenital and acquired forms of long QT syndromes (LQTS). ...Although many drugs prolong the QT interval, TdP is a rare event. The following conditions …
Risk of severe and fatal ventricular arrhythmias, presenting as Torsade de Pointes (TdP), is increased in congenital and acquired for …
Cholinesterase inhibitors-associated torsade de pointes/QT prolongation: a real-world pharmacovigilance study.
Zhang N, Gan L, Xiang G, Xu J, Jiang T, Li Y, Wu Y, Ni R, Liu Y. Zhang N, et al. Front Pharmacol. 2024 Jan 11;14:1343650. doi: 10.3389/fphar.2023.1343650. eCollection 2023. Front Pharmacol. 2024. PMID: 38273821 Free PMC article.
Objective: Cholinesterase inhibitor (ChEIs) is the first-line drug for Alzheimer's disease (AD). Understanding torsade de pointes (TdP)/QT prolongation with different ChEIs is essential for its safe and rational administration. ...The patients were mostly elderly pe …
Objective: Cholinesterase inhibitor (ChEIs) is the first-line drug for Alzheimer's disease (AD). Understanding torsade de pointes (Td …
Cardiovascular effects of drugs used to treat Alzheimer's disease.
Howes LG. Howes LG. Drug Saf. 2014 Jun;37(6):391-5. doi: 10.1007/s40264-014-0161-z. Drug Saf. 2014. PMID: 24777654 Review.
Drugs that are used to treat Alzheimer's disease include the acetyl cholinesterase inhibitors (ACHIs) donepezil, rivastigmine and galantamine and the NMDA receptor antagonist memantine. Adverse cardiovascular events with these drugs are very uncommon. ...There are also a f …
Drugs that are used to treat Alzheimer's disease include the acetyl cholinesterase inhibitors (ACHIs) donepezil, rivastigmine and gal …
44 results