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1967 1
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1974 1
1975 8
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1978 6
1979 9
1980 8
1981 2
1982 9
1983 5
1984 8
1985 11
1986 12
1987 6
1988 6
1989 4
1990 11
1991 7
1992 10
1993 10
1994 10
1995 14
1996 14
1997 6
1998 9
1999 12
2000 13
2001 13
2002 17
2003 9
2004 21
2005 14
2006 30
2007 25
2008 23
2009 23
2010 30
2011 37
2012 30
2013 27
2014 20
2015 26
2016 19
2017 21
2018 24
2019 20
2020 10
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2022 23
2023 17
2024 6

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Depression: the case for a monoamine deficiency.
Delgado PL. Delgado PL. J Clin Psychiatry. 2000;61 Suppl 6:7-11. J Clin Psychiatry. 2000. PMID: 10775018 Review.
The monoamine hypothesis of depression predicts that the underlying pathophysiologic basis of depression is a depletion in the levels of serotonin, norepinephrine, and/or dopamine in the central nervous system. ...In contrast, monoamine depletion does …
The monoamine hypothesis of depression predicts that the underlying pathophysiologic basis of depression is a depletion …
The receptor hypothesis and the pathogenesis of depression: Genetic bases and biological correlates.
Wang HQ, Wang ZZ, Chen NH. Wang HQ, et al. Pharmacol Res. 2021 May;167:105542. doi: 10.1016/j.phrs.2021.105542. Epub 2021 Mar 10. Pharmacol Res. 2021. PMID: 33711432 Review.
Receptor theory has been pointed out to explain the pathogenesis of depression, while it is still subject to debate. Additionally, gene abnormality accounts for nearly 40-50% of depression risk, which is a significant factor contributing to the onset of depressio
Receptor theory has been pointed out to explain the pathogenesis of depression, while it is still subject to debate. Additionally, ge …
Dopamine neurons modulate neural encoding and expression of depression-related behaviour.
Tye KM, Mirzabekov JJ, Warden MR, Ferenczi EA, Tsai HC, Finkelstein J, Kim SY, Adhikari A, Thompson KR, Andalman AS, Gunaydin LA, Witten IB, Deisseroth K. Tye KM, et al. Nature. 2013 Jan 24;493(7433):537-541. doi: 10.1038/nature11740. Epub 2012 Dec 12. Nature. 2013. PMID: 23235822 Free PMC article.
Until now it has not been possible to test this hypothesis directly, even in animal models, as existing therapeutic interventions are unable to specifically target dopamine neurons. ...We found that bidirectional control (inhibition or excitation) of specified midbr …
Until now it has not been possible to test this hypothesis directly, even in animal models, as existing therapeutic interventions are …
Dopamine and depression.
Brown AS, Gershon S. Brown AS, et al. J Neural Transm Gen Sect. 1993;91(2-3):75-109. doi: 10.1007/BF01245227. J Neural Transm Gen Sect. 1993. PMID: 8099801 Review.
The dopamine hypothesis of schizophrenia and the emphasis on other neurotransmitters, most notably norepinephrine, serotonin, and acetylcholine, in the pathogenesis of depression, have focused attention away from substantial evidence implicating dopamine
The dopamine hypothesis of schizophrenia and the emphasis on other neurotransmitters, most notably norepinephrine, serotonin, …
Functional connectivity in reward circuitry and symptoms of anhedonia as therapeutic targets in depression with high inflammation: evidence from a dopamine challenge study.
Bekhbat M, Li Z, Mehta ND, Treadway MT, Lucido MJ, Woolwine BJ, Haroon E, Miller AH, Felger JC. Bekhbat M, et al. Mol Psychiatry. 2022 Oct;27(10):4113-4121. doi: 10.1038/s41380-022-01715-3. Epub 2022 Aug 4. Mol Psychiatry. 2022. PMID: 35927580 Free PMC article. Clinical Trial.
Increased inflammation in major depressive disorder (MDD) has been associated with low functional connectivity (FC) in corticostriatal reward circuits and symptoms of anhedonia, relationships which may involve the impact of inflammation on synthesis and release of …
Increased inflammation in major depressive disorder (MDD) has been associated with low functional connectivity (FC) in cortico …
The dopamine hypothesis of bipolar affective disorder: the state of the art and implications for treatment.
Ashok AH, Marques TR, Jauhar S, Nour MM, Goodwin GM, Young AH, Howes OD. Ashok AH, et al. Mol Psychiatry. 2017 May;22(5):666-679. doi: 10.1038/mp.2017.16. Epub 2017 Mar 14. Mol Psychiatry. 2017. PMID: 28289283 Free PMC article. Review.
Bipolar affective disorder is a common neuropsychiatric disorder. Although its neurobiological underpinnings are incompletely understood, the dopamine hypothesis has been a key theory of the pathophysiology of both manic and depressive phases of …
Bipolar affective disorder is a common neuropsychiatric disorder. Although its neurobiological underpinnings are incompletely …
Cerebrospinal fluid levels of 5-HIAA and dopamine in people with HIV and depression.
Fu R, Jinnah H, Mckay JL, Miller AH, Felger JC, Farber EW, Sharma S, Whicker N, Moore RC, Franklin D, Letendre SL, Anderson AM. Fu R, et al. J Neurovirol. 2023 Aug;29(4):440-448. doi: 10.1007/s13365-023-01142-2. Epub 2023 Jun 8. J Neurovirol. 2023. PMID: 37289360 Free PMC article.
Participants with depression had significantly lower dopamine levels (median 0.49 ng/mL versus 0.62 ng/mL, P = 0.03) and significantly lower 5-HIAA levels (median 12.57 ng/mL versus 15.41 ng/mL, P = 0.015). ...The associations between lower 5-HIAA, lower dopamine
Participants with depression had significantly lower dopamine levels (median 0.49 ng/mL versus 0.62 ng/mL, P = 0.03) and signi …
Dopamine D(3) receptor as a new pharmacological target for the treatment of depression.
Leggio GM, Salomone S, Bucolo C, Platania C, Micale V, Caraci F, Drago F. Leggio GM, et al. Eur J Pharmacol. 2013 Nov 5;719(1-3):25-33. doi: 10.1016/j.ejphar.2013.07.022. Epub 2013 Jul 18. Eur J Pharmacol. 2013. PMID: 23872400 Review.
So far, antidepressant drugs have been developed based on the "monoaminergic hypothesis" of depression, which considers a synaptic deficiency in 5-hydroxytryptamine (5-HT; serotonin) or noradrenaline as main cause. ...Dysfunction of dopaminergic neurotransmission wi …
So far, antidepressant drugs have been developed based on the "monoaminergic hypothesis" of depression, which considers a syna …
Dopamine dysregulation syndrome: implications for a dopamine hypothesis of bipolar disorder.
Berk M, Dodd S, Kauer-Sant'anna M, Malhi GS, Bourin M, Kapczinski F, Norman T. Berk M, et al. Acta Psychiatr Scand Suppl. 2007;(434):41-9. doi: 10.1111/j.1600-0447.2007.01058.x. Acta Psychiatr Scand Suppl. 2007. PMID: 17688462 Review.
However, there is a wealth of converging data on the role of dopamine in bipolar disorder. This paper therefore examines the possibility of a dopamine hypothesis for bipolar disorder. ...CONCLUSION: Pharmacological models suggest a role of incre …
However, there is a wealth of converging data on the role of dopamine in bipolar disorder. This paper therefore examines the p …
A corticosteroid/dopamine hypothesis for psychotic depression and related states.
Schatzberg AF, Rothschild AJ, Langlais PJ, Bird ED, Cole JO. Schatzberg AF, et al. J Psychiatr Res. 1985;19(1):57-64. doi: 10.1016/0022-3956(85)90068-8. J Psychiatr Res. 1985. PMID: 2859366
In recent years, considerable data have emerged that psychotic (delusional) depression is characterized by pronounced increases in hypothalamic-pituitary-adrenal (HPA) axis activity and positive responses to combined treatment with tricyclic antidepressants and antipsychot …
In recent years, considerable data have emerged that psychotic (delusional) depression is characterized by pronounced increases in hy …
Pathobiological targets of depression.
Chopra K, Kumar B, Kuhad A. Chopra K, et al. Expert Opin Ther Targets. 2011 Apr;15(4):379-400. doi: 10.1517/14728222.2011.553603. Epub 2011 Jan 23. Expert Opin Ther Targets. 2011. PMID: 21254923 Review.
About 21% of the world's population is affected by depression. AREAS COVERED: The various pathological factors involved in depression are: monoamine hypothesis, neurotransmitter receptor hypothesis, neurotrophic factor hypothesis, hypothalamic-p …
About 21% of the world's population is affected by depression. AREAS COVERED: The various pathological factors involved in depress
Acetylcholine-dopamine balance hypothesis in the striatum: an update.
Aosaki T, Miura M, Suzuki T, Nishimura K, Masuda M. Aosaki T, et al. Geriatr Gerontol Int. 2010 Jul;10 Suppl 1:S148-57. doi: 10.1111/j.1447-0594.2010.00588.x. Geriatr Gerontol Int. 2010. PMID: 20590830 Review.
Inactivation of muscarinic receptors on the projection neurons eventually yields endocannabinoid-mediated, dopamine-dependent long-term depression in the medium spiny projection neurons. Breakdown of acetylcholine-dopamine balance hampers proper functioning o …
Inactivation of muscarinic receptors on the projection neurons eventually yields endocannabinoid-mediated, dopamine-dependent long-te …
Dopamine dysregulation hypothesis: the common basis for motivational anhedonia in major depressive disorder and schizophrenia?
Szczypiński JJ, Gola M. Szczypiński JJ, et al. Rev Neurosci. 2018 Sep 25;29(7):727-744. doi: 10.1515/revneuro-2017-0091. Rev Neurosci. 2018. PMID: 29573379 Review.
Abnormalities in reward processing are crucial symptoms of major depressive disorder (MDD) and schizophrenia (SCH). Recent neuroscientific findings regarding MDD have led to conclusions about two different symptoms related to reward processing: motivational and cons …
Abnormalities in reward processing are crucial symptoms of major depressive disorder (MDD) and schizophrenia (SCH). Recent neu …
Association Between Bipolar Disorder and Parkinson's Disease.
Geelhand de Merxem R, Launay S, Hanak C. Geelhand de Merxem R, et al. Psychiatr Danub. 2023 Oct;35(Suppl 2):66-71. Psychiatr Danub. 2023. PMID: 37800205 Free article. Review.
The dopaminergic hypothesis suggests that both bipolar disorder and Parkinson's disease involve impairments in the nigrostriatal or mesolimbic dopaminergic pathways. Studies have demonstrated alterations in dopamine regulation during manic and depressive
The dopaminergic hypothesis suggests that both bipolar disorder and Parkinson's disease involve impairments in the nigrostriat …
Dopamine autoreceptor agonists in the treatment of schizophrenia and major depression.
Benkert O, Gründer G, Wetzel H. Benkert O, et al. Pharmacopsychiatry. 1992 Nov;25(6):254-60. doi: 10.1055/s-2007-1014417. Pharmacopsychiatry. 1992. PMID: 1362997 Review.
In order to reduce the excess of central dopaminergic activity postulated by the dopamine hypothesis of schizophrenia, dopamine autoreceptor agonists have been tested in open clinical trials in positive schizophrenic symptomatology. ...For certain subgroups o …
In order to reduce the excess of central dopaminergic activity postulated by the dopamine hypothesis of schizophrenia, dopa
Dopamine and depression: a review of recent evidence. I. Empirical studies.
Willner P. Willner P. Brain Res. 1983 Dec;287(3):211-24. doi: 10.1016/0165-0173(83)90005-x. Brain Res. 1983. PMID: 6140979 Review.
This paper reviews evidence from human, predominantly clinical, studies, relevant to the hypothesis that depression involves reduced levels of dopamine (DA) function. ...There is good evidence that the nigro-striatal DA system is underactive in retarded de
This paper reviews evidence from human, predominantly clinical, studies, relevant to the hypothesis that depression involves r …
Neurobiological similarities in depression and drug dependence: a self-medication hypothesis.
Markou A, Kosten TR, Koob GF. Markou A, et al. Neuropsychopharmacology. 1998 Mar;18(3):135-74. doi: 10.1016/S0893-133X(97)00113-9. Neuropsychopharmacology. 1998. PMID: 9471114 Review.
Thus, these two psychiatric disorders may be linked by some shared neurobiology. Nevertheless, it remains unclear whether drug abuse and depression are different symptomatic expressions of the same preexisting neurobiological abnormalities, or whether repeated drug abuse l …
Thus, these two psychiatric disorders may be linked by some shared neurobiology. Nevertheless, it remains unclear whether drug abuse and …
The catecholaminergic-cholinergic balance hypothesis of bipolar disorder revisited.
van Enkhuizen J, Janowsky DS, Olivier B, Minassian A, Perry W, Young JW, Geyer MA. van Enkhuizen J, et al. Eur J Pharmacol. 2015 Apr 15;753:114-26. doi: 10.1016/j.ejphar.2014.05.063. Epub 2014 Aug 5. Eur J Pharmacol. 2015. PMID: 25107282 Free PMC article. Review.
Bipolar disorder is a unique illness characterized by fluctuations between mood states of depression and mania. ...Despite increasing evidence supporting this hypothesis, a relationship between these two neurotransmitter systems that could explain cycling bet …
Bipolar disorder is a unique illness characterized by fluctuations between mood states of depression and mania. ...Despite inc …
Dopamine sudden depletion as a model for mixed depression.
Strejilevich SA, Teitelbaum J, Martino DJ, Quiroz D, Kapczinski F. Strejilevich SA, et al. Med Hypotheses. 2012 Jan;78(1):107-12. doi: 10.1016/j.mehy.2011.10.004. Epub 2011 Oct 27. Med Hypotheses. 2012. PMID: 22036092
Furthermore, renewed interest in the role of dopamine in Bipolar Disorders' physiopathology has left aside hypothesis that may account for the aforementioned clinical presentation. ...This hypothesis provides with a beginning step for the neglected problem of …
Furthermore, renewed interest in the role of dopamine in Bipolar Disorders' physiopathology has left aside hypothesis that may …
Restless legs syndrome: revisiting the dopamine hypothesis from the spinal cord perspective.
Clemens S, Rye D, Hochman S. Clemens S, et al. Neurology. 2006 Jul 11;67(1):125-30. doi: 10.1212/01.wnl.0000223316.53428.c9. Neurology. 2006. PMID: 16832090 Review.
They assert that, as the sole source of spinal dopamine, reduced drive in this system can lead to spinal network changes wholly consistent with RLS. ...Excessive locomotor behavior is evident in both sets of animals, and D(3)KO mice exhibit facilitation rather than the exp …
They assert that, as the sole source of spinal dopamine, reduced drive in this system can lead to spinal network changes wholly consi …
Role of the dopaminergic system in depression.
Kapur S, Mann JJ. Kapur S, et al. Biol Psychiatry. 1992 Jul 1;32(1):1-17. doi: 10.1016/0006-3223(92)90137-o. Biol Psychiatry. 1992. PMID: 1391289 Review.
A hypothesis implicating dopamine in depression was proposed over 15 years ago (Randrup et al 1975). ...Dopamine precursors, dopamine agonists, and dopamine reuptake inhibitors show therapeutic efficacy in depression. ...
A hypothesis implicating dopamine in depression was proposed over 15 years ago (Randrup et al 1975). ...Dopamine
Tyrosine for depression.
Gelenberg AJ, Wojcik JD, Gibson CJ, Wurtman RJ. Gelenberg AJ, et al. J Psychiatr Res. 1982-1983;17(2):175-80. doi: 10.1016/0022-3956(82)90019-x. J Psychiatr Res. 1982. PMID: 6764934 Review.
The catecholamine hypothesis of affective disorders postulates that depression reflects inadequate norepinephrine activity at unspecified brain centers that regulate mood. In light of experimental data showing that the oral administration of tyrosine, precursor of t …
The catecholamine hypothesis of affective disorders postulates that depression reflects inadequate norepinephrine activity at …
Is depression associated with dysfunction of the central reward system?
Martin-Soelch C. Martin-Soelch C. Biochem Soc Trans. 2009 Feb;37(Pt 1):313-7. doi: 10.1042/BST0370313. Biochem Soc Trans. 2009. PMID: 19143654 Free article. Review.
The neural substrates of MDD (major depressive disorder) are complex and not yet fully understood. In the present review, I provide a short overview of the findings supporting the hypothesis of a dysfunctional dopamine system in the pathophysiology of …
The neural substrates of MDD (major depressive disorder) are complex and not yet fully understood. In the present review, I pr …
Role of dopamine and clinical heterogeneity in cognitive dysfunction in Parkinson's disease.
Cools R, Tichelaar JG, Helmich RCG, Bloem BR, Esselink RAJ, Smulders K, Timmer MHM. Cools R, et al. Prog Brain Res. 2022;269(1):309-343. doi: 10.1016/bs.pbr.2022.01.012. Epub 2022 Feb 9. Prog Brain Res. 2022. PMID: 35248200 Review.
Parkinson's disease (PD) is commonly treated with dopaminergic medication, which enhances some, while impairing other cognitive functions. It can even contribute to impulse control disorder and addiction. We describe the history of research supporting the dopamine o …
Parkinson's disease (PD) is commonly treated with dopaminergic medication, which enhances some, while impairing other cognitive functions. I …
Tianeptine, an atypical pharmacological approach to depression.
Alamo C, García-Garcia P, Lopez-Muñoz F, Zaragozá C. Alamo C, et al. Rev Psiquiatr Salud Ment (Engl Ed). 2019 Jul-Sep;12(3):170-186. doi: 10.1016/j.rpsm.2018.09.002. Epub 2019 Jan 3. Rev Psiquiatr Salud Ment (Engl Ed). 2019. PMID: 30612921 Review. English, Spanish.
Chronic administration of tianeptine does not alter the density or affinity of more than a hundred classical receptors related to depression. Recently, a weak action of tianeptine on Mu opioid receptors has been described that could explain the release of dopamine i …
Chronic administration of tianeptine does not alter the density or affinity of more than a hundred classical receptors related to depress
Gray colored glasses: is major depression partially a sensory perceptual disorder?
Fitzgerald PJ. Fitzgerald PJ. J Affect Disord. 2013 Nov;151(2):418-422. doi: 10.1016/j.jad.2013.06.045. Epub 2013 Jul 29. J Affect Disord. 2013. PMID: 23906865 Review.
BACKGROUND: Major depression is a neuropsychiatric disorder that can involve profound dysregulation of mood. ...Recent studies have shown that visual processing, in as early a stage as the retina, is impaired in depression. This paper examines the hypothes
BACKGROUND: Major depression is a neuropsychiatric disorder that can involve profound dysregulation of mood. ...Recent studies …
Beyond the reward hypothesis: alternative functions of nucleus accumbens dopamine.
Salamone JD, Correa M, Mingote SM, Weber SM. Salamone JD, et al. Curr Opin Pharmacol. 2005 Feb;5(1):34-41. doi: 10.1016/j.coph.2004.09.004. Curr Opin Pharmacol. 2005. PMID: 15661623 Review.
According to the dopamine (DA) hypothesis of reward, DA systems in the brain, particularly in the nucleus accumbens, are thought to directly mediate the rewarding or primary motivational characteristics of natural stimuli such as food, water and sex, as well as vari …
According to the dopamine (DA) hypothesis of reward, DA systems in the brain, particularly in the nucleus accumbens, are thoug …
The Aversive Lens: Stress effects on the prefrontal-cingulate cortical pathways that regulate emotion.
Arnsten AFT, Joyce MKP, Roberts AC. Arnsten AFT, et al. Neurosci Biobehav Rev. 2023 Feb;145:105000. doi: 10.1016/j.neubiorev.2022.105000. Epub 2022 Dec 15. Neurosci Biobehav Rev. 2023. PMID: 36529312 Free PMC article. Review.
NEUROSCI BIOBEHAV REV XXX-XXX, 2022. The symptoms of major-depressive-disorder include psychic pain and anhedonia, i.e. seeing the world through an "aversive lens". ...Here these data are reviewed, focusing on how activation of subgenual cingulate (BA25) induces an …
NEUROSCI BIOBEHAV REV XXX-XXX, 2022. The symptoms of major-depressive-disorder include psychic pain and anhedonia, i.e. seeing …
Uptake inhibition of biogenic amines by newer antidepressant drugs: relevance to the dopamine hypothesis of depression.
Randrup A, Braestrup C. Randrup A, et al. Psychopharmacology (Berl). 1977 Aug 16;53(3):309-14. doi: 10.1007/BF00492370. Psychopharmacology (Berl). 1977. PMID: 408861
The dopamine theory of depression was studied by assessing the effect of antidepressant drugs on uptake of dopamine, noradrenaline, and serotonin in synaptosomes from rat brain. ...These results are discussed in relation to comprehensive recent literature as …
The dopamine theory of depression was studied by assessing the effect of antidepressant drugs on uptake of dopamine, no …
The role of dopamine in mood disorders.
Diehl DJ, Gershon S. Diehl DJ, et al. Compr Psychiatry. 1992 Mar-Apr;33(2):115-20. doi: 10.1016/0010-440x(92)90007-d. Compr Psychiatry. 1992. PMID: 1347497 Review.
The findings on dopamine in mood disorders suggest that decreased dopamine activity is involved in depression, while increased dopamine function contributes to mania. This report reviews the considerable preclinical and clinical evidence supporting thi …
The findings on dopamine in mood disorders suggest that decreased dopamine activity is involved in depression, while in …
Pathophysiology of Depression: Stingless Bee Honey Promising as an Antidepressant.
Zakaria FH, Samhani I, Mustafa MZ, Shafin N. Zakaria FH, et al. Molecules. 2022 Aug 10;27(16):5091. doi: 10.3390/molecules27165091. Molecules. 2022. PMID: 36014336 Free PMC article. Review.
Depression is a debilitating psychiatric disorder impacting an individual's quality of life. It is the most prevalent mental illness across all age categories, incurring huge socio-economic impacts. Most depression treatments currently focus on the elevation
Depression is a debilitating psychiatric disorder impacting an individual's quality of life. It is the most prevalent mental i
Testing the hypothesis that locus coeruleus hyperactivity produces depression-related changes via galanin.
Weiss JM, Boss-Williams KA, Moore JP, Demetrikopoulos MK, Ritchie JC, West CH. Weiss JM, et al. Neuropeptides. 2005 Jun;39(3):281-7. doi: 10.1016/j.npep.2004.12.028. Epub 2005 Feb 16. Neuropeptides. 2005. PMID: 15944023 Review.
This paper reviews progress made in testing the idea that depression-related behavioral changes can arise from hyperactivity of locus coeruleus (LC) neurons which consequently inhibits activity of mesocorticolimbic dopamine neurons in the ventral tegmentum (VTA) via …
This paper reviews progress made in testing the idea that depression-related behavioral changes can arise from hyperactivity of locus …
Post-stroke depression: mechanisms, translation and therapy.
Loubinoux I, Kronenberg G, Endres M, Schumann-Bard P, Freret T, Filipkowski RK, Kaczmarek L, Popa-Wagner A. Loubinoux I, et al. J Cell Mol Med. 2012 Sep;16(9):1961-9. doi: 10.1111/j.1582-4934.2012.01555.x. J Cell Mol Med. 2012. PMID: 22348642 Free PMC article. Review.
The interaction between depression and stroke is highly complex. Post-stroke depression (PSD) is among the most frequent neuropsychiatric consequences of stroke. ...Antidepressants such as the commonly prescribed selective serotonin reuptake inhibitors improve strok …
The interaction between depression and stroke is highly complex. Post-stroke depression (PSD) is among the most frequent neuro …
Oscillatory serotonin function in depression.
Salomon RM, Cowan RL. Salomon RM, et al. Synapse. 2013 Nov;67(11):801-20. doi: 10.1002/syn.21675. Epub 2013 May 21. Synapse. 2013. PMID: 23592367 Free PMC article. Review.
Ultradian (faster than circadian) rhythms of mood behaviors and associated central nervous system activities are altered in depression. Recent data suggest that ultradian rhythms in serotonin (5HT) function also change in depression. ...Further studies of 5HT oscill …
Ultradian (faster than circadian) rhythms of mood behaviors and associated central nervous system activities are altered in depression
The genetics of selective serotonin reuptake inhibitors.
Kroeze Y, Zhou H, Homberg JR. Kroeze Y, et al. Pharmacol Ther. 2012 Dec;136(3):375-400. doi: 10.1016/j.pharmthera.2012.08.015. Epub 2012 Sep 1. Pharmacol Ther. 2012. PMID: 22944042 Review.
Based on the fact that SSRIs increase extracellular monoamine levels in the brain, the monoamine hypothesis of depression was introduced, postulating that depression is associated with too low serotonin, dopamine and noradrenaline levels. However, seve …
Based on the fact that SSRIs increase extracellular monoamine levels in the brain, the monoamine hypothesis of depression was …
From Serotonin to Neuroplasticity: Evolvement of Theories for Major Depressive Disorder.
Liu B, Liu J, Wang M, Zhang Y, Li L. Liu B, et al. Front Cell Neurosci. 2017 Sep 28;11:305. doi: 10.3389/fncel.2017.00305. eCollection 2017. Front Cell Neurosci. 2017. PMID: 29033793 Free PMC article. Review.
The serotonin (5-HT) hypothesis of depression has played an important role in the history of psychiatry, yet it has also been criticized for the delayed onset and inadequate efficacy of selective serotonin reuptake inhibitors (SSRIs). With evolvement of neuroscience …
The serotonin (5-HT) hypothesis of depression has played an important role in the history of psychiatry, yet it has also been …
Role of neurotrophic factors in depression.
Castrén E, Võikar V, Rantamäki T. Castrén E, et al. Curr Opin Pharmacol. 2007 Feb;7(1):18-21. doi: 10.1016/j.coph.2006.08.009. Epub 2006 Oct 17. Curr Opin Pharmacol. 2007. PMID: 17049922 Review.
Major depression is associated with reduced volumes in the hippocampus and prefrontal cortex, whereas antidepressant treatments promote several forms of neuronal plasticity, including neurogenesis, synaptogenesis and neuronal maturation, in the hippocampus. ...This signali …
Major depression is associated with reduced volumes in the hippocampus and prefrontal cortex, whereas antidepressant treatments promo …
Basal ganglia circuit loops, dopamine and motivation: A review and enquiry.
Ikemoto S, Yang C, Tan A. Ikemoto S, et al. Behav Brain Res. 2015 Sep 1;290:17-31. doi: 10.1016/j.bbr.2015.04.018. Epub 2015 Apr 20. Behav Brain Res. 2015. PMID: 25907747 Free PMC article. Review.
Dopamine neurons located in the midbrain play a role in motivation that regulates approach behavior (approach motivation). ...The present paper reviews previous rodent work concerning dopamine's role in approach motivation and the connectivity of dopamine
Dopamine neurons located in the midbrain play a role in motivation that regulates approach behavior (approach motivation). ...The pre
Memantine: New prospective in bipolar disorder treatment.
Serra G, Demontis F, Serra F, De Chiara L, Spoto A, Girardi P, Vidotto G, Serra G. Serra G, et al. World J Psychiatry. 2014 Dec 22;4(4):80-90. doi: 10.5498/wjp.v4.i4.80. World J Psychiatry. 2014. PMID: 25540723 Free PMC article. Review.
We have demonstrated that 21 d administration of imipramine causes a behavioural syndrome similar to a cycle of bipolar disorder, i.e., a mania followed by a depression, in rats. Indeed, such treatment causes a behavioural supersensitivity to dopamine D2 rece …
We have demonstrated that 21 d administration of imipramine causes a behavioural syndrome similar to a cycle of bipolar disorder, i.e …
Mechanisms Underlying Dopamine-Induced Risky Choice in Parkinson's Disease With and Without Depression (History).
Timmer MHM, Sescousse G, Esselink RAJ, Piray P, Cools R. Timmer MHM, et al. Comput Psychiatr. 2018 Feb 1;2:11-27. doi: 10.1162/CPSY_a_00011. eCollection 2018 Feb. Comput Psychiatr. 2018. PMID: 30090860 Free PMC article.
Here we characterize the computational mechanisms that contribute to dopamine-induced changes in risky choice in PD patients with and without a depression (history). ...Moreover, the current study raises the hypothesis that dopamine-induced reductions …
Here we characterize the computational mechanisms that contribute to dopamine-induced changes in risky choice in PD patients with and …
Serotonin and depression - a riposte to Moncrieff et al. (2022).
Rihmer Z, Dome P, Katona C. Rihmer Z, et al. Neuropsychopharmacol Hung. 2022 Sep 1;24(3):120-125. Neuropsychopharmacol Hung. 2022. PMID: 36356194 Free article.
It has long been known that depression is a heterogeneous disorder not only genetically, clinically and biologically but also from a pharmacotherapeutic perspective. ...SNRI) antidepressants. Results of serotonin and catecholamine (dopamine, noradrenaline) de …
It has long been known that depression is a heterogeneous disorder not only genetically, clinically and biologically but also …
Pain-related depression of the mesolimbic dopamine system in rats: expression, blockade by analgesics, and role of endogenous kappa-opioids.
Leitl MD, Onvani S, Bowers MS, Cheng K, Rice KC, Carlezon WA Jr, Banks ML, Negus SS. Leitl MD, et al. Neuropsychopharmacology. 2014 Feb;39(3):614-24. doi: 10.1038/npp.2013.236. Epub 2013 Sep 6. Neuropsychopharmacology. 2014. PMID: 24008352 Free PMC article.
Pain is often associated with depression of behavior and mood, and relief of pain-related depression is a common goal of treatment. This study tested the hypothesis that pain-related behavioral depression is mediated by activation of endogenous kappa-o …
Pain is often associated with depression of behavior and mood, and relief of pain-related depression is a common goal of treat …
Current perspectives on immunology and psychiatry.
O'Donnell M, Silove D, Wakefield D. O'Donnell M, et al. Aust N Z J Psychiatry. 1988 Dec;22(4):366-82. doi: 10.3109/00048678809161345. Aust N Z J Psychiatry. 1988. PMID: 3071320 Review.
Our examination of research implicating immunological or infective mechanisms in the aetiology of schizophrenia indicates that most studies have been unable to control for major methodological difficulties but the compatibility of these theories with the dopamine hypoth
Our examination of research implicating immunological or infective mechanisms in the aetiology of schizophrenia indicates that most studies …
New approaches to the treatment of depression.
Leonard BE. Leonard BE. J Clin Psychiatry. 1996;57 Suppl 4:26-33. J Clin Psychiatry. 1996. PMID: 8636063 Review.
Whereas the monoamine theory of depression and the receptor adaptation hypothesis of antidepressant action have been influential in helping to unify the mechanisms of action of antidepressants with the possible pathologic basis of depression, the introduction …
Whereas the monoamine theory of depression and the receptor adaptation hypothesis of antidepressant action have been influenti …
Selective Serotonin Reuptake Inhibitors and Clozapine: Clinically Relevant Interactions and Considerations.
Edinoff AN, Fort JM, Woo JJ, Causey CD, Burroughs CR, Cornett EM, Kaye AM, Kaye AD. Edinoff AN, et al. Neurol Int. 2021 Sep 1;13(3):445-463. doi: 10.3390/neurolint13030044. Neurol Int. 2021. PMID: 34564289 Free PMC article. Review.
The monoamine hypothesis of depression attributes the symptoms of major depressive disorders to imbalances of serotonin, noradrenaline, and dopamine in the limbic areas of the brain. ...Negative symptoms include the diminution of motivation, interest, …
The monoamine hypothesis of depression attributes the symptoms of major depressive disorders to imbalances of serotonin …
Synaptic plasticity in the basal ganglia.
Wickens JR. Wickens JR. Behav Brain Res. 2009 Apr 12;199(1):119-28. doi: 10.1016/j.bbr.2008.10.030. Epub 2008 Nov 6. Behav Brain Res. 2009. PMID: 19026691 Review.
As in other systems, both long-term potentiation and long-term depression have been described, and intracellular calcium signalling plays an important role in the induction of plasticity. ...Endocannabinoids also play an important role in mediating presynaptic expression o …
As in other systems, both long-term potentiation and long-term depression have been described, and intracellular calcium signalling p …
The role of serotonergic, adrenergic and dopaminergic receptors in antidepressant-like effect.
Pytka K, Podkowa K, Rapacz A, Podkowa A, Żmudzka E, Olczyk A, Sapa J, Filipek B. Pytka K, et al. Pharmacol Rep. 2016 Apr;68(2):263-74. doi: 10.1016/j.pharep.2015.08.007. Epub 2015 Aug 25. Pharmacol Rep. 2016. PMID: 26922526 Review.
Depression is a serious global illness, becoming more and more common in developed countries. ...The heterogeneous nature of the illness and its complex, unclear aetiology may be responsible for these difficulties. Next to the main monoaminergic hypothesis of dep
Depression is a serious global illness, becoming more and more common in developed countries. ...The heterogeneous nature of the illn
Antidepressant-induced Dopamine Receptor Dysregulation: A Valid Animal Model of Manic-Depressive Illness.
Demontis F, Serra F, Serra G. Demontis F, et al. Curr Neuropharmacol. 2017 Apr;15(3):417-423. doi: 10.2174/1570159X14666160715165648. Curr Neuropharmacol. 2017. PMID: 28503114 Free PMC article. Review.
This review aims to report the experimental evidence that led to the hypothesis that antidepressant-induced DA receptors dysregulation can be considered an animal model of bipolar disorder. ...CONCLUSION: We suggest that chronic treatment with antidepressants induce …
This review aims to report the experimental evidence that led to the hypothesis that antidepressant-induced DA receptors dysregulatio …
Striatal dopamine transporter density in major depression.
Laasonen-Balk T, Kuikka J, Viinamäki H, Husso-Saastamoinen M, Lehtonen J, Tiihonen J. Laasonen-Balk T, et al. Psychopharmacology (Berl). 1999 Jun;144(3):282-5. doi: 10.1007/s002130051005. Psychopharmacology (Berl). 1999. PMID: 10435396
RATIONALE: There are no previous data available regarding [123I]beta-CIT binding to the dopamine transporter sites in the basal ganglia in depressed patients. OBJECTIVE: The present study tested the hypothesis that the brain DAT density in depressed pa …
RATIONALE: There are no previous data available regarding [123I]beta-CIT binding to the dopamine transporter sites in the basal gangl …
Impulse control disorder in Parkinson's disease is associated with abnormal frontal value signalling.
Tichelaar JG, Sayalı C, Helmich RC, Cools R. Tichelaar JG, et al. Brain. 2023 Sep 1;146(9):3676-3689. doi: 10.1093/brain/awad162. Brain. 2023. PMID: 37192341 Free PMC article.
We aimed to unravel the mechanisms underlying this individual variability in a large heterogeneous sample of early-stage patients with Parkinson's disease as a function of comorbid neuropsychiatric symptomatology, in particular impulse control disorders and depression. One …
We aimed to unravel the mechanisms underlying this individual variability in a large heterogeneous sample of early-stage patients with Parki …
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