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Page 1
[Oxidative stress and the brain].
Tanaka M. Tanaka M. Nihon Ronen Igakkai Zasshi. 1997 Sep;34(9):706-10. Nihon Ronen Igakkai Zasshi. 1997. PMID: 9430979 Free article. Review. Japanese.
Although the cause of Parkinson's disease is unknown, oxidative stress has been implicated in its pathogenesis. This theory postulates that normal metabolic processes in the nigrostriatal dopaminergic system may lead to loss of neurons, and that iron-d …
Although the cause of Parkinson's disease is unknown, oxidative stress has been implicated in its pathogenesis. This theory postulate …
Impaired iron homeostasis in Parkinson's disease.
Double KL, Gerlach M, Youdim MB, Riederer P. Double KL, et al. J Neural Transm Suppl. 2000;(60):37-58. doi: 10.1007/978-3-7091-6301-6_3. J Neural Transm Suppl. 2000. PMID: 11205155 Review.
Such a iron source is neuromelanin (NM), a dark-coloured pigment found in the dopaminergic neurons of the human SN. ...On the other hand, in the presence of iron NM appears to act as a proxidant, increasing the rate of free radical production an …
Such a iron source is neuromelanin (NM), a dark-coloured pigment found in the dopaminergic neurons of the human …
The role of alpha-synuclein as ferrireductase in neurodegeneration associated with Parkinson's disease.
Sian-Hulsmann J, Riederer P. Sian-Hulsmann J, et al. J Neural Transm (Vienna). 2020 May;127(5):749-754. doi: 10.1007/s00702-020-02192-0. Epub 2020 Apr 21. J Neural Transm (Vienna). 2020. PMID: 32318880 Review.
Furthermore, the loss of an important iron chelator, neuromelanin (due to dopaminergic neuronal death), may then result in the release and increase in unbound free iron. ...In addition, loss of energy supply may contribute to the alteration in activity …
Furthermore, the loss of an important iron chelator, neuromelanin (due to dopaminergic neuronal death), may then result …
Neuronal vulnerability in Parkinson's disease.
Double KL. Double KL. Parkinsonism Relat Disord. 2012 Jan;18 Suppl 1:S52-4. doi: 10.1016/S1353-8020(11)70018-9. Parkinsonism Relat Disord. 2012. PMID: 22166454 Review.
The classic motor symptoms of Parkinson's disease result from the progressive death of dopaminergic neurons within the substantia nigra. To date the relatively selective vulnerability of this brain region is not understood. The unique feature of dopaminerg …
The classic motor symptoms of Parkinson's disease result from the progressive death of dopaminergic neurons within the substan …
Toxic Feedback Loop Involving Iron, Reactive Oxygen Species, alpha-Synuclein and Neuromelanin in Parkinson's Disease and Intervention with Turmeric.
Jansen van Rensburg Z, Abrahams S, Bardien S, Kenyon C. Jansen van Rensburg Z, et al. Mol Neurobiol. 2021 Nov;58(11):5920-5936. doi: 10.1007/s12035-021-02516-5. Epub 2021 Aug 23. Mol Neurobiol. 2021. PMID: 34426907 Review.
Parkinson's disease (PD) is a movement disorder associated with severe loss of mainly dopaminergic neurons in the substantia nigra. Pathological hallmarks include Lewy bodies, and loss of neuromelanin, due to degeneration of neuromelanin-containing …
Parkinson's disease (PD) is a movement disorder associated with severe loss of mainly dopaminergic neurons in the substantia n …
New face of neuromelanin.
Double KL, Halliday GM. Double KL, et al. J Neural Transm Suppl. 2006;(70):119-23. doi: 10.1007/978-3-211-45295-0_19. J Neural Transm Suppl. 2006. PMID: 17017518 Review.
The massive, early and relatively circumscribed death of the dopaminergic neurons of the substantia nigra in Parkinson's disease has not yet been adequately explained. ...The available data suggest that the melaninisation of the dopaminergic neurons of …
The massive, early and relatively circumscribed death of the dopaminergic neurons of the substantia nigra in Parkinson's disea …
Iron-binding characteristics of neuromelanin of the human substantia nigra.
Double KL, Gerlach M, Schünemann V, Trautwein AX, Zecca L, Gallorini M, Youdim MB, Riederer P, Ben-Shachar D. Double KL, et al. Biochem Pharmacol. 2003 Aug 1;66(3):489-94. doi: 10.1016/s0006-2952(03)00293-4. Biochem Pharmacol. 2003. PMID: 12907248
The vulnerability of the dopaminergic neurons of the substantia nigra (SN) in Parkinson's disease has been related to the presence of the pigment neuromelanin (NM) in these neurons. ...These findings are consistent with the hypothesis that NM ma …
The vulnerability of the dopaminergic neurons of the substantia nigra (SN) in Parkinson's disease has been related to t …
Parkinson's disease as multifactorial oxidative neurodegeneration: implications for integrative management.
Kidd PM. Kidd PM. Altern Med Rev. 2000 Dec;5(6):502-29. Altern Med Rev. 2000. PMID: 11134975 Review.
Clinical, experimental, microanatomic, and biochemical evidence suggests PD involves multifactorial, oxidative neurodegeneration, and that levodopa therapy adds to the oxidative burden. The SN is uniquely vulnerable to oxidative damage, having high con …
Clinical, experimental, microanatomic, and biochemical evidence suggests PD involves multifactorial, oxidative neurodegeneration, and …
Biochemistry of Parkinson's disease with special reference to the dopaminergic systems.
Hirsch EC. Hirsch EC. Mol Neurobiol. 1994 Aug-Dec;9(1-3):135-42. doi: 10.1007/BF02816113. Mol Neurobiol. 1994. PMID: 7888089 Review.
This heterogeneity provides a good paradigm for analyzing the factors implicated in this differential vulnerability. So far, the neurons that degenerate have been shown to contain neuromelanin, high amounts of iron, and no calbindin28K, and to be poorl …
This heterogeneity provides a good paradigm for analyzing the factors implicated in this differential vulnerability. So far, the n …
Does oxidative stress participate in nerve cell death in Parkinson's disease?
Hirsch EC. Hirsch EC. Eur Neurol. 1993;33 Suppl 1:52-9. doi: 10.1159/000118538. Eur Neurol. 1993. PMID: 8375433 Review.
However, the most consistent lesions are observed in dopaminergic systems including nigral neurons. Although the cause of this neuronal loss remains unknown, oxidative stress has been suspected to participate in the mechanism of nerve cell death for several r …
However, the most consistent lesions are observed in dopaminergic systems including nigral neurons. Although the cause of this …
15 results