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Page 1
Nattokinase Supplementation and Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Li X, Long J, Gao Q, Pan M, Wang J, Yang F, Zhang Y. Li X, et al. Rev Cardiovasc Med. 2023 Aug 15;24(8):234. doi: 10.31083/j.rcm2408234. eCollection 2023 Aug. Rev Cardiovasc Med. 2023. PMID: 39076715 Free PMC article.
Nattokinase group with relatively high total dosage also had a higher total cholesterol (MD = 3.18, 95% CI: 2.29 to 4.06, p < 0.00001) than control interventions, but no significant differences were found in levels of high-density lipoprotein cholesterol and low- …
Nattokinase group with relatively high total dosage also had a higher total cholesterol (MD = 3.18, 95% CI: 2.29 to 4.06, p &l …
Nattokinase: An Oral Antithrombotic Agent for the Prevention of Cardiovascular Disease.
Weng Y, Yao J, Sparks S, Wang KY. Weng Y, et al. Int J Mol Sci. 2017 Feb 28;18(3):523. doi: 10.3390/ijms18030523. Int J Mol Sci. 2017. PMID: 28264497 Free PMC article. Review.
Natto, a fermented soybean product, has been consumed as a traditional food in Japan for thousands of years. Nattokinase (NK), a potent blood-clot dissolving protein used for the treatment of cardiovascular diseases, is produced by the bacterium Bacillus subtilis during th …
Natto, a fermented soybean product, has been consumed as a traditional food in Japan for thousands of years. Nattokinase (NK), a pote …
Toxicological assessment of nattokinase derived from Bacillus subtilis var. natto.
Lampe BJ, English JC. Lampe BJ, et al. Food Chem Toxicol. 2016 Feb;88:87-99. doi: 10.1016/j.fct.2015.12.025. Epub 2015 Dec 29. Food Chem Toxicol. 2016. PMID: 26740078 Free article.
Additionally consumption of 10 mg/kg-day nattokinase for 4 weeks was well tolerated in healthy human volunteers. These findings suggest that the oral consumption of nattokinase is of low toxicological concern. The 90-day oral subchronic NOAEL for nattokinase …
Additionally consumption of 10 mg/kg-day nattokinase for 4 weeks was well tolerated in healthy human volunteers. These findings sugge …
Inhibition of nattokinase against the production of poly (gamma-glutamic Acid) in Bacillus subtilis natto.
Wang L, Liu N, Yu C, Chen J, Hong K, Zang Y, Wang M, Nie G. Wang L, et al. Biotechnol Lett. 2020 Nov;42(11):2285-2291. doi: 10.1007/s10529-020-02941-x. Epub 2020 Jun 28. Biotechnol Lett. 2020. PMID: 32596743
RESULTS: gamma-PGA yield significantly decreased as NK was added in the original medium. With the increment of NK dosage, the yield decreased increasingly, but biomass increased instead of decreasing. ...
RESULTS: gamma-PGA yield significantly decreased as NK was added in the original medium. With the increment of NK dosage, the yield d …
Pharmacotherapy of Vitreomacular Traction.
Wan R, Hong T, Tariq Y, Chang A. Wan R, et al. Curr Pharm Des. 2018;24(41):4874-4881. doi: 10.2174/1381612825666190124102148. Curr Pharm Des. 2018. PMID: 30674252 Review.
Many agents have been investigated and trialled including plasmin, microplasmin (Ocriplasmin), hyaluronidase, nattokinase, chondroitinase and dispase. This review will focus on the progress and current status in this research....
Many agents have been investigated and trialled including plasmin, microplasmin (Ocriplasmin), hyaluronidase, nattokinase, chondroiti …
Development of a nattokinase-polysialic acid complex for advanced tumor treatment.
Kou Y, Feng R, Chen J, Duan L, Wang S, Hu Y, Zhang N, Wang T, Deng Y, Song Y. Kou Y, et al. Eur J Pharm Sci. 2020 Mar 30;145:105241. doi: 10.1016/j.ejps.2020.105241. Epub 2020 Jan 28. Eur J Pharm Sci. 2020. PMID: 32001345
Cancer-associated thrombus (CAT) impedes delivery of nanoparticles to tumor sites and also inhibits the ability of immune cells to detect and attack these tumors, particularly in advanced tumors with old thrombi. Nattokinase (NK) is an extract from a popular Japanese food, …
Cancer-associated thrombus (CAT) impedes delivery of nanoparticles to tumor sites and also inhibits the ability of immune cells to detect an …
Preparation and toxicity evaluation of a novel nattokinase-tauroursodeoxycholate complex.
Feng R, Li J, Chen J, Duan L, Liu X, Di D, Deng Y, Song Y. Feng R, et al. Asian J Pharm Sci. 2018 Mar;13(2):173-182. doi: 10.1016/j.ajps.2017.11.001. Epub 2017 Nov 10. Asian J Pharm Sci. 2018. PMID: 32104390 Free PMC article.
Nattokinase (NK), which has been identified as a potent fibrinolytic protease, has remarkable potential in treatment of thrombolysis, and even has the ability to ameliorate chronic vein thrombosis. To reduce the hemorrhagic risk from an intravenous injection of NK, natt …
Nattokinase (NK), which has been identified as a potent fibrinolytic protease, has remarkable potential in treatment of thrombolysis, …
The effects of nattokinase supplementation on collagen-epinephrine closure time, prothrombin time and activated partial thromboplastin time in nondiabetic and hypercholesterolemic subjects.
Yoo HJ , Kim M , Kim M , Lee A , Jin C , Lee SP , Kim TS , Lee SH , Lee JH . Yoo HJ , et al. Food Funct. 2019 May 22;10(5):2888-2893. doi: 10.1039/c8fo02324g. Food Funct. 2019. PMID: 31070609 Clinical Trial.
After 8 weeks of treatment, the nattokinase group exhibited significant increases in C-EPI CT, PT, and aPTT. The nattokinase group showed significantly greater increases in C-EPI CT (P = 0.001) and aPTT (P = 0.016) than the placebo group. Moreover, at 8 weeks, the …
After 8 weeks of treatment, the nattokinase group exhibited significant increases in C-EPI CT, PT, and aPTT. The nattokinase g …
Development of surface-engineered PLGA nanoparticulate-delivery system of Tet1-conjugated nattokinase enzyme for inhibition of Abeta(40) plaques in Alzheimer's disease.
Bhatt PC, Verma A, Al-Abbasi FA, Anwar F, Kumar V, Panda BP. Bhatt PC, et al. Int J Nanomedicine. 2017 Dec 13;12:8749-8768. doi: 10.2147/IJN.S144545. eCollection 2017. Int J Nanomedicine. 2017. PMID: 29263666 Free PMC article.
The antiamyloid activity, antifibrinolytic activity, and antithrombotic activity of nattokinase holds potential for the treatment of AD. As nattokinase is a protein, its stability restricts its usage to a greater extent, but this limitation can be overcome by nanoen …
The antiamyloid activity, antifibrinolytic activity, and antithrombotic activity of nattokinase holds potential for the treatment of …
Ameliorated effects of nattokinase on high-fat diet and carrageenan-induced tail-thrombosis mice.
Chen X, Cao G, Meng F, Tang C, Lu Z, Lu Y. Chen X, et al. J Sci Food Agric. 2025 Sep;105(12):6630-6640. doi: 10.1002/jsfa.14376. Epub 2025 Jul 10. J Sci Food Agric. 2025. PMID: 40637357
In the present study, the activity of nattokinase (NK) from Bacillus natto fmb 401 reached 484.0 FU mL(-1) at the end point of fermentation. ...
In the present study, the activity of nattokinase (NK) from Bacillus natto fmb 401 reached 484.0 FU mL(-1) at the end point of fermen …
31 results