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Year Number of Results
1971 2
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1981 7
1982 10
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1994 36
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2004 71
2005 59
2006 73
2007 61
2008 59
2009 73
2010 62
2011 80
2012 121
2013 151
2014 169
2015 143
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2017 223
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2020 225
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3,679 results

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Page 1
Homologous Recombination Repair Deficiency: An Overview for Pathologists.
Doig KD, Fellowes AP, Fox SB. Doig KD, et al. Mod Pathol. 2023 Mar;36(3):100049. doi: 10.1016/j.modpat.2022.100049. Epub 2023 Jan 10. Mod Pathol. 2023. PMID: 36788098 Free article. Review.
The repair of DNA double-stranded breaks relies on the homologous recombination repair pathway and is critical to cell function. However, this pathway can be lost in some cancers such as breast, ovarian, endometrial, pancreatic, and prost …
The repair of DNA double-stranded breaks relies on the homologous recombination repair pathway and …
Double-strand break end resection and repair pathway choice.
Symington LS, Gautier J. Symington LS, et al. Annu Rev Genet. 2011;45:247-71. doi: 10.1146/annurev-genet-110410-132435. Epub 2011 Sep 12. Annu Rev Genet. 2011. PMID: 21910633 Review.
DNA double-strand breaks (DSBs) are cytotoxic lesions that can result in mutagenic events or cell death if left unrepaired or repaired inappropriately. ...A critical determinant of repair pathway choice is the initiation of 5'-3' resection of DNA …
DNA double-strand breaks (DSBs) are cytotoxic lesions that can result in mutagenic events or cell death if left unrepai …
Shelterin-Mediated Telomere Protection.
de Lange T. de Lange T. Annu Rev Genet. 2018 Nov 23;52:223-247. doi: 10.1146/annurev-genet-032918-021921. Epub 2018 Sep 12. Annu Rev Genet. 2018. PMID: 30208292 Review.
Much progress has been made on the mechanism by which shelterin prevents telomeres from inadvertently activating DNA damage signaling and double-strand break (DSB) repair pathways. Shelterin averts activation of three DNA damage response …
Much progress has been made on the mechanism by which shelterin prevents telomeres from inadvertently activating DNA damage signaling …
Irinotecan alleviates chemoresistance to anthracyclines through the inhibition of AARS1-mediated BLM lactylation and homologous recombination repair.
Li X, Zhang C, Mei Y, Zhong W, Fan W, Liu L, Feng Z, Bai X, Liu C, Xiao M, He W, Lin T, Gou X. Li X, et al. Signal Transduct Target Ther. 2025 Jul 10;10(1):214. doi: 10.1038/s41392-025-02302-y. Signal Transduct Target Ther. 2025. PMID: 40634292 Free PMC article. Clinical Trial.
Specifically, BLM, a crucial helicase in the HR repair process, is highly lactylated at Lys24 by AARS1 in response to chemotherapy. Mechanistically, hyperlactylation of BLM improves its stability by inhibiting MIB1-mediated ubiquitination and increasing its interaction wit …
Specifically, BLM, a crucial helicase in the HR repair process, is highly lactylated at Lys24 by AARS1 in response to chemotherapy. M …
Transcription-coupled DNA double-strand break repair.
Guha S, Bhaumik SR. Guha S, et al. DNA Repair (Amst). 2022 Jan;109:103211. doi: 10.1016/j.dnarep.2021.103211. Epub 2021 Aug 13. DNA Repair (Amst). 2022. PMID: 34883263 Review.
Among the various DNA damages, DNA double-strand breaks are quite toxic to the cells. If DNA double-strand break occurs at the active gene, it would interfere with transcription/gene expression, thus threatening cellular via …
Among the various DNA damages, DNA double-strand breaks are quite toxic to the cells. If DNA double …
Biochemical Mechanisms of Genetic Recombination and DNA Repair.
Raina VB, Jessop A, Greene EC. Raina VB, et al. Annu Rev Biochem. 2025 Jun;94(1):161-193. doi: 10.1146/annurev-biochem-083024-113931. Epub 2025 Mar 28. Annu Rev Biochem. 2025. PMID: 40153609 Free PMC article. Review.
Genetic recombination involves the exchange of genetic material between homologous sequences of DNA. It is employed during meiosis in sexually reproducing organisms or in somatic cells to accurately repair toxic DNA lesions like double- …
Genetic recombination involves the exchange of genetic material between homologous sequences of DNA. It is employed dur …
CTC1-STN1-TEN1 controls DNA break repair pathway choice via DNA end resection blockade.
Rogers CM, Kaur H, Swift ML, Raina VB, Zhou S, Kawale AS, Syed S, Kelly KG, Jasper AM, Salunkhe S, Kwon Y, Wang J, Shabestari AB, Daley JM, Sacks A, Gaczynska ME, Osmulski PA, Rawal Y, Tomimatsu N, Gayther SA, Lawrenson K, Burma S, Wasmuth EV, Olsen SK, Zhao W, Hromas R, Libich DS, Mazin AV, Zhou D, Greene EC, Chowdhury D, Sung P. Rogers CM, et al. Science. 2025 May 22;388(6749):881-888. doi: 10.1126/science.adt3034. Epub 2025 May 22. Science. 2025. PMID: 40403056 Free PMC article.
Antagonistic activities of the 53BP1 axis and the tumor suppressor BRCA1-BARD1 determine whether DNA double-strand breaks (DSBs) are repaired by end joining or homologous recombination. ...Our findings mechanistically define the crucial role of …
Antagonistic activities of the 53BP1 axis and the tumor suppressor BRCA1-BARD1 determine whether DNA double-strand brea …
Double-Strand DNA Break Repair in Mycobacteria.
Glickman MS. Glickman MS. Microbiol Spectr. 2014 Oct;2(5). doi: 10.1128/microbiolspec.MGM2-0024-2013. Microbiol Spectr. 2014. PMID: 26104351 Free article. Review.
Discontinuity of both strands of the chromosome is a lethal event in all living organisms because it compromises chromosome replication. As such, a diversity of DNA repair systems has evolved to repair double-strand DNA breaks (DSBs). In …
Discontinuity of both strands of the chromosome is a lethal event in all living organisms because it compromises chromosome replication. As …
Cohesin guides homology search during DNA repair using loops and sister chromatid linkages.
Teloni F, Takacs Z, Mitter M, Langer CCH, Prlesi I, Steinacker TL, Reuter VP, Mylarshchikov D, Gerlich DW. Teloni F, et al. Science. 2025 Dec 4;390(6777):eadw0566. doi: 10.1126/science.adw0566. Epub 2025 Dec 4. Science. 2025. PMID: 41343653
Accurate repair of DNA double-strand breaks (DSBs) is essential for genome stability, and defective repair underlies diseases such as cancer. Homologous recombination uses an intact homologous sequence to faithfully restore …
Accurate repair of DNA double-strand breaks (DSBs) is essential for genome stability, and defective repair …
3,679 results