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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1910 1
1959 1
1963 1
1964 1
1965 1
1967 4
1969 2
1970 4
1972 1
1973 3
1974 2
1975 15
1976 17
1977 18
1978 28
1979 33
1980 61
1981 84
1982 125
1983 192
1984 222
1985 293
1986 302
1987 406
1988 515
1989 658
1990 1015
1991 1238
1992 1266
1993 1406
1994 1659
1995 1908
1996 2070
1997 2220
1998 2456
1999 2679
2000 3171
2001 3751
2002 4233
2003 4939
2004 5699
2005 6575
2006 7196
2007 7548
2008 8369
2009 8641
2010 9547
2011 10544
2012 11284
2013 11333
2014 11583
2015 12155
2016 11808
2017 11703
2018 11999
2019 12476
2020 11935
2021 10469
2022 7165
2023 5942
2024 6639
2025 6244
2026 1582

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219,351 results

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Page 1
Cadherins down-regulation: towards a better understanding of their relevance in colorectal cancer.
Losi L, Zanocco-Marani T, Grande A. Losi L, et al. Histol Histopathol. 2020 Dec;35(12):1391-1402. doi: 10.14670/HH-18-236. Epub 2020 Jun 22. Histol Histopathol. 2020. PMID: 32567668 Review.
The down-regulation of cadherin expression in colorectal cancer (CRC) has been widely studied. ...This review examines published studies on cadherins whose down-regulation has been already demonstrated in CRC, trying to establish a relationship with pr …
The down-regulation of cadherin expression in colorectal cancer (CRC) has been widely studied. ...This review examines publish …
Differential down-regulation of alpha-2 adrenergic receptor subtypes.
Heck DA, Bylund DB. Heck DA, et al. Life Sci. 1998;62(17-18):1467-72. doi: 10.1016/s0024-3205(98)00091-5. Life Sci. 1998. PMID: 9585120 Review.
Our previous studies have shown significant differences in the concentration of agonist required to produce down-regulation of alpha-2 adrenergic receptor subtypes (3;4). Here we review the mechanisms and molecular determinants for receptor down-regulation …
Our previous studies have shown significant differences in the concentration of agonist required to produce down-regulation of …
Neurofunctional alterations of cognitive down-regulation of craving in quitting motivated smokers.
Kunas SL, Stuke H, Plank IS, Laing EM, Bermpohl F, Ströhle A. Kunas SL, et al. Psychol Addict Behav. 2022 Dec;36(8):1012-1022. doi: 10.1037/adb0000820. Epub 2022 Feb 17. Psychol Addict Behav. 2022. PMID: 35175067
OBJECTIVE: Cognitive down-regulation of craving involves a neural network within the prefrontal cortex. Tobacco use disorder (TUD) and trait impulsivity have been associated with prefrontal cortex impairments and down-regulation deficits. ...Subjects a …
OBJECTIVE: Cognitive down-regulation of craving involves a neural network within the prefrontal cortex. Tobacco use disorder ( …
Down-regulation of allergic responses in conditions of experimental diabetes: a role for glucocorticoids?
e Silva PM, Carvalho VF, Cordeiro RS, Martins MA. e Silva PM, et al. Neuroimmunomodulation. 2009 Jan;16(1):13-8. doi: 10.1159/000179662. Epub 2008 Dec 15. Neuroimmunomodulation. 2009. PMID: 19077441 Review.
Previously published studies suggest that the Th1/Th2 concept could explain the inverse relationship between allergic diseases and type 1 diabetes. However, down-regulation of the IgE-mast cell system can also markedly contribute to the lack of responsiveness to loc …
Previously published studies suggest that the Th1/Th2 concept could explain the inverse relationship between allergic diseases and type 1 di …
[Down regulation].
Ogawa R. Ogawa R. Masui. 1998 Dec;47 Suppl:S88-92. Masui. 1998. PMID: 9921169 Review. Japanese. No abstract available.
Up- and down-regulation of adiponectin expression and multimerization: mechanisms and therapeutic implication.
Liu M, Liu F. Liu M, et al. Biochimie. 2012 Oct;94(10):2126-30. doi: 10.1016/j.biochi.2012.01.008. Epub 2012 Feb 10. Biochimie. 2012. PMID: 22342903 Free PMC article. Review.
The precise mechanisms underlying adiponectin up- and down-regulation remain largely unknown, but recent studies indicate that the cellular and plasma levels of adiponectin could be regulated at both transcriptional and post-transcriptional levels. At the post-trans …
The precise mechanisms underlying adiponectin up- and down-regulation remain largely unknown, but recent studies indicate that …
Long-term pituitary down-regulation pretreatment for endometriosis - chronicles of guidelines and recommendations.
Michaeli J, Dior UP, Fainaru O, Revel A. Michaeli J, et al. Reprod Biomed Online. 2022 Nov;45(5):843-846. doi: 10.1016/j.rbmo.2022.08.095. Epub 2022 Aug 9. Reprod Biomed Online. 2022. PMID: 36151012
It was suggested in the 1980s that long-term pituitary down-regulation by a gonadotrophin-releasing hormone agonist, termed the ultra-long protocol, inducing a hypo-oestrogenic state, might improve reproductive outcomes in women with endometriosis. Subsequently, int …
It was suggested in the 1980s that long-term pituitary down-regulation by a gonadotrophin-releasing hormone agonist, termed th …
Inducible down-regulation of MHC class I results in natural killer cell tolerance.
Bern MD, Parikh BA, Yang L, Beckman DL, Poursine-Laurent J, Yokoyama WM. Bern MD, et al. J Exp Med. 2019 Jan 7;216(1):99-116. doi: 10.1084/jem.20181076. Epub 2018 Dec 17. J Exp Med. 2019. PMID: 30559128 Free PMC article.
Global down-regulation of MHC-I induced NK cell hyporesponsiveness and tolerance to missing-self without overt missing-self reactivity. In contrast, down-regulation of MHC-I on a small fraction of hematopoietic cells triggered missing-self reactivity. …
Global down-regulation of MHC-I induced NK cell hyporesponsiveness and tolerance to missing-self without overt missing-self re …
Fluid shear stress-induced down-regulation of miR-146a-5p inhibits osteoblast apoptosis via targeting SMAD4.
Liu X, Zhang K, Wang L, Geng B, Liu Z, Yi Q, Xia Y. Liu X, et al. Physiol Res. 2022 Dec 16;71(6):835-848. doi: 10.33549/physiolres.934922. Epub 2022 Oct 13. Physiol Res. 2022. PMID: 36281726 Free PMC article.
FSS could down-regulate the expression of miR-146a-5p in MC3T3-E1 cells. We confirm that up-regulation of miR-146a-5p promotes osteoblasts apoptosis and down-regulation of miR-146a-5p inhibits osteoblasts apoptosis. ...Taken together, our present study showed …
FSS could down-regulate the expression of miR-146a-5p in MC3T3-E1 cells. We confirm that up-regulation of miR-146a-5p promotes osteob …
219,351 results
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