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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1910 1
1959 1
1963 1
1964 1
1965 1
1967 4
1969 2
1970 4
1972 1
1973 3
1974 2
1975 15
1976 17
1977 18
1978 29
1979 39
1980 66
1981 97
1982 144
1983 230
1984 272
1985 352
1986 393
1987 530
1988 668
1989 917
1990 1271
1991 1624
1992 1708
1993 1969
1994 2332
1995 2701
1996 3125
1997 3365
1998 3860
1999 4095
2000 4812
2001 5454
2002 6168
2003 7185
2004 8211
2005 9591
2006 10767
2007 11605
2008 12793
2009 13534
2010 15265
2011 17022
2012 18682
2013 19782
2014 21131
2015 23008
2016 23367
2017 25680
2018 27562
2019 30255
2020 32900
2021 33769
2022 32380
2023 29262
2024 30083
2025 35716
2026 22039
2027 2

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498,693 results

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Page 1
Down-regulation of hepatic CLOCK by PPARalpha is involved in inhibition of NAFLD.
Luo J, Yan Z, Dai M, Xu L, Zhang H, Xi Y, Yang J, Liu A. Luo J, et al. J Mol Med (Berl). 2023 Feb;101(1-2):139-149. doi: 10.1007/s00109-022-02279-z. Epub 2022 Dec 17. J Mol Med (Berl). 2023. PMID: 36527474
Down-regulation of hepatic CLOCK by basal PPARalpha contributes to tolerance against development of NAFLD. ...PPARalpha mediated modifications of circadian rhythm and the hepatic circadian factor CLOCK in NAFLD models. Down-regulation of hepatic CLOC …
Down-regulation of hepatic CLOCK by basal PPARalpha contributes to tolerance against development of NAFLD. ...PPARalpha mediat …
CD45 engagement induces L-selectin down-regulation.
Stibenz D, Bührer C, Laufer D, Obladen M. Stibenz D, et al. Scand J Immunol. 1996 Jul;44(1):37-44. doi: 10.1046/j.1365-3083.1996.d01-282.x. Scand J Immunol. 1996. PMID: 8693290
Monoclonal antibodies (MoAbs) IOL1b and AICD45.2, but not GAP8.3, all of which are directed against common CD45 epitopes, were found to elicit lymphocyte L-selectin down-regulation. Lymphocyte L-selectin down-regulation in response to anti-CD45 MoAbs w …
Monoclonal antibodies (MoAbs) IOL1b and AICD45.2, but not GAP8.3, all of which are directed against common CD45 epitopes, were found to elic …
Fluid shear stress-induced down-regulation of miR-146a-5p inhibits osteoblast apoptosis via targeting SMAD4.
Liu X, Zhang K, Wang L, Geng B, Liu Z, Yi Q, Xia Y. Liu X, et al. Physiol Res. 2022 Dec 16;71(6):835-848. doi: 10.33549/physiolres.934922. Epub 2022 Oct 13. Physiol Res. 2022. PMID: 36281726 Free PMC article.
FSS could down-regulate the expression of miR-146a-5p in MC3T3-E1 cells. We confirm that up-regulation of miR-146a-5p promotes osteoblasts apoptosis and down-regulation of miR-146a-5p inhibits osteoblasts apoptosis. ...Taken together, our present study showed …
FSS could down-regulate the expression of miR-146a-5p in MC3T3-E1 cells. We confirm that up-regulation of miR-146a-5p promotes osteob …
Small-Molecule Kinase Downregulators.
Jones LH. Jones LH. Cell Chem Biol. 2018 Jan 18;25(1):30-35. doi: 10.1016/j.chembiol.2017.10.011. Epub 2017 Nov 22. Cell Chem Biol. 2018. PMID: 29174540 Free article. Review.
New opportunities to advance small-molecule kinase ligands that downregulate their cognate target binding proteins are discussed. Rationally designed heterobifunctional kinase degraders are compared with ATP site ligands that were serendipitously found to cause kinase d …
New opportunities to advance small-molecule kinase ligands that downregulate their cognate target binding proteins are discussed. Rat …
Inducible down-regulation of MHC class I results in natural killer cell tolerance.
Bern MD, Parikh BA, Yang L, Beckman DL, Poursine-Laurent J, Yokoyama WM. Bern MD, et al. J Exp Med. 2019 Jan 7;216(1):99-116. doi: 10.1084/jem.20181076. Epub 2018 Dec 17. J Exp Med. 2019. PMID: 30559128 Free PMC article.
Global down-regulation of MHC-I induced NK cell hyporesponsiveness and tolerance to missing-self without overt missing-self reactivity. In contrast, down-regulation of MHC-I on a small fraction of hematopoietic cells triggered missing-self reactivity. …
Global down-regulation of MHC-I induced NK cell hyporesponsiveness and tolerance to missing-self without overt missing-self re …
Down-regulation and release of CD14 on human monocytes by IL-4 depends on the presence of serum or GM-CSF.
Ruppert J, Schütt C, Ostermeier D, Peters JH. Ruppert J, et al. Adv Exp Med Biol. 1993;329:281-6. doi: 10.1007/978-1-4615-2930-9_47. Adv Exp Med Biol. 1993. PMID: 7691031
IL-4 induces down-regulation of CD14 expression on human monocytes only when the cells are cultured with serum. ...On day 6, high amounts of CD14 molecules were detected in the SUP of these cultures, whereas intracellular immunofluorescence staining revealed no dete …
IL-4 induces down-regulation of CD14 expression on human monocytes only when the cells are cultured with serum. ...On day 6, h …
Physiological and pathophysiological down-regulation of cough.
Widdicombe J, Singh V. Widdicombe J, et al. Respir Physiol Neurobiol. 2006 Feb 28;150(2-3):105-17. doi: 10.1016/j.resp.2005.04.013. Respir Physiol Neurobiol. 2006. PMID: 15878697 Review.
Recent clinical studies have emphasized the up-regulation (sensitization) of cough in pathological conditions of the airways. However there are also many situations where voluntary and reflex cough can be down-regulated. ...
Recent clinical studies have emphasized the up-regulation (sensitization) of cough in pathological conditions of the airways. However …
The influence of emotion down-regulation on the expectation of sexual reward.
Brom M, Laan E, Everaerd W, Spinhoven P, Cousijn J, Both S. Brom M, et al. Behav Ther. 2015 May;46(3):379-94. doi: 10.1016/j.beth.2015.01.005. Epub 2015 Feb 17. Behav Ther. 2015. PMID: 25892173
Emotion regulation research has shown successful altering of unwanted aversive emotional reactions. ...A differential conditioning paradigm was applied, with genital vibrostimulation as unconditioned stimulus (US) and sexually relevant pictures as conditional stimuli (CSs) …
Emotion regulation research has shown successful altering of unwanted aversive emotional reactions. ...A differential conditioning pa …
Meta-analytic evidence for downregulation of the amygdala during working memory maintenance.
de Voogd LD, Hermans EJ. de Voogd LD, et al. Hum Brain Mapp. 2022 Jun 15;43(9):2951-2971. doi: 10.1002/hbm.25828. Epub 2022 Mar 29. Hum Brain Mapp. 2022. PMID: 35349194 Free PMC article.
The amygdala is a region critically implicated in affective processes. Downregulation of the amygdala is one of the hallmarks of successful emotion regulation. Top-down inhibition of the amygdala is thought to involve activation of the executive control network. Thi …
The amygdala is a region critically implicated in affective processes. Downregulation of the amygdala is one of the hallmarks of succ …
Distraction and expressive suppression strategies in down-regulation of high- and low-intensity positive emotions.
Li P, Zhu C, Leng Y, Luo W. Li P, et al. Int J Psychophysiol. 2020 Dec;158:56-61. doi: 10.1016/j.ijpsycho.2020.09.010. Epub 2020 Oct 17. Int J Psychophysiol. 2020. PMID: 33080296
Emotion intensity is important for emotional regulation process. The studies in this literature, however, have generally focused on the down-regulation of negative emotions. Few studies have examined the down-regulation of positive emotions. Dis …
Emotion intensity is important for emotional regulation process. The studies in this literature, however, have generally focused on t …
498,693 results
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